SitesBLAST
Comparing PP_4493 FitnessBrowser__Putida:PP_4493 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:454/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (≠ N44), P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), W322 (vs. gap), E413 (= E494), H414 (= H495), N450 (= N529)
- binding 3-methyl-2-oxobutanoic acid: R318 (= R397), H369 (= H450), H376 (= H457), H414 (= H495)
- binding manganese (ii) ion: H369 (= H450), H376 (= H457), E413 (= E494)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:454/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R397), W322 (vs. gap), H369 (= H450), H376 (= H457), H414 (= H495)
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), W322 (vs. gap), E413 (= E494), N450 (= N529)
- binding manganese (ii) ion: H369 (= H450), H376 (= H457), E413 (= E494)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:455/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ N44), P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), W323 (vs. gap), E414 (= E494), H415 (= H495), N451 (= N529)
- binding manganese (ii) ion: H370 (= H450), H377 (= H457), E414 (= E494)
- binding pyruvic acid: R319 (= R397), H370 (= H450), H377 (= H457), H415 (= H495)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:453/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (≠ T89), R317 (= R397), W321 (vs. gap), H368 (= H450), H375 (= H457), H413 (= H495)
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), W321 (vs. gap), Y322 (≠ V401), E412 (= E494), H413 (= H495), N449 (= N529)
- binding manganese (ii) ion: H368 (= H450), H375 (= H457), E412 (= E494)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:454/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R397), H369 (= H450), H376 (= H457), H414 (= H495)
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), W322 (vs. gap), E413 (= E494), H414 (= H495), N450 (= N529)
- binding manganese (ii) ion: H369 (= H450), H376 (= H457), E413 (= E494)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:453/454 of 8jdzA
- binding (3S)-3-methyl-2-oxopentanoic acid: R318 (= R397), W322 (vs. gap), H369 (= H450), H376 (= H457), H413 (= H495)
- binding flavin-adenine dinucleotide: E32 (≠ N44), P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), W322 (vs. gap), E412 (= E494), H413 (= H495), N449 (= N529)
- binding manganese (ii) ion: H369 (= H450), H376 (= H457), E412 (= E494)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:453/454 of 8jdyA
- binding 2-oxo-4-methylpentanoic acid: R318 (= R397), W322 (vs. gap), S336 (≠ V417), H369 (= H450), H376 (= H457), H413 (= H495)
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), E412 (= E494), N449 (= N529)
- binding manganese (ii) ion: H369 (= H450), H376 (= H457), E412 (= E494)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:454/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), W322 (vs. gap), E413 (= E494), H414 (= H495), N450 (= N529)
- binding lactic acid: R318 (= R397), H369 (= H450), H376 (= H457), H414 (= H495)
- binding manganese (ii) ion: H369 (= H450), H376 (= H457), E413 (= E494)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:455/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), Y324 (≠ V401), H370 (= H450), E414 (= E494), N451 (= N529)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R397), W323 (vs. gap), H415 (= H495)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:455/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R397), W323 (vs. gap), H370 (= H450), H415 (= H495)
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), H370 (= H450), E414 (= E494), N451 (= N529)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:455/456 of 8jdoA
- binding (2R)-2-hydroxyhexanoic acid: R319 (= R397), W323 (vs. gap), H415 (= H495)
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), Y324 (≠ V401), H370 (= H450), E414 (= E494), N451 (= N529)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:455/456 of 8jdnA
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), H370 (= H450), E414 (= E494), N451 (= N529)
- binding (2R)-2-oxidanylpentanoic acid: R319 (= R397), W323 (vs. gap), H415 (= H495)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:455/456 of 8jdgA
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), H370 (= H450), E414 (= E494), N451 (= N529)
- binding (2R)-2-oxidanylbutanoic acid: R319 (= R397), H415 (= H495)
8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:455/456 of 8jdbA
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), Y324 (≠ V401), H370 (= H450), E414 (= E494), N451 (= N529)
- binding (2R)-2-oxidanyloctanoic acid: V75 (≠ T89), R319 (= R397), W323 (vs. gap), H415 (= H495)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
26% identity, 51% coverage: 16:533/1006 of query aligns to 4:454/455 of 8jdpA
- binding flavin-adenine dinucleotide: P68 (= P82), G70 (= G84), T71 (≠ G85), G72 (= G86), T73 (= T87), G74 (= G88), G78 (≠ Q92), V79 (vs. gap), L90 (= L102), P132 (≠ T147), G133 (≠ S148), A134 (≠ N149), G140 (= G155), M141 (= M156), A143 (≠ N158), T144 (= T159), A146 (= A161), S147 (= S162), E200 (= E263), G201 (= G264), I206 (≠ V269), H369 (= H450), E413 (= E494), N450 (= N529)
- binding deaminohydroxyvaline: R319 (= R397), H414 (= H495)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
26% identity, 47% coverage: 65:534/1006 of query aligns to 56:464/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ P82), G75 (= G84), S76 (≠ G85), G77 (= G86), T78 (= T87), G79 (= G88), L80 (≠ T89), A83 (≠ Q92), C84 (≠ S93), P137 (≠ S146), G138 (≠ T147), E139 (≠ S148), A142 (= A151), T143 (= T152), G146 (= G155), N147 (≠ M156), S149 (≠ N158), T150 (= T159), A152 (= A161), G153 (≠ S162), E203 (= E263), G204 (= G264), I209 (≠ V269), E422 (= E494), H423 (= H495)
- binding fe (iii) ion: H377 (= H450), H384 (= H457), E422 (= E494)
Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Homo sapiens (Human) (see 7 papers)
24% identity, 45% coverage: 76:532/1006 of query aligns to 122:515/521 of Q8N465
- N127 (≠ T81) to K: in D2HGA1; uncertain significance; complete loss of catalytic activity; dbSNP:rs762857195
- G131 (= G85) to V: in D2HGA1; uncertain significance; complete loss of catalytic activity
- I147 (≠ V99) to S: in D2HGA1; uncertain significance; severe phenotype; almost complete loss of catalytic activity; dbSNP:rs121434361
- M153 (= M106) to T: in D2HGA1; uncertain significance; significant loss of catalytic activity; to V: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs1432270139
- C172 (≠ T125) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs773735172
- P189 (≠ A142) to L: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs587783517
- A205 (≠ N158) to V: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs750889931
- A231 (≠ L184) to V: in D2HGA1; uncertain significance; significant loss of catalytic activity
- G233 (= G186) to S: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs374535734
- D375 (≠ G386) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs267606759
- R386 (= R397) binding ; binding ; binding ; mutation to A: Loss of catalytic activity.
- T390 (≠ V401) binding ; binding ; mutation to A: Significantly reduced catalytic activity.
- V399 (= V411) to M: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746519212
- K401 (≠ V417) binding ; binding ; mutation to A: Loss of catalytic activity.
- R419 (= R435) to H: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs199908032
- A426 (≠ G442) to T: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs146578303
- H434 (= H450) binding ; mutation to A: Loss of catalytic activity.
- G436 (≠ D452) to V: slight reduction in catalytic activity
- N439 (≠ V455) to D: in D2HGA1; uncertain significance; mild phenotype; moderate reduction in catalytic activity; dbSNP:rs121434362
- H441 (= H457) binding ; mutation to A: Loss of catalytic activity.
- N443 (≠ R459) binding ; mutation to A: Significantly reduced catalytic activity.
- V444 (≠ P460) to A: in D2HGA1; uncertain significance; severe phenotype; significant reduction in catalytic activity; dbSNP:rs121434360
- A446 (≠ L462) to V: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746956176
- E475 (= E494) binding ; mutation to A: Loss of catalytic activity.
- H476 (= H495) binding ; binding ; binding ; mutation to A: Loss of catalytic activity.
- G477 (= G496) to R: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs1453924640
Sites not aligning to the query:
- 15 R → G: in dbSNP:rs4675887
- 109 S → W: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs142050154
- 169:521 natural variant: Missing (in D2HGA1; uncertain significance)
- 400:521 natural variant: Missing (in D2HGA1; uncertain significance; complete loss of catalytic activity)
3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
24% identity, 48% coverage: 57:534/1006 of query aligns to 47:465/465 of 3pm9A
- active site: A149 (= A161), L159 (≠ K171)
- binding flavin-adenine dinucleotide: P69 (= P82), Q70 (≠ R83), G71 (= G84), G72 (= G85), N73 (≠ G86), T74 (= T87), G75 (= G88), L76 (vs. gap), G79 (= G91), Q80 (= Q92), L91 (≠ S103), L133 (= L145), G134 (≠ S146), A135 (≠ T147), C139 (≠ A151), T140 (= T152), G142 (= G154), G143 (= G155), S146 (≠ N158), T147 (= T159), A149 (= A161), G150 (≠ S162), E200 (= E263), G201 (= G264), I205 (≠ Y268), I206 (≠ V269), E423 (= E494)
6lpnB Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
24% identity, 45% coverage: 76:532/1006 of query aligns to 70:463/467 of 6lpnB
- binding flavin-adenine dinucleotide: P76 (= P82), G78 (= G84), G79 (= G85), N80 (≠ G86), T81 (= T87), G82 (= G88), M83 (≠ T89), G86 (≠ Q92), S87 (= S93), L140 (= L145), A142 (≠ T147), C146 (≠ A151), H147 (≠ T152), G150 (= G155), N151 (≠ M156), A153 (≠ N158), T154 (= T159), G208 (= G264), I212 (≠ Y268), I213 (≠ V269), E423 (= E494), N460 (= N529)
Sites not aligning to the query:
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
24% identity, 45% coverage: 76:532/1006 of query aligns to 69:462/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R397), T337 (≠ V401), K348 (≠ V417), Y379 (≠ F448), H381 (= H450), H388 (= H457), H423 (= H495)
- binding flavin-adenine dinucleotide: P75 (= P82), Q76 (≠ R83), G77 (= G84), G78 (= G85), N79 (≠ G86), T80 (= T87), G81 (= G88), M82 (≠ T89), G85 (≠ Q92), S86 (= S93), L139 (= L145), G140 (≠ S146), A141 (≠ T147), C145 (≠ A151), G149 (= G155), N150 (≠ M156), A152 (≠ N158), T153 (= T159), G157 (= G163), G207 (= G264), I212 (≠ V269), E422 (= E494), N459 (= N529)
- binding zinc ion: H381 (= H450), H388 (= H457), E422 (= E494)
Sites not aligning to the query:
Query Sequence
>PP_4493 FitnessBrowser__Putida:PP_4493
MIAQLSTVAPSANYPEFLEALRNSGFRGQISADYATRTVLATDNSIYQRLPQAAVFPLDA
DDVARVATLMGEPRFQQVKLTPRGGGTGTNGQSLTDGIVVDLSRHMNNILEINVEERWVR
VQAGTVKDQLNAALKPHGLFFAPELSTSNRATVGGMINTDASGQGSCTYGKTRDHVLELH
SVLLGGERLHSLPIDDAALEQACAAPGRVGEVYRMAREIQETQAELIETTFPKLNRCLTG
YDLAHLRDEQGRFNLNSVLCGAEGSLGYVVEAKLNVLPIPKYAVLVNVRYTSFMDALRDA
NALMAHKPLSIETVDSKVLMLAMKDIVWHSVAEYFPADPERPTLGINLVEFCGDEPAEVN
AKVQAFIQHLQSDTSVERLGHTLAEGAEAVTRVYTMRKRSVGLLGNVEGEVRPQPFVEDT
AVPPEQLADYIADFRALLDGYGLAYGMFGHVDAGVLHVRPALDMKDPVQAALVKPISDAV
AALTKRYGGLLWGEHGKGLRSEYVPEYFGELYPALQRLKGAFDPHNQLNPGKICTPLGSA
EGLTPVDGVTLRGDLDRTIDERVWQDFPSAVHCNGNGACYNYDPNDAMCPSWKATRERQH
SPKGRASLMREWLRLQGEANIDVLAAARNKVSWLKGLPARLRNNRARNQGQEDFSHEVYD
AMAGCLACKSCAGQCPIKVNVPDFRSRFLELYHGRYQRPLRDYLIGSLEFTIPYLAHAPG
LYNAVMGSKWVSQLLADKVGMVDSPLISRFNFQATLTRCRVGMATVPALRELTPAQRERS
IVLVQDAFTRYFETPLLSAFIDLAHRLGHRVFLAPYSANGKPLHVQGFLGAFAKAAIRNA
TQLKALADCGVPLVGLDPAMTLVYRQEYQKVPGLEGCPKVLLPQEWLMDVLPEQAPAAPG
SFRLMAHCTEKTNVPASTRQWEQVFARLGLKLVTEATGCCGMSGTYGHEARNQETSRTIF
EQSWATKLDKDGEPLATGYSCRSQVKRMTERKMRHPLEVVLQYAQR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory