Comparing Pf1N1B4_24 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_24 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8vc5A Crystal structure of glutamyl-tRNA synthetase glurs from pseudomonas aeruginosa (zinc bound)
81% identity, 97% coverage: 1:423/437 of query aligns to 25:442/488 of 8vc5A
2cv2A Glutamyl-tRNA synthetase from thermus thermophilus in complex with tRNA(glu) and an enzyme inhibitor, glu-ams (see paper)
45% identity, 96% coverage: 1:420/437 of query aligns to 23:440/468 of 2cv2A
Sites not aligning to the query:
2cv1A Glutamyl-tRNA synthetase from thermus thermophilus in complex with tRNA(glu), atp, and an analog of l-glutamate: a quaternary complex
45% identity, 96% coverage: 1:420/437 of query aligns to 23:440/468 of 2cv1A
Sites not aligning to the query:
2cuzA Glutamyl-tRNA synthetase from thermus thermophilus in complex with l-glutamate (see paper)
45% identity, 96% coverage: 1:420/437 of query aligns to 23:440/468 of 2cuzA
Sites not aligning to the query:
1n78A Crystal structure of thermus thermophilus glutamyl-tRNA synthetase complexed with tRNA(glu) and glutamol-amp. (see paper)
45% identity, 96% coverage: 1:420/437 of query aligns to 23:440/468 of 1n78A
Sites not aligning to the query:
1j09A Crystal structure of thermus thermophilus glutamyl-tRNA synthetase complexed with atp and glu (see paper)
45% identity, 96% coverage: 1:420/437 of query aligns to 23:440/468 of 1j09A
Sites not aligning to the query:
P27000 Glutamate--tRNA ligase; Glutamyl-tRNA synthetase; GluRS; EC 6.1.1.17 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
45% identity, 96% coverage: 1:420/437 of query aligns to 23:440/468 of P27000
1g59A Glutamyl-tRNA synthetase complexed with tRNA(glu). (see paper)
45% identity, 96% coverage: 1:420/437 of query aligns to 23:440/468 of 1g59A
Sites not aligning to the query:
4griB Crystal structure of a glutamyl-tRNA synthetase glurs from borrelia burgdorferi bound to glutamic acid and zinc (see paper)
36% identity, 96% coverage: 1:421/437 of query aligns to 23:454/485 of 4griB
Sites not aligning to the query:
6brlA Crystal structure of a glutamate tRNA ligase from elizabethkingia meningosepticum ccug26117 in complex with its amino acid
37% identity, 96% coverage: 1:418/437 of query aligns to 24:470/502 of 6brlA
Sites not aligning to the query:
P04805 Glutamate--tRNA ligase; Glutamyl-tRNA synthetase; GluRS; EC 6.1.1.17 from Escherichia coli (strain K12) (see 4 papers)
36% identity, 96% coverage: 1:420/437 of query aligns to 24:434/471 of P04805
8i9iA Glutamyl-tRNA synthetase from escherichia coli bound to glutamate and zinc
36% identity, 96% coverage: 1:420/437 of query aligns to 24:434/468 of 8i9iA
Sites not aligning to the query:
3al0C Crystal structure of the glutamine transamidosome from thermotoga maritima in the glutamylation state. (see paper)
35% identity, 96% coverage: 1:421/437 of query aligns to 124:533/564 of 3al0C
Sites not aligning to the query:
2cfoA Non-discriminating glutamyl-tRNA synthetase from thermosynechococcus elongatus in complex with glu (see paper)
36% identity, 96% coverage: 1:420/437 of query aligns to 23:449/484 of 2cfoA
Sites not aligning to the query:
Q8DLI5 Glutamate--tRNA ligase; Glutamyl-tRNA synthetase; GluRS; EC 6.1.1.17 from Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1) (see paper)
36% identity, 96% coverage: 1:420/437 of query aligns to 24:450/485 of Q8DLI5
Sites not aligning to the query:
4g6zA Crystal structure of a glutamyl-tRNA synthetase glurs from burkholderia thailandensis bound to l-glutamate (see paper)
35% identity, 70% coverage: 1:304/437 of query aligns to 24:298/380 of 4g6zA
Sites not aligning to the query:
P27305 Glutamyl-Q tRNA(Asp) synthetase; Glu-Q-RSs; EC 6.1.1.- from Escherichia coli (strain K12) (see paper)
30% identity, 65% coverage: 1:282/437 of query aligns to 37:293/308 of P27305
4a91A Crystal structure of the glutamyl-queuosine trnaasp synthetase from e. Coli complexed with l-glutamate (see paper)
32% identity, 53% coverage: 1:231/437 of query aligns to 25:230/290 of 4a91A
Sites not aligning to the query:
3aiiA Archaeal non-discriminating glutamyl-tRNA synthetase from methanothermobacter thermautotrophicus (see paper)
27% identity, 60% coverage: 1:263/437 of query aligns to 32:283/455 of 3aiiA
Sites not aligning to the query:
7waoA Glutamyl-tRNA synthetase from plasmodium falciparum (pfers) in complex with mn (see paper)
24% identity, 44% coverage: 1:193/437 of query aligns to 31:212/502 of 7waoA
Sites not aligning to the query:
>Pf1N1B4_24 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_24
LFNYCFAKQHGGEFILRIEDTDQLRSTRESEQQIFDALRWLGIDWSEGPDVGGPHGPYRQ
SERGDIYQKYCQQLVDMGHAFPCFCTAEELDQMRAEQMARGETPRYDGRALLLSKEEVAR
RLAAGEPHVIRMKVPTEGVCVVPDMLRGDVEIPWDRMDMQVLMKTDGLPTYFLANVVDDH
LMGITHVLRGEEWLPSAPKLILLYEYFGWEQPQLCYMPLLRNPDKSKLSKRKNPTSVTFY
ERMGFMPEAMLNYLGRMGWSMPDEREKFSLQEMVDNFDLSRVSLGGPIFDIEKLSWLNGQ
WLRDLPVEEFAARLQKWALNPEYMMKIAPHVQGRVETFSQVAPLAGFFFAGGVNPDAKLF
ESKKLSGDQVRQLMQLILWKLESLRQWEKDSITATIQAVVESLELKLRDAMPLMFAAITG
RPARCRCSTRWKSSVRT
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory