SitesBLAST
Comparing PP_3819 FitnessBrowser__Putida:PP_3819 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4dnaA Crystal structure of putative glutathione reductase from sinorhizobium meliloti 1021
53% identity, 99% coverage: 2:446/451 of query aligns to 1:447/461 of 4dnaA
- active site: Y37 (≠ L38), C41 (= C42), C46 (= C47), K49 (= K50), Y178 (= Y176), E182 (= E180), A435 (≠ G434), H437 (= H436), E442 (= E441)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G11 (≠ A12), G12 (= G13), G14 (= G15), E33 (= E34), E34 (≠ S35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), R112 (≠ H113), A113 (= A114), V139 (≠ T138), G140 (= G139), Y178 (= Y176), R264 (= R262), G303 (= G301), D304 (= D302), Q310 (= Q308), L311 (= L309), T312 (= T310)
Sites not aligning to the query:
3o0hB Crystal structure of glutathione reductase from bartonella henselae
48% identity, 99% coverage: 2:446/451 of query aligns to 1:445/459 of 3o0hB
- active site: S13 (= S14), I37 (≠ L38), C41 (= C42), C46 (= C47), K49 (= K50), D74 (≠ E75), P75 (≠ G76), Y177 (= Y176), E181 (= E180), I314 (≠ L314), A433 (≠ G434), H435 (= H436), E440 (= E441)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), A32 (= A33), E33 (= E34), E34 (≠ S35), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), R112 (≠ H113), A113 (= A114), T139 (= T138), G140 (= G139), Y177 (= Y176), R262 (= R262), N265 (≠ M265), G301 (= G301), D302 (= D302), Q308 (= Q308), L309 (= L309), T310 (= T310)
Sites not aligning to the query:
6n7fA 1.90 angstrom resolution crystal structure of glutathione reductase from streptococcus pyogenes in complex with fad.
44% identity, 99% coverage: 1:447/451 of query aligns to 2:451/451 of 6n7fA
- active site: C43 (= C42), C48 (= C47), K51 (= K50), Y178 (= Y176), E182 (= E180), H440 (= H436), E445 (= E441)
- binding flavin-adenine dinucleotide: I11 (= I10), G12 (= G11), G14 (= G13), S15 (= S14), A16 (≠ G15), A34 (= A33), E35 (= E34), G36 (≠ S35), K37 (≠ R36), G41 (= G40), T42 (= T41), C43 (= C42), G47 (= G46), C48 (= C47), K51 (= K50), Y115 (≠ H113), A116 (= A114), T140 (= T138), G141 (= G139), Y178 (= Y176), I179 (= I177), R264 (= R262), G303 (= G301), D304 (= D302), L311 (= L309), T312 (= T310)
- binding riboflavin: G36 (≠ S35), K37 (≠ R36), Y115 (≠ H113), G270 (≠ N268)
1getA Anatomy of an engineered NAD-binding site (see paper)
46% identity, 94% coverage: 23:447/451 of query aligns to 21:448/448 of 1getA
- active site: L36 (= L38), C40 (= C42), C45 (= C47), K48 (= K50), Y175 (= Y176), E179 (= E180), A435 (≠ G434), H437 (= H436), E442 (= E441)
- binding flavin-adenine dinucleotide: E32 (= E34), A33 (≠ S35), G38 (= G40), T39 (= T41), C40 (= C42), G44 (= G46), C45 (= C47), K48 (= K50), F112 (≠ H113), A113 (= A114), T137 (= T138), I176 (= I177), R261 (= R262), G300 (= G301), D301 (= D302), E307 (≠ Q308), L308 (= L309), T309 (= T310)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: A173 (≠ G174), G174 (= G175), Y175 (= Y176), I176 (= I177), E179 (= E180), R196 (= R197), R202 (= R203), I259 (≠ T260), G260 (= G261), E307 (≠ Q308), L308 (= L309), V340 (≠ A341)
Sites not aligning to the query:
P06715 Glutathione reductase; GR; GRase; EC 1.8.1.7 from Escherichia coli (strain K12) (see paper)
46% identity, 94% coverage: 23:447/451 of query aligns to 23:450/450 of P06715
- C42 (= C42) modified: Disulfide link with 47, Redox-active
- C47 (= C47) modified: Disulfide link with 42, Redox-active
1gerB The structure of glutathione reductase from escherichia coli at 1.86 angstroms resolution: comparison with the enzyme from human erythrocytes (see paper)
46% identity, 94% coverage: 23:447/451 of query aligns to 22:449/449 of 1gerB
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y176 (= Y176), E180 (= E180), A436 (≠ G434), H438 (= H436), E443 (= E441)
- binding flavin-adenine dinucleotide: E33 (= E34), A34 (≠ S35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), F113 (≠ H113), A114 (= A114), T138 (= T138), Y176 (= Y176), I177 (= I177), R262 (= R262), G301 (= G301), D302 (= D302), E308 (≠ Q308), L309 (= L309), T310 (= T310)
Sites not aligning to the query:
5grtA Human glutathione reductase a34e, r37w mutant, glutathionylspermidine complex (see paper)
43% identity, 98% coverage: 4:447/451 of query aligns to 3:461/461 of 5grtA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (≠ G434), H450 (= H436), E455 (= E441)
- binding flavin-adenine dinucleotide: I9 (= I10), G12 (= G13), G14 (= G15), V32 (≠ A33), E33 (= E34), S34 (= S35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (= T138), Y180 (= Y176), G313 (= G301), D314 (= D302), L320 (≠ Q308), L321 (= L309), T322 (= T310)
- binding glutathionylspermidine disulfide: S13 (= S14), E17 (≠ R18), C41 (= C42), V42 (= V43), Y89 (≠ E90), L93 (= L94), I96 (= I97), Y97 (= Y98), T322 (= T310), I326 (≠ L314)
4grtA Human glutathione reductase a34e, r37w mutant, mixed disulfide between trypanothione and the enzyme (see paper)
43% identity, 98% coverage: 4:447/451 of query aligns to 3:461/461 of 4grtA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (≠ G434), H450 (= H436), E455 (= E441)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G11 (≠ A12), G12 (= G13), S13 (= S14), G14 (= G15), V32 (≠ A33), E33 (= E34), S34 (= S35), H35 (≠ R36), G39 (= G40), T40 (= T41), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (= T138), G140 (= G139), Y180 (= Y176), G313 (= G301), D314 (= D302), L320 (≠ Q308), L321 (= L309), T322 (= T310), A325 (= A313)
- binding bis(gamma-glutamyl-cysteinyl-glycinyl)spermidine: S13 (= S14), L16 (≠ V17), E17 (≠ R18), C41 (= C42), V42 (= V43), V47 (= V48), L93 (= L94), Y97 (= Y98), I326 (≠ L314)
3grtA Human glutathione reductase a34e, r37w mutant, oxidized trypanothione complex (see paper)
43% identity, 98% coverage: 4:447/451 of query aligns to 3:461/461 of 3grtA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (≠ G434), H450 (= H436), E455 (= E441)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), V32 (≠ A33), E33 (= E34), S34 (= S35), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (= T138), G140 (= G139), Y180 (= Y176), G313 (= G301), D314 (= D302), L321 (= L309), T322 (= T310)
- binding 2-amino-4-[4-(4-amino-4-carboxy-butyrylamino)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaaza-cyclotetracos-23-ylcarbamoyl]-butyric acid: S13 (= S14), E17 (≠ R18), W20 (≠ R21), V42 (= V43), L93 (= L94), Y97 (= Y98), T322 (= T310), I326 (≠ L314)
2grtA Human glutathione reductase a34e, r37w mutant, oxidized glutathione complex (see paper)
43% identity, 98% coverage: 4:447/451 of query aligns to 3:461/461 of 2grtA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (≠ G434), H450 (= H436), E455 (= E441)
- binding flavin-adenine dinucleotide: I9 (= I10), G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), S34 (= S35), G39 (= G40), T40 (= T41), C41 (= C42), V44 (= V45), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (= T138), G140 (= G139), Y180 (= Y176), G313 (= G301), D314 (= D302), L321 (= L309), T322 (= T310)
- binding oxidized glutathione disulfide: E17 (≠ R18), W20 (≠ R21), V42 (= V43), L93 (= L94), I96 (= I97), Y97 (= Y98)
5vdnA 1.55 angstrom resolution crystal structure of glutathione reductase from yersinia pestis in complex with fad
46% identity, 94% coverage: 23:447/451 of query aligns to 22:449/449 of 5vdnA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y176 (= Y176), E180 (= E180), A436 (≠ G434), H438 (= H436), E443 (= E441)
- binding beta-D-fructopyranose: K35 (≠ R36), T40 (= T41), G140 (= G140), D157 (≠ N157)
- binding flavin-adenine dinucleotide: E33 (= E34), A34 (≠ S35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), F113 (≠ H113), A114 (= A114), T138 (= T138), G139 (= G139), Y176 (= Y176), I177 (= I177), R262 (= R262), G301 (= G301), D302 (= D302), E308 (≠ Q308), L309 (= L309), T310 (= T310)
Sites not aligning to the query:
D0VWY5 Glutathione amide reductase; GAR; EC 1.8.1.16 from Marichromatium gracile (Chromatium gracile) (see 2 papers)
42% identity, 100% coverage: 1:451/451 of query aligns to 1:452/463 of D0VWY5
- M1 (= M1) modified: Initiator methionine, Removed
- T2 (≠ A2) binding
- Q3 (≠ F3) binding
- H4 (≠ D4) binding
- SG 14:15 (= SG 14:15) binding
- E34 (= E34) binding
- T41 (= T41) binding
- C42 (= C42) modified: Disulfide link with 47, Redox-active
- C47 (= C47) modified: Disulfide link with 42, Redox-active
- K50 (= K50) binding ; binding
- HA 113:114 (= HA 113:114) binding
- 174:180 (vs. 174:180, 57% identical) binding
- LE 197:198 (≠ RG 197:198) binding
- V230 (≠ I230) binding
- G261 (= G261) binding
- D302 (= D302) binding
- Q308 (= Q308) binding
- QLT 308:310 (= QLT 308:310) binding
- V341 (≠ A341) binding
- H437 (= H436) active site, Proton acceptor; binding
Sites not aligning to the query:
- 2:463 modified: mature protein, Glutathione amide reductase
2rabA Structure of glutathione amide reductase from chromatium gracile in complex with NAD (see paper)
42% identity, 99% coverage: 5:451/451 of query aligns to 4:448/451 of 2rabA
- active site: S13 (= S14), L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y173 (= Y176), E177 (= E180), I310 (≠ L314), A431 (≠ G434), H433 (= H436), E438 (= E441)
- binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), I32 (≠ A33), E33 (= E34), S34 (= S35), T40 (= T41), G45 (= G46), C46 (= C47), K49 (= K50), H110 (= H113), A111 (= A114), T135 (= T138), G136 (= G139), R258 (= R262), G297 (= G301), D298 (= D302), Q304 (= Q308), L305 (= L309), T306 (= T310)
- binding nicotinamide-adenine-dinucleotide: K49 (= K50), I169 (≠ V172), G172 (= G175), Y173 (= Y176), I174 (= I177), E177 (= E180), A193 (≠ Y196), L194 (≠ R197), E195 (≠ G198), V227 (≠ I230), V256 (≠ T260), G257 (= G261), Q304 (= Q308), V337 (≠ A341)
1geuA Anatomy of an engineered NAD-binding site (see paper)
46% identity, 94% coverage: 23:447/451 of query aligns to 21:448/448 of 1geuA
- active site: L36 (= L38), C40 (= C42), C45 (= C47), K48 (= K50), Y175 (= Y176), E179 (= E180), A435 (≠ G434), H437 (= H436), E442 (= E441)
- binding flavin-adenine dinucleotide: E32 (= E34), A33 (≠ S35), K34 (≠ R36), G38 (= G40), T39 (= T41), C40 (= C42), G44 (= G46), C45 (= C47), K48 (= K50), F112 (≠ H113), A113 (= A114), T137 (= T138), G300 (= G301), D301 (= D302), L308 (= L309), T309 (= T310)
- binding nicotinamide-adenine-dinucleotide: Y175 (= Y176), I176 (= I177), E179 (= E180), E195 (≠ Y196), M196 (≠ R197), F197 (≠ G198), A258 (= A259), I259 (≠ T260), G260 (= G261), E307 (≠ Q308), L308 (= L309), V340 (≠ A341)
Sites not aligning to the query:
3djjA Catalytic cycle of human glutathione reductase near 1 a resolution (see paper)
43% identity, 98% coverage: 4:447/451 of query aligns to 4:462/462 of 3djjA
- active site: L38 (= L38), C42 (= C42), C47 (= C47), K50 (= K50), Y181 (= Y176), E185 (= E180), A449 (≠ G434), H451 (= H436), E456 (= E441)
- binding flavin-adenine dinucleotide: G13 (= G13), E34 (= E34), S35 (= S35), G40 (= G40), T41 (= T41), G46 (= G46), C47 (= C47), K50 (= K50), H113 (= H113), A114 (= A114), T140 (= T138), G141 (= G139), R275 (= R262), G314 (= G301), D315 (= D302), L321 (≠ Q308), L322 (= L309), T323 (= T310)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: A179 (≠ G174), G180 (= G175), Y181 (= Y176), I182 (= I177), E185 (= E180), R202 (= R197), R208 (= R203), I273 (≠ T260), G274 (= G261), L321 (≠ Q308), V354 (≠ A341)
4gr1A The binding of the retro-analogue of glutathione disulfide to glutathione reductase (see paper)
43% identity, 98% coverage: 4:447/451 of query aligns to 3:461/461 of 4gr1A
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (≠ G434), H450 (= H436), E455 (= E441)
- binding flavin-adenine dinucleotide: G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), S34 (= S35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (= T138), G140 (= G139), Y180 (= Y176), G313 (= G301), D314 (= D302), L321 (= L309), T322 (= T310)
- binding 4n-malonyl-cysteinyl-2,4-diaminobutyrate disulfide: L93 (= L94), Y97 (= Y98), R330 (≠ M318)
3sqpA Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity (see paper)
43% identity, 98% coverage: 4:447/451 of query aligns to 3:461/461 of 3sqpA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (≠ G434), H450 (= H436), E455 (= E441)
- binding 5-methylphenazin-1(5H)-one: V57 (≠ H58), V57 (≠ H58), H58 (≠ V59), F61 (≠ E62), F61 (≠ E62)
- binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), S34 (= S35), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (= T138), Y180 (= Y176), R274 (= R262), G313 (= G301), D314 (= D302), L320 (≠ Q308), L321 (= L309), T322 (= T310), P323 (= P311)
2gh5A Crystal structure of human glutathione reductase complexed with a fluoro-analogue of the menadione derivative m5 (see paper)
43% identity, 98% coverage: 4:447/451 of query aligns to 3:461/461 of 2gh5A
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (≠ G434), H450 (= H436), E455 (= E441)
- binding 6-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)hexanoic acid: S13 (= S14), A17 (≠ R18), R20 (= R21), C41 (= C42), V42 (= V43), L93 (= L94), Y97 (= Y98)
- binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), V32 (≠ A33), E33 (= E34), S34 (= S35), G39 (= G40), T40 (= T41), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (= T138), G140 (= G139), Y180 (= Y176), I181 (= I177), R274 (= R262), G313 (= G301), D314 (= D302), L320 (≠ Q308), L321 (= L309), T322 (= T310)
2aaqA Crystal structure analysis of the human glutahione reductase, complexed with gopi (see paper)
43% identity, 98% coverage: 4:447/451 of query aligns to 3:461/461 of 2aaqA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (≠ G434), H450 (= H436), E455 (= E441)
- binding gold ion: C41 (= C42), C46 (= C47), T322 (= T310)
- binding 2-(2-phenyl-3-pyridin-2-yl-4,5,6,7-tetrahydro-2h-isophosphindol-1-yl)pyridine: L156 (= L152), I158 (= I154), G162 (≠ E158), L244 (≠ R240), D266 (= D254), C267 (= C255)
- binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), G14 (= G15), V32 (≠ A33), E33 (= E34), S34 (= S35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (= T138), G140 (= G139), S160 (= S156), R274 (= R262), D314 (= D302), L321 (= L309), T322 (= T310)
1xanA Human glutathione reductase in complex with a xanthene inhibitor (see paper)
43% identity, 98% coverage: 4:447/451 of query aligns to 3:461/461 of 1xanA
- active site: L37 (= L38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (≠ G434), H450 (= H436), E455 (= E441)
- binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), S34 (= S35), H35 (≠ R36), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (= T138), Y180 (= Y176), R274 (= R262), G313 (= G301), D314 (= D302), L320 (≠ Q308), L321 (= L309), T322 (= T310)
- binding 3,6-dihydroxy-xanthene-9-propionic acid: V57 (≠ H58), F61 (≠ E62), H65 (≠ A66), Y390 (≠ K376)
Query Sequence
>PP_3819 FitnessBrowser__Putida:PP_3819
MAFDFDLFVIGAGSGGVRAARFAAGFGAKVAVAESRYLGGTCVNVGCVPKKLLVYGAHVA
DELEQAAGFGWTLEEGHFDWGTLIANKNREIERLNGIYRNLLVNSGVTLLQGHARLTGAN
EVEVDGQRYTAEHILIATGGWPQVPDIPGKELAITSNEAFYLKDLPRRVLVVGGGYIAVE
FAGIFQGLGADTTLLYRGDLFLRGFDGSVRTHLKQELEKRGLDLQFNADIQRIDKLEDGR
LKATLKDGRELVADCVFYATGRRPMLDNLGLENTGVELDERGYIRVDEQYQTTAPSILAI
GDVIGRVQLTPVALAEGMAVARRLFKPEQYRPVDYQNIPTAVFSQPPIGTVGLTEEQALE
AGHKVQVFESRFRAMKLTLTDIQEKTLMKLVVDAETDKVLGCHMVGPDAGEIIQGLGIAL
KAGATKQQFDETIGVHPTAAEEFVTMRTVTR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory