SitesBLAST

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
30% identity, 33% coverage: 19:123/323 of query aligns to 58:182/203 of P07464

query
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P07464

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S71 (≠ Q32) binding
N85 (≠ G43) binding in other chain; binding in other chain
D93 (≠ L48) binding
H115 (≠ Q70) mutation to A: Results in an 1800-fold decrease in catalytic activity.
S142 (≠ A83) binding in other chain
A160 (= A101) binding in other chain
TK 165:166 (≠ VS 106:107) binding
R180 (= R121) binding

Sites not aligning to the query:

1 modified: Initiator methionine, Removed; Partial
17 binding
183 binding in other chain

3igjC Crystal structure of maltose o-acetyltransferase complexed with acetyl coenzyme a from bacillus anthracis
32% identity, 28% coverage: 33:123/323 of query aligns to 76:183/188 of 3igjC

query
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binding acetyl coenzyme *a: F84 (= F41), A106 (= A60), Y112 (≠ L66), A114 (≠ T68), H116 (≠ Q70), G142 (= G82), N148 (≠ K88), A160 (= A100), S161 (≠ A101), T166 (≠ V106), N178 (≠ R118)

7uujA Crystal structure of aminoglycoside resistance enzyme apma, complex with gentamicin
31% identity, 32% coverage: 25:126/323 of query aligns to 131:232/272 of 7uujA

query
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binding (2r,3r,4r,5r)-2-((1s,2s,3r,4s,6r)-4,6-diamino-3-((2r,3r,6s)-3-amino-6-(aminomethyl)-tetrahydro-2h-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-methyl-4-(methylamino)-tetrahydro-2h-pyran-3,5-diol: H135 (≠ S29), D144 (= D38), D145 (= D39)

Sites not aligning to the query:

binding (2r,3r,4r,5r)-2-((1s,2s,3r,4s,6r)-4,6-diamino-3-((2r,3r,6s)-3-amino-6-(aminomethyl)-tetrahydro-2h-pyran-2-yloxy)-2-hydroxycyclohexyloxy)-5-methyl-4-(methylamino)-tetrahydro-2h-pyran-3,5-diol: 55, 85, 102

7jm2A Crystal structure of aminoglycoside resistance enzyme apma, complex with apramycin
31% identity, 32% coverage: 25:126/323 of query aligns to 131:232/272 of 7jm2A

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binding apramycin: H135 (≠ S29), D144 (= D38), D145 (= D39), Q147 (≠ F41), Y170 (≠ L66), Y172 (≠ T68)

Sites not aligning to the query:

binding apramycin: 85, 102

7jm1A Crystal structure of aminoglycoside resistance enzyme apma, complex with acetyl-coa
31% identity, 32% coverage: 25:126/323 of query aligns to 131:232/272 of 7jm1A

query
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binding acetyl coenzyme *a: H132 (≠ R26), N134 (≠ A28), Y184 (≠ W80), G186 (= G82), F190 (≠ T86), G206 (≠ A100), S207 (≠ A101), L212 (≠ V106), V222 (= V116), V224 (≠ R118), K229 (≠ I123)

Sites not aligning to the query:

binding acetyl coenzyme *a: 102, 124, 125, 126

7uunA Crystal structure of aminoglycoside resistance enzyme apma, complex with neomycin (see paper)
31% identity, 32% coverage: 25:126/323 of query aligns to 132:233/273 of 7uunA

query
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7uunA

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binding neomycin: H136 (≠ S29), D145 (= D38), D146 (= D39)

Sites not aligning to the query:

binding neomycin: 113

7uumA Crystal structure of aminoglycoside resistance enzyme apma, complex with paromomycin and coenzyme a (see paper)
31% identity, 32% coverage: 25:126/323 of query aligns to 133:234/274 of 7uumA

query
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7uumA

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binding coenzyme a: H134 (≠ R26), N136 (≠ A28), K169 (≠ V63), F192 (≠ T86), P227 (= P119)
binding paromomycin: H137 (≠ S29), D146 (= D38), D147 (= D39)

Sites not aligning to the query:

binding paromomycin: 114, 115

7uulA Crystal structure of aminoglycoside resistance enzyme apma, complex with kanamycin b and coenzyme a (see paper)
31% identity, 32% coverage: 25:126/323 of query aligns to 132:233/274 of 7uulA

query
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7uulA

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binding (1r,2s,3s,4r,6s)-4,6-diamino-3-[(3-amino-3-deoxy-alpha-d-glucopyranosyl)oxy]-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-d-glucopyranoside: H136 (≠ S29), D145 (= D38), D146 (= D39)
binding coenzyme a: N135 (≠ A28), L138 (= L31), Y185 (≠ W80), G187 (= G82), A188 (= A83), F191 (≠ T86), S208 (≠ A101), L213 (≠ V106), V223 (= V116), K230 (≠ I123), R231 (≠ A124)

Sites not aligning to the query:

7uukC Crystal structure of aminoglycoside resistance enzyme apma, complex with tobramycin (see paper)
31% identity, 32% coverage: 25:126/323 of query aligns to 133:234/276 of 7uukC

query
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binding tobramycin: H137 (≠ S29), D146 (= D38), D147 (= D39)

Sites not aligning to the query:

binding tobramycin: 83, 87, 104, 105, 115

3nz2C Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
31% identity, 28% coverage: 32:123/323 of query aligns to 70:178/183 of 3nz2C

query
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3nz2C

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D

I

V

P

P

D

D

A

T

I

L

A

V

V
x
G

G

G

R
x
T

P
|
P

A

A

R

R

I

I

I
x
L

binding acetyl coenzyme *a: Y107 (≠ A60), H111 (≠ Q64), G137 (= G82), A155 (= A100), A156 (= A101), N161 (≠ V106), G171 (≠ V116), T173 (≠ R118), P174 (= P119), L178 (≠ I123)
binding magnesium ion: N157 (≠ G102), T173 (≠ R118)

Sites not aligning to the query:

binding acetyl coenzyme *a: 179

3ectA Crystal structure of the hexapeptide-repeat containing- acetyltransferase vca0836 from vibrio cholerae
31% identity, 28% coverage: 32:123/323 of query aligns to 63:171/176 of 3ectA

query
sites
3ectA

Q

K

N

T

V

I

Q

R

L

I

G

G

D

D

D

H

C

T

F

F

V

I

G

N

F

M

K

N

S

V

D

V

L

M

-

L

-

D

-

G

-

A

-

P

-

I

-

T

-

I

-

G

R

D

F

H

V

V

A

L

I

I

G

G

K

P

A

S

S

T

M

Q

L

F

A

Y

T

T

G

A

V

S

Q

H

C

S

L

L

G

D

-

Y

-

R

-

Q

-

A

-

W

-

E

T

T

A

I

Q

C

S

K

P

P

I

I

Q

V

I

I

G

E

A

D

N

D

A

V

W

W

L

I

G

G

A

G

K

N

V

V

T

V

V

I

K

N

A

Q

G
|
G

V

V

S

T

I

I

G

G

A

A

G

R

A

S

V

V

A

A

G

N

A

S

L

V

V

V

V

N

S

Q

D
|
D

I

V

P

P

D

D

A

T

I

L

A

V

V

G

G

G

R

T

P

P

A

A

R

R

I

I

I

L

binding calcium ion: G138 (= G90), D156 (= D108)

3nz2J Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
31% identity, 28% coverage: 32:123/323 of query aligns to 73:181/185 of 3nz2J

query
sites
3nz2J

Q

K

N

T

V

I

Q

R

L

I

G

G

D

D

D

H

C

T

F

F

V

I

G

N

F

M

K

N

S

V

D

V

L

M

-

L

-

D

-

G

-

A

-

P

-

I

-

T

-

I

-

G

R

D

F

H

V

V

A

L

I

I

G
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G

K

P

A

S

S

T

M

Q

L

F

A
x
Y

T

T

G

A

V

S

Q
x
H

C

S

L

L

G

D

-

Y

-

R

-

Q

-

A

-

W

-

E

T

T

A

I

Q

C

S

K

P

P

I

I

Q

V

I

I

G

E

A

D

N

D

A

V

W
|
W

L

I

G
|
G

A

G

K

N

V

V

T

V

V

I

K

N

A

Q

G

G

V

V

S

T

I

I

G

G

A

A

G

R

A

S

V

V

A
|
A

G

N

A

S

L

V

V

V

V
x
N

S

Q

D

D

I

V

P

P

D

D

A

T

I

L

A

V

V
x
G

G

G

R
x
T

P
|
P

A

A

R

R

I

I

I

L

binding acetyl coenzyme *a: G104 (= G54), Y110 (≠ A60), H114 (≠ Q64), W138 (= W80), G140 (= G82), A158 (= A100), A159 (= A101), N164 (≠ V106), G174 (≠ V116), T176 (≠ R118), P177 (= P119)

Sites not aligning to the query:

binding acetyl coenzyme *a: 182

4mzuF Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
28% identity, 58% coverage: 2:189/323 of query aligns to 15:203/294 of 4mzuF

query
sites
4mzuF

D

D

D

N

T

T

N

K

V

V

V
x
W

E
x
Q

V

-

L

F

T

C

T

V

I

I

D

L

S

A

G

G

S

A

E

V

L

I

G

G

R

R

H

N

V

C

W

N

I

I

R
x
C

A

A

A

N

S

S

R

L

L

I

Q

E

N

N

-

D

V

V

Q

V

L

I

G

G

D

D

D

N

C

-

F

-

V

V

G

T

F

I

K

K

S

S

D

G

L

V

R

Q

F

I

-

W

-

D

-

G

-

I

-

H

-

I

-

Q

-

D

V

V

A

F

I

I

G

G

K

P

A

N

S

V

M

T

L

F

A

T

T
x
N

G
x
D

V
x
K

Q

Q

C

P

L

R

G

S

T

K

A

I

Q

K

S

T

P

I

I

V

Q

K

I

K

G

G

A

A

N

S

A

-

W

-

L

I

G
|
G

A
|
A

K

N

V

S

T

T

V

I

K
x
L

A

P

G

G

V

I

S

L

I

I

G

G

A

E

G

N

A

A

V

M

V

V

A
x
G

A
|
A

G

G

A

A

L

V

V

I

V
x
T

S
x
K

D

N

I

V

P

P

P

D

D

N

A

A

I

I

A

V

V
x
I

G

G

R
x
N

P

P

A

G

R
|
R

I

I

I

T

A

G

Y

Y

R

V

S

E

V

A

V

F

E

E

D

L

G

K

A

L

P

Q

S

-

P

-

E

-

H

-

V

-

L

M

A

S

K

K

V

V

R

K

E

G

R

V

A

S

R

L

Q

H

G

K

M

F

P

H

S

L

L

V

L

N

D

D

-

L

R

R

A

G

S

N

L

L

S

S

V

V

A

G

R

E

L

F

K

E

E

K

L

D

N

I

P

P

D

F

T

T

Q

P

T

K

W
x
R

D

Y

I

F

S

T

E

V

D

F

T

G

L

V

I

P

D

N

A

K

E

E

L

V

R

R

G
|
G

binding coenzyme a: N81 (≠ T61), D82 (≠ G62), K83 (≠ V63), G100 (= G82), A101 (= A83), L106 (≠ K88), G118 (≠ A100), A119 (= A101), T124 (≠ V106), K125 (≠ S107), I134 (≠ V116), N136 (≠ R118), R139 (= R121)
binding thymine: W20 (≠ V7), Q21 (≠ E8), C38 (≠ R26)
binding thymidine-5'-diphosphate: R189 (≠ W175), G203 (= G189)

Sites not aligning to the query:

binding thymidine-5'-diphosphate: 205, 270

1kk4A Crystal structure of vat(d) in complex with acetyl-coa (see paper)
46% identity, 18% coverage: 70:126/323 of query aligns to 107:167/205 of 1kk4A

query
sites
1kk4A

Q

Q

S

L

P

P

I

I

Q
x
K

-

G

-

D

-

T

-

I

I

I

G

G

A

N

N

D

A

V

W
|
W

L

I

G
|
G

A
x
K

K

D

V

V

T

V

V

I

K

M

A

P

G

G

V

V

S

K

I

I

G

G

A

D

G

G

A

A

V

I

V

V

A
|
A

G

N

A

S

L

V

V

V

V
|
V

S
x
K

D

D

I

I

P

A

P

P

D

Y

A

M

I
x
L

A

A

V
x
G

G
|
G

R

N

P
|
P

A

A

R

N

I

E

I
|
I

A

K

Y

Q

R

R

binding acetyl coenzyme *a: K111 (≠ Q74), W121 (= W80), G123 (= G82), K124 (≠ A83), A141 (= A100), A142 (= A101), V147 (= V106), K148 (≠ S107), L155 (≠ I114), G157 (≠ V116), G158 (= G117), P160 (= P119), I164 (= I123)

Sites not aligning to the query:

binding acetyl coenzyme *a: 69, 70

1mrlA Crystal structure of streptogramin a acetyltransferase with dalfopristin (see paper)
46% identity, 18% coverage: 70:126/323 of query aligns to 107:167/204 of 1mrlA

query
sites
1mrlA

Q

Q

S
x
L

P

P

I

I

Q

K

-

G

-

D

-

T

-

I

I

I

G

G

A

N

N

D

A

V

W

W

L

I

G

G

A

K

K

D

V

V

T

V

V

I

K

M

A

P

G

G

V

V

S

K

I

I

G

G

A

D

G

G

A

A

V

I

V

V

A

A

G

N

A

S

L

V

V

V

S

K

D

D

I

I

P

A

P

P

D

Y

A

M

I

L

A

A

V

G

G

G

R

N

P

P

A

A

R

N

I

E

I

I

A

K

Y

Q

R

R

binding 5-(2-diethylamino-ethanesulfonyl)-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triaza-tricyclo[23.2.1.00,255]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetraone: L108 (≠ S71)

Sites not aligning to the query:

binding 5-(2-diethylamino-ethanesulfonyl)-21-hydroxy-10-isopropyl-11,19-dimethyl-9,26-dioxa-3,15,28-triaza-tricyclo[23.2.1.00,255]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetraone: 37, 39, 54, 56, 81, 82, 93, 102

Query Sequence

>Pf1N1B4_1226 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_1226
VDDTNVVEVLTTIDSGSELGRHVWIRAASRLQNVQLGDDCFVGFKSDLRFVAIGKASMLA
TGVQCLGTAQSPIQIGANAWLGAKVTVKAGVSIGAGAVVAAGALVVSDIPPDAIAVGRPA
RIIAYRSVVEDGAPSPEHVLAKVRERARQGMPSLLDRASLSVARLKELNPDTQTWDISED
TLIDAELRGGASVEIARDCILIGRSVRQGGMSQLGGIDIGTGTSLGEGIVIEAAGGVTIG
AFSELGARVTVVTSSHDHSFRSLPWEEAPVHIGSRCVIGEGAIIVGPLSIGDGAVIKPYS
VVIRDVLENTVVNGVVQLMEIQE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory