SitesBLAST
Comparing PP_3723 FitnessBrowser__Putida:PP_3723 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
30% identity, 98% coverage: 6:530/535 of query aligns to 6:518/539 of 6lpiB
- active site: I27 (= I27), G29 (= G29), G30 (≠ V30), S31 (≠ H31), I32 (≠ T32), E53 (= E52), C76 (≠ I75), F115 (≠ H117), Q116 (≠ E118), E117 (≠ T119), K165 (≠ L167), M256 (≠ S256), A283 (≠ D283), V375 (≠ M383), G401 (= G409), M403 (≠ L411), D428 (= D436), N455 (= N464), A457 (= A466), L458 (= L467), L460 (≠ Q469), V461 (≠ I470), Q464 (≠ D473)
- binding flavin-adenine dinucleotide: R155 (= R157), G212 (= G214), G213 (= G215), G214 (= G216), T236 (≠ S238), L237 (≠ V239), M238 (≠ A240), L254 (vs. gap), M256 (≠ S256), H257 (≠ L257), G276 (= G276), A277 (≠ T277), R278 (≠ E278), D280 (≠ A280), R282 (≠ T282), A283 (≠ D283), D300 (= D299), I301 (= I300), D319 (= D318), V320 (≠ A319), M380 (≠ Y388), G398 (≠ T406)
- binding magnesium ion: D428 (= D436), N455 (= N464)
- binding thiamine diphosphate: E53 (= E52), C76 (≠ I75), P79 (= P78), G376 (≠ T384), Q377 (= Q385), H378 (≠ L386), G401 (= G409), M403 (≠ L411), G427 (= G435), D428 (= D436), G429 (= G437), S430 (≠ G438), M433 (≠ Y441), N455 (= N464), A457 (= A466), L458 (= L467), G459 (= G468), L460 (≠ Q469), V461 (≠ I470)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 8:552/595 of 1t9bB
- active site: Y29 (≠ I27), G31 (= G29), G32 (≠ V30), A33 (≠ H31), I34 (≠ T32), E55 (= E52), T78 (≠ I75), F117 (≠ H117), Q118 (≠ E118), E119 (≠ T119), K167 (≠ L167), R226 (vs. gap), M262 (vs. gap), V289 (vs. gap), V405 (≠ M383), L430 (≠ Y408), G431 (= G409), M433 (≠ L411), D458 (= D436), N485 (= N464), E487 (≠ A466), Q488 (≠ L467), M490 (≠ Q469), V491 (≠ I470), W494 (vs. gap), L516 (= L494), G521 (= G499), L522 (≠ C500)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ N104), P108 (≠ H105), D287 (= D281), R288 (vs. gap), M490 (≠ Q469), W494 (vs. gap)
- binding flavin-adenine dinucleotide: R157 (= R157), G215 (= G214), A216 (≠ G215), G217 (= G216), N220 (≠ H219), T242 (≠ S238), L243 (≠ V239), Q244 (≠ A240), M259 (vs. gap), L260 (vs. gap), M262 (vs. gap), H263 (vs. gap), G282 (= G276), A283 (≠ T277), R284 (≠ E278), D286 (≠ A280), R288 (vs. gap), V289 (vs. gap), E315 (≠ D299), V316 (≠ I300), N320 (≠ K304), G333 (= G317), D334 (= D318), A335 (= A319), Q409 (≠ A387), M410 (≠ Y388), G428 (≠ T406), G429 (= G407)
- binding magnesium ion: D458 (= D436), N485 (= N464), E487 (≠ A466)
Sites not aligning to the query:
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 8:553/596 of 1t9cA
- active site: Y29 (≠ I27), G31 (= G29), G32 (≠ V30), A33 (≠ H31), I34 (≠ T32), E55 (= E52), T78 (≠ I75), F117 (≠ H117), Q118 (≠ E118), E119 (≠ T119), K167 (≠ L167), R227 (vs. gap), M263 (vs. gap), V290 (vs. gap), V406 (≠ M383), L431 (≠ Y408), G432 (= G409), M434 (≠ L411), D459 (= D436), N486 (= N464), E488 (≠ A466), Q489 (≠ L467), M491 (≠ Q469), V492 (≠ I470), W495 (vs. gap), L517 (= L494), G522 (= G499), L523 (≠ C500)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ V30), V107 (≠ N104), P108 (≠ H105), F117 (≠ H117), K167 (≠ L167), D288 (= D281), R289 (vs. gap), W495 (vs. gap)
- binding flavin-adenine dinucleotide: R157 (= R157), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (≠ H219), T243 (≠ S238), L244 (≠ V239), Q245 (≠ A240), L261 (vs. gap), M263 (vs. gap), H264 (vs. gap), G283 (= G276), A284 (≠ T277), R285 (≠ E278), D287 (≠ A280), R289 (vs. gap), V290 (vs. gap), E316 (≠ D299), V317 (≠ I300), N321 (≠ K304), G334 (= G317), D335 (= D318), A336 (= A319), M411 (≠ Y388), G429 (≠ T406), G430 (= G407)
- binding magnesium ion: D459 (= D436), N486 (= N464), E488 (≠ A466)
Sites not aligning to the query:
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 8:553/596 of 1t9dA
- active site: Y29 (≠ I27), G31 (= G29), G32 (≠ V30), A33 (≠ H31), I34 (≠ T32), E55 (= E52), T78 (≠ I75), F117 (≠ H117), Q118 (≠ E118), E119 (≠ T119), K167 (≠ L167), R227 (vs. gap), M263 (vs. gap), V290 (vs. gap), V406 (≠ M383), L431 (≠ Y408), G432 (= G409), M434 (≠ L411), D459 (= D436), N486 (= N464), E488 (≠ A466), Q489 (≠ L467), M491 (≠ Q469), V492 (≠ I470), W495 (vs. gap), L517 (= L494), G522 (= G499), L523 (≠ C500)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ V30), A33 (≠ H31), V107 (≠ N104), P108 (≠ H105), F117 (≠ H117), K167 (≠ L167), M263 (vs. gap), D288 (= D281), R289 (vs. gap), W495 (vs. gap)
- binding flavin-adenine dinucleotide: R157 (= R157), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (≠ H219), T243 (≠ S238), L244 (≠ V239), Q245 (≠ A240), M260 (vs. gap), L261 (vs. gap), H264 (vs. gap), G283 (= G276), A284 (≠ T277), R285 (≠ E278), D287 (≠ A280), R289 (vs. gap), V290 (vs. gap), E316 (≠ D299), V317 (≠ I300), N321 (≠ K304), G334 (= G317), D335 (= D318), A336 (= A319), Q410 (≠ A387), M411 (≠ Y388), G429 (≠ T406), G430 (= G407)
- binding magnesium ion: D459 (= D436), N486 (= N464), E488 (≠ A466)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E52), P81 (= P78), Q118 (≠ E118), G432 (= G409), M434 (≠ L411), M464 (≠ Y441)
Sites not aligning to the query:
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 9:554/597 of 1t9aA
- active site: Y30 (≠ I27), G32 (= G29), G33 (≠ V30), A34 (≠ H31), I35 (≠ T32), E56 (= E52), T79 (≠ I75), F118 (≠ H117), Q119 (≠ E118), E120 (≠ T119), K168 (≠ L167), R228 (vs. gap), M264 (vs. gap), V291 (vs. gap), V407 (≠ M383), L432 (≠ Y408), G433 (= G409), M435 (≠ L411), D460 (= D436), N487 (= N464), E489 (≠ A466), Q490 (≠ L467), M492 (≠ Q469), V493 (≠ I470), W496 (vs. gap), L518 (= L494), G523 (= G499), L524 (≠ C500)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (≠ V30), V108 (≠ N104), P109 (≠ H105), F118 (≠ H117), K168 (≠ L167), M264 (vs. gap), D289 (= D281), R290 (vs. gap), M492 (≠ Q469), V493 (≠ I470), W496 (vs. gap)
- binding flavin-adenine dinucleotide: R158 (= R157), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ H219), T244 (≠ S238), L245 (≠ V239), Q246 (≠ A240), L262 (vs. gap), M264 (vs. gap), H265 (vs. gap), G284 (= G276), A285 (≠ T277), R286 (≠ E278), D288 (≠ A280), R290 (vs. gap), V291 (vs. gap), E317 (≠ D299), V318 (≠ I300), N322 (≠ K304), G335 (= G317), D336 (= D318), A337 (= A319), Q411 (≠ A387), M412 (≠ Y388), G430 (≠ T406), G431 (= G407)
- binding magnesium ion: D460 (= D436), N487 (= N464), E489 (≠ A466)
- binding propyl trihydrogen diphosphate: V407 (≠ M383), G408 (≠ T384), Q409 (= Q385), H410 (≠ L386), M435 (≠ L411), G459 (= G435), D460 (= D436), A461 (≠ G437), S462 (≠ G438), N487 (= N464), E489 (≠ A466), Q490 (≠ L467), G491 (= G468), M492 (≠ Q469)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G409), M435 (≠ L411), M465 (≠ Y441)
Sites not aligning to the query:
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 8:548/591 of 5wkcA
- active site: Y29 (≠ I27), G31 (= G29), G32 (≠ V30), A33 (≠ H31), I34 (≠ T32), E55 (= E52), T78 (≠ I75), F117 (≠ H117), Q118 (≠ E118), E119 (≠ T119), K167 (≠ L167), R222 (vs. gap), M258 (vs. gap), V285 (vs. gap), V401 (≠ M383), L426 (≠ Y408), G427 (= G409), M429 (≠ L411), D454 (= D436), N481 (= N464), E483 (≠ A466), Q484 (≠ L467), M486 (≠ Q469), V487 (≠ I470), W490 (vs. gap), L512 (= L494), G517 (= G499), L518 (≠ C500)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ M383), G402 (≠ T384), Q403 (= Q385), H404 (≠ L386), G427 (= G409), M429 (≠ L411), G453 (= G435), D454 (= D436), A455 (≠ G437), S456 (≠ G438), M459 (≠ Y441), N481 (= N464), E483 (≠ A466), Q484 (≠ L467), G485 (= G468), M486 (≠ Q469), V487 (≠ I470)
- binding ethaneperoxoic acid: G32 (≠ V30), Q118 (≠ E118)
- binding flavin-adenine dinucleotide: R157 (= R157), G211 (= G214), A212 (≠ G215), G213 (= G216), N216 (≠ H219), T238 (≠ S238), L239 (≠ V239), Q240 (≠ A240), L256 (vs. gap), M258 (vs. gap), G278 (= G276), A279 (≠ T277), R280 (≠ E278), R284 (vs. gap), V285 (vs. gap), E311 (≠ D299), V312 (≠ I300), N316 (≠ K304), D330 (= D318), A331 (= A319), M406 (≠ Y388), G424 (≠ T406)
- binding magnesium ion: D454 (= D436), N481 (= N464), E483 (≠ A466)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (≠ V30), A33 (≠ H31), V107 (≠ N104), F117 (≠ H117), K167 (≠ L167), M258 (vs. gap), R284 (vs. gap), M486 (≠ Q469), W490 (vs. gap)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P28), E55 (= E52)
Sites not aligning to the query:
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 8:540/583 of 1t9bA
- active site: Y29 (≠ I27), G31 (= G29), G32 (≠ V30), A33 (≠ H31), I34 (≠ T32), E55 (= E52), T78 (≠ I75), F117 (≠ H117), Q118 (≠ E118), E119 (≠ T119), K167 (≠ L167), R214 (vs. gap), M250 (vs. gap), V277 (vs. gap), V393 (≠ M383), L418 (≠ Y408), G419 (= G409), M421 (≠ L411), D446 (= D436), N473 (= N464), E475 (≠ A466), Q476 (≠ L467), M478 (≠ Q469), V479 (≠ I470), W482 (vs. gap), L504 (= L494), G509 (= G499), L510 (≠ C500)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ N104), P108 (≠ H105), F117 (≠ H117), D275 (= D281), R276 (vs. gap), M478 (≠ Q469), W482 (vs. gap)
- binding flavin-adenine dinucleotide: R157 (= R157), G203 (= G214), A204 (≠ G215), G205 (= G216), N208 (≠ H219), T230 (≠ S238), L231 (≠ V239), Q232 (≠ A240), M247 (vs. gap), L248 (vs. gap), M250 (vs. gap), H251 (vs. gap), G270 (= G276), A271 (≠ T277), R272 (≠ E278), D274 (≠ A280), R276 (vs. gap), V277 (vs. gap), E303 (≠ D299), V304 (≠ I300), N308 (≠ K304), D322 (= D318), A323 (= A319), Q397 (≠ A387), M398 (≠ Y388), G416 (≠ T406), G417 (= G407)
- binding magnesium ion: D446 (= D436), N473 (= N464), E475 (≠ A466)
Sites not aligning to the query:
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 7:539/582 of 1t9dB
- active site: Y28 (≠ I27), G30 (= G29), G31 (≠ V30), A32 (≠ H31), I33 (≠ T32), E54 (= E52), T77 (≠ I75), F116 (≠ H117), Q117 (≠ E118), E118 (≠ T119), K166 (≠ L167), R213 (vs. gap), M249 (vs. gap), V276 (vs. gap), V392 (≠ M383), L417 (≠ Y408), G418 (= G409), M420 (≠ L411), D445 (= D436), N472 (= N464), E474 (≠ A466), Q475 (≠ L467), M477 (≠ Q469), V478 (≠ I470), W481 (vs. gap), L503 (= L494), G508 (= G499), L509 (≠ C500)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (≠ V30), A32 (≠ H31), V106 (≠ N104), P107 (≠ H105), F116 (≠ H117), K166 (≠ L167), M249 (vs. gap), D274 (= D281), R275 (vs. gap), W481 (vs. gap)
- binding flavin-adenine dinucleotide: R156 (= R157), G202 (= G214), A203 (≠ G215), G204 (= G216), N207 (≠ H219), T229 (≠ S238), L230 (≠ V239), Q231 (≠ A240), L247 (vs. gap), M249 (vs. gap), H250 (vs. gap), G269 (= G276), A270 (≠ T277), R271 (≠ E278), D273 (≠ A280), R275 (vs. gap), V276 (vs. gap), E302 (≠ D299), V303 (≠ I300), N307 (≠ K304), G320 (= G317), D321 (= D318), A322 (= A319), Q396 (≠ A387), M397 (≠ Y388), G415 (≠ T406), G416 (= G407)
- binding magnesium ion: D445 (= D436), N472 (= N464), E474 (≠ A466)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E52), P80 (= P78), G418 (= G409), M420 (≠ L411), M450 (≠ Y441)
Sites not aligning to the query:
1jscA Crystal structure of the catalytic subunit of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors (see paper)
28% identity, 98% coverage: 6:530/535 of query aligns to 10:537/541 of 1jscA
- active site: Y31 (≠ I27), G33 (= G29), G34 (≠ V30), A35 (≠ H31), I36 (≠ T32), E57 (= E52), T80 (≠ I75), F119 (≠ H117), Q120 (≠ E118), E121 (≠ T119), K169 (≠ L167), M263 (vs. gap), V290 (vs. gap), V406 (≠ M383), G432 (= G409), M434 (≠ L411), D459 (= D436), N486 (= N464), E488 (≠ P481)
- binding dihydrogenphosphate ion: G33 (= G29), G34 (≠ V30), Q120 (≠ E118)
- binding flavin-adenine dinucleotide: R159 (= R157), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (≠ H219), T243 (≠ S238), L244 (≠ V239), L261 (vs. gap), G262 (vs. gap), H264 (vs. gap), G283 (= G276), A284 (≠ T277), R285 (≠ E278), D287 (≠ A280), R289 (vs. gap), V290 (vs. gap), E316 (≠ D299), V317 (≠ I300), N321 (≠ K304), G334 (= G317), D335 (= D318), A336 (= A319)
- binding magnesium ion: D459 (= D436), N486 (= N464)
- binding thiamine diphosphate: Y31 (≠ I27), P32 (= P28), E57 (= E52), P83 (= P78), V406 (≠ M383), G407 (≠ T384), Q408 (= Q385), H409 (≠ L386), M434 (≠ L411), D459 (= D436), A460 (≠ G437), S461 (≠ G438), N486 (= N464)
Sites not aligning to the query:
5imsA Saccharomyces cerevisiae acetohydroxyacid synthase
28% identity, 98% coverage: 6:530/535 of query aligns to 10:538/541 of 5imsA
- active site: Y31 (≠ I27), G33 (= G29), G34 (≠ V30), A35 (≠ H31), I36 (≠ T32), E57 (= E52), T80 (≠ I75), F119 (≠ H117), Q120 (≠ E118), E121 (≠ T119), K169 (≠ L167), R229 (vs. gap), M265 (vs. gap), V292 (vs. gap), V408 (≠ M383), L433 (≠ Y408), G434 (= G409), M436 (≠ L411), D461 (= D436), N488 (= N464), E490 (≠ A466), L502 (= L494), G507 (= G499), L508 (≠ C500)
- binding flavin-adenine dinucleotide: R159 (= R157), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (≠ H219), T245 (≠ S238), L246 (≠ V239), L263 (vs. gap), G264 (vs. gap), H266 (vs. gap), G285 (= G276), A286 (≠ T277), R287 (≠ E278), D289 (≠ A280), R291 (vs. gap), V292 (vs. gap), E318 (≠ D299), V319 (≠ I300), N323 (≠ K304), D337 (= D318), A338 (= A319)
- binding magnesium ion: D461 (= D436), N488 (= N464)
- binding oxygen molecule: G34 (≠ V30), T80 (≠ I75), Q120 (≠ E118)
- binding thiamine diphosphate: P32 (= P28), E57 (= E52), V408 (≠ M383), G409 (≠ T384), Q410 (= Q385), H411 (≠ L386), G434 (= G409), M436 (≠ L411), G460 (= G435), D461 (= D436), A462 (≠ G437), S463 (≠ G438), M466 (≠ Y441), N488 (= N464)
Sites not aligning to the query:
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 10:556/599 of 1n0hA
- active site: Y31 (≠ I27), G33 (= G29), G34 (≠ V30), A35 (≠ H31), I36 (≠ T32), E57 (= E52), T80 (≠ I75), F119 (≠ H117), Q120 (≠ E118), E121 (≠ T119), K169 (≠ L167), R230 (vs. gap), M266 (vs. gap), V293 (vs. gap), V409 (≠ M383), L434 (≠ Y408), G435 (= G409), M437 (≠ L411), D462 (= D436), N489 (= N464), E491 (≠ A466), Q492 (≠ L467), M494 (≠ Q469), V495 (≠ I470), W498 (vs. gap), L520 (= L494), G525 (= G499), L526 (≠ C500)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ M383), G410 (≠ T384), Q411 (= Q385), H412 (≠ L386), G435 (= G409), M437 (≠ L411), G461 (= G435), D462 (= D436), A463 (≠ G437), S464 (≠ G438), M467 (≠ Y441), N489 (= N464), E491 (≠ A466), Q492 (≠ L467), G493 (= G468), V495 (≠ I470)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ V30), A35 (≠ H31), V109 (≠ N104), P110 (≠ H105), F119 (≠ H117), K169 (≠ L167), M266 (vs. gap), D291 (= D281), R292 (vs. gap), V495 (≠ I470), W498 (vs. gap)
- binding flavin-adenine dinucleotide: R159 (= R157), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (≠ H219), T246 (≠ S238), L247 (≠ V239), Q248 (≠ A240), L264 (vs. gap), G265 (vs. gap), M266 (vs. gap), H267 (vs. gap), G286 (= G276), A287 (≠ T277), R288 (≠ E278), D290 (≠ A280), R292 (vs. gap), V293 (vs. gap), E319 (≠ D299), V320 (≠ I300), N324 (≠ K304), G337 (= G317), D338 (= D318), A339 (= A319), M414 (≠ Y388), G432 (≠ T406), G433 (= G407)
- binding magnesium ion: D462 (= D436), N489 (= N464), E491 (≠ A466)
- binding thiamine diphosphate: Y31 (≠ I27), E57 (= E52), P83 (= P78)
Sites not aligning to the query:
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 12:564/607 of 6u9dB
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), I38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ H117), Q122 (≠ E118), E123 (≠ T119), K171 (≠ L167), M274 (vs. gap), V301 (vs. gap), V417 (≠ M383), G443 (= G409), M445 (≠ L411), D470 (= D436), N497 (= N464), E499 (≠ A466), Q500 (≠ L467), M502 (≠ Q469), V503 (≠ I470), W506 (vs. gap)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (≠ V30), V111 (≠ N104), P112 (≠ H105), F121 (≠ H117), K171 (≠ L167), D299 (= D281), R300 (vs. gap), M502 (≠ Q469), W506 (vs. gap)
- binding flavin-adenine dinucleotide: R161 (= R157), A228 (≠ G215), G229 (= G216), N232 (≠ H219), T254 (≠ S238), L255 (≠ V239), Q256 (≠ A240), L272 (vs. gap), M274 (vs. gap), G294 (= G276), R296 (≠ E278), D298 (≠ A280), R300 (vs. gap), V301 (vs. gap), E327 (≠ D299), V328 (≠ I300), N332 (≠ K304), D346 (= D318), A347 (= A319), M422 (≠ Y388), G440 (≠ T406), G441 (= G407)
- binding magnesium ion: D470 (= D436), N497 (= N464)
- binding thiamine diphosphate: E59 (= E52), P85 (= P78), V417 (≠ M383), G418 (≠ T384), Q419 (= Q385), H420 (≠ L386), G443 (= G409), M445 (≠ L411), A471 (≠ G437), S472 (≠ G438), N497 (= N464), E499 (≠ A466), Q500 (≠ L467), G501 (= G468), M502 (≠ Q469), V503 (≠ I470)
6bd9A Saccharomyces cerevisiae acetohydroxyacid synthase
29% identity, 98% coverage: 6:530/535 of query aligns to 10:538/542 of 6bd9A
- active site: Y31 (≠ I27), G33 (= G29), G34 (≠ V30), A35 (≠ H31), I36 (≠ T32), E57 (= E52), T80 (≠ I75), F119 (≠ H117), Q120 (≠ E118), E121 (≠ T119), K169 (≠ L167), R228 (vs. gap), M264 (vs. gap), V291 (vs. gap), V407 (≠ M383), L432 (≠ Y408), G433 (= G409), M435 (≠ L411), D460 (= D436), N487 (= N464), E489 (≠ P481), L502 (= L494), G507 (= G499), L508 (≠ C500)
- binding flavin-adenine dinucleotide: R159 (= R157), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ H219), T244 (≠ S238), L245 (≠ V239), L262 (vs. gap), G263 (vs. gap), H265 (vs. gap), G284 (= G276), A285 (≠ T277), R286 (≠ E278), D288 (≠ A280), R290 (vs. gap), V291 (vs. gap), E317 (≠ D299), V318 (≠ I300), N322 (≠ K304), G335 (= G317), D336 (= D318), A337 (= A319)
- binding magnesium ion: D460 (= D436), N487 (= N464)
- binding oxygen molecule: G34 (≠ V30), T80 (≠ I75), Q120 (≠ E118), A461 (≠ G437), Q494 (≠ P486)
- binding pyruvic acid: G33 (= G29), G34 (≠ V30), G34 (≠ V30), A35 (≠ H31), Q120 (≠ E118)
- binding thiamine diphosphate: P32 (= P28), E57 (= E52), V407 (≠ M383), G408 (≠ T384), Q409 (= Q385), H410 (≠ L386), G433 (= G409), M435 (≠ L411), G459 (= G435), D460 (= D436), A461 (≠ G437), S462 (≠ G438), M465 (≠ Y441), N487 (= N464)
Sites not aligning to the query:
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 92:644/687 of P07342
- R241 (= R157) binding
- 355:376 (vs. 253:278, 31% identical) binding
- 407:426 (vs. 299:318, 30% identical) binding
6bd3A Saccharomyces cerevisiae acetohydroxyacid synthase
29% identity, 98% coverage: 6:530/535 of query aligns to 10:534/538 of 6bd3A
- active site: Y31 (≠ I27), G33 (= G29), G34 (≠ V30), A35 (≠ H31), I36 (≠ T32), E57 (= E52), T80 (≠ I75), F119 (≠ H117), Q120 (≠ E118), E121 (≠ T119), K169 (≠ L167), R225 (vs. gap), M261 (vs. gap), V288 (vs. gap), V404 (≠ M383), L429 (≠ Y408), G430 (= G409), M432 (≠ L411), D457 (= D436), N484 (= N464), L498 (= L494), G503 (= G499), L504 (≠ C500)
- binding flavin-adenine dinucleotide: R159 (= R157), G214 (= G214), A215 (≠ G215), G216 (= G216), N219 (≠ H219), T241 (≠ S238), L242 (≠ V239), Q243 (≠ A240), L259 (vs. gap), G260 (vs. gap), H262 (vs. gap), G281 (= G276), A282 (≠ T277), R283 (≠ E278), D285 (≠ A280), R287 (vs. gap), V288 (vs. gap), E314 (≠ D299), V315 (≠ I300), D333 (= D318), A334 (= A319)
- binding 2-acetyl-thiamine diphosphate: P32 (= P28), E57 (= E52), P83 (= P78)
- binding magnesium ion: D457 (= D436), N484 (= N464)
- binding oxygen molecule: A35 (≠ H31), T80 (≠ I75), S81 (≠ T76), Q120 (≠ E118)
- binding thiamine diphosphate: V404 (≠ M383), G405 (≠ T384), Q406 (= Q385), H407 (≠ L386), G430 (= G409), M432 (≠ L411), D457 (= D436), A458 (≠ G437), S459 (≠ G438), M462 (≠ Y441), N484 (= N464)
Sites not aligning to the query:
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
31% identity, 86% coverage: 12:470/535 of query aligns to 17:485/582 of 3ea4A
- active site: Y32 (≠ I27), G34 (= G29), G35 (≠ V30), A36 (≠ H31), S37 (≠ T32), E58 (= E52), T81 (≠ I75), F120 (≠ L116), Q121 (≠ H117), E122 (= E118), K170 (≠ L167), M265 (≠ A255), V292 (≠ D283), V399 (≠ M383), G425 (= G409), M427 (≠ L411), D452 (= D436), N479 (= N464), H481 (≠ A466), L482 (= L467), M484 (≠ Q469), V485 (≠ I470)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D281), R291 (≠ T282)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R157), G221 (= G214), G222 (= G215), G223 (= G216), T245 (≠ S238), L246 (≠ V239), M247 (≠ A240), L263 (≠ A253), G264 (= G254), M265 (≠ A255), H266 (≠ S256), G285 (= G276), R287 (≠ E278), D289 (≠ A280), R291 (≠ T282), D309 (= D299), I310 (= I300), G327 (= G317), D328 (= D318), V329 (≠ A319), M404 (≠ Y388), G422 (≠ T406)
- binding magnesium ion: D452 (= D436), N479 (= N464), H481 (≠ A466)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ M383), G400 (≠ T384), Q401 (= Q385), H402 (≠ L386), M427 (≠ L411), G451 (= G435), D452 (= D436), G453 (= G437), S454 (≠ G438), N479 (= N464), H481 (≠ A466), L482 (= L467), G483 (= G468), M484 (≠ Q469), V485 (≠ I470)
Sites not aligning to the query:
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
31% identity, 86% coverage: 12:470/535 of query aligns to 17:485/582 of 3e9yA
- active site: Y32 (≠ I27), G34 (= G29), G35 (≠ V30), A36 (≠ H31), S37 (≠ T32), E58 (= E52), T81 (≠ I75), F120 (≠ L116), Q121 (≠ H117), E122 (= E118), K170 (≠ L167), M265 (≠ A255), V292 (≠ D283), V399 (≠ M383), G425 (= G409), M427 (≠ L411), D452 (= D436), N479 (= N464), H481 (≠ A466), L482 (= L467), M484 (≠ Q469), V485 (≠ I470)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D281), R291 (≠ T282)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R157), G221 (= G214), G222 (= G215), G223 (= G216), T245 (≠ S238), L246 (≠ V239), M247 (≠ A240), L263 (≠ A253), G285 (= G276), R287 (≠ E278), D289 (≠ A280), R291 (≠ T282), D309 (= D299), I310 (= I300), G327 (= G317), D328 (= D318), V329 (≠ A319), M404 (≠ Y388), G422 (≠ T406)
- binding magnesium ion: D452 (= D436), N479 (= N464), H481 (≠ A466)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ M383), G400 (≠ T384), Q401 (= Q385), H402 (≠ L386), M427 (≠ L411), G451 (= G435), G453 (= G437), S454 (≠ G438), N479 (= N464), H481 (≠ A466), L482 (= L467), G483 (= G468), M484 (≠ Q469), V485 (≠ I470)
Sites not aligning to the query:
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
31% identity, 86% coverage: 12:470/535 of query aligns to 18:486/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (≠ A255), R292 (≠ T282)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ M383), G401 (≠ T384), Q402 (= Q385), H403 (≠ L386), G426 (= G409), M428 (≠ L411), G452 (= G435), D453 (= D436), G454 (= G437), S455 (≠ G438), L483 (= L467), G484 (= G468), M485 (≠ Q469), V486 (≠ I470)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), M263 (vs. gap), L264 (≠ A253), M266 (≠ A255), H267 (≠ S256), G286 (= G276), R288 (≠ E278), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406)
- binding magnesium ion: A37 (≠ H31), T82 (≠ I75), S83 (≠ T76), Q122 (≠ H117), Y381 (≠ I369), D453 (= D436), M458 (≠ Y441), Q461 (= Q444), N480 (= N464), H482 (≠ A466)
Sites not aligning to the query:
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
31% identity, 86% coverage: 12:470/535 of query aligns to 18:486/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ M383), G401 (≠ T384), Q402 (= Q385), H403 (≠ L386), G426 (= G409), M428 (≠ L411), G452 (= G435), D453 (= D436), G454 (= G437), S455 (≠ G438), M458 (≠ Y441), N480 (= N464), H482 (≠ A466), L483 (= L467), G484 (= G468), M485 (≠ Q469), V486 (≠ I470)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), L264 (≠ A253), M266 (≠ A255), H267 (≠ S256), G286 (= G276), V287 (≠ T277), R288 (≠ E278), D290 (≠ A280), R292 (≠ T282), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406)
- binding magnesium ion: F370 (vs. gap), D453 (= D436), M458 (≠ Y441), Q461 (= Q444), N480 (= N464), H482 (≠ A466)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ A255), R292 (≠ T282), M485 (≠ Q469)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
31% identity, 86% coverage: 12:470/535 of query aligns to 18:486/582 of 5wj1A
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ A255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), M263 (vs. gap), L264 (≠ A253), G286 (= G276), R288 (≠ E278), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406), G424 (= G407)
- binding magnesium ion: D453 (= D436), N480 (= N464), H482 (≠ A466)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ A255), D291 (= D281), R292 (≠ T282), M485 (≠ Q469)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ M383), G401 (≠ T384), Q402 (= Q385), H403 (≠ L386), M428 (≠ L411), D453 (= D436), G454 (= G437), S455 (≠ G438), M458 (≠ Y441), N480 (= N464), H482 (≠ A466), L483 (= L467), G484 (= G468), M485 (≠ Q469), V486 (≠ I470)
Sites not aligning to the query:
Query Sequence
>PP_3723 FitnessBrowser__Putida:PP_3723
MNDLTLTAGQALVRLLANYGVETVFGIPGVHTLELYRGLPGSGIRHVLTRHEQGAGFMAD
GYARVSGKPGVCFVITGPGVTNVATPIGQAYADSVPMLVISSVNHTASLGKGWGCLHETQ
DQRAMTAPITAFSAVALQGDDLPELIARAWAVFDSERPRPVHISVPLDVLAASVSRDWSG
EVVRRPGRGQPCRETLEQAALKLAAAQRPMIIAGGGALHAAEQLQQLSTRLAAPLFTSVA
GKGLLPPDAPLNAGASLCVEPGWQLISQADVVLAVGTEMADTDFWRERLPIRGELLRVDI
DPRKFNDFYPCAIALQGDARQTLDGLLEHLPALQRDPAQASAAVATLRQAIRNGHAPLQA
THQAILDRIAAVLPDDAFISSDMTQLAYTGNYAFASRAPRSWLHPTGYGTLGYGLPAGIG
GMFASDHRPGLVLVGDGGFLYTAQELATAVEELHRPLVVLLWNNDALGQIRDDMLGLDIE
PVGVLPRNPDFIGLARAFGCTVHQPRDLDALQADLASGFATPGVTFIELKHTCVC
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory