SitesBLAST
Comparing Pf1N1B4_1947 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_1947 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2j6hA E. Coli glucosamine-6-p synthase in complex with glucose-6p and 5-oxo-l-norleucine (see paper)
63% identity, 100% coverage: 2:610/610 of query aligns to 1:608/608 of 2j6hA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W75), N98 (= N99), G99 (= G100), Y248 (≠ F249), E481 (= E483), K485 (= K487), E488 (= E490), H504 (= H506), K603 (= K605)
- binding glucose-6-phosphate: C300 (= C301), G301 (= G302), T302 (= T303), S303 (= S304), S347 (= S348), Q348 (= Q349), S349 (= S350), T352 (= T353), V399 (= V400), S401 (= S402), K485 (= K487), E488 (= E490)
- binding 5-oxo-l-norleucine: C1 (= C2), R73 (= R74), W74 (= W75), T76 (= T77), H77 (= H78), H86 (= H87), H97 (= H98), N98 (= N99), G99 (= G100), D123 (= D124), T124 (= T125), V607 (= V609)
4amvA E.Coli glucosamine-6p synthase in complex with fructose-6p (see paper)
63% identity, 100% coverage: 2:610/610 of query aligns to 1:608/608 of 4amvA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W75), N98 (= N99), G99 (= G100), Y248 (≠ F249), E481 (= E483), K485 (= K487), E488 (= E490), H504 (= H506), K603 (= K605)
- binding fructose -6-phosphate: C300 (= C301), G301 (= G302), T302 (= T303), S303 (= S304), S347 (= S348), Q348 (= Q349), S349 (= S350), T352 (= T353), V399 (= V400), A400 (= A401), S401 (= S402), K485 (= K487), E488 (= E490)
1jxaA Glucosamine 6-phosphate synthase with glucose 6-phosphate (see paper)
63% identity, 100% coverage: 2:610/610 of query aligns to 1:608/608 of 1jxaA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W75), N98 (= N99), G99 (= G100), Y248 (≠ F249), E481 (= E483), K485 (= K487), E488 (= E490), H504 (= H506), K603 (= K605)
- binding glucose-6-phosphate: C300 (= C301), G301 (= G302), T302 (= T303), S303 (= S304), S347 (= S348), Q348 (= Q349), S349 (= S350), T352 (= T353), A400 (= A401), S401 (= S402), L484 (= L486), K485 (= K487), E488 (= E490)
1mosA Isomerase domain of glucosamine 6-phosphate synthase complexed with 2- amino-2-deoxyglucitol 6-phosphate (see paper)
64% identity, 60% coverage: 243:610/610 of query aligns to 1:367/367 of 1mosA
- active site: E240 (= E483), K244 (= K487), E247 (= E490), H263 (= H506), K362 (= K605)
- binding 2-deoxy-2-amino glucitol-6-phosphate: C59 (= C301), G60 (= G302), T61 (= T303), S62 (= S304), S106 (= S348), Q107 (= Q349), S108 (= S350), T111 (= T353), V158 (= V400), A159 (= A401), S160 (= S402), K244 (= K487), E247 (= E490), K362 (= K605)
1morA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucose 6-phosphate (see paper)
64% identity, 60% coverage: 245:610/610 of query aligns to 2:366/366 of 1morA
- active site: E239 (= E483), K243 (= K487), E246 (= E490), H262 (= H506), K361 (= K605)
- binding 6-O-phosphono-alpha-D-glucopyranose: C58 (= C301), G59 (= G302), T60 (= T303), S61 (= S304), S105 (= S348), Q106 (= Q349), S107 (= S350), T110 (= T353), V157 (= V400), S159 (= S402), A360 (= A604), K361 (= K605)
1moqA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucosamine 6-phosphate (see paper)
64% identity, 60% coverage: 245:610/610 of query aligns to 2:366/366 of 1moqA
- active site: E239 (= E483), K243 (= K487), E246 (= E490), H262 (= H506), K361 (= K605)
- binding 2-amino-2-deoxy-6-O-phosphono-alpha-D-glucopyranose: C58 (= C301), G59 (= G302), T60 (= T303), S61 (= S304), S105 (= S348), Q106 (= Q349), S107 (= S350), T110 (= T353), V157 (= V400), A158 (= A401), S159 (= S402), A360 (= A604), K361 (= K605)
7dnrA Crystal structure of zn-bound sis domain of glucosamine-6-p synthase from e. Coli
64% identity, 59% coverage: 245:601/610 of query aligns to 2:357/357 of 7dnrA
6svmA Crystal structure of human gfat-1 in complex with glucose-6-phosphate, l-glu, and udp-galnac (see paper)
38% identity, 100% coverage: 2:610/610 of query aligns to 1:660/660 of 6svmA
- active site: L7 (≠ V8), R32 (= R27), W95 (= W75), N122 (= N99), G123 (= G100), E533 (= E483), K537 (= K487), E540 (= E490), H556 (= H506), K655 (= K605)
- binding glucose-6-phosphate: C353 (= C301), G354 (= G302), T355 (= T303), S356 (= S304), S400 (= S348), Q401 (= Q349), S402 (= S350), T405 (= T353), A452 (= A401), S453 (= S402), L536 (= L486), K537 (= K487), E540 (= E490)
- binding glutamic acid: C1 (= C2), H92 (= H72), R94 (= R74), W95 (= W75), A96 (= A76), T97 (= T77), H98 (= H78), H107 (= H87), H121 (= H98), N122 (= N99), G123 (= G100), T146 (= T123), D147 (= D124), T148 (= T125)
- binding magnesium ion: S434 (≠ V383), R435 (= R384), T437 (≠ S386)
- binding uridine-diphosphate-n-acetylgalactosamine: Q289 (= Q236), R322 (= R271), G333 (≠ F282), G334 (= G283), G424 (≠ A373), T426 (≠ C375), S434 (≠ V383), T437 (≠ S386), C439 (≠ L388), G440 (≠ T389), V441 (≠ L390), H442 (≠ L391)
6r4eA Crystal structure of human gfat-1 in complex with glucose-6-phosphate and l-glu (see paper)
39% identity, 100% coverage: 2:610/610 of query aligns to 1:663/663 of 6r4eA