SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Pf1N1B4_1379 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_1379 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
33% identity, 96% coverage: 5:283/290 of query aligns to 4:253/253 of 1g9xB

query
sites
1g9xB

V

I

L

L

S

R

V

T

D

E

K

N

L

I

M

V

M

K

H

Y

F
|
F

G

G

G

E

I
x
F

K

K

A

A

L

L

S

D

D

G

V

V

S

S

L

I

K

S

V

V

K

C

R

K

N

G

S

D

I

V

F

T

A

L

L

I

I

I

G

G

P

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

I

N

N

C

V

L

I

T

T

G

G

F

F

Y

L

K

K

A

A

S

D

G

E

G

G

H

R

I

V

E

Y

L

F

N

E

T

N

R

K

G

D

V

I

K

T

T

N

D

K

V

-

I

-

K

-

M

-

L

-

G

-

E

E

P

P

F

A

K

E

A

L

V

Y

D

H

F

Y

V

-

S

-

P

-

K

-

S

-

F

-

I

-

N

-

R

-

L

-

R

-

Y

-

K

-

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

-

A

-

G

G

L

I

A

V

R

R

T

T

F

F

Q

Q

N

T

I

P

R

Q

L

P

F

L

R

K

E

E

M

M

S

T

V

V

L

L

E

E

N

N

L

L

L

L

V

I

A

G

Q

E

H

-

M

-

W

-

V

I

N

N

R

P

G

G

M

-

L

-

A

E

G

S

I

P

L

L

N

N

T

S

K

L

G

F

Y

Y

R

K

K

K

-

W

-

I

-

P

A

K

E

E

S

E

D

E

A

M

L

V

D

E

H

K

A

A

F

F

Y

K

W

I

L

L

E

E

V

F

V

L

D

K

L

L

V

S

D

H

C

L

A

Y

N

D

R

R

L

K

A

A

G

G

E

E

L

L

S

S

Y

G

G

G

Q

Q

Q

M

R

K

R

L

L

V

E

E

I

I

A

G

R

R

A

A

M

L

C

M

T

T

R

N

P

P

Q

K

I

M

I

I

C

V

L

M

D

D

E
|
E

P

P

A

I

A

A

G

G

L

V

N

A

P

P

Q

G

E

L

T

A

E

H

A

D

L

I

S

F

A

N

M

H

I

V

R

L

L

E

L

L

R

K

D

A

E

K

H

-

D

G

L

I

T

T

V

F

V

L

L

I

I

I

E

E

H

H

D

R

M

L

G

D

M

I

V

V

M

L

S

N

I

Y

S

I

D

D

H

H

I

L

V

Y

V

V

L

M

D

F

H

N

G

G

V

Q

V

I

I

I

A

A

E

E

G

G

-

R

G

G

P

E

E

E

A

E

I

I

R

K

H

N

-

V

-

L

-

S

D

D

P

P

K

K

V

V

I

V

A

E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (= F15), F17 (≠ I18), N39 (= N40), G40 (= G41), S41 (≠ A42), G42 (= G43), K43 (= K44), S44 (≠ T45), T45 (= T46)
binding magnesium ion: S44 (≠ T45), E176 (= E209)

1g6hA Crystal structure of the adp conformation of mj1267, an atp- binding cassette of an abc transporter (see paper)
33% identity, 96% coverage: 5:283/290 of query aligns to 4:253/254 of 1g6hA

query
sites
1g6hA

V

I

L

L

S

R

V

T

D

E

K

N

L

I

M

V

M

K

H

Y

F
|
F

G

G

G

E

I
x
F

K

K

A

A

L

L

S

D

D

G

V

V

S

S

L

I

K

S

V

V

K

N

R

K

N

G

S

D

I

V

F

T

A

L

L

I

I

I

G

G

P

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

I

N

N

C

V

L

I

T

T

G

G

F

F

Y

L

K

K

A

A

S

D

G

E

G

G

H

R

I

V

E

Y

L

F

N

E

T

N

R

K

G

D

V

I

K

T

T

N

D

K

V

-

I

-

K

-

M

-

L

-

G

-

E

E

P

P

F

A

K

E

A

L

V

Y

D

H

F

Y

V

-

S

-

P

-

K

-

S

-

F

-

I

-

N

-

R

-

L

-

R

-

Y

-

K

-

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

-

A

-

G

G

L

I

A

V

R

R

T

T

F

F

Q

Q

N

T

I

P

R

Q

L

P

F

L

R

K

E

E

M

M

S

T

V

V

L

L

E

E

N

N

L

L

L

L

V

I

A

G

Q

E

H

-

M

-

W

-

V

I

N

C

R

P

G

G

M

-

L

-

A

E

G

S

I

P

L

L

N

N

T

S

K

L

G

F

Y

Y

R

K

K

K

-

W

-

I

-

P

A

K

E

E

S

E

D

E

A

M

L

V

D

E

H

K

A

A

F

F

Y

K

W

I

L

L

E

E

V

F

V

L

D

K

L

L

V

S

D

H

C

L

A

Y

N

D

R

R

L

K

A

A

G

G

E

E

L

L

S

S

Y

G

G

G

Q

Q

Q

M

R

K

R

L

L

V

E

E

I

I

A

G

R

R

A

A

M

L

C

M

T

T

R

N

P

P

Q

K

I

M

I

I

C

V

L

M

D

D

E

E

P

P

A

I

A

A

G

G

L

V

N

A

P

P

Q

G

E

L

T

A

E

H

A

D

L

I

S

F

A

N

M

H

I

V

R

L

L

E

L

L

R

K

D

A

E

K

H

-

D

G

L

I

T

T

V

F

V

L

L

I

I

I

E

E

H

H

D

R

M

L

G

D

M

I

V

V

M

L

S

N

I

Y

S

I

D

D

H

H

I

L

V

Y

V

V

L

M

D

F

H

N

G

G

V

Q

V

I

I

I

A

A

E

E

G

G

-

R

G

G

P

E

E

E

A

E

I

I

R

K

H

N

-

V

-

L

-

S

D

D

P

P

K

K

V

V

I

V

A

E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (= F15), F17 (≠ I18), N39 (= N40), G40 (= G41), S41 (≠ A42), G42 (= G43), K43 (= K44), S44 (≠ T45), T45 (= T46)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
28% identity, 93% coverage: 8:276/290 of query aligns to 4:228/240 of 4ymuJ

query
sites
4ymuJ

V

V

D

N

K

D

L

V

M

Y

M

K

H

N

F
|
F

G

G

G

S

I
x
L

K

E

A
x
V

L

L

S

K

D

G

V

V

S

T

L

L

K

K

V

V

K

N

R

K

N

G

S

E

I

V

F

V

A

V

L

I

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

L

N

R

C

C

L

I

T

N

G

L

F

L

Y
x
E

K

E

A

P

S

T

G

K

G

G

H

E

I

V

E

F

L

I

N

D

T

-

R

-

G

G

V

V

K

K

T

I

D

N

V

-

I

-

K

-

M

-

L

-

G

-

E

-

P

-

F

-

K

-

A

-

V

-

D

-

F

-

V

-

S

N

P

G

K

K

S

V

F

N

I

I

N

N

R

K

L

V

R

R

Y

Q

K

K

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

-

A

-

G

-

L

V

A

G

R

M

T

V

F

F

Q

Q

N

H

I

F

R

N

L

L

F

F

R

P

E

H

M

L

S

T

V

A

L

I

E

E

N

N

L

I

L

T

V

L

A

A

Q

P

H

-

M

-

W

-

V

-

N

-

R

-

G

-

M

-

L

-

A

-

G

-

I

-

L

V

N

K

T

V

K

K

G

K

Y

M

R

N

K

K

A

K

E

E

S

A

D

E

A

E

L

L

D

-

H

-

A

A

F

V

Y

D

W

L

L

L

E

A

V

K

V

V

D

G

L

L

V

L

D

D

C

K

A

K

N

D

R

Q

L

Y

A

P

G

I

E

K

L

L

S

S

Y

G

G

G

Q

Q

Q

K

R

Q

R

R

L

L

E

A

I

I

A

A

R

R

A

A

M

L

C

A

T

M

R

Q

P

P

Q

E

I

V

I

M

C

L

L

F

D

D

E
|
E

P

P

A

T

A

S

G

A

L

L

N

D

P

P

Q

E

E

M

T

V

E

K

A

E

L

V

S

L

A

N

M

V

I

M

R

K

L

Q

L

L

R

A

D

N

E

E

H

-

D

G

L

M

T

T

V

M

V

V

L

V

I

V

E

T

H
|
H

D

E

M

M

G

G

M

F

V

A

M

R

S

E

I

V

S

G

D

D

H

R

I

V

V

I

V

F

L

M

D

D

H

D

G

G

V

V

V

I

I

V

A

E

E

E

G

G

G

T

P

P

E

E

A

E

I

I

R

F

H

Y

D

R

P

A

K

K

binding adenosine-5'-triphosphate: F11 (= F15), L14 (≠ I18), V16 (≠ A20), S36 (≠ N40), G37 (= G41), S38 (≠ A42), G39 (= G43), K40 (= K44), S41 (≠ T45), T42 (= T46), E51 (≠ Y55), E162 (= E209), H194 (= H242)
binding magnesium ion: S41 (≠ T45), E162 (= E209)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
27% identity, 98% coverage: 1:283/290 of query aligns to 2:238/240 of 1ji0A

query
sites
1ji0A

M

V

S

S

E

D

V

I

V

V

L

L

S

E

V

V

D

Q

K

S

L

L

M

H

M

V

H

Y

F
x
Y

G

G

G

A

I
|
I

K

H

A
|
A

L

I

S

K

D

G

V

I

S

D

L

L

K

K

V

V

K

P

R

R

N

G

S

Q

I

I

F

V

A

T

L

L

I

I

G

G

P

A

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

T
|
T

V

T

F

L

N

S

C

A

L

I

T

A

G

G

F

L

Y

V

K

R

A

A

S

Q

G

K

G

G

H

K

I

I

E

I

L

F

N

N

T

G

R

Q

G

D

V

I

K

T

T

N

D

-

V

-

I

-

K

-

M

-

L

-

G

-

E

K

P

P

F

-

K

-

A

-

V

-

D

-

F

-

V

-

S

-

P

-

K

-

S

-

F

-

I

-

N

-

R

-

L

-

R

-

Y

-

K

-

M

-

F

-

G

-

G

-

T

A

H

H

L

V

I

I

N

N

R

R

A

M

G

G

L

I

A

A

R

L

T

V

F

P

Q
x
E

N

G

I

R

R

R

L

I

F

F

R

P

E

E

M

L

S

T

V

V

L

Y

E

E

N

N

L

L

L

M

V

M

A

G

Q

-

H

-

M

-

W

-

V

-

N

-

R

-

G

-

M

-

L

-

A

-

G

-

I

-

L

-

N

-

T

-

K

-

G

A

Y

Y

R

N

K

R

A

K

E

D

S

K

D

E

A

G

L

I

D

K

H

R

A

D

F

L

Y

E

W

W

L

I

E

F

V

S

V

L

-

F

-

P

D

R

L

L

V

K

D

E

C

R

A

L

N

K

R

Q

L

L

A

G

G

G

E

T

L

L

S

S

Y

G

G

G

Q

E

Q

Q

R

Q

R

M

L

L

E

A

I

I

A

G

R

R

A

A

M

L

C

M

T

S

R

R

P

P

Q

K

I

L

I

L

C

M

L

M

D
|
D

E
|
E

P

P

A

S

A

L

G

G

L

L

N

A

P

P

Q

I

E

L

T

V

E

S

A

E

L

V

S

F

A

E

M

V

I

I

R

Q

L

K

L

I

R

N

D

Q

E

E

H

G

D

T

L

-

T

T

V

I

V

L

L

L

I

V

E

E

H

Q

D

N

M

A

G

L

M

G

V

A

M

L

S

K

I

V

S

A

D

H

H

Y

I

G

V

Y

V

V

L

L

D

E

H

T

G

G

V

Q

V

I

I

V

A

L

E

E

G

G

G

K

P

A

E

S

A

E

I

L

R

L

H

D

D

N

P

E

K

M

V

V

I

R

A

K

A

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (≠ F15), I19 (= I18), A21 (= A20), N41 (= N40), G42 (= G41), A43 (= A42), G44 (= G43), K45 (= K44), T46 (= T45), T47 (= T46), E88 (≠ Q117), D164 (= D208), E165 (= E209)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
29% identity, 94% coverage: 5:276/290 of query aligns to 2:228/241 of 4u00A

query
sites
4u00A

V

I

L

I

S

R

V

I

D

R

K

N

L

L

M

H

M

K

H

W

F
|
F

G

G

G

P

I
x
L

K

H

A
x
V

L

L

S

K

D

G

V

I

S

H

L

L

K

E

V

V

K

A

R

P

N

G

S

E

I

K

F

L

A

V

L

I

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

L

F

I

N

R

C

T

L

I

T

N

G

R

F

L

Y

E

K

D

A

F

S

Q

G

E

G

G

H

E

I

V

E

V

L

V

N

D

T

G

R

L

G

S

V

V

K

K

T

D

D

D

V

-

I

-

K

R

M

A

L

L

G

R

E

E

P

I

F

R

K

R

A

E

V

V

D

G

F

M

V

V

S

-

P

-

K

-

S

-

F

-

I

-

N

-

R

-

L

-

R

-

Y

-

K

-

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

-

A

-

G

-

L

-

A

-

R

-

T

-

F

F

Q

Q

N

Q

I

F

R

N

L

L

F

F

R

P

E

H

M

M

S

T

V

V

L

L

E

E

N

N

L

V

L

T

V

L

A

A

Q

P

H

-

M

M

W

R

V

V

N

R

R

R

G

W

M

-

L

-

A

-

G

-

I

-

L

-

N

-

T

-

K

-

G

P

Y

R

R

E

K

K

A

A

E

E

S

K

D

K

A

A

L

L

D

E

H

-

A

-

F

-

Y

-

W

L

L

L

E

E

V

R

V

V

D

G

L

I

V

L

D

D

C

Q

A

A

N

R

R

K

L

Y

A

P

G

A

E

Q

L

L

S

S

Y

G

G

G

Q

Q

Q

Q

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

M

L

C

A

T

M

R

E

P

P

Q

K

I

I

I

M

C

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

L

L

N

D

P

P

Q

-

E

-

T

-

E

E

A

M

L

V

S

G

A

E

M

V

I

L

R

D

L

V

L

M

R

R

D

D

-

L

-

A

E

Q

H

G

D

G

L

M

T

T

V

M

V

V

L

V

I

V

E

T

H

H

D

E

M

M

G

G

M

F

V

A

M

R

S

E

I

V

S

A

D

D

H

R

I

V

V

V

V

F

L

M

D

D

H

G

G

G

V

Q

V

I

I

V

A

E

E

E

G

G

G

R

P

P

E

E

A

E

I

I

R

F

H

T

D

R

P

P

K

K

binding adenosine-5'-diphosphate: F12 (= F15), L15 (≠ I18), V17 (≠ A20), S37 (≠ N40), G38 (= G41), S39 (≠ A42), G40 (= G43), K41 (= K44), S42 (≠ T45), T43 (= T46)

7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation (see paper)
28% identity, 93% coverage: 2:272/290 of query aligns to 1:229/263 of 7d0aB

query
sites
7d0aB

S

T

E

Q

V

S

V

L

L

I

S

E

V

V

D

K

K

N

L

L

M

S

M

F

H

N

F
x
R

G
|
G

G

E

I
x
R

K

V

A

I

L

Y

S

D

D

N

V

I

S

S

L

L

K

N

V

I

K

R

R

R

N

G

S

Q

I

I

F

T

A

A

L

I

I

M

G

G

P

P

N
x
S

G
|
G

A
x
T

G
|
G

K
|
K

T

T

T

T

V

L

F

L

N

R

C

L

L

I

T

G

G

G

F

Q

Y
x
L

K

V

A

P

S

D

G

Q

G

G

H

E

I

V

E

L

L

L

N

D

T

G

R

K

G

-

V

-

K

-

T

-

D

D

V

I

I

A

K

Q

M

M

L

S

G

-

E

-

P

-

F

-

K

-

A

-

V

-

D

-

F

-

V

-

S

-

P

-

K

-

S

-

F

-

I

-

N

-

R

-

L

-

R

R

Y

Q

K

E

M

L

F

F

G

A

G

A

T

-

H

-

L

-

I

-

N

-

R

R

A

A

G

R

L

M

A

G

R

M

T

L

F

F

Q

Q

N

S

I

G

R

A

L

L

F

F

R

T

E

D

M

M

S

S

V

V

L

Y

E

E

N

N

L

V

L

A

-

F

-

P

V

I

A

R

Q

A

H

H

M

T

W

K

V

L

N

S

R

E

G

N

M

L

L

I

A

A

G

E

I

L

L

V

N

A

T

L

K

K

G

-

Y

-

R

-

K

-

A

-

E

-

S

-

D

-

A

-

L

-

D

-

H

-

A

-

F

-

Y

-

W

-

L

L

E

E

V

S

V

V

D

G

L

L

V

R

D

G

C

T

A

E

N

Q

R

L

L

M

A

P

G

T

E
|
E

L

L

S
|
S

Y

G

G
|
G

Q
x
M

Q

N

R

R

R

R

L

V

E

A

I

L

A

A

R

R

A

A

M

I

C

A

T

L

R

D

P

P

Q

D

I

L

I

I

C

M

L

Y

D

D

E

E

P

P

A

F

A

A

G

G

L

Q

N

D

P

P

Q

I

E

V

T

K

E

G

A

V

L

L

S

T

A

R

M

L

I

I

R

R

L

S

L

L

R

R

D

E

E

A

H

L

D

D

L

L

T

T

V

T

V

I

L

I

I

V

E

S

H

H

D

D

M

V

G

P

M

E

V

T

M

L

S

S

I

I

S

A

D

D

H

Y

I

I

V

Y

V

V

L

V

D

A

H

E

G

G

V

K

V

I

I

Q

A

G

E

E

G

G

G

T

P

P

E

E

A

E

I

L

R

Q

binding adenosine-5'-diphosphate: R14 (≠ F15), G15 (= G16), R17 (≠ I18), S39 (≠ N40), G40 (= G41), T41 (≠ A42), G42 (= G43), K43 (= K44), L54 (≠ Y55), E140 (= E183), S142 (= S185), G144 (= G187), M145 (≠ Q188)

7d08B Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
28% identity, 93% coverage: 2:272/290 of query aligns to 1:229/263 of 7d08B

query
sites
7d08B

S

T

E

Q

V

S

V

L

L

I

S

E

V

V

D

K

K

N

L

L

M

S

M

F

H

N

F
x
R

G

G

G

E

I
x
R

K

V

A

I

L

Y

S

D

D

N

V

I

S

S

L

L

K

N

V

I

K

R

R

R

N

G

S

Q

I

I

F

T

A

A

L

I

I

M

G

G

P

P

N

S

G
|
G

A
x
T

G
|
G

K
|
K

T
|
T

T
|
T

V

L

F

L

N

R

C

L

L

I

T

G

G

G

F

Q

Y

L

K

V

A

P

S

D

G

Q

G

G

H

E

I

V

E

L

L

L

N

D

T

G

R

K

G

-

V

-

K

-

T

-

D

D

V

I

I

A

K

Q

M

M

L

S

G

-

E

-

P

-

F

-

K

-

A

-

V

-

D

-

F

-

V

-

S

-

P

-

K

-

S

-

F

-

I

-

N

-

R

-

L

-

R

R

Y

Q

K

E

M

L

F

F

G

A

G

A

T

-

H

-

L

-

I

-

N

-

R

R

A

A

G

R

L

M

A

G

R

M

T

L

F

F

Q
|
Q

N

S

I

G

R

A

L

L

F

F

R

T

E

D

M

M

S

S

V

V

L

Y

E

E

N

N

L

V

L

A

-

F

-

P

V

I

A

R

Q

A

H

H

M

T

W

K

V

L

N

S

R

E

G

N

M

L

L

I

A

A

G

E

I

L

L

V

N

A

T

L

K

K

G

-

Y

-

R

-

K

-

A

-

E

-

S

-

D

-

A

-

L

-

D

-

H

-

A

-

F

-

Y

-

W

-

L

L

E

E

V

S

V

V

D

G

L

L

V

R

D

G

C

T

A

E

N

Q

R

L

L

M

A

P

G

T

E

E

L

L

S

S

Y

G

G

G

Q

M

Q

N

R

R

R

R

L

V

E

A

I

L

A

A

R

R

A

A

M

I

C

A

T

L

R

D

P

P

Q

D

I

L

I

I

C

M

L

Y

D
|
D

E
|
E

P

P

A

F

A

A

G

G

L

Q

N

D

P

P

Q

I

E

V

T

K

E

G

A

V

L

L

S

T

A

R

M

L

I

I

R

R

L

S

L

L

R

R

D

E

E

A

H

L

D

D

L

L

T

T

V

T

V

I

L

I

I

V

E

S

H

H

D

D

M

V

G

P

M

E

V

T

M

L

S

S

I

I

S

A

D

D

H

Y

I

I

V

Y

V

V

L

V

D

A

H

E

G

G

V

K

V

I

I

Q

A

G

E

E

G

G

G

T

P

P

E

E

A

E

I

L

R

Q

binding adenosine-5'-triphosphate: R14 (≠ F15), R17 (≠ I18), G40 (= G41), T41 (≠ A42), G42 (= G43), K43 (= K44), T44 (= T45), T45 (= T46), Q88 (= Q117), D165 (= D208), E166 (= E209)

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
28% identity, 93% coverage: 3:272/290 of query aligns to 2:224/285 of 4yerA

query
sites
4yerA

E

E

V

D

V

I

L

I

S

V

V

V

D

E

K

N

L

L

M

V

M

K

H

K

F
|
F

G

G

G

D

I
x
F

K

E

A
|
A

L

V

S

K

D

G

V

V

S

S

L

F

K

S

V

V

K

K

R

K

N

G

S

E

I

I

F

F

A

A

L

F

I

L

G

G

P
|
P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

T
|
T

T
|
T

V

T

F

I

N

H

C

M

L

L

T

T

G

T

F

L

Y

L

K

K

A

P

S

T

G

S

G

G

H

K

I

A

E

W

L

V

N

A

T

G

R

H

G

D

V

V

K

-

T

-

D

-

V

-

I

-

K

-

M

-

L

L

G

K

E

E

P

P

F

R

K

E

A

V

V

-

D

-

F

-

V

-

S

-

P

-

K

-

S

-

F

-

I

-

N

-

R

-

L

-

R

-

Y

-

K

-

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

R

A

R

G

K

L

I

A

G

R

I

T

V

F

F

Q

Q

N

D

I

Q

R

S

L

L

F

D

R

R

E

E

M

L

S

T

V

A

L

Y

E

E

N

N

L

M

L

Y

V

I

A

-

Q

-

H

-

M

-

W

-

V

-

N

-

R

H

G

G

M

K

L

I

A

Y

G

G

I

Y

L

G

N

G

T

E

K

K

G

L

Y

K

R

K

K

R

A

I

E

L

S

E

D

L

A

L

L

E

D

-

H

-

A

-

F

-

Y

-

W

-

L

-

E

-

V

F

V

V

D

E

L

L

V

L

D

E

C

F

A

K

N

D

R

K

L

P

A

V

G

K

E
x
T

L
x
F

S
|
S

Y

G

G

G

Q

M

Q

A

R

R

R

R

L

L

E

E

I

I

A

A

R

R

A

S

M

L

C

I

T

H

R

E

P

P

Q

E

I

V

I

L

C

F

L

L

D

D

E

E

P

P

A

T

A

I

G

G

L

L

N

D

P

P

Q

H

E

T

T

R

E

A

A

H

L

M

S

W

A

E

M

Y

I

I

R

S

L

K

L

M

R

K

D

K

E

E

H

H

D

N

L

M

T

T

V

I

V

F

L

L

I

T

E

T

H

H

D

Y

M

M

G

D

M

E

V

A

M

E

S

Q

I

L

S

A

D

D

H

R

I

V

V

A

V

I

L

I

D

D

H

H

G

G

V

K

V

I

I

I

A

A

E

L

G

G

G

T

P

P

E

T

A

E

I

L

R

K

binding adenosine-5'-diphosphate: F14 (= F15), F17 (≠ I18), A19 (= A20), P38 (= P39), N39 (= N40), G40 (= G41), A41 (= A42), G42 (= G43), K43 (= K44), T44 (= T45), T45 (= T46), T135 (≠ E183), F136 (≠ L184), S137 (= S185)

6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp (see paper)
29% identity, 86% coverage: 23:272/290 of query aligns to 20:227/253 of 6z5uK

query
sites
6z5uK

D

N

V

I

S

S

L

L

K

N

V

I

K

R

R

R

N

G

S

Q

I

I

F

T

A

A

L

I

I

M

G

G

P

P

N
x
S

G
|
G

A
x
T

G
|
G

K
|
K

T
|
T

T
|
T

V

L

F

L

N

R

C

L

L

I

T

G

G

G

F

Q

Y

L

K

V

A

P

S

D

G

Q

G

G

H

E

I

V

E

L

L

L

N

D

T

G

R

K

G

-

V

-

K

-

T

-

D

D

V

I

I

A

K

Q

M

M

L

S

G

-

E

-

P

-

F

-

K

-

A

-

V

-

D

-

F

-

V

-

S

-

P

-

K

-

S

-

F

-

I

-

N

-

R

-

L

-

R

R

Y

Q

K

E

M

L

F

F

G

A

G

A

T

-

H

-

L

-

I

-

N

-

R

R

A

A

G

R

L

M

A

G

R

M

T

L

F

F

Q
|
Q

N

S

I

G

R

A

L

L

F

F

R

T

E

D

M

M

S

S

V

V

L

Y

E

E

N

N

L

V

L

A

-

F

-

P

V

I

A

R

Q

A

H

H

M

T

W

K

V

L

N

S

R

E

G

N

M

L

L

I

A

A

G

E

I

L

L

V

N

A

T

L

K

K

G

-

Y

-

R

-

K

-

A

-

E

-

S

-

D

-

A

-

L

-

D

-

H

-

A

-

F

-

Y

-

W

-

L

L

E

E

V

S

V

V

D

G

L

L

V

R

D

G

C

T

A

E

N

Q

R

L

L

M

A

P

G

T

E

E

L

L

S

S

Y

G

G

G

Q

M

Q

N

R

R

R

R

L

V

E

A

I

L

A

A

R

R

A

A

M

I

C

A

T

L

R

D

P

P

Q

D

I

L

I

I

C

M

L

Y

D

D

E
|
E

P

P

A

F

A

A

G

G

L

Q

N

D

P

P

Q

I

E

V

T

K

E

G

A

V

L

L

S

T

A

R

M

L

I

I

R

R

L

S

L

L

R

R

D

E

E

A

H

L

D

D

L

L

T

T

V

T

V

I

L

I

I

V

E

S

H
|
H

D

D

M

V

G

P

M

E

V

T

M

L

S

S

I

I

S

A

D

D

H

Y

I

I

V

Y

V

V

L

V

D

A

H

E

G

G

V

K

V

I

I

Q

A

G

E

E

G

G

G

T

P

P

E

E

A

E

I

L

R

Q

binding phosphoaminophosphonic acid-adenylate ester: S37 (≠ N40), G38 (= G41), T39 (≠ A42), G40 (= G43), K41 (= K44), T42 (= T45), T43 (= T46), Q86 (= Q117), E164 (= E209), H197 (= H242)
binding magnesium ion: Q86 (= Q117), E164 (= E209)

Sites not aligning to the query:

binding phosphoaminophosphonic acid-adenylate ester: 12

3c4jA Abc protein artp in complex with atp-gamma-s
27% identity, 94% coverage: 5:276/290 of query aligns to 3:230/242 of 3c4jA

query
sites
3c4jA

V

M

L

I

S

D

V

V

D

H

K

Q

L

L

M

K

M

K

H

S

F
|
F

G

G

G

S

I

L

K

E

A
x
V

L

L

S

K

D

G

V

I

S

N

L

V

K

H

V

I

K

R

R

E

N

G

S

E

I

V

F

V

A

V

L

V

I

I

G

G

P
|
P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

F

F

L

N

R

C

C

L

L

T

N

G

L

F

L

Y

E

K

D

A

F

S

D

G

E

G

G

H

E

I

I

E

I

L

I

N

D

T

-

R

-

G

-

V

-

K

-

T

-

D

-

V

-

I

-

K

-

M

-

L

-

G

G

E

I

P

N

F

L

K

K

A

A

V

K

D

D

F

-

V

-

S

-

P

-

K

-

S

T

F

N

I

L

N

N

R

K

L

V

R

R

Y

E

K

E

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

-

A

-

G

-

L

V

A

G

R

M

T

V

F

F

Q

Q

N

R

I

F

R

N

L

L

F

F

R

P

E

H

M

M

S

T

V

V

L

L

E

N

N

N

L

I

L

T

V

L

A

A

Q

P

H

-

M

-

W

-

V

-

N

-

R

-

G

-

M

-

L

-

A

-

G

-

I

-

L

M

N

K

T

V

K

R

G

K

Y

W

R

P

K

R

A

E

E

K

S

A

D

E

A

A

L

-

D

-

H

K

A

A

F

M

Y

E

W

L

L

L

E

D

V

K

V

V

D

G

L

L

V

K

D

D

C

K

A

A

N
x
H

R

A

L
x
Y

A

P

G

D

E

S

L

L

S

S

Y

G

G

G

Q

Q

Q

A

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

M

L

C

A

T

M

R

E

P

P

Q

K

I

I

I

M

C

L

L

F

D

D

E
|
E

P

P

A

T

A

S

G

A

L

L

N

D

P

P

Q

E

E

M

T

V

-

G

E

E

A

V

L

L

S

S

A

V

M

M

I

K

R

Q

L

L

L

A

R

N

D

E

E

-

H

-

D

G

L

M

T

T

V

M

V

V

L

V

I

V

E

T

H

H

D

E

M

M

G

G

M

F

V

A

M

R

S

E

I

V

S

G

D

D

H

R

I

V

V

L

V

F

L

M

D

D

H

G

G

G

V

Y

V

I

I

I

A

E

E

E

G

G

G

K

P

P

E

E

A

D

I

L

R

F

H

D

D

R

P

P

K

Q

binding phosphothiophosphoric acid-adenylate ester: F13 (= F15), V18 (≠ A20), P37 (= P39), S38 (≠ N40), G39 (= G41), S40 (≠ A42), G41 (= G43), K42 (= K44), S43 (≠ T45), T44 (= T46), H133 (≠ N178), Y135 (≠ L180), E164 (= E209)

3c41J Abc protein artp in complex with amp-pnp/mg2+
27% identity, 94% coverage: 5:276/290 of query aligns to 3:230/242 of 3c41J

query
sites
3c41J

V

M

L

I

S

D

V

V

D

H

K

Q

L

L

M

K

M

K

H

S

F
|
F

G

G

G

S

I

L

K

E

A
x
V

L

L

S

K

D

G

V

I

S

N

L

V

K

H

V

I

K

R

R

E

N

G

S

E

I

V

F

V

A

V

L

V

I

I

G

G

P
|
P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

F

F

L

N
x
R

C

C

L

L

T

N

G

L

F

L

Y

E

K

D

A

F

S

D

G

E

G

G

H

E

I

I

E

I

L

I

N

D

T

-

R

-

G

-

V

-

K

-

T

-

D

-

V

-

I

-

K

-

M

-

L

-

G

G

E

I

P

N

F

L

K

K

A

A

V

K

D

D

F

-

V

-

S

-

P

-

K

-

S

T

F

N

I

L

N

N

R

K

L

V

R

R

Y

E

K

E

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

-

A

-

G

-

L

V

A

G

R

M

T

V

F

F

Q

Q

N

R

I

F

R

N

L

L

F

F

R

P

E

H

M

M

S

T

V

V

L

L

E

N

N

N

L

I

L

T

V

L

A

A

Q

P

H

-

M

-

W

-

V

-

N

-

R

-

G

-

M

-

L

-

A

-

G

-

I

-

L

M

N

K

T

V

K

R

G

K

Y

W

R

P

K

R

A

E

E

K

S

A

D

E

A

A

L

-

D

-

H

K

A

A

F

M

Y

E

W

L

L

L

E

D

V

K

V

V

D

G

L

L

V

K

D

D

C

K

A

A

N
x
H

R

A

L
x
Y

A

P

G

D

E

S

L

L

S

S

Y

G

G

G

Q

Q

Q

A

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

M

L

C

A

T

M

R

E

P

P

Q

K

I

I

I

M

C

L

L

F

D
|
D

E

E

P

P

A

T

A

S

G

A

L

L

N

D

P

P

Q

E

E

M

T

V

-

G

E

E

A

V

L

L

S

S

A

V

M

M

I

K

R

Q

L

L

L

A

R

N

D

E

E

-

H

-

D

G

L

M

T

T

V

M

V

V

L

V

I

V

E

T

H

H

D

E

M

M

G

G

M

F

V

A

M

R

S

E

I

V

S

G

D

D

H

R

I

V

V

L

V

F

L

M

D

D

H

G

G

G

V

Y

V

I

I

I

A

E

E

E

G

G

G

K

P

P

E

E

A

D

I

L

R

F

H

D

D

R

P

P

K

Q

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F15), V18 (≠ A20), P37 (= P39), S38 (≠ N40), G39 (= G41), S40 (≠ A42), G41 (= G43), K42 (= K44), S43 (≠ T45), T44 (= T46), R47 (≠ N49), H133 (≠ N178), Y135 (≠ L180)
binding magnesium ion: S43 (≠ T45), D163 (= D208)

2olkA Abc protein artp in complex with adp-beta-s
27% identity, 94% coverage: 5:276/290 of query aligns to 3:230/242 of 2olkA

query
sites
2olkA

V

M

L

I

S

D

V

V

D

H

K

Q

L

L

M

K

M

K

H

S

F
|
F

G

G

G

S

I
x
L

K

E

A
x
V

L

L

S

K

D

G

V

I

S

N

L

V

K

H

V

I

K

R

R

E

N

G

S

E

I

V

F

V

A

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

F

F

L

N

R

C

C

L

L

T

N

G

L

F

L

Y

E

K

D

A

F

S

D

G

E

G

G

H

E

I

I

E

I

L

I

N

D

T

-

R

-

G

-

V

-

K

-

T

-

D

-

V

-

I

-

K

-

M

-

L

-

G

G

E

I

P

N

F

L

K

K

A

A

V

K

D

D

F

-

V

-

S

-

P

-

K

-

S

T

F

N

I

L

N

N

R

K

L

V

R

R

Y

E

K

E

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

-

A

-

G

-

L

V

A

G

R

M

T

V

F

F

Q

Q

N

R

I

F

R

N

L

L

F

F

R

P

E

H

M

M

S

T

V

V

L

L

E

N

N

N

L

I

L

T

V

L

A

A

Q

P

H

-

M

-

W

-

V

-

N

-

R

-

G

-

M

-

L

-

A

-

G

-

I

-

L

M

N

K

T

V

K

R

G

K

Y

W

R

P

K

R

A

E

E

K

S

A

D

E

A

A

L

-

D

-

H

K

A

A

F

M

Y

E

W

L

L

L

E

D

V

K

V

V

D

G

L

L

V

K

D

D

C

K

A

A

N

H

R

A

L

Y

A

P

G

D

E

S

L

L

S

S

Y

G

G

G

Q

Q

Q

A

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

M

L

C

A

T

M

R

E

P

P

Q

K

I

I

I

M

C

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

L

L

N

D

P

P

Q

E

E

M

T

V

-

G

E

E

A

V

L

L

S

S

A

V

M

M

I

K

R

Q

L

L

L

A

R

N

D

E

E

-

H

-

D

G

L

M

T

T

V

M

V

V

L

V

I

V

E

T

H

H

D

E

M

M

G

G

M

F

V

A

M

R

S

E

I

V

S

G

D

D

H

R

I

V

V

L

V

F

L

M

D

D

H

G

G

G

V

Y

V

I

I

I

A

E

E

E

G

G

G

K

P

P

E

E

A

D

I

L

R

F

H

D

D

R

P

P

K

Q

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (= F15), L16 (≠ I18), V18 (≠ A20), S38 (≠ N40), G39 (= G41), S40 (≠ A42), G41 (= G43), K42 (= K44), S43 (≠ T45), T44 (= T46)

2oljA Abc protein artp in complex with adp/mg2+
27% identity, 94% coverage: 5:276/290 of query aligns to 3:230/242 of 2oljA

query
sites
2oljA

V

M

L

I

S

D

V

V

D

H

K

Q

L

L

M

K

M

K

H

S

F
|
F

G

G

G

S

I

L

K

E

A
x
V

L

L

S

K

D

G

V

I

S

N

L

V

K

H

V

I

K

R

R

E

N

G

S

E

I

V

F

V

A

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

V

F

F

L

N

R

C

C

L

L

T

N

G

L

F

L

Y

E

K

D

A

F

S

D

G

E

G

G

H

E

I

I

E

I

L

I

N

D

T

-

R

-

G

-

V

-

K

-

T

-

D

-

V

-

I

-

K

-

M

-

L

-

G

G

E

I

P

N

F

L

K

K

A

A

V

K

D

D

F

-

V

-

S

-

P

-

K

-

S

T

F

N

I

L

N

N

R

K

L

V

R

R

Y

E

K

E

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

-

A

-

G

-

L

V

A

G

R

M

T

V

F

F

Q

Q

N

R

I

F

R

N

L

L

F

F

R

P

E

H

M

M

S

T

V

V

L

L

E

N

N

N

L

I

L

T

V

L

A

A

Q

P

H

-

M

-

W

-

V

-

N

-

R

-

G

-

M

-

L

-

A

-

G

-

I

-

L

M

N

K

T

V

K

R

G

K

Y

W

R

P

K

R

A

E

E

K

S

A

D

E

A

A

L

-

D

-

H

K

A

A

F

M

Y

E

W

L

L

L

E

D

V

K

V

V

D

G

L

L

V

K

D

D

C

K

A

A

N
x
H

R

A

L
x
Y

A

P

G

D

E

S

L

L

S

S

Y

G

G

G

Q

Q

Q

A

R

Q

R

R

L

V

E

A

I

I

A

A

R

R

A

A

M

L

C

A

T

M

R

E

P

P

Q

K

I

I

I

M

C

L

L

F

D

D

E

E

P

P

A

T

A

S

G

A

L

L

N

D

P

P

Q

E

E

M

T

V

-

G

E

E

A

V

L

L

S

S

A

V

M

M

I

K

R

Q

L

L

L

A

R

N

D

E

E

-

H

-

D

G

L

M

T

T

V

M

V

V

L

V

I

V

E

T

H

H

D

E

M

M

G

G

M

F

V

A

M

R

S

E

I

V

S

G

D

D

H

R

I

V

V

L

V

F

L

M

D

D

H

G

G

G

V

Y

V

I

I

I

A

E

E

E

G

G

G

K

P

P

E

E

A

D

I

L

R

F

H

D

D

R

P

P

K

Q

binding adenosine-5'-diphosphate: F13 (= F15), V18 (≠ A20), S38 (≠ N40), G39 (= G41), S40 (≠ A42), G41 (= G43), K42 (= K44), S43 (≠ T45), T44 (= T46), H133 (≠ N178), Y135 (≠ L180)

1g291 Malk (see paper)
26% identity, 93% coverage: 15:284/290 of query aligns to 13:242/372 of 1g291

query
sites
1g291

F

F

G

G

G

E

I

V

K

T

A

A

L

V

S

R

D

E

V

M

S

S

L

L

K

E

V

V

K

K

R

D

N

G

S

E

I

F

F

M

A

I

L

L

I

L

G

G

P
|
P

N
x
S

G
|
G

A
x
C

G
|
G

K
|
K

T
|
T

T
|
T

V

T

F

L

N

R

C

M

L

I

T

A

G

G

F

L

Y

E

K

E

A

P

S

S

G

R

G

G

H

Q

I

I

E

Y

L

I

N

G

T

D

R

-

G

-

V

-

K

-

T

-

D

-

V

-

I

-

K

K

M

L

L

V

G

A

E
x
D

P

P

F
x
E

K
|
K

A

G

V

I

D

-

F

F

V

V

S

P

P

P

K
|
K

S
x
D

F

-

I

-

N

-

R

-

L

-

R

-

Y

-

K

-

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

-

A

R

G

D

L

I

A

A

R

M

T

V

F

F

Q

Q

N

S

I

Y

R

A

L

L

F

Y

R

P

E

H

M

M

S

T

V

V

L

Y

E

D

N

N

L

I

L

A

V

F

A

P

Q

L

H

K

M

L

W

-

V

-

N

-

R

-

G

-

M

-

L

-

A

-

G

-

I

-

L

-

N

-

T

-

K

-

G

-

Y

-

R

R

K

K

A

V

E

P

S

R

D

Q

A

E

L

I

D

D

H

Q

A

R

F

V

Y

R

W

E

L

V

-

A

E

E

V

L

V

L

D

G

L

L

V

T

D

E

C

L

A

L

N

N

R

R

L

K

A

P

G

R

E

E

L

L

S

S

Y

G

G

G

Q

Q

Q

R

R

Q

R

R

L

V

E

A

I

L

A

G

R

R

A

A

M

I

C

V

T

R

R

K

P

P

Q

Q

I

V

I

F

C

L

L

M

D

D

E

E

P

P

A

L

A

S

G

N

L

L

N

D

P

A

Q

K

E

L

T

R

E

V

A

R

L

M

S

R

A

A

M

E

I

L

R

K

L

K

L

L

R

Q

D

R

E

Q

H

L

D

G

L

V

T

T

V

T

V

I

L

Y

I

V

E

T

H

H

D

D

M

Q

G

V

M

E

V

A

M

M

S

T

I

M

S

G

D

D

H

R

I

I

V

A

V

V

L

M

D

N

H

R

G

G

V

V

V

L

I

Q

A

Q

E

V

G

G

G

S

P

P

E

D

A

E

I

V

R
x
Y

H
x
D

D

K

P

P

-

A

-

N

K

T

V

F

I

V

A

A

A

G

Y

F

L

I

G

G

A

S

binding magnesium ion: D69 (≠ E79), E71 (≠ F81), K72 (= K82), K79 (= K90), D80 (≠ S91), Y228 (≠ R272), D229 (≠ H273)
binding pyrophosphate 2-: P37 (= P39), S38 (≠ N40), G39 (= G41), C40 (≠ A42), G41 (= G43), K42 (= K44), T43 (= T45), T44 (= T46)

Sites not aligning to the query:

binding magnesium ion: 292, 293, 341, 342, 359

2d62A Crystal structure of multiple sugar binding transport atp- binding protein
25% identity, 93% coverage: 14:284/290 of query aligns to 15:245/375 of 2d62A

query
sites
2d62A

H

R

F

F

G

G

G

D

I

V

K

T

A

A

L

V

S

K

D

D

V

L

S

S

L

L

K

E

V

I

K

K

R

D

N

G

S

E

I

F

F

L

A

V

L

L

I

L

G

G

P
|
P

N
x
S

G
|
G

A
x
C

G
|
G

K
|
K

T
|
T

T
|
T

V

T

F

L

N

R

C

M

L

I

T

A

G

G

F

L

Y

E

K

E

A

P

S

T

G

R

G

G

H

Q

I

I

E

Y

L

I

N

E

T

D

R

-

G

-

V

-

K

-

T

-

D

-

V

-

I

-

K

N

M

L

L

V

G

A

E

D

P

P

F

E

K

K

A

G

V

V

D

-

F

F

V

V

S

P

P

P

K

K

S

E

F

-

I

-

N

-

R

-

L

-

R

-

Y

-

K

-

M

-

F

-

G

-

G

-

T

-

H

-

L

-

I

-

N

-

R

-

A

R

G

D

L

V

A

A

R

M

T

V

F

F

Q

Q

N

S

I

Y

R

A

L

L

F

Y

R

P

E

H

M

M

S

T

V

V

L

Y

E

D

N

N

L

I

L

A

V

F

A

P

Q

L

H

K

M

L

W

-

V

-

N

-

R

-

G

-

M

-

L

-

A

-

G

-

I

-

L

-

N

-

T

-

K

-

G

-

Y

-

R

R

K

K

A

V

E

P

S

K

D

Q

A

E

L

I

D

D

H

K

A

R

F

V

Y

R

W

E

L

V

-

A

E

E

V

M

V

L

D

G

L

L

V

T

D

E

C

L

A

L

N

N

R

R

L

K

A

P

G

R

E

E

L

L

S

S

Y

G

G

G

Q

Q

Q

R

R

Q

R

R

L

V

E

A

I

L

A

G

R

R

A

A

M

I

C

I

T

R

R

R

P

P

Q

K

I

V

I

F

C

L

L

M

D

D

E

E

P

P

A

L

A

S

G

N

L

L

N

D

P

A

Q

K

E

L

T

R

E

V

A

K

L

M

S

R

A

A

M

E

I

L

R

K

L

K

L

L

R

Q

D

R

E

Q

H

L

D

G

L

V

T

T

V

T

V

I

L

Y

I

V

E

T

H

H

D

D

M

Q

G

V

M

E

V

A

M

M

S

T

I

M

S

G

D

D

H

R

I

I

V

A

V

V

L

M

D

N

H

K

G

G

V

E

V

L

I

Q

A

Q

E

V

G

G

G

T

P

P

E

D

A

E

I

V

R

Y

H

Y

D

K

P

P

-

V

-

N

K

T

V

F

I

V

A

A

A

G

Y

F

L

I

G

G

A

S

binding pyrophosphate 2-: P40 (= P39), S41 (≠ N40), G42 (= G41), C43 (≠ A42), G44 (= G43), K45 (= K44), T46 (= T45), T47 (= T46)

6mjpB Lptb(e163q)fgc from vibrio cholerae (see paper)
27% identity, 97% coverage: 5:285/290 of query aligns to 2:237/240 of 6mjpB

query
sites
6mjpB

V

I

L

L

S

K

V

A

D

Q

K

H

L

L

M

A

M

K

H

S

F

Y

G

K

G

K

I

R

K

K

A

V

L

V

S

S

D

D

V

V

S

S

L

L

K

Q

V

V

K

E

R

S

N

G

S

Q

I

I

F

V

A

G

L

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

T

T

V

S

F

F

N

Y

C

M

L

I

T

V

G

G

F

L

Y

V

K

A

A

R

S

D

G

E

G

G

H

T

I

I

E

T

L

I

N

D

T

D

R

N

G

D

V

I

K

S

T

-

D

-

V

I

I

L

K

P

M

M

L

-

G

-

E

-

P

-

F

-

K

-

A

-

V

-

D

-

F

-

V

-

S

-

P

-

K

-

S

-

F

-

I

-

N

-

R

-

L

-

R

-

Y

-

K

-

M

-

F

-

G

-

G

-

T

-

H

H

L

S

I

R

N

S

R

R

A

M

G

G

L

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

I

A

R

S

L

I

F

F

R
|
R

E
x
K

M

L

S

S

V

V

L

E

E

D

N

N

L

I

L

M

V

-

A

-

Q

-

H

-

M

-

W

-

V

-

N

-

R

-

G

-

M

-

L

-

A

-

G

A

I

V

L

L

N

Q

T

T

K

R

G

-

Y

-

R

-

K

-

A

-

E

-

S

-

D

E

A

E

L

L

D

T

H

H

A

E

F

E

Y

R

W

Q

L

D

E

K

V

L

V

E

D

D

L

L

-

L

-

E

-

E

-

F

-

H

V

I

D

Q

C

H

A

I

N

R

R

K

L

S

A

A

G

G

-

M

E

A

L

L

S

S

Y

G

G

G

Q

E

Q

R

R

R

R

R

L

V

E

E

I

I

A

A

R

R

A

A

M

L

C

A

T

A

R

N

P

P

Q

Q

I

F

I

I

C

L

L

L

D

D

E

Q

P

P

A

F

A

A

G

G

L

V

N

D

P

P

Q

I

E

S

T

V

E

I

A

D

L

I

S

K

A

K

M

I

I

I

R

E

L

H

L

L

R

R

D

D

E

-

H

R

D

G

L

L

T

G

V

V

V

L

L

I

I

T

E

D

H

H

D

N

M

V

G

R

M

E

V

T

M

L

S

D

I

V

S

C

D

E

H

K

I

A

V

Y

V

I

L

V

D

S

H

Q

G

G

V

R

V

L

I

I

A

A

E

E

G

G

G

T

P

P

E

Q

A

D

I

V

R

L

H

N

D

N

P

E

K

Q

V

V

I

K

A

Q

A

V

Y

Y

L

L

G

G

A

E

E

Q

binding 6-cyclohexylhexyl beta-D-glucopyranoside: R90 (= R123), K91 (≠ E124)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
27% identity, 97% coverage: 5:285/290 of query aligns to 2:237/240 of 6mjpA

query
sites
6mjpA

V

I

L

L

S

K

V

A

D

Q

K

H

L

L

M

A

M

K

H

S

F

Y

G

K

G

K

I

R

K

K

A

V

L

V

S

S

D

D

V

V

S

S

L

L

K

Q

V

V

K

E

R

S

N

G

S

Q

I

I

F

V

A

G

L

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

T

T

T

T

V

S

F

F

N

Y

C

M

L

I

T

V

G

G

F

L

Y

V

K

A

A

R

S

D

G

E

G

G

H

T

I

I

E

T

L

I

N

D

T

D

R

N

G

D

V

I

K

S

T

-

D

-

V

I

I

L

K

P

M

M

L

-

G

-

E

-

P

-

F

-

K

-

A

-

V

-

D

-

F

-

V

-

S

-

P

-

K

-

S

-

F

-

I

-

N

-

R

-

L

-

R

-

Y

-

K

-

M

-

F

-

G

-

G

-

T

-

H

H

L

S

I

R

N

S

R

R

A

M

G

G

L

I

A

G

R

Y

T

L

F

P

Q

Q

N

E

I

A

R

S

L

I

F

F

R

R

E

K

M

L

S

S

V

V

L

E

E

D

N

N

L

I

L

M

V

-

A

-

Q

-

H

-

M

-

W

-

V

-

N

-

R

-

G

-

M

-

L

-

A

-

G

A

I

V

L

L

N

Q

T

T

K

R

G

-

Y

-

R

-

K

-

A

-

E

-

S

-

D

E

A

E

L

L

D

T

H

H

A
x
E

F

E

Y

R

W

Q

L
x
D

E

K

V

L

V

E

D

D

L

L

-

L

-

E

-

E

-

F

-

H

V

I

D

Q

C

H

A

I

N

R

R

K

L

S

A

A

G

G

-

M

E

A

L

L

S

S

Y

G

G

G

Q

E

Q

R

R

R

R

R

L

V

E

E

I

I

A

A

R

R

A

A

M

L

C

A

T

A

R

N

P

P

Q

Q

I<