SitesBLAST
Comparing PP_3383 FitnessBrowser__Putida:PP_3383 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 3 hits to proteins with known functional sites (download)
8jejA Cryo-em structure of na-dithionite reduced membrane-bound fructose dehydrogenase from gluconobacter japonicus
26% identity, 96% coverage: 9:580/594 of query aligns to 7:535/540 of 8jejA
- binding fe3-s4 cluster: R203 (≠ N223), C214 (≠ Q235), C215 (≠ M236), G216 (= G237), N217 (≠ P238), N218 (≠ C239), N219 (= N240), C220 (≠ F241), C224 (= C245), I226 (≠ G247), M229 (≠ C250), S341 (≠ G375)
- binding flavin-adenine dinucleotide: I11 (≠ V13), G12 (= G14), G14 (= G16), I15 (≠ W17), C16 (≠ A18), D35 (≠ E37), A36 (≠ R38), G97 (= G96), K100 (= K97), G101 (= G98), G104 (= G101), T105 (≠ A102), T106 (≠ G103), H108 (= H105), W109 (= W106), A110 (≠ S107), S112 (≠ V109), M221 (≠ C242), A250 (= A278), V252 (= V280), A287 (= A316), N288 (≠ F317), E291 (≠ N320), N475 (≠ T520), H476 (= H521), N519 (= N564), T521 (= T566), M524 (≠ V569)
7w2jD Cryo-em structure of membrane-bound fructose dehydrogenase from gluconobacter japonicus
26% identity, 96% coverage: 9:580/594 of query aligns to 4:532/537 of 7w2jD
- binding fe3-s4 cluster: R200 (≠ N223), C211 (≠ Q235), G213 (= G237), N214 (≠ P238), N215 (≠ C239), C217 (≠ F241), C221 (= C245), I223 (≠ G247), A225 (≠ V249), S338 (≠ G375)
- binding flavin-adenine dinucleotide: G9 (= G14), G11 (= G16), D32 (≠ E37), A33 (≠ R38), Y59 (≠ V69), K97 (= K97), G101 (= G101), T102 (≠ A102), T103 (≠ G103), H105 (= H105), W106 (= W106), S109 (≠ V109), V249 (= V280), A284 (= A316), N285 (≠ F317), E288 (≠ N320), K291 (≠ R323), L292 (= L324), N472 (≠ T520), N516 (= N564), S517 (≠ P565), T518 (= T566)
- binding heme c: P209 (≠ G233), I223 (≠ G247)
8grjB Crystal structure of gamma-alpha subunit complex from burkholderia cepacia fad glucose dehydrogenase in complex with gluconolactone
24% identity, 55% coverage: 21:347/594 of query aligns to 14:309/531 of 8grjB
- binding fe3-s4 cluster: C204 (≠ F241), C205 (= C242), G206 (= G243), N207 (≠ F244), N209 (≠ S246), C210 (≠ G247), C214 (= C250)
- binding flavin-adenine dinucleotide: E30 (= E37), A31 (≠ R38), Q86 (vs. gap), R89 (≠ K97), T94 (≠ A102), H97 (= H105), W98 (= W106), A99 (≠ S107), S101 (≠ V109), M211 (≠ Y248), V242 (= V280), A277 (= A316), N278 (≠ F317), E281 (≠ N320), I285 (≠ L324)
- binding D-glucono-1,5-lactone: M211 (≠ Y248)
Sites not aligning to the query:
- binding fe3-s4 cluster: 331
- binding flavin-adenine dinucleotide: 7, 9, 10, 11, 467, 511, 513
- binding D-glucono-1,5-lactone: 333, 355, 466, 467, 468, 511
Query Sequence
>PP_3383 FitnessBrowser__Putida:PP_3383
MATVLNKVDAVIVGFGWAGAIMAKELTEAGLHVVALERGPMQDTYPEGSYPQVIDELTYS
VRKKLFVDVSKETVTVRHSVNDVALPNRQLGAFLPGKGVGGAGLHWSGVHFRVDPVELRL
RSHYEERYGRTFIPEGMTIQDFGVSYEELEPYFDFAEKVFGTSGQAWTVKGQVVGEGKGG
NPYAPDRSNPFPLPAQKNVVSARLFEKAATSLGYKPYNLPSANTSGPYTNPYGAQMGPCN
FCGFCSGYVCYMYSKASPNVNILPALRQVPNFELRPNAHVLRVNLDDSKRRATGVTYIDA
QGREVEQPAELVILAAFQFNNVRLMLLSGIGKPYDPVKNEGVVGRNFAYQNMGTVKAFFD
KDTYTNNFIGAGGNGIAIDDFNADNFDHGPHGFVGGSPMWVNQAGSRPIAGTSNPPGTPA
WGSAWKKATADYYTHQVSMDAHGAHQSYRGNYLDLDPTYRDAYGQPLLRMTFDWQENDIK
MNQFMVDKLSKIAQAMNPKAIAVLGKQVKDHFNTTSYQTTHLNGGAIMGTDPKTSALNRY
LQSWDVHNVFVPGASAFPQGLGYNPTGLVAALTYWSARAIREQYLKNPGPLVQA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory