SitesBLAST

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
31% identity, 61% coverage: 61:202/231 of query aligns to 64:196/203 of P07464

query
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P07464

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S71 (≠ A68) binding substrate
N85 (= N83) binding in other chain; binding in other chain
D93 (≠ P91) binding substrate
H115 (= H110) mutation to A: Results in an 1800-fold decrease in catalytic activity.
S142 (≠ H141) binding in other chain
A160 (= A159) binding in other chain
TK 165:166 (= TK 164:165) binding acetyl-CoA
R180 (≠ Q186) binding acetyl-CoA
R183 (≠ K189) binding in other chain

Sites not aligning to the query:

1 modified: Initiator methionine, Removed; Partial
17 binding substrate

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal (see paper)
31% identity, 61% coverage: 61:202/231 of query aligns to 63:195/201 of 1krvA

query
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1krvA

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binding 4-nitrophenyl beta-D-galactopyranoside: S70 (≠ A68), Y82 (= Y81), N84 (= N83), V90 (≠ L89), D92 (≠ P91), M126 (≠ S127)
binding coenzyme a: A104 (≠ S103), S110 (≠ T106), T112 (≠ I108), W138 (≠ F138), G140 (= G140), S141 (≠ H141), N146 (≠ M146), A159 (= A159), P177 (= P177), R179 (≠ Q186), R182 (≠ K189)

Sites not aligning to the query:

binding 4-nitrophenyl beta-D-galactopyranoside: 16, 25

1kruA Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
31% identity, 61% coverage: 61:202/231 of query aligns to 63:195/201 of 1kruA

query
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1kruA

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binding coenzyme a: H114 (= H110), W138 (≠ F138), G140 (= G140), S141 (≠ H141), G158 (≠ A158), A159 (= A159), P177 (= P177), R182 (≠ K189)
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: S70 (≠ A68), Y82 (= Y81), Y82 (= Y81), N84 (= N83), V90 (≠ L89), D92 (≠ P91), L102 (≠ G101), H114 (= H110), M126 (≠ S127)

Sites not aligning to the query:

binding 1-methylethyl 1-thio-beta-D-galactopyranoside: 16, 22, 25, 62

1krrA Galactoside acetyltransferase in complex with acetyl-coenzyme a (see paper)
31% identity, 61% coverage: 61:202/231 of query aligns to 63:195/200 of 1krrA

query
sites
1krrA

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binding acetyl coenzyme *a: N84 (= N83), I103 (≠ L102), A104 (≠ S103), P105 (vs. gap), T112 (≠ I108), H114 (= H110), G140 (= G140), S141 (≠ H141), N146 (≠ M146), G158 (≠ A158), A159 (= A159), A174 (≠ G174), P177 (= P177), R182 (≠ K189)

3fscA Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-fucose (see paper)
43% identity, 25% coverage: 143:200/231 of query aligns to 181:237/259 of 3fscA

query
sites
3fscA

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binding coenzyme a: G196 (≠ A158), A197 (= A159), V212 (≠ G174), K228 (≠ R190)

Sites not aligning to the query:

3fs8A Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with acetyl-coa (see paper)
43% identity, 25% coverage: 143:200/231 of query aligns to 181:237/259 of 3fs8A

query
sites
3fs8A

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binding acetyl coenzyme *a: G196 (≠ A158), A197 (= A159), V212 (≠ G174), K228 (≠ R190)

Sites not aligning to the query:

binding acetyl coenzyme *a: 150, 151, 178, 179
binding thymine: 84, 102

3fsbA Crystal structure of qdtc, the dtdp-3-amino-3,6-dideoxy-d-glucose n- acetyl transferase from thermoanaerobacterium thermosaccharolyticum in complex with coa and dtdp-3-amino-quinovose (see paper)
43% identity, 25% coverage: 143:200/231 of query aligns to 181:237/260 of 3fsbA

query
sites
3fsbA

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binding coenzyme a: G196 (≠ A158), A197 (= A159), V212 (≠ G174)

Sites not aligning to the query:

4hurA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with acetyl coenzyme a (see paper)
47% identity, 26% coverage: 123:181/231 of query aligns to 105:163/211 of 4hurA

query
sites
4hurA

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binding acetyl coenzyme *a: K110 (≠ V128), W120 (≠ F138), I121 (= I139), G122 (= G140), R123 (≠ H141), M128 (= M146), A140 (= A158), A141 (= A159), T146 (= T164), G156 (= G174), P159 (= P177), I163 (= I181)

Sites not aligning to the query:

binding acetyl coenzyme *a: 51, 67, 68, 69, 79, 80, 164

6x3cA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f1037 (47) (see paper)
47% identity, 26% coverage: 123:181/231 of query aligns to 105:163/207 of 6x3cA

query
sites
6x3cA

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binding thioacetic acid s-{2-[3-(2-hydroxy-3,3-dimethyl-4-phosphonooxy-butyrylamino)-propionylamino]-ethyl} ester: W120 (≠ F138), G122 (= G140), R123 (≠ H141), M128 (= M146), A140 (= A158), A141 (= A159)

Sites not aligning to the query:

4husA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with virginiamycin m1 (see paper)
47% identity, 26% coverage: 123:181/231 of query aligns to 105:163/212 of 4husA

query
sites
4husA

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Sites not aligning to the query:

binding virginiamycin m1: 17, 36, 38

6x3jA Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f0224 (46) (see paper)
47% identity, 26% coverage: 123:181/231 of query aligns to 105:163/206 of 6x3jA

query
sites
6x3jA

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Sites not aligning to the query:

3nz2J Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
30% identity, 50% coverage: 66:181/231 of query aligns to 67:181/185 of 3nz2J

query
sites
3nz2J

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I

S

R

V

I

G

G

S

D

N

H

F

T

Y

F

V

I

N

N

T

M

G

N

C

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K

V

F

M

L

L

D

D

P

G

S

A

L

P

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R

T

I

I

G

G

N

D

S

H

V

V

G

L

L

I

S
x
G

D

P

C

S

T

T

L

Q

I

F

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x
Y

H

T

D

A

G

S

V
x
H

V

S

L

L

L

-

I

-

E

D

H

Y

R

R

F

R

G

R

K

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L

W

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E

S

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I

-

C

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I

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D

D

N

D

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x
W

I

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G

H

G

G

N

A

V

I

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V

I

M

N

P

Q

R

G

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V

T

T

I

I

G

G

P

A

E

R

S

S

I

V

V

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A
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A

G

N

A

S

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x
N

K

Q

D

D

V

V

P

P

G

D

T

T

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G

G

G

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x
T

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P

A

A

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binding acetyl coenzyme *a: G104 (≠ S103), Y110 (≠ G109), H114 (≠ V113), W138 (≠ F138), G140 (= G140), A158 (= A158), A159 (= A159), N164 (≠ T164), G174 (= G174), T176 (≠ N176), P177 (= P177)

Sites not aligning to the query:

binding acetyl coenzyme *a: 182

3ectA Crystal structure of the hexapeptide-repeat containing- acetyltransferase vca0836 from vibrio cholerae
30% identity, 50% coverage: 66:181/231 of query aligns to 57:171/176 of 3ectA

query
sites
3ectA

Y

F

L

H

A

C

R

E

W

F

G

G

N

K

F

T

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N

H

F

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Y

F

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I

N

N

T

M

G

N

C

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K

V

F

M

L

L

D

D

P

G

S

A

L

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T

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I

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G

N

D

S

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V

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L

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C

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T

T

L

Q

I

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G

Y

H

T

D

A

G

S

V

H

V

S

L

L

L

-

I

-

E

D

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Y

R

R

F

R

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W

I

I

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G

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G

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A

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x
G

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V

T

T

I

I

G

G

P

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R

S

S

I

V

V

V

A

A

G

N

A

S

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D
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D

V

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P

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T

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L

Y

V

G

G

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T

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P

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binding calcium ion: G138 (≠ R148), D156 (= D166)

6x3cE Crystal structure of streptogramin a acetyltransferase vata from staphylococcus aureus in complex with streptogramin analog f1037 (47) (see paper)
47% identity, 26% coverage: 123:181/231 of query aligns to 105:163/203 of 6x3cE

query
sites
6x3cE

K

K

H

D

L

L

D

P

S

L

V

K

G

G

F

D

I

I

D

E

I

I

K

G

D

N

N

D

C

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F
x
W

I

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G
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G

H

R

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A

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M

M

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G

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V

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K

I

I

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E

G

S

A

I

I

V

I

A
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A

G

E

A

A

V

V

T

T

K

K

D

N

V

V

P

A

P

P

G

Y

T

S

V

I

Y

V

G

G

N
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N

P
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P

A

L

E

K

F

F

I

I

binding magnesium ion: N158 (= N176), P159 (= P177)
binding thioacetic acid s-{2-[3-(2-hydroxy-3,3-dimethyl-4-phosphonooxy-butyrylamino)-propionylamino]-ethyl} ester: W120 (≠ F138), G122 (= G140), A140 (= A158), A141 (= A159)

Sites not aligning to the query:

3nz2C Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
30% identity, 50% coverage: 66:181/231 of query aligns to 64:178/183 of 3nz2C

query
sites
3nz2C

Y

F

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K

F

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N

H

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Y

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N

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x
Y

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x
H

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S

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L

L

-

I

-

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Y

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G

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T

I

I

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G

P

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S

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A

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x
N

A

S

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T
x
N

K

Q

D

D

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G

G

G

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x
T

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P

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x
L

binding acetyl coenzyme *a: Y107 (≠ G109), H111 (≠ V113), G137 (= G140), A155 (= A158), A156 (= A159), N161 (≠ T164), G171 (= G174), T173 (≠ N176), P174 (= P177), L178 (≠ I181)
binding magnesium ion: N157 (≠ G160), T173 (≠ N176)

Sites not aligning to the query:

binding acetyl coenzyme *a: 179

8bpxy Cytochrome b-c1 complex subunit Rieske-1, mitochondrial (see paper)
31% identity, 48% coverage: 78:188/231 of query aligns to 90:198/265 of 8bpxy

query
sites
8bpxy

S

N

N

N

F

I

Y

S

V

V

N

G

T

S

G

G

C

T

K

N

F

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N

S

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L

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x
H

I

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A

-

K

-

T

N

N

S

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G

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K

S

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L

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T

T

L

L

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I

G

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G

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I

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G

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H

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F

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M

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G

A

A

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M

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E

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A
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A

G

G

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S

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L

V

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K

K

Q

D

N

-

T

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R

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P

S

G

G

T

E

V

V

Y

W

G

G

N

N

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P

A

A

E

K

F

F

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x
M

-
x
R

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K

C

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T

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E

E

Q

E

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binding crotonyl coenzyme a: F144 (= F138), G146 (= G140), M147 (≠ H141), A164 (= A158), A165 (= A159), M189 (≠ I181), R190 (vs. gap)
binding zinc ion: H107 (≠ R95), H135 (≠ G129)

Sites not aligning to the query:

binding crotonyl coenzyme a: 203
binding : 1, 4, 5, 8, 9

8befy Cryo-em structure of the arabidopsis thaliana i+iii2 supercomplex (ci membrane core) (see paper)
31% identity, 48% coverage: 78:188/231 of query aligns to 90:198/265 of 8befy

query
sites
8befy

S

N

N

N

F

I

Y

S

V

V

N

G

T

S

G

G

C

T

K

N

F

I

L

Q

D

D

P

N

S

T

L

L

V

V

R
x
H

I

V

G

A

-

K

-

T

N

N

S

I

V

S

G

G

L

K

S

V

D

L

C

P

T

T

L

L

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I

G

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D

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G

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V

L

-

I

-

E

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H

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R

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F

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G

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K

G

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H

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A

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H

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F

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G

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x
M

G

G

A

A

I

T

V

L

M

L

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R

G

V

V

T

V

I

V

G

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P

K

E

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S

A

I

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V

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A
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A

G

G

A

S

V

L

V

V

T

K

K

Q

D

N

-

T

-

R

V

I

P

P

P

S

G

G

T

E

V

V

Y

W

G

G

N

N

P

P

A

A

E

K

F

F

I

M

-
x
R

-

K

C

L

T

T

T

D

E

E

Q

E

L

I

I

V

binding Butyryl Coenzyme A: F144 (= F138), G146 (= G140), M147 (≠ H141), A164 (= A158), A165 (= A159), R190 (vs. gap)
binding zinc ion: H107 (≠ R95), H135 (≠ G129)

Sites not aligning to the query:

binding Butyryl Coenzyme A: 203
binding : 1, 4, 5, 8, 9

Query Sequence

>PP_3134 FitnessBrowser__Putida:PP_3134
MSAMRSAPRRTRPERLRRLQIVQIARPGSMKGWIRKAVARYAHATGRGGKFYRRFCNPSG
LEWGAYLARWGNFHSVGSNFYVNTGCKFLDPSLVRIGNSVGLSDCTLIGHDGVVLLIEHR
FGKHLDSVGFIDIKDNCFIGHGAIVMPRVTIGPESIVAAGAVVTKDVPPGTVYGGNPAEF
ICTTEQLIKRVEARCEAYPWIDLVKQRNGAYDPEVEPLLMAQRRQYFFGDS

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory