SitesBLAST

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
41% identity, 96% coverage: 1:181/188 of query aligns to 1:181/203 of P07464

query
sites
P07464

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M1 (= M1) modified: Initiator methionine, Removed; Partial
D17 (≠ A17) binding
S71 (≠ D71) binding
N85 (= N85) binding in other chain; binding in other chain
D93 (≠ V93) binding
H115 (= H115) mutation to A: Results in an 1800-fold decrease in catalytic activity.
S142 (≠ G142) binding in other chain
A160 (= A160) binding in other chain
TK 165:166 (≠ TR 165:166) binding
R180 (= R180) binding

Sites not aligning to the query:

183 binding in other chain

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal (see paper)
41% identity, 96% coverage: 1:181/188 of query aligns to 2:180/201 of 1krvA

query
sites
1krvA

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binding 4-nitrophenyl beta-D-galactopyranoside: D16 (≠ A17), R25 (≠ Q26), S70 (≠ D71), Y82 (≠ F83), N84 (= N85), V90 (≠ L91), D92 (≠ V93), M126 (≠ E127)
binding coenzyme a: A104 (≠ G105), S110 (≠ Y111), T112 (≠ A113), W138 (= W139), G140 (= G141), S141 (≠ G142), N146 (≠ L147), A159 (= A160), P177 (= P178), R179 (= R180)

Sites not aligning to the query:

binding coenzyme a: 182

1kruA Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
41% identity, 96% coverage: 1:181/188 of query aligns to 2:180/201 of 1kruA

query
sites
1kruA

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binding coenzyme a: H114 (= H115), W138 (= W139), G140 (= G141), S141 (≠ G142), G158 (= G159), A159 (= A160), P177 (= P178)
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: D16 (≠ A17), P22 (≠ Q23), R25 (≠ Q26), W62 (≠ V63), S70 (≠ D71), Y82 (≠ F83), Y82 (≠ F83), N84 (= N85), V90 (≠ L91), D92 (≠ V93), L102 (≠ Q103), H114 (= H115), M126 (≠ E127)

Sites not aligning to the query:

binding coenzyme a: 182

1krrA Galactoside acetyltransferase in complex with acetyl-coenzyme a (see paper)
41% identity, 96% coverage: 1:181/188 of query aligns to 2:180/200 of 1krrA

query
sites
1krrA

M

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binding acetyl coenzyme *a: N84 (= N85), I103 (= I104), A104 (≠ G105), P105 (= P106), T112 (≠ A113), H114 (= H115), G140 (= G141), S141 (≠ G142), N146 (≠ L147), G158 (= G159), A159 (= A160), A174 (≠ V175), P177 (= P178)

Sites not aligning to the query:

binding acetyl coenzyme *a: 182

3nz2J Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
40% identity, 96% coverage: 1:181/188 of query aligns to 2:180/185 of 3nz2J

query
sites
3nz2J

M

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binding acetyl coenzyme *a: G104 (= G105), Y110 (= Y111), H114 (= H115), W138 (= W139), G140 (= G141), A158 (≠ G159), A159 (= A160), N164 (≠ T165), G174 (≠ V175), T176 (≠ N177), P177 (= P178)

Sites not aligning to the query:

binding acetyl coenzyme *a: 182

3nz2C Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
40% identity, 95% coverage: 3:181/188 of query aligns to 1:177/183 of 3nz2C

query
sites
3nz2C

L

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binding acetyl coenzyme *a: Y107 (= Y111), H111 (= H115), G137 (= G141), A155 (≠ G159), A156 (= A160), N161 (≠ T165), G171 (≠ V175), T173 (≠ N177), P174 (= P178)
binding magnesium ion: N157 (≠ G161), T173 (≠ N177)

Sites not aligning to the query:

binding acetyl coenzyme *a: 178, 179

5u2kA Crystal structure of galactoside o-acetyltransferase complex with coa (h3 space group)
39% identity, 95% coverage: 3:181/188 of query aligns to 1:180/190 of 5u2kA

query
sites
5u2kA

L

M

S

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K

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E

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K

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A

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G

N

C

F

P

D

E

Q

-

Y

L

L

Q

I

A

N

E

E

Q

R

I

A

A

R

N

A

K

K

H

D

W

I

M

C

H

F

R

E

Y

L

N

N

N

H

S

T

V

R

E

P

L

S

L

A

N

T

D

N

A

K

R

R

H

K

G

E

L

L

L

I

V

D

E

Q

H

L

F

F

G

Q

Q

T

V

T

G

T

E

D

G

N

A

V

V

S

I

I

R

S

P

I

P

P

F

F

Y

D

C

T

D

D

Y

Y

G

G

Y

W

N

N

I

V

S

K

V

L

G

G

R

K

N

N

T

V

F

Y

M

V

N

N

F

T

N

N

C

C

V

Y

I

F

L
x
M

D

D

V

G

P

Q

V

I

R

T

I

I

G

G

E

D

D

N

C

V

Q

F

I

I

G

G

P

P

N

N

V

C

Q

G

I

F

Y
|
Y

T

T

A
|
A

D

T

H
|
H

P

P

L

L

D

N

P

F

E

H

V

H

R

R

R

N

S

E

G

G

L

F

E

E

S

K

G

A

R

G

P

P

V

I

T

H

I

I

G

G

D

S

N

N

V

T

W

W

I

F

G

G

A

H

A

V

I

A

I

V

L
|
L

P

P

G

G

V

V

T

T

I

I

G

G

D

E

N

G

A

S

I

V

V

I

G

G

A

A

G

G

S

S

V

V

T
|
T

R
x
K

D

D

V

I

P

P

A

P

G

H

A

S

T

L

V

A

V

V

G

G

N

N

P

P

A

C

R

K

V

V

binding coenzyme a: M90 (≠ L91), Y110 (= Y111), A112 (= A113), H114 (= H115), L146 (= L147), T164 (= T165), K165 (≠ R166)

3ectA Crystal structure of the hexapeptide-repeat containing- acetyltransferase vca0836 from vibrio cholerae
41% identity, 93% coverage: 8:181/188 of query aligns to 3:170/176 of 3ectA

query
sites
3ectA

K

K

M

M

L

L

T

K

G

G

Q

-

L

-

Y

-

H

H

A

A

G

S

C

A

P

-

E

E

L

I

Q

E

A

A

E

L

Q

R

I

S

A

Q

N

A

K

G

H

R

W

L

M

K

H

L

R

E

Y

I

N

N

N

Q

S

S

V

L

E

D

L

-

N

E

D

A

A

E

R

R

H

Y

G

A

L

L

L

Q

V

R

E

E

H

L

F

F

G

G

Q

H

V

L

G

G

E

H

G

K

A

S

V

C

I

V

R

Q

P

P

F

F

Y

H

C

C

D

E

Y

F

G

G

Y

K

N

T

I

I

S

R

V

I

G

G

R

D

N

H

T

T

F

F

M

I

N

N

F

M

N

N

C

V

V

V

I

M

L

L

D

D

V

G

V

A

P

P

V

I

R

T

I

I

G

G

E

D

D

H

C

V

Q

L

I

I

G

G

P

P

N

S

V

T

Q

Q

I

F

Y

Y

T

T

A

A

D

S

H

H

P

S

L

L

D

D

P

Y

E

R

V

R

R

R

R

Q

S

A

G

W

L

E

E

T

S

I

G

C

R

K

P

P

V

I

T

V

I

I

G

E

D

D

N

D

V

V

W

W

I

I

G

G

A

N

A

V

I

V

I

I

L

N

P

Q

G
|
G

V

V

T

T

I

I

G

G

D

A

N

R

A

S

I

V

V

V

G

A

A

A

G

N

S

S

V

V

T

N

R

Q

D
|
D

V

V

P

P

A

P

G

D

A

T

T

L

V

V

V

G

G

G

N

T

P

P

A

A

R

R

V

I

binding calcium ion: G138 (= G149), D156 (= D167)

A1ADJ6 Polysialic acid O-acetyltransferase; Capsule O-acetyl transferase; EC 2.3.1.136 from Escherichia coli O1:K1 / APEC (see paper)
29% identity, 68% coverage: 54:181/188 of query aligns to 147:276/307 of A1ADJ6

query
sites
A1ADJ6

H

N

F

Y

G

V

Q

R

V

I

G

H

E

K

G

N

A

S

V

K

I

I

R

K

P

G

P

D

F

I

Y

V

C

A

D

T

Y

K

G

G

Y

S

N

K

I

V

S

I

V

I

G

G

R

R

N

R

T

T

F

T

M

I

N

G

-

A

-

G

F

F

N

E

C

-

V

V

I

V

L

T

D

D

V

K

V

C

P

N

V

V

R

T

I

I

G

G

E

H

D

D

C

C

Q

M

I

I

G

A

P

R

N

D

V

V

Q

I

I

L

Y

R

T

A

A

S

D

D

-

G

H
|
H

P

P

L

I

D

F

P

D

E

I

V

H

R

S

R

K

S

K

G

R

L

I

E

N

S

W

G

A

R

K

P

D

V

I

T

I

I

I

G

S

D

S

N

Y

V

V

W
|
W

I

V

G

G

G

R

A

N

A

V

I

S

I

I

L

M

P

K

G

G

V

V

T

S

I

V

G

G

D

S

N

G

A

S

I

V

V

I

G

G

A

Y

G

G

S

S

V

I

V

V

T

T

R

K

D

D

V

V

P

P

A

S

G

M

A

C

T

A

V

A

G

G

N

N

P

P

A

A

R

K

V

I

H210 (= H115) mutation to A: Loss of activity.
W234 (= W139) mutation to A: Loss of activity.

4mzuF Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
34% identity, 69% coverage: 52:181/188 of query aligns to 19:140/294 of 4mzuF

query
sites
4mzuF

V

V

E
x
W

H
x
Q

F

F

G

C

Q

V

V

I

G

L

E

A

G

G

A

A

V

V

I

I

R

-

P

-

F

-

Y

-

C

-

D

-

Y

-

G

G

Y

R

N

N

I

C

S

N

V

I

G
x
C

R

A

N

N

T

S

F

L

M

I

N

E

F

N

N

D

C

V

V

V

I

I

L

G

D

D

V

N

V

V

P

T

V

I

R

K

I

S

G

G

-

V

-

Q

-

I

-

W

-

D

-

G

-

I

-

H

-

I

-

Q

E

D

D

D

C

V

Q

F

I

I

G

G

P

P

N

N

V

V

Q

T

I

F

Y

T

T
x
N

A
x
D

D
x
K

H

Q

P

P

L

-

D

-

P

-

E

-

V

-

R

-

R

R

S

S

G

K

L

I

E

K

S

T

G

-

R

-

P

-

V

-

T

I

I

V

G

K

D

K

N

G

V

A

W

S

I

I

G
|
G

G
x
A

A

N

A

S

I

T

I

I

L
|
L

P

P

G

G

V

I

T

L

I

I

G

G

D

E

N

N

A

A

I

M

V

V

G
|
G

A
|
A

G

G

S

A

V

V

V

I

T
|
T

R
x
K

D

N

V

V

P

P

A

D

G

N

A

A

T

I

V

V

V
x
I

G

G

N
|
N

P

P

A

G

R
|
R

V

I

binding coenzyme a: N81 (≠ T112), D82 (≠ A113), K83 (≠ D114), G100 (= G141), A101 (≠ G142), L106 (= L147), G118 (= G159), A119 (= A160), T124 (= T165), K125 (≠ R166), I134 (≠ V175), N136 (= N177), R139 (= R180)
binding thymine: W20 (≠ E53), Q21 (≠ H54), C38 (≠ G79)

Sites not aligning to the query:

binding thymidine-5'-diphosphate: 189, 203, 205, 270

4mzuB Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
34% identity, 69% coverage: 52:181/188 of query aligns to 19:139/290 of 4mzuB

query
sites
4mzuB

V

V

E
x
W

H
x
Q

F

F

G

C

Q

V

V

I

G

L

E

A

G

G

A

A

V

V

I

I

R

-

P

-

F

-

Y

-

C

-

D

-

Y

-

G

G

Y

R

N

N

I

C

S

N

V

I

G
x
C

R
x
A

N

N

T

S

F

L

M

I

N

E

F

N

N

D

C

V

V

V

I

I

L

G

D

D

V

N

V

V

P

T

V

I

R

K

I

S

G
|
G

-

V

-

Q

-

I

-

W

-

D

-

G

-

I

-

H

-

I

-

Q

E

D

D

D

C

V

Q
x
F

I

I

G

G

P

P

N
|
N

V

V

Q

T

I

-

Y

F

T
|
T

A
x
N

D
|
D

H
x
K

P

-

L

-

D

Q

P
|
P

E

R

V

S

R

L

R

K

S

T

G

I

L

V

E

K

S

K

G

G

R

A

P

S

V

-

T

-

I

-

G

-

D

-

N

-

V

-

W

-

I

I

G
|
G

G
x
A

A

N

A

S

I

T

I

I

L

L

P

P

G

G

V

I

T

L

I

I

G

G

D

E

N

N

A

A

I

M

V

V

G
|
G

A
|
A

G

G

S

A

V

V

V

I

T
|
T

R
x
K

D

N

V

V

P

P

A

D

G

N

A

A

T

I

V

V

V
x
I

G

G

N

N

P

P

A

G

R
|
R

V

I

binding coenzyme a: F72 (≠ Q103), T80 (= T112), N81 (≠ A113), D82 (= D114), K83 (≠ H115), P85 (= P119), G99 (= G141), A100 (≠ G142), G117 (= G159), A118 (= A160), T123 (= T165), K124 (≠ R166), I133 (≠ V175), R138 (= R180)
binding magnesium ion: G58 (= G99), N76 (= N107)
binding thymine: W20 (≠ E53), Q21 (≠ H54), C38 (≠ G79), A39 (≠ R80)

Sites not aligning to the query:

binding coenzyme a: 199
binding thymidine-5'-diphosphate: 171, 176, 189, 191, 202, 203, 270

P50870 Streptogramin A acetyltransferase; Virginiamycin acetyltransferase D; Vat(D); EC 2.3.1.- from Enterococcus faecium (Streptococcus faecium) (see paper)
35% identity, 56% coverage: 75:179/188 of query aligns to 29:161/209 of P50870

query
sites
P50870

N

N

I

V

S

E

V

V

G

G

R

E

N

Y

T

S

F

Y

M

Y

N

D

-

S

-

K

-

N

-

G

-

E

-

T

F

F

N

D

C

K

V

Q

I

I

L

L

D

Y

V

H

V

Y

P

P

V

I

-

L

-

N

-

D

-

K

-

L

R

K

I

I

G

G

E

K

D

F

C

C

Q

S

I

I

G

G

P

P

N

G

V

V

Q

T

I

I

Y

I

T

M

-

N

-

G

A

A

D

N

H
|
H

P

R

L

M

D

D

P

G

E

S

-

T

-

Y

-

P

-

F

-

N

V

L

R

F

R

G

S

N

G

G

L

W

E

E

S

K

G

H

R

M

P

P

-

K

-

L

-

D

-

Q

-

L

-

P

-

I

-

K

-

G

-

D

V

T

T

I

I

I

G

G

D

N

N

D

V

V

W

W

I

I

G

G

G

K

A

D

A

V

I

V

I

I

L

M

P

P

G

G

V

V

T

K

I

I

G

G

D

D

N

G

A

A

I

I

V

V

G

A

A

A

G

N

S

S

V

V

T

V

R

K

D

D

V

I

P

A

A

P

G

Y

A

M

T

L

V

A

V

G

G

G

N

N

P

P

A

A

H82 (= H115) mutation to A: 105-fold decrease in activity.

3dhoA Structure of streptogramin acetyltransferase in complex with an inhibitor
39% identity, 45% coverage: 96:179/188 of query aligns to 61:161/203 of 3dhoA

query
sites
3dhoA

V

L

R

K

I

I

G

G

E

K

D

F

C

C

Q

S

I

I

G

G

P

P

N

G

V

V

Q

T

I

I

Y

I

T

M

-

N

-

G

A

A

D

N

H

H

P

R

L
x
M

D

D

P

G

E

S

-

T

-

Y

-

P

-

F

-

N

V

L

R

F

R

G

S

N

G

G

L

W

E

E

S

K

G

H

R

M

P

P

-

K

-

L

-

D

-

Q

-

L

-

P

-

I

-

K

-

G

-

D

V

T

T

I

I

I

G

G

D

N

N

D

V

V

W

W

I

I

G

G

G

K

A

D

A

V

I

V

I

I

L

M

P

P

G

G

V

V

T

K

I

I

G

G

D

D

N

G

A

A

I
|
I

V

V

G
x
A

A

A

G

N

S

S

V

V

T
x
V

R

K

D

D

V

I

P

A

A

P

G

Y

A

M

T
x
L

V

A

V
x
G

G

G

N

N

P
|
P

A

A

binding 6-bromo-N'-[(1Z)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-methylquinoline-4-carbohydrazide: M84 (≠ L117), I139 (= I157), A141 (≠ G159), V147 (≠ T165), L155 (≠ T173), G157 (≠ V175), P160 (= P178)

Sites not aligning to the query:

binding 6-bromo-N'-[(1Z)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-2-methylquinoline-4-carbohydrazide: 164

1mrlA Crystal structure of streptogramin a acetyltransferase with dalfopristin (see paper)
35% identity, 56% coverage: 75:179/188 of query aligns to 29:161/204 of 1mrlA

query
sites
1mrlA

N

N

I

V

S

E

V

V

G

G

R

E

N

Y

T

S

F
x
Y

M

Y

N
x
D

-

S

-

K

-

N

-

G

-

E

-

T

F

F

N

D

C

K

V

Q

I

I

L

L

D

Y

V

H

V
x
Y

P

P

V
x
I

-

L

-

N

-

D

-

K

-

L

R

K

I

I

G

G

E

K

D

F

C

C

Q

S

I

I

G

G

P

P

N

G

V

V

Q

T

I

I

Y

I

T

M

-

N

-

G

A

A

D
x
N

H
|
H

P

R

L

M

D

D

P

G

E

S

V

T

R

Y

R

P

-

F

-

N

-
x
L

-

F

-

G

S

N

G

G

L

W

E

E

S

K

G

H

R
x
M

P

P

-

K

-

L

-

D

-

Q

-
x
L

-

P

-

I

-

K

-

G

-

D

V

T

T

I

I

I

G

G

D

N

N

D

V

V

W

W

I

I

G

G

G

K

A

D

A

V

I

V

I

I

L

M

P

P

G

G

V

V

T

K

I

I

G

G

D

D

N

G

A

A

I

I

V

V

G

A

A

A

G

N

S

S

V

V

T

V

R

K

D

D

V

I

P

A

A

P

G

Y

A

M

T

L

V

A

V

G

G

G

N

N

P

P

A

A

binding 5-(2-diethylamino-ethanesulfonyl)-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triaza-tricyclo[23.2.1.00,255]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetraone: Y37 (≠ F83), D39 (≠ N85), Y54 (≠ V94), I56 (≠ V96), N81 (≠ D114), H82 (= H115), L93 (vs. gap), M102 (≠ R130), L108 (vs. gap)

1khrA Crystal structure of vat(d) in complex with virginiamycin and coenzyme a (see paper)
39% identity, 45% coverage: 96:179/188 of query aligns to 61:161/206 of 1khrA

query
sites
1khrA

V

L

R

K

I

I

G

G

E

K

D

F

C

C

Q

S

I

I

G

G

P

P

N

G

V

V

Q

T

I

I

Y

I

T

M

-

N

-

G

A
|
A

D
x
N

H
|
H

P

R

L
x
M

D

D

P

G

E

S

V

T

R

Y

R

P

-

F

-

N

-
x
L

-

F

-

G

S

N

G

G

L

W

E

E

S

K

G

H

R

M

P

P

-

K

-

L

-

D

-

Q

-

L

-

P

-

I

-

K

-

G

-

D

V

T

T

I

I

I

G

G

D

N

N

D

V

V

W
|
W

I

I

G

G

G

K

A

D

A

V

I

V

I

I

L

M

P

P

G

G

V

V

T

K

I

I

G

G

D

D

N

G

A

A

I

I

V

V

G
x
A

A
|
A

G

N

S

S

V

V

T
x
V

R

K

D

D

V

I

P

A

A

P

G

Y

A

M

T
x
L

V

A

V
x
G

G

G

N

N

P
|
P

A

A

binding coenzyme a: H82 (= H115), M84 (≠ L117), W121 (= W139), A141 (≠ G159), A142 (= A160), V147 (≠ T165), L155 (≠ T173), G157 (≠ V175), P160 (= P178)
binding virginiamycin m1: A80 (= A113), N81 (≠ D114), H82 (= H115), L93 (vs. gap)

Sites not aligning to the query:

1kk4A Crystal structure of vat(d) in complex with acetyl-coa (see paper)
39% identity, 45% coverage: 96:179/188 of query aligns to 61:161/205 of 1kk4A

query
sites
1kk4A

V

L

R

K

I

I

G

G

E

K

D

F

C

C

Q

S

I
|
I

G
|
G

P

P

N

G

V

V

Q

T

I

I

Y

I

T

M

-

N

-

G

A

A

D

N

H

H

P

R

L

M

D

D

P

G

E

S

-

T

-

Y

-

P

-

F

-

N

V

L

R

F

R

G

S

N

G

G

L

W

E

E

S

K

G

H

R

M

P

P

-

K

-

L

-

D

-

Q

-

L

-

P

-

I

-
x
K

-

G

-

D

V

T

T

I

I

I

G

G

D

N

N

D

V

V

W
|
W

I

I

G
|
G

G
x
K

A

D

A

V

I

V

I

I

L

M

P

P

G

G

V

V

T

K

I

I

G

G

D

D

N

G

A

A

I

I

V

V

G
x
A

A
|
A

G

N

S

S

V

V

T
x
V

R
x
K

D

D

V

I

P

A

A

P

G

Y

A

M

T
x
L

V

A

V
x
G

G
|
G

N

N

P
|
P

A

A

binding acetyl coenzyme *a: I69 (= I104), G70 (= G105), K111 (vs. gap), W121 (= W139), G123 (= G141), K124 (≠ G142), A141 (≠ G159), A142 (= A160), V147 (≠ T165), K148 (≠ R166), L155 (≠ T173), G157 (≠ V175), G158 (= G176), P160 (= P178)

Sites not aligning to the query:

binding acetyl coenzyme *a: 164

4n6bA Soybean serine acetyltransferase complexed with coa (see paper)
47% identity, 46% coverage: 96:181/188 of query aligns to 154:232/233 of 4n6bA

query
sites
4n6bA

V

V

R

V

I

V

G

G

E

E

D

T

C

A

Q

V

I

I

G

G

P

N

N

N

V

V

Q

S

I

I

Y
x
L

T

-

A

-

D

-

H

-

P

-

L

-

D

-

P

H

E

H

V

V

R

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R

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G

G
|
G

L

T

E

G

S

G

G

D

R

R

P

H

V

P

T

K

I

I

G

G

D

D

N

G

V

V

W

L

I

I

G

G

G

A

A

G

A

A

I

T

I

I

L

L

P

G

G

N

V

I

T

K

I

I

G

G

D

E

N

G

A

A

I
x
K

V

V

G
|
G

A
|
A

G

G

S

S

V

V

T
x
L

R

I

D

D

V

V

P

P

A

P

G

R

A

T

T

T

V

A

V
|
V

G

G

N

N

P

P

A

A

R

R

V

L

binding coenzyme a: L169 (≠ Y111), G176 (= G125), K208 (≠ I157), G210 (= G159), A211 (= A160), L216 (≠ T165), V226 (= V175)

Sites not aligning to the query:

binding coenzyme a: 150

8vr6A Crystal structure of the pcryo_0619 n-acetryltransferase from psychrobacter cryohalolentis k5 in the presence of coa-disulfide
37% identity, 55% coverage: 76:179/188 of query aligns to 61:165/177 of 8vr6A

query
sites
8vr6A

I

V

S

K

V

V

G

G

R

K

N

D

T

T

F

W

M

I

N

G

F

P

N

N

C

-

V

T

I

I

L

L

D

D

V

G

V

S

P

G

V

G

R

G

I

L

G

I

E

I

-

G

-

S

D

N

C

C

Q

S

I

I

G

S

P

A

N

G

V

V

Q

Q

I

I

Y
|
Y

T

T

A
x
H

D
|
D

H

-

P

-

L

-

D

-

P

-

E
x
T

V

V

R

R

R

K

S

S

G

-

L

L

E

S

S

G

G

G

R

K

-

A

-

D

-

I

-

D

-

K

-

A

P

S

V

T

T

R

I

I

G

G

D

S

N

D

V

C

W

Y

I

L

G

G

G

P

A

N

A

T

I

I

L
x
V

P

K

G

G

V

V

T

K

I

I

G

G

D

D

N

R

A

V

I

V

V

V

G

G

A

A

G

N

S

S

V
x
L

V

V

T
x
L

R

K

D

D

V

I

P

P

A

S

G

D

A

C

T

K

V

V

V

F

G

G

N
x
S

P
|
P

A

A

binding [[(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{R})-4-[[3-[2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate: Y97 (= Y111), H99 (≠ A113), D100 (= D114), T101 (≠ E120), V133 (≠ L147), L149 (≠ V163), L151 (≠ T165), S163 (≠ N177), P164 (= P178)

Query Sequence

>PP_5163 FitnessBrowser__Putida:PP_5163
MSLSEKHKMLTGQLYHAGCPELQAEQIANKHWMHRYNNSVELLNDARHGLLVEHFGQVGE
GAVIRPPFYCDYGYNISVGRNTFMNFNCVILDVVPVRIGEDCQIGPNVQIYTADHPLDPE
VRRSGLESGRPVTIGDNVWIGGAAIILPGVTIGDNAIVGAGSVVTRDVPAGATVVGNPAR
VRQPDQGQ

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory