SitesBLAST
Comparing PP_3646 FitnessBrowser__Putida:PP_3646 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
47% identity, 96% coverage: 7:481/493 of query aligns to 5:479/489 of 4o6rA
- active site: N150 (= N154), K173 (= K177), E248 (= E252), C282 (= C286), E383 (= E385), E460 (= E462)
- binding adenosine monophosphate: I146 (= I150), V147 (≠ I151), K173 (= K177), G206 (= G210), G210 (= G214), Q211 (≠ A215), F224 (= F228), G226 (= G230), S227 (≠ G231), T230 (= T234), R233 (≠ H237)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 15:489/494 of 5l13A
- active site: N163 (= N154), K186 (= K177), E262 (= E252), C296 (= C286), E393 (= E385), E470 (= E462)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ S155), M168 (≠ L159), W171 (≠ I162), F290 (≠ A280), C295 (≠ S285), C296 (= C286), C297 (≠ V287), D451 (≠ R443), F453 (≠ V445)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 15:489/494 of 4kwgA
- active site: N163 (= N154), K186 (= K177), E262 (= E252), C296 (= C286), E393 (= E385), E470 (= E462)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (≠ S155), M168 (≠ L159), C295 (≠ S285), C296 (= C286), C297 (≠ V287), D451 (≠ R443), F453 (≠ V445)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 15:489/494 of 4kwfA
- active site: N163 (= N154), K186 (= K177), E262 (= E252), C296 (= C286), E393 (= E385), E470 (= E462)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (≠ S155), M168 (≠ L159), W171 (≠ I162), E262 (= E252), C295 (≠ S285), C296 (= C286), C297 (≠ V287), D451 (≠ R443), F453 (≠ V445), F459 (≠ I451)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 15:489/494 of 3sz9A
- active site: N163 (= N154), K186 (= K177), E262 (= E252), C296 (= C286), E393 (= E385), E470 (= E462)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (≠ S155), C295 (≠ S285), C296 (= C286), D451 (≠ R443), F453 (≠ V445), F459 (≠ I451)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 15:489/494 of 3injA
- active site: N163 (= N154), K186 (= K177), E262 (= E252), C296 (= C286), E393 (= E385), E470 (= E462)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ Y108), F164 (≠ S155), L167 (≠ Y158), F286 (≠ A276), F290 (≠ A280), D451 (≠ R443), F453 (≠ V445)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 15:489/494 of 2vleA
- active site: N163 (= N154), K186 (= K177), E262 (= E252), C296 (= C286), E393 (= E385), E470 (= E462)
- binding daidzin: M118 (≠ Y108), F164 (≠ S155), M168 (≠ L159), W171 (≠ I162), F286 (≠ A276), F290 (≠ A280), C295 (≠ S285), C296 (= C286), D451 (≠ R443), V452 (≠ A444), F453 (≠ V445)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 15:489/494 of 1o01B
- active site: N163 (= N154), K186 (= K177), E262 (= E252), C296 (= C286), E393 (= E385), E470 (= E462)
- binding (2e)-but-2-enal: C296 (= C286), C297 (≠ V287), F453 (≠ V445)
- binding nicotinamide-adenine-dinucleotide: I159 (= I150), I160 (= I151), P161 (= P152), W162 (= W153), K186 (= K177), E189 (= E180), G219 (= G210), G223 (= G214), A224 (= A215), F237 (= F228), G239 (= G230), S240 (≠ G231), I243 (≠ T234), L263 (= L253), G264 (= G254), C296 (= C286), Q343 (= Q333), E393 (= E385), F395 (= F387)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 15:489/494 of 1cw3A
- active site: N163 (= N154), K186 (= K177), E262 (= E252), C296 (= C286), E393 (= E385), E470 (= E462)
- binding magnesium ion: V34 (≠ L26), D103 (= D94), Q190 (≠ H181)
- binding nicotinamide-adenine-dinucleotide: I159 (= I150), I160 (= I151), P161 (= P152), W162 (= W153), K186 (= K177), G219 (= G210), G223 (= G214), A224 (= A215), F237 (= F228), G239 (= G230), S240 (≠ G231), I243 (≠ T234), L263 (= L253), G264 (= G254), C296 (= C286), Q343 (= Q333), K346 (≠ V336), E393 (= E385), F395 (= F387)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 17:491/496 of 4fr8C
- active site: N165 (= N154), K188 (= K177), Q264 (≠ E252), C298 (= C286), E395 (= E385), E472 (= E462)
- binding nicotinamide-adenine-dinucleotide: I161 (= I150), I162 (= I151), W164 (= W153), K188 (= K177), G221 (= G210), G225 (= G214), A226 (= A215), F239 (= F228), G241 (= G230), S242 (≠ G231), I245 (≠ T234), Q345 (= Q333), E395 (= E385), F397 (= F387)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 14:488/493 of 4fr8A
- active site: N162 (= N154), K185 (= K177), Q261 (≠ E252), C295 (= C286), E392 (= E385), E469 (= E462)
- binding nicotinamide-adenine-dinucleotide: I158 (= I150), I159 (= I151), W161 (= W153), K185 (= K177), G218 (= G210), G222 (= G214), A223 (= A215), F236 (= F228), G238 (= G230), S239 (≠ G231), I242 (≠ T234), Q342 (= Q333), K345 (≠ V336), E392 (= E385), F394 (= F387)
- binding propane-1,2,3-triyl trinitrate: F163 (≠ S155), L166 (≠ Y158), W170 (≠ I162), F289 (≠ A280), S294 (= S285), C295 (= C286), D450 (≠ R443), F452 (≠ V445)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
44% identity, 97% coverage: 5:481/493 of query aligns to 16:490/491 of 5gtlA
- active site: N165 (= N154), K188 (= K177), E263 (= E252), C297 (= C286), E394 (= E385), E471 (= E462)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I150), P163 (= P152), K188 (= K177), A190 (≠ S179), E191 (= E180), Q192 (≠ H181), G221 (= G210), G225 (= G214), G241 (= G230), S242 (≠ G231), T245 (= T234), L264 (= L253), C297 (= C286), E394 (= E385), F396 (= F387)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
44% identity, 97% coverage: 5:481/493 of query aligns to 16:490/491 of 5gtkA
- active site: N165 (= N154), K188 (= K177), E263 (= E252), C297 (= C286), E394 (= E385), E471 (= E462)
- binding nicotinamide-adenine-dinucleotide: I161 (= I150), I162 (= I151), P163 (= P152), W164 (= W153), K188 (= K177), E191 (= E180), G221 (= G210), G225 (= G214), A226 (= A215), F239 (= F228), G241 (= G230), S242 (≠ G231), T245 (= T234), Y248 (≠ H237), L264 (= L253), C297 (= C286), Q344 (= Q333), R347 (≠ V336), E394 (= E385), F396 (= F387)
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+ (see paper)
46% identity, 96% coverage: 7:481/493 of query aligns to 15:489/494 of 1nzwA
- active site: N163 (= N154), K186 (= K177), E262 (= E252), S296 (≠ C286), E393 (= E385), E470 (= E462)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (= I150), I160 (= I151), P161 (= P152), K186 (= K177), E189 (= E180), G219 (= G210), P220 (= P211), G223 (= G214), A224 (= A215), F237 (= F228), G239 (= G230), S240 (≠ G231), I243 (≠ T234), E262 (= E252), G264 (= G254), S296 (≠ C286), Q343 (= Q333), E393 (= E385), F395 (= F387)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
46% identity, 98% coverage: 7:487/493 of query aligns to 4:483/487 of 4go4A
- active site: N149 (= N154), K172 (= K177), E247 (= E252), C281 (= C286), E381 (= E385), E458 (= E462)
- binding nicotinamide-adenine-dinucleotide: I145 (= I150), V146 (≠ I151), W148 (= W153), N149 (= N154), F154 (≠ L159), K172 (= K177), G205 (= G210), G209 (= G214), Q210 (≠ A215), F223 (= F228), T224 (= T229), G225 (= G230), S226 (≠ G231), T229 (= T234), E247 (= E252), G249 (= G254), C281 (= C286), E381 (= E385), F383 (= F387)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
46% identity, 96% coverage: 7:481/493 of query aligns to 41:515/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
1o9jA The x-ray crystal structure of eta-crystallin (see paper)
43% identity, 98% coverage: 1:482/493 of query aligns to 6:490/494 of 1o9jA
- active site: N163 (= N154), K186 (= K177), E262 (= E252), C296 (= C286), E393 (= E385), E470 (= E462)
- binding nicotinamide-adenine-dinucleotide: I159 (= I150), F160 (≠ I151), P161 (= P152), W162 (= W153), N163 (= N154), K186 (= K177), E189 (= E180), G219 (= G210), G223 (= G214), F237 (= F228), T238 (= T229), G239 (= G230), S240 (≠ G231), V243 (≠ T234), E262 (= E252), L263 (= L253), C296 (= C286), E393 (= E385), F395 (= F387), L421 (= L413)
Q28399 Aldehyde dehydrogenase, cytosolic 1; ALDH class 1; ETA-crystallin; EC 1.2.1.3 from Elephantulus edwardii (Cape long-eared elephant shrew) (see paper)
43% identity, 98% coverage: 1:482/493 of query aligns to 13:497/501 of Q28399
7radA Crystal structure analysis of aldh1b1
44% identity, 96% coverage: 7:481/493 of query aligns to 14:488/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I150), I159 (= I151), P160 (= P152), W161 (= W153), N162 (= N154), M167 (≠ L159), K185 (= K177), E188 (= E180), G218 (= G210), G222 (= G214), A223 (= A215), T237 (= T229), G238 (= G230), S239 (≠ G231), V242 (≠ T234), E261 (= E252), L262 (= L253), C295 (= C286), E392 (= E385), F394 (= F387)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (vs. gap), E117 (≠ Y108), F163 (≠ S155), E285 (≠ A276), F289 (≠ A280), N450 (≠ R443), V452 (= V445)
7mjdA Crystal structure analysis of aldh1b1
44% identity, 96% coverage: 7:481/493 of query aligns to 14:488/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I150), I159 (= I151), P160 (= P152), W161 (= W153), N162 (= N154), M167 (≠ L159), K185 (= K177), E188 (= E180), G218 (= G210), G222 (= G214), F236 (= F228), T237 (= T229), G238 (= G230), S239 (≠ G231), V242 (≠ T234), E261 (= E252), L262 (= L253), C295 (= C286), E392 (= E385), F394 (= F387)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ Y108), E285 (≠ A276), F289 (≠ A280), N450 (≠ R443), V452 (= V445)
Query Sequence
>PP_3646 FitnessBrowser__Putida:PP_3646
MTLVRFQMCIDGQWRDAQSGKTFDSLNPATAQAWAQLPDADEADVELAVQAAQRAFDSKA
WRSITATARGKLLRRLGDLIAENKEHLAQLESRDNGKLIRETRGQVGYLPEFFHYTAGLA
DKLEGGTLPLDKPDLFAYTVHEPIGVVAGIIPWNSPLYLTAIKLAPALAAGNTIVLKPSE
HASATILELARLALEAGFPAGVVNVVTGYGPSTGAALTRHPLVRKIAFTGGAATARHVVR
SSAENFAKLSLELGGKSPNIIFADADLDSAINGAVAGIYAASGQSCVAGSRLLVQDEIFD
EFVERLIARAKRIRIGNPQDDASEMGPMATAQQLAVVEGLVAAAKAEGAKLHMGGKRADV
EGDGWFYEPTLFECDSNAMTIMQEEVFGPVAAVIRFKTEEEALAMANDSQFGLAAGIWTR
DLGRAHRLARDVRSGIIWVNTYRAVSAMAPIGGFKNSGYGRESGIDSVLAYTELKTVWIN
LSTAPMPDPFVMR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory