SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Pf1N1B4_1079 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_1079 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6mjpB Lptb(e163q)fgc from vibrio cholerae (see paper)
73% identity, 100% coverage: 2:241/241 of query aligns to 1:240/240 of 6mjpB

query
sites
6mjpB

A

A

T

I

L

L

K

K

A

A

Q

Q

H

H

L

L

A

A

K

K

S

S

Y

Y

K

K

S

K

R

R

Q

K

V

V

R

S

D

D

V

V

S

S

L

L

S

Q

I

V

D

E

S

S

G

G

Q

Q

I

I

V

V

G

G

L

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

C

S

F

F

Y

Y

M

M

I

I

V

V

G

G

L

L

V

V

Q

A

A

R

D

D

Q

E

G

G

R

T

V

I

L

T

I

I

D

D

L

N

D

D

V

I

S

S

H

I

Q

L

P

P

M

M

H

H

G

S

R

R

A

S

K

R

A

M

G

G

I

I

G

G

Y

Y

L

L

P

P

Q

Q

E

E

A

A

S

S

I

I

F

F

R
|
R

K
|
K

L

L

S

S

V

V

A

E

D

D

N

N

I

I

M

M

A

A

I

V

L

L

E

Q

T

T

R

R

K

E

E

E

L

L

D

T

Q

H

A

E

G

E

R

R

R

Q

Q

D

E

K

L

L

E

E

S

D

L

L

Q

E

E

E

F

F

H

H

I

I

H

Q

H

H

I

I

R

R

D

K

N

S

L

A

G

G

M

M

S

A

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

N

N

P

P

K

Q

F

F

I

I

L

L

D

D

E

Q

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

Q

K

I

I

H

E

H

H

L

L

K

R

A

D

K

R

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

D

I

V

C

C

E

E

T

K

A

A

Y

Y

I

I

V

V

N

S

D

Q

G

G

Q

R

L

L

I

I

A

A

E

E

G

G

D

T

S

P

A

Q

T

D

I

V

L

L

A

N

N

N

E

E

L

Q

V

V

K

K

E

Q

V

V

Y

Y

L

L

G

G

H

E

E

Q

F

F

R

R

L

L

binding 6-cyclohexylhexyl beta-D-glucopyranoside: R90 (= R91), K91 (= K92)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
73% identity, 100% coverage: 2:241/241 of query aligns to 1:240/240 of 6mjpA

query
sites
6mjpA

A

A

T

I

L

L

K

K

A

A

Q

Q

H

H

L

L

A

A

K

K

S

S

Y

Y

K

K

S

K

R

R

Q

K

V

V

R

S

D

D

V

V

S

S

L

L

S

Q

I

V

D

E

S

S

G

G

Q

Q

I

I

V

V

G

G

L

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

C

S

F

F

Y

Y

M

M

I

I

V

V

G

G

L

L

V

V

Q

A

A

R

D

D

Q

E

G

G

R

T

V

I

L

T

I

I

D

D

L

N

D

D

V

I

S

S

H

I

Q

L

P

P

M

M

H

H

G

S

R

R

A

S

K

R

A

M

G

G

I

I

G

G

Y

Y

L

L

P

P

Q

Q

E

E

A

A

S

S

I

I

F

F

R

R

K

K

L

L

S

S

V

V

A

E

D

D

N

N

I

I

M

M

A

A

I

V

L

L

E

Q

T

T

R

R

K

E

E

E

L

L

D

T

Q

H

A
x
E

G

E

R

R

R

Q

Q
x
D

E

K

L

L

E

E

S

D

L

L

Q

E

E

E

F

F

H

H

I

I

H

Q

H

H

I

I

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R

D

K

N

S

L

A

G

G

M

M

S

A

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

N

N

P

P

K

Q

F

F

I

I

L

L

D

D

E

Q

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

Q

K

I

I

H

E

H

H

L

L

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R

A

D

K

R

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

D

I

V

C

C

E

E

T

K

A

A

Y

Y

I

I

V

V

N

S

D

Q

G

G

Q

R

L

L

I

I

A

A

E

E

G

G

D

T

S

P

A

Q

T

D

I

V

L

L

A

N

N

N

E

E

L

Q

V

V

K

K

E

Q

V

V

Y

Y

L

L

G

G

H

E

E

Q

F

F

R

R

L

L

binding calcium ion: E111 (≠ A112), D115 (≠ Q116)

6mbnA Lptb e163q in complex with atp (see paper)
67% identity, 100% coverage: 2:241/241 of query aligns to 2:241/241 of 6mbnA

query
sites
6mbnA

A

A

T

T

L

L

K

T

A

A

Q

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

S

G

R
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R

Q

R

V
|
V

V

V

R

E

D

D

V

V

S

S

L

L

S

T

I

V

D

N

S

S

G

G

Q

E

I

I

V

V

G

G

L

L

G

G

P
|
P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

L

I

V

V

Q

P

A

R

D

D

Q

A

G

G

R

N

V

I

L

I

I

I

D

D

L

D

D

D

V

I

S

S

H

L

Q

L

P

P

M

L

H

H

G

A

R

R

A

A

K

R

A

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q
|
Q

E

E

A

A

S

S

I

I

F

F

R

R

K

R

L

L

S

S

V

V

A

Y

D

D

N

N

I

L

M

M

A

A

I

V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

D

S

Q

A

A

E

G

Q

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D

E

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A

E

N

S

E

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L

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M

Q

E

E

E

F

F

H

H

I

I

H

E

H

H

I

L

R

R

D

D

N

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G

G

E

E

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V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

N

N

P

P

K

K

F

F

I

I

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L

D

D

E

Q

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

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V

G

I

D

D

I

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K

K

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R

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E

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A

D

K

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H
|
H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

E

E

T

R

A

A

Y

Y

I

I

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V

N

S

D

Q

G

G

Q

H

L

L

I

I

A

A

E

H

G

G

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P

A

T

T

E

I

I

L

L

A

Q

N

D

E

E

L

H

V

V

K

K

E

R

V

V

Y

Y

L

L

G

G

H

E

E

D

F

F

R

R

L

L

binding adenosine-5'-triphosphate: Y13 (= Y13), R16 (= R16), V18 (= V18), P37 (= P37), N38 (= N38), G39 (= G39), A40 (= A40), G41 (= G41), K42 (= K42), T43 (= T43), T44 (= T44), Q85 (= Q85), H195 (= H195)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
67% identity, 99% coverage: 2:239/241 of query aligns to 1:238/238 of 6s8nB

query
sites
6s8nB

A

A

T

T

L

L

K

T

A

A

Q

K

H

N

L

L

A

A

K

K

S

A

Y

Y

K

K

S

G

R

R

Q

R

V

V

R

E

D

D

V

V

S

S

L

L

S

T

I

V

D

N

S

S

G

G

Q

E

I

I

V

V

G

G

L

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

L

I

V

V

Q

P

A

R

D

D

Q

A

G

G

R

N

V

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I

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D

D

L

D

D

D

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I

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S

H

L

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L

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P

M

L

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H

G

A

R

R

A

A

K

R

A

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q

Q

E

E

A

A

S

S

I

I

F

F

R
|
R

K

R

L

L

S

S

V

V

A

Y

D

D

N

N

I

L

M

M

A

A

I

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L

E

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T

I

R

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K

D

E

D

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L

D

S

Q

A

A

E

G

Q

R

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E

Q

D

E

R

L

A

E

N

S

E

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L

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M

Q

E

E

E

F

F

H

H

I

I

H

E

H

H

I

L

R

R

D

D

N

S

L
x
M

G
|
G

M
x
Q

S

S

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

E

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

Q

R

I

I

H

E

H

H

L

L

K

R

A

D

K

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

E

E

T

R

A

A

Y

Y

I

I

V

V

N

S

D

Q

G

G

Q

H

L

L

I

I

A

A

E

H

G

G

D

T

S

P

A

T

T

E

I

I

L

L

A

Q

N

D

E

E

L

H

V

V

K

K

E

R

V

V

Y

Y

L

L

G

G

H

E

E

D

F

F

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (= R91), M133 (≠ L134), G134 (= G135), Q135 (≠ M136)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
67% identity, 99% coverage: 2:239/241 of query aligns to 1:238/238 of 6s8gA

query
sites
6s8gA

A

A

T

T

L

L

K

T

A

A

Q

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

S

G

R
|
R

Q

R

V
|
V

V

V

R

E

D

D

V

V

S

S

L

L

S

T

I

V

D

N

S

S

G

G

Q

E

I

I

V

V

G

G

L

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

L

I

V

V

Q

P

A

R

D

D

Q

A

G

G

R

N

V

I

L

I

I

I

D

D

L

D

D

D

V

I

S

S

H

L

Q

L

P

P

M

L

H

H

G

A

R

R

A

A

K

R

A

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q
|
Q

E

E

A

A

S

S

I

I

F

F

R

R

K

R

L

L

S

S

V

V

A

Y

D

D

N

N

I

L

M

M

A

A

I

V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

D

S

Q

A

A

E

G

Q

R

R

R

E

Q

D

E

R

L

A

E

N

S

E

L

L

L

M

Q

E

E

E

F

F

H

H

I

I

H

E

H

H

I

L

R

R

D

D

N

S

L

M

G

G

M

Q

S
|
S

L

L

S
|
S

G

G

E
|
E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

E

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

Q

R

I

I

H

E

H

H

L

L

K

R

A

D

K

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H
|
H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

E

E

T

R

A

A

Y

Y

I

I

V

V

N

S

D

Q

G

G

Q

H

L

L

I

I

A

A

E

H

G

G

D

T

S

P

A

T

T

E

I

I

L

L

A

Q

N

D

E

E

L

H

V

V

K

K

E

R

V

V

Y

Y

L

L

G

G

H

E

E

D

F

F

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y13), R15 (= R16), V17 (= V18), N37 (= N38), G38 (= G39), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44), Q84 (= Q85), S136 (= S137), S138 (= S139), E141 (= E142), H194 (= H195)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
68% identity, 98% coverage: 2:236/241 of query aligns to 1:235/235 of 6mhzA

query
sites
6mhzA

A

A

T

T

L

L

K

T

A

A

Q

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

S

G

R

R

Q

R

V

V

R

E

D

D

V

V

S

S

L

L

S

T

I

V

D

N

S

S

G

G

Q

E

I

I

V

V

G

G

L

L

G

G

P
|
P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

L

I

V

V

Q

P

A

R

D

D

Q

A

G

G

R

N

V

I

L

I

I

I

D

D

L

D

D

D

V

I

S

S

H

L

Q

L

P

P

M

L

H

H

G

A

R

R

A

A

K

R

A

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q
|
Q

E

E

A

A

S

S

I

I

F

F

R

R

K

R

L

L

S

S

V

V

A

Y

D

D

N

N

I

L

M

M

A

A

I

V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

D

S

Q

A

A

E

G

Q

R

R

R

E

Q

D

E

R

L

A

E

N

S

E

L

L

L

M

Q

E

E

E

F

F

H

H

I

I

H

E

H

H

I

L

R

R

D

D

N

S

L

M

G

G

M

Q

S
|
S

L

L

S
|
S

G
|
G

E
|
E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E
|
E

P

P

F

F

A

A

G
|
G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

Q

R

I

I

H

E

H

H

L

L

K

R

A

D

K

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H
|
H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

E

E

T

R

A

A

Y

Y

I

I

V

V

N

S

D

Q

G

G

Q

H

L

L

I

I

A

A

E

H

G

G

D

T

S

P

A

T

T

E

I

I

L

L

A

Q

N

D

E

E

L

H

V

V

K

K

E

R

V

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y13), P36 (= P37), N37 (= N38), G38 (= G39), A39 (= A40), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44), Q84 (= Q85), S136 (= S137), S138 (= S139), G139 (= G140), G140 (= G141), E141 (= E142), E162 (= E163), G166 (= G167), H194 (= H195)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
68% identity, 97% coverage: 2:235/241 of query aligns to 1:234/234 of 6b89A

query
sites
6b89A

A

A

T

T

L

L

K

T

A

A

Q

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

S

G

R
|
R

Q

R

V
|
V

V

V

R

E

D

D

V

V

S

S

L

L

S

T

I

V

D

N

S

S

G

G

Q

E

I

I

V

V

G

G

L

L

G

G

P

P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

L

I

V

V

Q

P

A

R

D

D

Q

A

G

G

R

N

V

I

L

I

I

I

D

D

L

D

D

D

V

I

S

S

H

L

Q

L

P

P

M
x
L

H
|
H

G

A

R

R

A

A

K

R

A

R

G

G

I

I

G

G

Y
|
Y

L

L

P
|
P

Q
|
Q

E
|
E

A
|
A

S
|
S

I

I

F
|
F

R
|
R

K
x
R

L
|
L

S

S

V

V

A

Y

D

D

N

N

I

L

M

M

A

A

I
x
V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

D

S

Q

A

A

E

G

Q

R

R

R

E

Q

D

E

R

L

A

E

N

S

E

L

L

L

M

Q

E

E

E

F

F

H

H

I

I

H

E

H

H

I

L

R

R

D

D

N

S

L

M

G

G

M
x
Q

S

S

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R
|
R

A

A

L

L

A

A

T

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

E

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

Q

R

I

I

H

E

H

H

L

L

K

R

A

D

K

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

E

E

T

R

A

A

Y

Y

I

I

V

V

N

S

D

Q

G

G

Q

H

L

L

I

I

A

A

E

H

G

G

D

T

S

P

A

T

T

E

I

I

L

L

A

Q

N

D

E

E

L

H

V

V

K

K

E

R

V

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y13), R15 (= R16), V17 (= V18), N37 (= N38), G38 (= G39), A39 (= A40), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44)
binding magnesium ion: T42 (= T43), Q84 (= Q85)
binding novobiocin: L71 (≠ M72), H72 (= H73), Y81 (= Y82), P83 (= P84), E85 (= E86), A86 (= A87), S87 (= S88), F89 (= F90), F89 (= F90), R90 (= R91), R91 (≠ K92), L92 (= L93), V101 (≠ I102), Q135 (≠ M136), R149 (= R150)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
68% identity, 97% coverage: 2:235/241 of query aligns to 1:234/234 of 4p31A

query
sites
4p31A

A

A

T

T

L

L

K

T

A

A

Q

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

S

G

R
|
R

Q

R

V
|
V

V

V

R

E

D

D

V

V

S

S

L

L

S

T

I

V

D

N

S

S

G

G

Q

E

I

I

V

V

G

G

L

L

G

G

P

P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

L

I

V

V

Q

P

A

R

D

D

Q

A

G

G

R

N

V

I

L

I

I

I

D

D

L

D

D

D

V

I

S

S

H

L

Q

L

P

P

M

L

H

H

G

A

R

R

A

A

K

R

A

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q
|
Q

E

E

A

A

S

S

I

I

F

F

R

R

K

R

L

L

S

S

V

V

A

Y

D

D

N

N

I

L

M

M

A

A

I

V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

D

S

Q

A

A

E

G

Q

R

R

R

E

Q

D

E

R

L

A

E

N

S

E

L

L

L

M

Q

E

E

E

F

F

H

H

I

I

H

E

H

H

I

L

R

R

D

D

N

S

L

M

G

G

M

Q

S

S

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

E

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

Q

R

I

I

H

E

H

H

L

L

K

R

A

D

K

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

E

E

T

R

A

A

Y

Y

I

I

V

V

N

S

D

Q

G

G

Q

H

L

L

I

I

A

A

E

H

G

G

D

T

S

P

A

T

T

E

I

I

L

L

A

Q

N

D

E

E

L

H

V

V

K

K

E

R

V

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y13), R15 (= R16), V17 (= V18), N37 (= N38), G38 (= G39), A39 (= A40), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44)
binding magnesium ion: T42 (= T43), Q84 (= Q85)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
67% identity, 97% coverage: 2:234/241 of query aligns to 1:233/233 of 6b8bA

query
sites
6b8bA

A

A

T

T

L

L

K

T

A

A

Q

K

H

N

L

L

A

A

K

K

S

A

Y
|
Y

K

K

S

G

R
|
R

Q

R

V
|
V

V

V

R

E

D

D

V

V

S

S

L

L

S

T

I

V

D

N

S

S

G

G

Q

E

I

I

V

V

G

G

L

L

G

G

P

P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

C

T

F

F

Y

Y

M

M

I

V

V

V

G

G

L

I

V

V

Q

P

A

R

D

D

Q

A

G

G

R

N

V

I

L

I

I

I

D

D

L

D

D

D

V

I

S

S

H

L

Q

L

P

P

M

L

H

H

G

A

R

R

A

A

K

R

A

R

G

G

I

I

G

G

Y

Y

L

L

P

P

Q

Q

E

E

A

A

S

S

I

I

F
|
F

R
|
R

K
x
R

L

L

S

S

V

V

A

Y

D

D

N

N

I

L

M

M

A

A

I

V

L

L

E

Q

T

I

R

R

K

D

E

D

L

L

D

S

Q

A

A

E

G

Q

R

R

R

E

Q

D

E

R

L

A

E

N

S

E

L

L

L

M

Q

E

E

E

F

F

H

H

I

I

H

E

H

H

I

L

R

R

D

D

N

S

L

M

G

G

M

Q

S

S

L

L

S

S

G

G

E

E

R

R

V

V

E

E

I

I

A

A

R

R

A

A

L

L

A

A

T

A

N

N

P

P

K

K

F

F

I

I

L

L

D

D

E

E

P

P

F

F

A

A

G

G

V

V

D

D

P

P

I

I

S

S

V

V

G

I

D

D

I

I

K

K

Q

R

I

I

H

E

H

H

L

L

K

R

A

D

K

S

G

G

I

L

G

G

V

V

L

L

I

I

T

T

D

D

H

H

N

N

V

V

R

R

E

E

T

T

L

L

D

A

I

V

C

C

E

E

T

R

A

A

Y

Y

I

I

V

V

N

S

D

Q

G

G

Q

H

L

L

I

I

A

A

E

H

G

G

D

T

S

P

A

T

T

E

I

I

L

L

A

Q

N

D

E

E

L

H

V

V

K

K

E

R

V

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y13), R15 (= R16), V17 (= V18), N37 (= N38), G38 (= G39), A39 (= A40), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F90), R90 (= R91), R91 (≠ K92)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
34% identity, 97% coverage: 3:236/241 of query aligns to 6:238/240 of 1ji0A

query
sites
1ji0A

T

V

L

L

K

E

A

V

Q

Q

H

S

L

L

A

H

K

V

S

Y

Y
|
Y

K

G

S

A

R
x
I

Q

H

V
x
A

V

I

R

K

D

G

V

I

S

D

L

L

S

K

I

V

D

P

S

R

G

G

Q

Q

I

I

V

V

G

T

L

L

L

I

G

G

P

A

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

C

T

F

L

Y

S

M

A

I

I

V

A

G

G

L

L

V

V

Q

R

A

A

D

Q

Q

K

G

G

R

K

V

I

L

I

I

F

D

N

D

G

L

Q

D

D

V

I

S

T

H

N

Q

K

P

P

M

A

H

H

G

V

R

I

A

N

K

R

A

M

G

G

I

I

G

A

Y

L

L

V

P

P

Q
x
E

E

G

A

R

S

R

I

I

F

F

R

P

K

E

L

L

S

T

V

V

A

Y

D

E

N

N

I

L

M

M

A

M

I

G

L

A

E

Y

T

N

R

R

K

K

E

-

L

-

D

D

Q

K

A

E

G

G

R

I

R

K

Q

R

E

D

L

L

E

E

S

W

L

I

L

F

Q

S

E

L

F

F

-

P

H

R

I

L

H

K

H

E

I

R

R

L

D

K

N

Q

L

L

G

G

M

G

S

T

L

L

S

S

G

G

E

E

R

Q

R

M

V

L

E

A

I

I

A

G

R

R

A

A

L

L

A

M

T

S

N

R

P

P

K

K

F

L

I

L

L

M

D
|
D

E
|
E

P

P

F

S

A

L

G

G

V

L

D

A

P

P

I

I

S

L

V

V

G

S

D

E

I

V

K

F

Q

E

I

V

I

I

H

Q

H

K

L

I

K

N

A

Q

K

E

G

G

I

T

G

T

V

I

L

L

I

L

T

V

D

E

H

Q

N

N

V

A

R

L

E

G

T

A

L

L

D

K

I

V

C

A

E

H

T

Y

A

G

Y

Y

I

V

V

L

N

E

D

T

G

G

Q

Q

L

I

I

V

A

L

E

E

G

G

D

K

S

A

A

S

T

E

I

L

L

L

A

D

N

N

E

E

L

M

V

V

K

R

E

K

V

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (= Y13), I19 (≠ R16), A21 (≠ V18), N41 (= N38), G42 (= G39), A43 (= A40), G44 (= G41), K45 (= K42), T46 (= T43), T47 (= T44), E88 (≠ Q85), D164 (= D162), E165 (= E163)

1g6hA Crystal structure of the adp conformation of mj1267, an atp- binding cassette of an abc transporter (see paper)
31% identity, 98% coverage: 1:236/241 of query aligns to 2:253/254 of 1g6hA

query
sites
1g6hA

M

M

A

E

T

I

L

L

K

R

A

T

Q

E

H

N

L

I

A

V

K

K

S

Y

Y
x
F

K

G

S

E

R
x
F

Q

K

V

A

V

L

R

D

D

G

V

V

S

S

L

I

S

S

I

V

D

N

S

K

G

G

Q

D

I

V

V

T

G

L

L

I

G

G

P

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

C

L

F

I

Y

N

M

V

I

I

V

T

G

G

L

F

V

L

Q

K

A

A

D

D

Q

E

G

G

R

R

V

V

L

Y

I

F

D

E

D

N

L

K

D

D

V

I

S

T

H

N

Q

K

P

E

M

P

H

A

G

E

R

L

A

Y

K

H

A

Y

G

G

I

I

G

V

Y

R

L

T

P

F

Q

Q

E

T

A

P

S

Q

I

P

F

L

R

K

K

E

L

M

S

T

V

V

A

L

D

E

N

N

I

L

M

L

-

I

-

G

A

E

I

I

L

C

E

P

T

G

R

E

K

S

E

P

L

L

D

N

Q

S

A

L

G

F

R

Y

R

K

Q

K

E

W

L

I

E

P

S

K

-

E

-

M

-

V

-

E

-

K

-

A

-

F

-

K

L

I

L

L

Q

E

E

F

F

L

H

K

I

L

H

S

H

H

I

L

R

Y

D

D

N

R

L

K

G

A

M

G

S

E

L

L

S

S

G

G

E

Q

R

M

R

K

R

L

V

V

E

E

I

I

A

G

R

R

A

A

L

L

A

M

T

T

N

N

P

P

K

K

F

M

I

I

L

V

L

M

D

D

E

E

P

P

F

I

A

A

G

G

V

V

D

A

P

P

I

G

S

L

V

A

G

H

D

D

I

I

K

F

Q

N

I

H

I

V

H

L

H

E

L

L

K

K

A

A

K

K

G

G

I

I

G

T

V

F

L

L

I

I

T

I

D

E

H

H

N

R

V

L

R

D

E

I

T

V

L

L

D

N

I

Y

C

I

E

D

T

H

A

L

Y

Y

I

V

V

M

N

F

D

N

G

G

Q

Q

L

I

I

I

A

A

E

E

G

G

-

R

-

G

-

E

D

E

S

I

A

K

T

N

I

V

L

L

A

S

N

D

E

P

L

K

V

V

K

V

E

E

V

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y13), F17 (≠ R16), N39 (= N38), G40 (= G39), S41 (≠ A40), G42 (= G41), K43 (= K42), S44 (≠ T43), T45 (= T44)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
32% identity, 98% coverage: 1:236/241 of query aligns to 2:253/253 of 1g9xB

query
sites
1g9xB

M

M

A

E

T

I

L

L

K

R

A

T

Q

E

H

N

L

I

A

V

K

K

S

Y

Y
x
F

K

G

S

E

R
x
F

Q

K

V

A

V

L

R

D

D

G

V

V

S

S

L

I

S

S

I

V

D

C

S

K

G

G

Q

D

I

V

V

T

G

L

L

I

G

G

P

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

C

L

F

I

Y

N

M

V

I

I

V

T

G

G

L

F

V

L

Q

K

A

A

D

D

Q

E

G

G

R

R

V

V

L

Y

I

F

D

E

D

N

L

K

D

D

V

I

S

T

H

N

Q

K

P

E

M

P

H

A

G

E

R

L

A

Y

K

H

A

Y

G

G

I

I

G

V

Y

R

L

T

P

F

Q

Q

E

T

A

P

S

Q

I

P

F

L

R

K

K

E

L

M

S

T

V

V

A

L

D

E

N

N

I

L

M

L

A

I

-

G

-

E

-

I

-

N

-

P

-

G

-

E

-

S

-

P

-

L

-

N

I

S

L

L

E

F

T

Y

R

K

K

K

E

W

L

I

D

P

Q

K

A

E

G

E

R

E

R

M

Q

V

E

E

L

K

E

A

S

F

L

K

L

I

Q

L

E

E

F

F

-

L

H

K

I

L

H

S

H

H

I

L

R

Y

D

D

N

R

L

K

G

A

M

G

S

E

L

L

S

S

G

G

E

Q

R

M

R

K

R

L

V

V

E

E

I

I

A

G

R

R

A

A

L

L

A

M

T

T

N

N

P

P

K

K

F

M

I

I

L

V

L

M

D

D

E
|
E

P

P

F

I

A

A

G

G

V

V

D

A

P

P

I

G

S

L

V

A

G

H

D

D

I

I

K

F

Q

N

I

H

I

V

H

L

H

E

L

L

K

K

A

A

K

K

G

G

I

I

G

T

V

F

L

L

I

I

T

I

D

E

H

H

N

R

V

L

R

D

E

I

T

V

L

L

D

N

I

Y

C

I

E

D

T

H

A

L

Y

Y

I

V

V

M

N

F

D

N

G

G

Q

Q

L

I

I

I

A

A

E

E

G

G

-

R

-

G

-

E

D

E

S

I

A

K

T

N

I

V

L

L

A

S

N

D

E

P

L

K

V

V

K

V

E

E

V

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y13), F17 (≠ R16), N39 (= N38), G40 (= G39), S41 (≠ A40), G42 (= G41), K43 (= K42), S44 (≠ T43), T45 (= T44)
binding magnesium ion: S44 (≠ T43), E176 (= E163)

7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation (see paper)
33% identity, 97% coverage: 4:236/241 of query aligns to 5:242/263 of 7d0aB

query
sites
7d0aB

L

I

K

E

A

V

Q

K

H

N

L

L

A

S

K

F

S

N

Y
x
R

K
x
G

S

E

R
|
R

Q

V

V

I

V

Y

R

D

D

N

V

I

S

S

L

L

S

N

I

I

D

R

S

R

G

G

Q

Q

I

I

V

T

G

A

L

I

L

M

G

G

P

P

N
x
S

G
|
G

A
x
T

G
|
G

K
|
K

T

T

C

L

F

L

Y

R

M

L

I

I

V

G

G

G

L

Q

V
x
L

Q

V

A

P

D

D

Q

Q

G

G

R

E

V

V

L

L

I

L

D

D

D

G

L

K

D

D

V

I

-

A

-

Q

-

M

S

S

H

R

Q

Q

P

E

M

L

H

F

G

A

R

-

A

A

K

R

A

A

G

R

I

M

G

G

Y

M

L

L

P

F

Q

Q

E

S

A

G

S

A

I

L

F

F

R

T

K

D

L

M

S

S

V

V

A

Y

D

E

N

N

I

V

M

A

A

F

I

P

L

I

E

R

T

A

R

H

K

T

E

K

L

L

D

S

Q

E

A

N

G

L

R

I

R

A

Q

E

E

L

L

V

E

A

S

L

L

K

L

L

Q

E

E

S

F

V

H

G

I

L

H

R

H

G

I

T

R

E

D

Q

N

L

L

M

G

P

M

T

S
x
E

L

L

S
|
S

G

G

G
|
G

E
x
M

R

N

R

R

V

V

E

A

I

L

A

A

R

R

A

A

L

I

A

A

T

L

N

D

P

P

K

D

F

L

I

I

L

M

L

Y

D

D

E

E

P

P

F

F

A

A

G

G

V

Q

D

D

P

P

I

I

S

V

V

K

G

G

D

V

I

L

K

T

Q

R

I

L

I

I

H

R

H

S

L

L

K

R

-

E

A

A

K

L

G

D

I

L

G

T

V

T

L

I

I

I

T

V

D

S

H

H

N

D

V

V

R

P

E

E

T

T

L

L

D

S

I

I

C

A

E

D

T

Y

A

I

Y

Y

I

V

V

V

N

A

D

E

G

G

Q

K

L

I

I

Q

A

G

E

E

G

G

D

T

S

P

A

E

T

E

I

L

-

Q

-

A

L

Y

A

A

N

S

E

P

L

F

V

V

K

K

E

Q

V

F

Y

L

L

T

G

G

binding adenosine-5'-diphosphate: R14 (≠ Y13), G15 (≠ K14), R17 (= R16), S39 (≠ N38), G40 (= G39), T41 (≠ A40), G42 (= G41), K43 (= K42), L54 (≠ V53), E140 (≠ S137), S142 (= S139), G144 (= G141), M145 (≠ E142)

7d08B Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
33% identity, 97% coverage: 4:236/241 of query aligns to 5:242/263 of 7d08B

query
sites
7d08B

L

I

K

E

A

V

Q

K

H

N

L

L

A

S

K

F

S

N

Y
x
R

K

G

S

E

R
|
R

Q

V

V

I

V

Y

R

D

D

N

V

I

S

S

L

L

S

N

I

I

D

R

S

R

G

G

Q

Q

I

I

V

T

G

A

L

I

L

M

G

G

P

P

N

S

G
|
G

A
x
T

G
|
G

K
|
K

T
|
T

C

L

F

L

Y

R

M

L

I

I

V

G

G

G

L

Q

V

L

Q

V

A

P

D

D

Q

Q

G

G

R

E

V

V

L

L

I

L

D

D

D

G

L

K

D

D

V

I

-

A

-

Q

-

M

S

S

H

R

Q

Q

P

E

M

L

H

F

G

A

R

-

A

A

K

R

A

A

G

R

I

M

G

G

Y

M

L

L

P

F

Q
|
Q

E

S

A

G

S

A

I

L

F

F

R

T

K

D

L

M

S

S

V

V

A

Y

D

E

N

N

I

V

M

A

A

F

I

P

L

I

E

R

T

A

R

H

K

T

E

K

L

L

D

S

Q

E

A

N

G

L

R

I

R

A

Q

E

E

L

L

V

E

A

S

L

L

K

L

L

Q

E

E

S

F

V

H

G

I

L

H

R

H

G

I

T

R

E

D

Q

N

L

L

M

G

P

M

T

S

E

L

L

S

S

G

G

E

M

R

N

R

R

V

V

E

A

I

L

A

A

R

R

A

A

L

I

A

A

T

L

N

D

P

P

K

D

F

L

I

I

L

M

L

Y

D
|
D

E
|
E

P

P

F

F

A

A

G

G

V

Q

D

D

P

P

I

I

S

V

V

K

G

G

D

V

I

L

K

T

Q

R

I

L

I

I

H

R

H

S

L

L

K

R

-

E

A

A

K

L

G

D

I

L

G

T

V

T

L

I

I

I

T

V

D

S

H

H

N

D

V

V

R

P

E

E

T

T

L

L

D

S

I

I

C

A

E

D

T

Y

A

I

Y

Y

I

V

V

V

N

A

D

E

G

G

Q

K

L

I

I

Q

A

G

E

E

G

G

D

T

S

P

A

E

T

E

I

L

-

Q

-

A

L

Y

A

A

N

S

E

P

L

F

V

V

K

K

E

Q

V

F

Y

L

L

T

G

G

binding adenosine-5'-triphosphate: R14 (≠ Y13), R17 (= R16), G40 (= G39), T41 (≠ A40), G42 (= G41), K43 (= K42), T44 (= T43), T45 (= T44), Q88 (= Q85), D165 (= D162), E166 (= E163)

6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp (see paper)
33% identity, 97% coverage: 4:236/241 of query aligns to 3:240/253 of 6z5uK

query
sites
6z5uK

L

I

K

E

A

V

Q

K

H

N

L

L

A

S

K

F

S

N

Y
x
R

K

G

S

E

R

R

Q

V

V

I

V

Y

R

D

D

N

V

I

S

S

L

L

S

N

I

I

D

R

S

R

G

G

Q

Q

I

I

V

T

G

A

L

I

L

M

G

G

P

P

N
x
S

G
|
G

A
x
T

G
|
G

K
|
K

T
|
T

C

L

F

L

Y

R

M

L

I

I

V

G

G

G

L

Q

V

L

Q

V

A

P

D

D

Q

Q

G

G

R

E

V

V

L

L

I

L

D

D

D

G

L

K

D

D

V

I

-

A

-

Q

-

M

S

S

H

R

Q

Q

P

E

M

L

H

F

G

A

R

-

A

A

K

R

A

A

G

R

I

M

G

G

Y

M

L

L

P

F

Q
|
Q

E

S

A

G

S

A

I

L

F

F

R

T

K

D

L

M

S

S

V

V

A

Y

D

E

N

N

I

V

M

A

A

F

I

P

L

I

E

R

T

A

R

H

K

T

E

K

L

L

D

S

Q

E

A

N

G

L

R

I

R

A

Q

E

E

L

L

V

E

A

S

L

L

K

L

L

Q

E

E

S

F

V

H

G

I

L

H

R

H

G

I

T

R

E

D

Q

N

L

L

M

G

P

M

T

S

E

L

L

S

S

G

G

E

M

R

N

R

R

V

V

E

A

I

L

A

A

R

R

A

A

L

I

A

A

T

L

N

D

P

P

K

D

F

L

I

I

L

M

L

Y

D

D

E
|
E

P

P

F

F

A

A

G

G

V

Q

D

D

P

P

I

I

S

V

V

K

G

G

D

V

I

L

K

T

Q

R

I

L

I

I

H

R

H

S

L

L

K

R

-

E

A

A

K

L

G

D

I

L

G

T

V

T

L

I

I

I

T

V

D

S

H
|
H

N

D

V

V

R

P

E

E

T

T

L

L

D

S

I

I

C

A

E

D

T

Y

A

I

Y

Y

I

V

V

V

N

A

D

E

G

G

Q

K

L

I

I

Q

A

G

E

E

G

G

D

T

S

P

A

E

T

E

I

L

-

Q

-

A

L

Y

A

A

N

S

E

P

L

F

V

V

K

K

E

Q

V

F

Y

L

L

T

G

G

binding phosphoaminophosphonic acid-adenylate ester: R12 (≠ Y13), S37 (≠ N38), G38 (= G39), T39 (≠ A40), G40 (= G41), K41 (= K42), T42 (= T43), T43 (= T44), Q86 (= Q85), E164 (= E163), H197 (= H195)
binding magnesium ion: Q86 (= Q85), E164 (= E163)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
27% identity, 99% coverage: 2:239/241 of query aligns to 3:242/501 of P04983

query
sites
P04983

A

A

T

L

L

L

K

Q

A

L

Q

K

H

G

L

I

A

D

K

K

S

A

Y

F

K

P

S

G

R

V

Q

K

V

A

V

L

R

S

D

G

V

A

S

A

L

L

S

N

I

V

D

Y

S

P

G

G

Q

R

I

V

V

M

G

A

L

L

L

V

G

G

P

E

N

N

G

G

A

A

G

G

K
|
K

T

S

T

T

C

M

F

M

Y

K

M

V

I

L

V

T

G

G

L

I

V

Y

Q

T

A

R

D

D

Q

A

G

G

R

T

V

L

L

L

I

W

D

L

D

G

L

K

D

E

V

T

S

T

H

F

Q

T

P

G

M

P

H

K

G

S

R

S

A

Q

K

E

A

A

G

G

I

I

G

G

Y

I

L

I

P

H

Q

Q

E

E

A

L

S

N

I

L

F

I

R

P

K

Q

L

L

S

T

V

I

A

A

D

E

N

N

I

I

M

F

-

L

-

G

-

R

A

E

I

F

L

V

E

N

T

R

R

F

K

G

E

K

L

I

D

D

Q

W

A

K

G

T

R

M

R

Y

Q

A

E

E

L

A

E

D

S

K

L

L

Q

A

E

K

F

L

H

N

I

L

H

R

H

F

I

K

R

S

D

D

N

K

L

L

G

V

M

G

S

D

L

L

S

S

G

I

G

G

E

D

R

Q

R

M

V

V

E

E

I

I

A

A

R

K

A

V

L

L

A

S

T

F

N

E

P

S

K

K

F

V

I

I

L

I

L

M

D

D

E

E

P

P

F

T

A

D

G

A

V

L

D

T

P

D

I

T

S

E

V

T

G

E

D

S

I

L

K

F

Q

R

I

V

I

I

H

R

H

E

L

L

K

K

A

S

K

Q

G

G

I

R

G

G

V

I

L

V

I

Y

T

I

D

S

H

H

N

R

V

M

R

K

E

E

T

I

L

F

D

E

I

I

C

C

E

D

T

D

A

V

Y

T

I

V

V

F

N

R

D

D

G

G

Q

Q

L

F

I

I

A

A

E

E

G

R

D

E

S

V

A

A

T

S

I

L

L

T

A

E

N

D

E

S

L

L

V

I

K

-

E

E

V

M

Y

M

L

V

G

G

H

R

E

K

F

L

K43 (= K42) mutation to R: Loss of transport.

3d31A Modbc from methanosarcina acetivorans (see paper)
31% identity, 92% coverage: 4:225/241 of query aligns to 2:216/348 of 3d31A

query
sites
3d31A

L

I

K

E

A

I

Q

E

H

S

L

L

A

S

K

R

S

K

Y

W

K

K

S

N

R

F

Q

S

V

L

V

-

R

D

D

N

V

L

S

S

L

L

S

K

I

V

D

E

S

S

G

G

Q

E

I

Y

V

F

G

V

L

I

L

L

G

G

P

P

N

T

G

G

A

A

G

G

K

K

T

T

T

L

C

F

F

L

Y

E

M

L

I

I

V

A

G

G

L

F

V

H

Q

V

A

P

D

D

Q

S

G

G

R

R

V

I

L

L

I

L

D

D

D

G

L

K

D

D

V

V

S

T

H

D

Q

L

P

-

M

-

H

-

G

S

R

P

A

E

K

K

A

H

G

D

I

I

G

A

Y

F

L

V

P

Y

Q

Q

E

N

A

Y

S

S

I

L

F

F

R

P

K

H

L

M

S

N

V

V

A

K

D

K

N

N

I

L

M

E

A

F

I

G

L

M

E

R

T

M

R

K

K

K

E

I

L

K

D

D

Q

P

A

-

G

-

R

-

Q

K

E

R

L

V

E

L

S

D

L

T

L

A

Q

R

E

D

F

L

H

K

I

I

H

E

H

H

I

L

R

L

D

D

N

R

L

N

G

P

M

L

S

T

L

L

S

S

G

G

E

E

R

Q

R

R

V

V

E

A

I

L

A

A

R

R

A

A

L

L

A

V

T

T

N

N

P

P

K

K

F

I

I

L

L

L

D

D

E

E

P

P

F

L

A

S

G

A

V

L

D

D

P

P

I

R

S

T

V

Q

G

E

D

N

I

A

K

R

Q

E

I

M

I

L

H

S

H

V

L

L

-

H

K

K

A

K

K

N

G

K

I

L

G

T

V

V

L

L

I

H

T

I

D

T

H

H

N

D

V

Q

R

T

E

E

T

A

L

R

D

I

I

M

C

A

E

D

T

R

A

I

Y

A

I

V

V

V

N

M

D

D

G

G

Q

K

L

L

I

I

A

Q

E

V

G

G

D

K

S

P

A

E

T

E

I

I

L

F

Sites not aligning to the query:

binding tungstate(vi)ion: 286, 287, 288, 319, 320, 323, 340, 341, 342

7chaI Cryo-em structure of p.Aeruginosa mlafebd with amppnp (see paper)
31% identity, 85% coverage: 15:219/241 of query aligns to 15:222/262 of 7chaI

query
sites
7chaI

S

S

R
|
R

Q

A

V
x
I

V

F

R

D

D

N

V

I

S

D

L

V

S

R

I

I

D

P

S

R

G

G

Q

K

I

V

V

T

G

G

L

I

L

M

G

G

P
|
P

N
x
S

G
|
G

A
x
C

G
|
G

K
|
K

T
|
T

C

L

F

L

Y

R

M

L

I

I

V

A

G

S

L

Q

V

L

Q

R

A

P

D

S

Q

K

G

G

R

E

V

V

L

W

I

V

D

N

D

G

L

-

D

-

V

-

S

Q

H

N

Q

L

P

P

M

Q

H

L

G

S

R

R

A

G

-

D

-

L

-

F

-

D

-

M

K

R

A

K

G

Q

I

F

G

G

Y

V

L

L

P

F

Q

Q

E

S

A

G

S

A

I

L

F

F

R

T

K

D

L

L

S

D

V

V

A

F

D

E

N

N

I

V

M

A

A

F

I

P

L

L

E

R

T

V

R

H

K

T

E

Q

L

L

D

P

Q

E

A

E

G

M

R

I

R

R

Q

D

E

I

L

V

E

L

S

M

L

K

L

L

Q

Q

E

A

F

V

H

G

I

L

H

R

H

G

I

A

R

V

D

E

N

L

L

M

G

P

M

D

S

E

L

L

S

S

G

G

E

M

R

K

R

R

V

V

E

A

I

L

A

A

R

R

A

A

L

I

A

A

T

L

N

D

P

P

K

Q

F

I

I

L

L

L

L

Y

D

D

E

E

P

P

F

F

A

V

G

G

V

Q

D

D

P

P

I

I

S

A

V

M

G

G

D

V

I

L

K

V

Q

R

I

L

I

I

H

R

H

L

L

L

K

N

-

D

A

A

K

L

G

G

I

I

G

T

V

S

L

I

I

V

T

V

D

S

H
|
H

N

D

V

L

R

A

E

E

T

T

L

A

D

S

I

I

C

A

E

D

T

Y

A

I

Y

Y

I

I

V

V

N

G

D

D

G

G

Q

R

L

V

I

L

A

G

E

H

G

G

binding phosphoaminophosphonic acid-adenylate ester: R16 (= R16), I18 (≠ V18), P37 (= P37), S38 (≠ N38), G39 (= G39), C40 (≠ A40), G41 (= G41), K42 (= K42), T43 (= T43), T44 (= T44), H198 (= H195)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 13

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
26% identity, 89% coverage: 11:225/241 of query aligns to 9:224/240 of 4ymuJ

query
sites
4ymuJ

K

K

S

N

Y
x
F

K

G

S

S

R
x
L

Q

E

V
|
V

V

L

R

K

D

G

V

V

S

T

L

L

S

K

I

V

D

N

S

K

G

G

Q

E

I

V

V

V

G

V

L

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

C

L

F

L

Y

R

M

C

I

I

V

N

G

L

L

L

V
x
E

Q

E

A

P

D

T

Q

K

G

G

R

E

V

V

L

F

I

I

D

D

D

G

L

V

D

K

V

I

S

N

H

N

Q

G

P

K

M

V

H

N

-

I

G

N

R

K

A

V

K

R

A

Q

G

K

I

V

G

G

Y

M

L

V

P

F

Q

Q

E

H

A

F

S

N

I

L

F

F

R

P

K

H

L

L

S

T

V

A

A

I

D

E

N

N

I

I

M

T

A

L

I

A

L

P

E

V

T

K

R

V

K

K

E

K

L

M

D

N

Q

K

A

K

G

E

R

A

R

E

Q

E

E

L

L

A

E

V

S

D

L

L

Q

A