SitesBLAST
Comparing PP_3073 FitnessBrowser__Putida:PP_3073 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2q2qD Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
95% identity, 100% coverage: 2:256/256 of query aligns to 1:255/255 of 2q2qD
- active site: G15 (= G16), S138 (= S139), Y151 (= Y152), K155 (= K156), R196 (= R197)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), F36 (= F37), D59 (= D60), L60 (= L61), N86 (= N87), G88 (= G89), L109 (= L110), I136 (= I137), S138 (= S139), Y151 (= Y152), K155 (= K156), P181 (= P182), G182 (= G183), W183 (= W184), V184 (= V185), T186 (= T187), L188 (= L189), V189 (= V190)
5yssB Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
69% identity, 99% coverage: 3:256/256 of query aligns to 2:255/255 of 5yssB
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), G35 (= G36), F36 (= F37), L60 (= L61), N86 (= N87), G88 (= G89), I89 (= I90), A137 (= A138), Y151 (= Y152), K155 (= K156), P181 (= P182), G182 (= G183), V184 (= V185), T186 (= T187)
2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate (see paper)
60% identity, 99% coverage: 3:256/256 of query aligns to 2:260/260 of 2ztlA
- active site: G15 (= G16), N114 (= N111), S142 (= S139), Y155 (= Y152), K159 (= K156), L200 (≠ R197)
- binding (3s)-3-hydroxybutanoic acid: Q94 (= Q91), S142 (= S139), H144 (= H141), K152 (= K149), Y155 (= Y152), Q196 (= Q193)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), G15 (= G16), I16 (= I17), F36 (= F37), L64 (= L61), N90 (= N87), A91 (= A88), G92 (= G89), L113 (= L110), Y155 (= Y152), K159 (= K156), P185 (= P182), W187 (= W184), V188 (= V185), T190 (= T187), V193 (= V190)
1wmbA Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
60% identity, 99% coverage: 3:256/256 of query aligns to 2:260/260 of 1wmbA
5b4tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
59% identity, 99% coverage: 3:256/256 of query aligns to 2:260/260 of 5b4tA
- active site: G15 (= G16), N114 (= N111), S142 (= S139), Y155 (= Y152), K159 (= K156), I200 (vs. gap)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q91), S142 (= S139), H144 (= H141), K152 (= K149), Y155 (= Y152), W187 (= W184), Q196 (= Q193)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), G15 (= G16), I16 (= I17), F36 (= F37), D63 (= D60), L64 (= L61), N90 (= N87), G92 (= G89), L113 (= L110), I140 (= I137), Y155 (= Y152), K159 (= K156), P185 (= P182), G186 (= G183), W187 (= W184), V188 (= V185), T190 (= T187), L192 (= L189), V193 (= V190)
3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
59% identity, 99% coverage: 3:256/256 of query aligns to 2:260/260 of 3w8dA
- active site: G15 (= G16), N114 (= N111), S142 (= S139), Y155 (= Y152), K159 (= K156), I200 (vs. gap)
- binding methylmalonic acid: Q94 (= Q91), S142 (= S139), H144 (= H141), K152 (= K149), Y155 (= Y152), W187 (= W184), Q196 (= Q193), W257 (= W253)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), F36 (= F37), A62 (= A59), D63 (= D60), L64 (= L61), N90 (= N87), A91 (= A88), G92 (= G89), L113 (= L110), S142 (= S139), Y155 (= Y152), K159 (= K156), P185 (= P182), G186 (= G183), W187 (= W184), V188 (= V185), T190 (= T187), L192 (= L189), V193 (= V190)
3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+) (see paper)
59% identity, 99% coverage: 3:256/256 of query aligns to 2:260/260 of 3vdrA
- active site: G15 (= G16), N114 (= N111), S142 (= S139), Y155 (= Y152), K159 (= K156), I200 (vs. gap)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q91), H144 (= H141), K152 (= K149), Y155 (= Y152), W187 (= W184), Q196 (= Q193), W257 (= W253)
- binding acetoacetic acid: Q94 (= Q91), H144 (= H141), K152 (= K149), Y155 (= Y152), W187 (= W184), Q196 (= Q193), W257 (= W253)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), I16 (= I17), F36 (= F37), D63 (= D60), L64 (= L61), N90 (= N87), A91 (= A88), G92 (= G89), L113 (= L110), K159 (= K156), G186 (= G183), V188 (= V185), T190 (= T187), L192 (= L189), V193 (= V190)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G12), T13 (= T14), I16 (= I17), F36 (= F37), D63 (= D60), L64 (= L61), N90 (= N87), A91 (= A88), G92 (= G89), L113 (= L110), S142 (= S139), Y155 (= Y152), K159 (= K156), G186 (= G183), V188 (= V185), T190 (= T187), L192 (= L189), V193 (= V190)
3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate (see paper)
59% identity, 99% coverage: 3:256/256 of query aligns to 2:260/260 of 3vdqA
- active site: G15 (= G16), N114 (= N111), S142 (= S139), Y155 (= Y152), K159 (= K156), I200 (vs. gap)
- binding acetate ion: Q94 (= Q91), H144 (= H141), K152 (= K149), W187 (= W184), L192 (= L189), Q196 (= Q193)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), S14 (= S15), I16 (= I17), F36 (= F37), D63 (= D60), L64 (= L61), N90 (= N87), A91 (= A88), G92 (= G89), L113 (= L110), I140 (= I137), S142 (= S139), Y155 (= Y152), K159 (= K156), P185 (= P182), G186 (= G183), W187 (= W184), V188 (= V185), T190 (= T187), L192 (= L189), V193 (= V190)
1x1tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
56% identity, 99% coverage: 3:256/256 of query aligns to 2:236/236 of 1x1tA
- active site: G15 (= G16), N114 (= N111), S142 (= S139), Y155 (= Y152), K159 (= K156)
- binding cacodylate ion: S142 (= S139), H144 (= H141), Y155 (= Y152), W187 (= W184), W233 (= W253)
- binding nicotinamide-adenine-dinucleotide: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), G35 (= G36), F36 (= F37), D63 (= D60), L64 (= L61), N90 (= N87), G92 (= G89), L113 (= L110), S142 (= S139), Y155 (= Y152), K159 (= K156), P185 (= P182), W187 (= W184), V188 (= V185), T190 (= T187)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
42% identity, 99% coverage: 3:256/256 of query aligns to 5:261/261 of 6zzsD
- active site: G18 (= G16), S143 (= S139), Y156 (= Y152)
- binding nicotinamide-adenine-dinucleotide: G14 (= G12), S17 (= S15), I19 (= I17), D38 (≠ G36), M39 (≠ F37), D64 (= D60), V65 (≠ L61), N91 (= N87), A92 (= A88), G93 (= G89), M141 (≠ I137), A142 (= A138), S143 (= S139), Y156 (= Y152), K160 (= K156), P186 (= P182), G187 (= G183), V189 (= V185), T191 (= T187), L193 (= L189)
- binding 3-oxidanylidenepentanoic acid: Q95 (= Q91), S143 (= S139), N145 (≠ H141), K153 (= K149), Y156 (= Y152), Q197 (= Q193)
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
42% identity, 99% coverage: 3:256/256 of query aligns to 4:260/260 of 6zzqA
- active site: G17 (= G16), S142 (= S139), Y155 (= Y152)
- binding acetoacetic acid: Q94 (= Q91), S142 (= S139), K152 (= K149), Y155 (= Y152), Q196 (= Q193)
- binding nicotinamide-adenine-dinucleotide: G13 (= G12), S16 (= S15), G17 (= G16), I18 (= I17), D37 (≠ G36), M38 (≠ F37), D63 (= D60), V64 (≠ L61), N90 (= N87), A91 (= A88), G92 (= G89), M140 (≠ I137), A141 (= A138), S142 (= S139), Y155 (= Y152), K159 (= K156), Y187 (≠ W184), V188 (= V185), T190 (= T187)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
40% identity, 99% coverage: 1:254/256 of query aligns to 1:246/247 of 4jroC
- active site: G16 (= G16), S142 (= S139), Q152 (≠ K149), Y155 (= Y152), K159 (= K156)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (≠ T14), R15 (≠ S15), G16 (= G16), I17 (= I17), N35 (= N35), Y36 (≠ G36), N37 (≠ F37), G38 (= G38), S39 (≠ D39), N63 (≠ D60), V64 (≠ L61), N90 (= N87), A91 (= A88), I93 (= I90), I113 (≠ L110), S142 (= S139), Y155 (= Y152), K159 (= K156), P185 (= P182), I188 (≠ V185), T190 (= T187)
7tzpG Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
39% identity, 99% coverage: 1:254/256 of query aligns to 4:246/247 of 7tzpG
- binding 1,4-dihydronicotinamide adenine dinucleotide: G15 (= G12), R18 (≠ S15), G19 (= G16), I20 (= I17), D39 (≠ G36), R40 (≠ F37), C63 (≠ A59), I65 (≠ L61), N91 (= N87), G93 (= G89), I94 (= I90), V114 (≠ L110), Y155 (= Y152), K159 (= K156), I188 (≠ V185), T190 (= T187), T193 (≠ V190)
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
36% identity, 99% coverage: 3:255/256 of query aligns to 3:247/248 of 6ixmC
- active site: G16 (= G16), S142 (= S139), Y155 (= Y152), K159 (= K156)
- binding nicotinamide-adenine-dinucleotide: G12 (= G12), S15 (= S15), G16 (= G16), I17 (= I17), D36 (≠ G36), I37 (≠ F37), A61 (= A59), D62 (= D60), T63 (≠ L61), N89 (= N87), A90 (= A88), M140 (≠ I137), S142 (= S139), Y155 (= Y152), K159 (= K156), P185 (= P182), A186 (≠ G183), Y187 (≠ W184), I188 (≠ V185), L192 (= L189)
2rh4B Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin (see paper)
36% identity, 98% coverage: 2:252/256 of query aligns to 10:264/268 of 2rh4B
- active site: G24 (= G16), N121 (= N111), S151 (= S139), Y164 (= Y152), K168 (= K156), Y209 (≠ R197)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G20 (= G12), T22 (= T14), S23 (= S15), I25 (= I17), A44 (≠ G36), R45 (≠ F37), G46 (= G38), C69 (≠ A59), D70 (= D60), V71 (≠ L61), N97 (= N87), S151 (= S139), Y164 (= Y152), K168 (= K156), G195 (= G183), V197 (= V185), T199 (= T187), M201 (≠ L189)
P16544 Putative ketoacyl reductase; EC 1.3.1.- from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see 2 papers)
36% identity, 98% coverage: 2:252/256 of query aligns to 3:257/261 of P16544
- 11:39 (vs. 10:38, 48% identical) binding
- D63 (= D60) binding
- K161 (= K156) binding
1w4zA Structure of actinorhodin polyketide (actiii) reductase (see paper)
36% identity, 98% coverage: 2:252/256 of query aligns to 1:255/259 of 1w4zA
- active site: G15 (= G16), N112 (= N111), S142 (= S139), Y155 (= Y152), K159 (= K156), Y200 (≠ R197)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G12), T13 (= T14), S14 (= S15), G15 (= G16), I16 (= I17), R36 (≠ F37), G37 (= G38), D61 (= D60), V62 (≠ L61), N88 (= N87), G90 (= G89), S142 (= S139), Y155 (= Y152), K159 (= K156), P185 (= P182), G186 (= G183), V188 (= V185), T190 (= T187)
2rh4A Actinorhodin ketoreductase, actkr, with NADPH and inhibitor emodin (see paper)
36% identity, 97% coverage: 4:252/256 of query aligns to 1:253/257 of 2rh4A
- active site: G13 (= G16), N110 (= N111), S140 (= S139), Y153 (= Y152), K157 (= K156), Y198 (≠ R197)
- binding 3-methyl-1,6,8-trihydroxyanthraquinone: T141 (≠ V140), Q145 (≠ V144), V147 (≠ S146), Y153 (= Y152), F185 (≠ W184)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G9 (= G12), T11 (= T14), S12 (= S15), G13 (= G16), I14 (= I17), A33 (≠ G36), R34 (≠ F37), G35 (= G38), C58 (≠ A59), D59 (= D60), V60 (≠ L61), N86 (= N87), G88 (= G89), S140 (= S139), Y153 (= Y152), K157 (= K156), P183 (= P182), G184 (= G183), V186 (= V185), T188 (= T187), M190 (≠ L189)
Sites not aligning to the query:
1xr3A Actinorhodin polyketide ketoreductase with NADP and the inhibitor isoniazid bound (see paper)
36% identity, 96% coverage: 6:252/256 of query aligns to 2:252/256 of 1xr3A
- active site: G12 (= G16), N109 (= N111), S139 (= S139), Y152 (= Y152), K156 (= K156), Y197 (≠ R197)
- binding 4-(diazenylcarbonyl)pyridine: T140 (≠ V140), G141 (≠ H141), V146 (≠ S146)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G12), T10 (= T14), S11 (= S15), G12 (= G16), I13 (= I17), A32 (≠ G36), R33 (≠ F37), G34 (= G38), C57 (≠ A59), D58 (= D60), V59 (≠ L61), N85 (= N87), A86 (= A88), G87 (= G89), S139 (= S139), Y152 (= Y152), K156 (= K156), G183 (= G183), V185 (= V185), T187 (= T187), P188 (= P188)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
34% identity, 99% coverage: 1:253/256 of query aligns to 4:244/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G12), S17 (≠ T14), R18 (≠ S15), I20 (= I17), T40 (vs. gap), N62 (≠ D60), V63 (≠ L61), N89 (= N87), A90 (= A88), I92 (= I90), V139 (≠ I137), S141 (= S139), Y154 (= Y152), K158 (= K156), P184 (= P182), G185 (= G183), I187 (≠ V185), T189 (= T187), M191 (≠ L189)
Query Sequence
>PP_3073 FitnessBrowser__Putida:PP_3073
MTLEGKTALVTGSTSGIGLGIAQVLARAGANIVLNGFGDPGPAMAEIARHGVKVVHHPAD
LSDVVQIEALFNLAEREFGGVDILVNNAGIQHVAPVEQFPPESWDKIIALNLSAVFHGTR
LALPGMRTRNWGRIINIASVHGLVGSIGKAAYVAAKHGVIGLTKVVGLETATSHVTCNAI
CPGWVLTPLVQKQIDDRAAKGGDRLQAQHDLLAEKQPSLAFVTPEHLGELVLFLCSEAGS
QVRGAAWNVDGGWLAQ
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory