SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Pf1N1B4_2878 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_2878 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
43% identity, 98% coverage: 11:565/566 of query aligns to 29:585/599 of 6denA

query
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6denA

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active site: Y35 (= Y17), G37 (= G19), G38 (= G20), A39 (= A21), I40 (≠ L22), E61 (= E43), T84 (= T66), F123 (= F105), Q124 (= Q106), E125 (= E107), K173 (= K155), K230 (vs. gap), M266 (= M252), V293 (= V279), V409 (= V389), L434 (= L414), G435 (= G415), M437 (= M417), D462 (≠ E442), N489 (= N469), E491 (≠ V471), Q492 (≠ L472), M494 (= M474), V495 (= V475), W498 (= W478), L520 (= L501), N525 (≠ G506), V526 (≠ H507)
binding flavin-adenine dinucleotide: R163 (= R145), G219 (= G206), A220 (≠ G207), G221 (= G208), N224 (≠ G212), T246 (= T232), L247 (= L233), Q248 (≠ M234), L264 (= L250), G286 (= G272), A287 (= A273), R288 (= R274), D290 (= D276), R292 (= R278), V293 (= V279), E319 (≠ D296), I320 (= I297), N324 (≠ S301), D338 (≠ P315), V339 (= V316), M414 (= M394), G432 (= G412)
binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M252), D291 (= D277), R292 (= R278), W498 (= W478)
binding magnesium ion: D462 (≠ E442), N489 (= N469), E491 (≠ V471)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V389), G410 (= G390), Q411 (= Q391), H412 (= H392), G435 (= G415), M437 (= M417), G461 (= G441), D462 (≠ E442), A463 (≠ G443), S464 (= S444), N489 (= N469), E491 (≠ V471), Q492 (≠ L472), G493 (= G473), M494 (= M474), V495 (= V475)

6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 27:583/597 of 6demA

query
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6demA

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active site: Y33 (= Y17), G35 (= G19), G36 (= G20), A37 (= A21), I38 (≠ L22), E59 (= E43), T82 (= T66), F121 (= F105), Q122 (= Q106), E123 (= E107), K171 (= K155), K228 (vs. gap), M264 (= M252), V291 (= V279), V407 (= V389), L432 (= L414), G433 (= G415), M435 (= M417), D460 (≠ E442), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), M492 (= M474), V493 (= V475), W496 (= W478), L518 (= L501), N523 (≠ G506), V524 (≠ H507)
binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M252), D289 (= D277), R290 (= R278), M492 (= M474), W496 (= W478), A567 (≠ K551)
binding flavin-adenine dinucleotide: R161 (= R145), G217 (= G206), A218 (≠ G207), G219 (= G208), N222 (≠ G212), T244 (= T232), L245 (= L233), Q246 (≠ M234), L262 (= L250), G284 (= G272), A285 (= A273), R286 (= R274), D288 (= D276), R290 (= R278), V291 (= V279), E317 (≠ D296), I318 (= I297), N322 (≠ S301), D336 (≠ P315), V337 (= V316), M412 (= M394), G430 (= G412)
binding magnesium ion: D460 (≠ E442), N487 (= N469), E489 (≠ V471)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V389), G408 (= G390), Q409 (= Q391), H410 (= H392), M435 (= M417), G459 (= G441), D460 (≠ E442), A461 (≠ G443), S462 (= S444), M465 (= M447), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), G491 (= G473), M492 (= M474), V493 (= V475)

6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 27:583/597 of 6delA

query
sites
6delA

V

V

K

D

Y

T

I

V

Y

F

G

G

Y
|
Y

P

A

G
|
G

A
|
A

L
x
I

L

L

H

P

V

V

Y

F

D

D

A

A

L

I

F

Y

K

N

E

S

P

D

E

K

V

F

T

K

H

F

I

V

L

L

V

P

R

R

H

H

E
|
E

Q

Q

A

G

A

A

T

G

H

H

M

M

A

A

D

E

G

G

Y

Y

A

A

R

R

A

A

T

S

G

G

K

K

A

P

G

G

V

V

L

L

V

V

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

A

V

I

I

T

T

G

P

I

M

A

A

T

D

A

A

Y

L

M

M

D

D

S

G

I

V

P

P

M

L

V

V

I

V

I

F

S

S

G

G

Q

Q

V

V

P

P

S

T

T

T

M

A

V

I

G

G

T

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

T

A

D

D

M

I

I

V

G

G

I

I

S

S

R

R

P

S

I

C

V

T

K

K

H

W

S

N

F

V

M

M

I

V

K

K

H

N

A

V

S

A

E

E

I

L

P

P

E

R

V

R

M

I

K

N

K

E

A

A

F

F

Y

E

L

I

A

A

Q

T

S

T

G

G

R
|
R

P

P

G

G

P

P

V

V

V

L

V

V

D

D

I

L

P

P

K
|
K

D

D

M

V

T

T

N

-

P

-

A

A

E

S

K

I

F

L

E

R

Y

E

I

S

F

I

P

P

K

I

K

N

A

T

K

T

L

L

R

P

S

S

Y

V

S

S

P

E

A

F

V

T

R

-

G

-

H

-

S

S

G

E

Q

A

I

I

R

K

K

R

A

A

E

N

M

I

L

L

L

N

A

K

A

A

K

K

R

K

P

P

V

I

L

I

Y

Y

S

A

G
|
G

G
x
A

G
|
G

V

-

I

I

L

L

G
x
N

G

N

G

E

S

Q

A

G

P

P

-
x
K

-

L

L

L

T

K

E

E

L

L

A

A

K

D

M

K

L

A

N

N

L

I

P

P

V

V

T

T

N

T

T
|
T

L
|
L

M
x
Q

G

G

L

L

G

G

A

A

Y

F

P

D

G

Q

T

R

D

D

R

P

Q

K

F

S

I

L

G

D

M

M

L
|
L

G

G

M
|
M

H

H

G

G

S

S

Y

A

T

A

A

A

N

N

L

T

A

A

M

I

H

Q

H

N

A

A

D

D

V

C

I

I

L

I

A

A

V

L

G
|
G

A
|
A

R
|
R

F

F

D
|
D

R
|
R

V
|
V

I

T

N

G

G

N

P

I

A

S

K

K

F

F

C

A

P

P

N

E

A

A

K

K

-

L

-

A

-

S

-

E

-

G

-

R

-

G

I

I

I

L

H

H

I

F

D
x
E

I
|
I

D

S

P

P

A

K

S
x
N

I

I

S

N

K

K

T

V

I

V

K

E

A

A

D

T

V

E

P

A

I

I

V

E

G

G

P
x
D

V
|
V

E

T

S

A

V

N

L

L

T

Q

E

S

M

F

V

I

A

P

I

L

L

V

K

D

E

S

I

I

G

E

E

N

T

R

P

P

N

-

K

-

E

-

S

-

V

-

A

-

S

E

W

W

W

F

K

N

Q

K

V

I

D

N

E

E

W

W

R

K

G

K

D

K

R

-

G

-

L

-

F

Y

P

P

Y

Y

D

S

-

Y

-

Q

-

L

K

E

G

T

D

P

G

G

S

S

V

L

I

I

K

K

P

P

Q

Q

T

T

V

L

I

I

E

K

T

E

L

I

C

S

E

D

V

Q

T

A

K

Q

-

T

-

Y

-

N

G

K

D

E

A

V

F

I

V

V

T

T

S

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

F

W

A

A

Q

Q

Y

H

Y

F

T

T

F

W

N

T

K

Q

P

P

N

R

R

T

W

M

I

I

N

T

S

S

G
|
G

G

G

L
|
L

G
|
G

T

T

M
|
M

G

G

F

Y

G

G

L

L

P

P

A

A

M

I

G

G

I

A

K

Q

L

V

S

A

F

K

P

P

D

D

D

A

D

I

V

V

A

I

C

D

V

I

T

D

G
|
G

E
x
D

G
x
A

S
|
S

I

F

Q

N

M
|
M

N

T

I

L

Q

T

E

E

L

L

S

S

T

S

C

A

L

V

Q

Q

Y

A

G

G

L

A

P

P

V

I

K

K

I

V

V

C

I

V

L

L

N

N

N
|
N

G

E

V
x
E

L
x
Q

G
|
G

M
|
M

V
|
V

R

T

Q

Q

W
|
W

Q

Q

D

S

M

L

S

F

Y

Y

G

E

S

H

R

R

H

Y

S

S

H

H

S

T

Y

H

M

-

E

Q

S

S

L

N

P

P

D

D

F

F

V

M

K

K

L
|
L

A

A

E

E

A

S

Y

M

G
x
N

H
x
V

V

K

G

G

V

I

R

R

I

I

T

T

E

N

S

Q

K

Q

D

E

L

L

K

K

S

S

K

G

M

V

E

K

E

E

A

-

F

F

A

L

M

D

K

A

D

T

R

E

L

P

V

V

V

L

I

L

D

E

I

V

S

I

V

V

D

E

T

K

S

K

E

V

H

P

V

V

Y

L

P

P

M

M

Q

V

I

P

K

A

D

G

G

K

S

A

M

L

R

D

D

D

-

F

-

I

M

L

W

W

L

D

S

A

K

E

T

V

E

E

R

K

active site: Y33 (= Y17), G35 (= G19), G36 (= G20), A37 (= A21), I38 (≠ L22), E59 (= E43), T82 (= T66), F121 (= F105), Q122 (= Q106), E123 (= E107), K171 (= K155), K228 (vs. gap), M264 (= M252), V291 (= V279), V407 (= V389), L432 (= L414), G433 (= G415), M435 (= M417), D460 (≠ E442), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), M492 (= M474), V493 (= V475), W496 (= W478), L518 (= L501), N523 (≠ G506), V524 (≠ H507)
binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D277), R290 (= R278), W496 (= W478)
binding flavin-adenine dinucleotide: R161 (= R145), G217 (= G206), A218 (≠ G207), G219 (= G208), N222 (≠ G212), T244 (= T232), L245 (= L233), Q246 (≠ M234), L262 (= L250), G284 (= G272), A285 (= A273), R286 (= R274), D288 (= D276), R290 (= R278), V291 (= V279), E317 (≠ D296), I318 (= I297), N322 (≠ S301), D336 (≠ P315), V337 (= V316), M412 (= M394), G430 (= G412)
binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V389), G408 (= G390), Q409 (= Q391), H410 (= H392), G433 (= G415), M435 (= M417), G459 (= G441), D460 (≠ E442), A461 (≠ G443), S462 (= S444), M465 (= M447), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), G491 (= G473), M492 (= M474), V493 (= V475)
binding magnesium ion: D460 (≠ E442), N487 (= N469), E489 (≠ V471)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V389), G408 (= G390), Q409 (= Q391), H410 (= H392), G433 (= G415), M435 (= M417), G459 (= G441), D460 (≠ E442), A461 (≠ G443), S462 (= S444), M465 (= M447), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), G491 (= G473), M492 (= M474), V493 (= V475)

6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 29:587/601 of 6deqA

query
sites
6deqA

V

V

K

D

Y

T

I

V

Y

F

G

G

Y
|
Y

P

A

G
|
G

A
|
A

L
x
I

L

L

H

P

V

V

Y

F

D

D

A

A

L

I

F

Y

K

N

E

S

P

D

E

K

V

F

T

K

H

F

I

V

L

L

V

P

R

R

H

H

E
|
E

Q

Q

A

G

A

A

T

G

H

H

M

M

A

A

D

E

G

G

Y

Y

A

A

R

R

A

A

T

S

G

G

K

K

A

P

G

G

V

V

L

L

V

V

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

A

V

I

I

T

T

G

P

I

M

A

A

T

D

A

A

Y

L

M

M

D

D

S

G

I

V

P

P

M

L

V

V

I

V

I

F

S

S

G

G

Q

Q

V

V

P

P

S

T

T

T

M

A

V

I

G

G

T

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

T

A

D

D

M

I

I

V

G

G

I

I

S

S

R

R

P

S

I

C

V

T

K

K

H

W

S

N

F

V

M

M

I

V

K

K

H

N

A

V

S

A

E

E

I

L

P

P

E

R

V

R

M

I

K

N

K

E

A

A

F

F

Y

E

L

I

A

A

Q

T

S

T

G

G

R
|
R

P

P

G

G

P

P

V

V

V

L

V

V

D

D

I

L

P

P

K
|
K

D

D

M

V

T

T

N

-

P

-

A

A

E

S

K

I

F

L

E

R

Y

E

I

S

F

I

P

P

K

I

K

N

A

T

K

T

L

L

R

P

S

S

Y

N

S

A

P

V

A

S

V

-

R

E

G

F

H

T

S

S

G

E

Q

A

I

I

R

K

K

R

A

A

E

N

M

I

L

L

L

N

A

K

A

A

K

K

R

K

P

P

V

I

L

I

Y

Y

S

A

G
|
G

G
x
A

G
|
G

V

-

I

I

L

L

G
x
N

G

N

G

E

S

Q

A

G

P

P

-
x
K

-

L

L

L

T

K

E

E

L

L

A

A

K

D

M

K

L

A

N

N

L

I

P

P

V

V

T

T

N

T

T
|
T

L
|
L

M
x
Q

G

G

L

L

G

G

A

A

Y

F

P

D

G

Q

T

R

D

D

R

P

Q

K

F

S

I

L

G

D

M

M

L
|
L

G

G

M
|
M

H

H

G

G

S

S

Y

A

T

A

A

A

N

N

L

T

A

A

M

I

H

Q

H

N

A

A

D

D

V

C

I

I

L

I

A

A

V

L

G
|
G

A
|
A

R
|
R

F

F

D
|
D

D

D

R
|
R

V
|
V

I

T

N

G

G

N

P

I

A

S

K

K

F

F

C

A

P

P

N

E

A

A

K

K

-

L

-

A

-

S

-

E

-

G

-

R

-

G

I

I

I

L

H

H

I

F

D
x
E

I
|
I

D

S

P

P

A

K

S

N

I

I

S

N

K

K

T

V

I

V

K

E

A

A

D

T

V

E

P

A

I

I

V

E

G

G

P
x
D

V
|
V

E

T

S

A

V

N

L

L

T

Q

E

S

M

F

V

I

A

P

I

L

L

V

K

D

E

S

I

I

G

E

E

N

T

R

P

P

N

-

K

-

E

-

S

-

V

-

A

-

S

E

W

W

W

F

K

N

Q

K

V

I

D

N

E

E

W

W

R

K

G

K

D

K

R

-

G

-

L

-

F

Y

P

P

Y

Y

D

S

-

Y

-

Q

-

L

K

E

G

T

D

P

G

G

S

S

V

L

I

I

K

K

P

P

Q

Q

T

T

V

L

I

I

E

K

T

E

L

I

C

S

E

D

V

Q

T

A

K

Q

-

T

-

Y

-

N

G

K

D

E

A

V

F

I

V

V

T

T

S

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

F

W

A

A

Q

Q

Y

H

Y

F

T

T

F

W

N

T

K

Q

P

P

N

R

R

T

W

M

I

I

N

T

S

S

G
|
G

G

G

L
|
L

G
|
G

T

T

M
|
M

G

G

F

Y

G

G

L

L

P

P

A

A

M

I

G

G

I

A

K

Q

L

V

S

A

F

K

P

P

D

D

D

A

D

I

V

V

A

I

C

D

V

I

T

D

G
|
G

E
x
D

G
x
A

S
|
S

I

F

Q

N

M

M

N

T

I

L

Q

T

E

E

L

L

S

S

T

S

C

A

L

V

Q

Q

Y

A

G

G

L

A

P

P

V

I

K

K

I

V

V

C

I

V

L

L

N

N

N
|
N

G

E

V
x
E

L
x
Q

G
|
G

M
|
M

V
|
V

R

T

Q

Q

W
|
W

Q

Q

D

S

M

L

S

F

Y

Y

G

E

S

H

R

R

H

Y

S

S

H

H

S

T

Y

H

M

-

E

Q

S

S

L

N

P

P

D

D

F

F

V

M

K

K

L
|
L

A

A

E

E

A

S

Y

M

G
x
N

H
x
V

V

K

G

G

V

I

R

R

I

I

T

T

E

N

S

Q

K

Q

D

E

L

L

K

K

S

S

K

G

M

V

E

K

E

E

A

-

F

F

A

L

M

D

K

A

D

T

R

E

L

P

V

V

V

L

I

L

D

E

I

V

S

I

V

V

D

E

T

K

S

K

E

V

H

P

V

V

Y

L

P

P

M

M

Q

V

I

P

K
x
A

D

G

G

K

S

A

M

L

R

D

D

D

-

F

-

I

M

L

W

W

L

D

S

A

K

E

T

V

E

E

R

K

active site: Y35 (= Y17), G37 (= G19), G38 (= G20), A39 (= A21), I40 (≠ L22), E61 (= E43), T84 (= T66), F123 (= F105), Q124 (= Q106), E125 (= E107), K173 (= K155), K232 (vs. gap), M268 (= M252), V295 (= V279), V411 (= V389), L436 (= L414), G437 (= G415), M439 (= M417), D464 (≠ E442), N491 (= N469), E493 (≠ V471), Q494 (≠ L472), M496 (= M474), V497 (= V475), W500 (= W478), L522 (= L501), N527 (≠ G506), V528 (≠ H507)
binding flavin-adenine dinucleotide: R163 (= R145), G221 (= G206), A222 (≠ G207), G223 (= G208), N226 (≠ G212), T248 (= T232), L249 (= L233), Q250 (≠ M234), L266 (= L250), G288 (= G272), A289 (= A273), R290 (= R274), D292 (= D276), R294 (= R278), V295 (= V279), E321 (≠ D296), I322 (= I297), D340 (≠ P315), V341 (= V316), M416 (= M394), G434 (= G412)
binding magnesium ion: D464 (≠ E442), N491 (= N469), E493 (≠ V471)
binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M252), R294 (= R278), M496 (= M474), V497 (= V475), W500 (= W478), A571 (≠ K551)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V389), G412 (= G390), Q413 (= Q391), H414 (= H392), M439 (= M417), G463 (= G441), D464 (≠ E442), A465 (≠ G443), S466 (= S444), N491 (= N469), E493 (≠ V471), Q494 (≠ L472), G495 (= G473), M496 (= M474), V497 (= V475)

6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 27:584/598 of 6desA

query
sites
6desA

V

V

K

D

Y

T

I

V

Y

F

G

G

Y
|
Y

P

A

G
|
G

A
|
A

L
x
I

L

L

H

P

V

V

Y

F

D

D

A

A

L

I

F

Y

K

N

E

S

P

D

E

K

V

F

T

K

H

F

I

V

L

L

V

P

R

R

H

H

E
|
E

Q

Q

A

G

A

A

T

G

H

H

M

M

A

A

D

E

G

G

Y

Y

A

A

R

R

A

A

T

S

G

G

K

K

A

P

G

G

V

V

L

L

V

V

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

A

V

I

I

T

T

G

P

I

M

A

A

T

D

A

A

Y

L

M

M

D

D

S

G

I

V

P

P

M

L

V

V

I

V

I

F

S

S

G

G

Q

Q

V

V

P

P

S

T

T

T

M

A

V

I

G

G

T

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

T

A

D

D

M

I

I

V

G

G

I

I

S

S

R

R

P

S

I

C

V

T

K

K

H

W

S

N

F

V

M

M

I

V

K

K

H

N

A

V

S

A

E

E

I

L

P

P

E

R

V

R

M

I

K

N

K

E

A

A

F

F

Y

E

L

I

A

A

Q

T

S

T

G

G

R
|
R

P

P

G

G

P

P

V

V

V

L

V

V

D

D

I

L

P

P

K
|
K

D

D

M

V

T

T

N

-

P

-

A

A

E

S

K

I

F

L

E

R

Y

E

I

S

F

I

P

P

K

I

K

N

A

T

K

T

L

L

R

P

S

S

Y

-

S

-

P

-

A

A

V

V

R

S

G

E

H

F

S

T

G

S

Q

E

-

A

I

I

R

K

K

R

A

A

E

N

M

I

L

L

L

N

A

K

A

A

K

K

R

K

P

P

V

I

L

I

Y

Y

S

A

G
|
G

G
x
A

G
|
G

V

-

I

I

L

L

G
x
N

G

N

G

E

S

Q

A

G

P

P

-
x
K

-

L

L

L

T

K

E

E

L

L

A

A

K

D

M

K

L

A

N

N

L

I

P

P

V

V

T

T

N

T

T
|
T

L
|
L

M
x
Q

G

G

L

L

G

G

A

A

Y

F

P

D

G

Q

T

R

D

D

R

P

Q

K

F

S

I

L

G

D

M

M

L
|
L

G

G

M
|
M

H

H

G

G

S

S

Y

A

T

A

A

A

N

N

L

T

A

A

M

I

H

Q

H

N

A

A

D

D

V

C

I

I

L

I

A

A

V

L

G
|
G

A
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A

R
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R

F

F

D
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D

R
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R

V
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V

I

T

N

G

G

N

P

I

A

S

K

K

F

F

C

A

P

P

N

E

A

A

K

K

-

L

-

A

-

S

-

E

-

G

-

R

-

G

I

I

I

L

H

H

I

F

D
x
E

I
|
I

D

S

P

P

A

K

S
x
N

I

I

S

N

K

K

T

V

I

V

K

E

A

A

D

T

V

E

P

A

I

I

V

E

G

G

P
x
D

V
|
V

E

T

S

A

V

N

L

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S

M

F

V

I

A

P

I

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L

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D

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S

I

I

G

E

E

N

T

R

P

P

N

-

K

-

E

-

S

-

V

-

A

-

S

E

W

W

W

F

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N

Q

K

V

I

D

N

E

E

W

W

R

K

G

K

D

K

R

-

G

-

L

-

F

Y

P

P

Y

Y

D

S

-

Y

-

Q

-

L

K

E

G

T

D

P

G

G

S

S

V

L

I

I

K

K

P

P

Q

Q

T

T

V

L

I

I

E

K

T

E

L

I

C

S

E

D

V

Q

T

A

K

Q

-

T

-

Y

-

N

G

K

D

E

A

V

F

I

V

V

T

T

S

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q
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Q

M
|
M

F

W

A

A

Q

Q

Y

H

Y

F

T

T

F

W

N

T

K

Q

P

P

N

R

R

T

W

M

I

I

N

T

S

S

G
|
G

G

G

L
|
L

G
|
G

T

T

M
|
M

G

G

F

Y

G

G

L

L

P

P

A

A

M

I

G

G

I

A

K

Q

L

V

S

A

F

K

P

P

D

D

D

A

D

I

V

V

A

I

C

D

V

I

T

D

G
|
G

E
x
D

G
x
A

S
|
S

I

F

Q

N

M

M

N

T

I

L

Q

T

E

E

L

L

S

S

T

S

C

A

L

V

Q

Q

Y

A

G

G

L

A

P

P

V

I

K

K

I

V

V

C

I

V

L

L

N

N

N
|
N

G

E

V
x
E

L
x
Q

G
|
G

M
|
M

V
|
V

R

T

Q

Q

W
|
W

Q

Q

D

S

M

L

S

F

Y

Y

G

E

S

H

R

R

H

Y

S

S

H

H

S

T

Y

H

M

-

E

Q

S

S

L

N

P

P

D

D

F

F

V

M

K

K

L
|
L

A

A

E

E

A

S

Y

M

G
x
N

H
x
V

V

K

G

G

V

I

R

R

I

I

T

T

E

N

S

Q

K

Q

D

E

L

L

K

K

S

S

K

G

M

V

E

K

E

E

A

-

F

F

A

L

M

D

K

A

D

T

R

E

L

P

V

V

V

L

I

L

D

E

I

V

S

I

V

V

D

E

T

K

S

K

E

V

H

P

V

V

Y

L

P

P

M

M

Q

V

I

P

K

A

D

G

G

K

S

A

M

L

R

D

D

D

-

F

-

I

M

L

W

W

L

D

S

A

K

E

T

V

E

E

R

K

active site: Y33 (= Y17), G35 (= G19), G36 (= G20), A37 (= A21), I38 (≠ L22), E59 (= E43), T82 (= T66), F121 (= F105), Q122 (= Q106), E123 (= E107), K171 (= K155), K229 (vs. gap), M265 (= M252), V292 (= V279), V408 (= V389), L433 (= L414), G434 (= G415), M436 (= M417), D461 (≠ E442), N488 (= N469), E490 (≠ V471), Q491 (≠ L472), M493 (= M474), V494 (= V475), W497 (= W478), L519 (= L501), N524 (≠ G506), V525 (≠ H507)
binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M252), D290 (= D277), R291 (= R278), W497 (= W478)
binding flavin-adenine dinucleotide: R161 (= R145), G218 (= G206), A219 (≠ G207), G220 (= G208), N223 (≠ G212), T245 (= T232), L246 (= L233), Q247 (≠ M234), L263 (= L250), G285 (= G272), A286 (= A273), R287 (= R274), D289 (= D276), R291 (= R278), V292 (= V279), E318 (≠ D296), I319 (= I297), N323 (≠ S301), D337 (≠ P315), V338 (= V316), Q412 (= Q393), M413 (= M394), G431 (= G412)
binding magnesium ion: D461 (≠ E442), N488 (= N469), E490 (≠ V471)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V389), G409 (= G390), Q410 (= Q391), H411 (= H392), G434 (= G415), M436 (= M417), G460 (= G441), D461 (≠ E442), A462 (≠ G443), S463 (= S444), N488 (= N469), E490 (≠ V471), Q491 (≠ L472), G492 (= G473), M493 (= M474), V494 (= V475)

6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 29:586/600 of 6derA

query
sites
6derA

V

V

K

D

Y

T

I

V

Y

F

G

G

Y
|
Y

P

A

G
|
G

A
|
A

L
x
I

L

L

H

P

V

V

Y

F

D

D

A

A

L

I

F

Y

K

N

E

S

P

D

E

K

V

F

T

K

H

F

I

V

L

L

V

P

R

R

H

H

E
|
E

Q

Q

A

G

A

A

T

G

H

H

M

M

A

A

D

E

G

G

Y

Y

A

A

R

R

A

A

T

S

G

G

K

K

A

P

G

G

V

V

L

L

V

V

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

A

V

I

I

T

T

G

P

I

M

A

A

T

D

A

A

Y

L

M

M

D

D

S

G

I

V

P

P

M

L

V

V

I

V

I

F

S

S

G

G

Q

Q

V

V

P

P

S

T

T

T

M

A

V

I

G

G

T

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

T

A

D

D

M

I

I

V

G

G

I

I

S

S

R

R

P

S

I

C

V

T

K

K

H

W

S

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F

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M

M

I

V

K

K

H

N

A

V

S

A

E

E

I

L

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P

E

R

V

R

M

I

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N

K

E

A

A

F

F

Y

E

L

I

A

A

Q

T

S

T

G

G

R
|
R

P

P

G

G

P

P

V

V

V

L

V

V

D

D

I

L

P

P

K
|
K

D

D

M

V

T

T

N

-

P

-

A

A

E

S

K

I

F

L

E

R

Y

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I

S

F

I

P

P

K

I

K

N

A

T

K

T

L

L

R

P

S

S

Y

-

S

-

P

-

A

A

V

V

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S

G

E

H

F

S

T

G

S

Q

E

-

A

I

I

R

K

K

R

A

A

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N

M

I

L

L

L

N

A

K

A

A

K

K

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K

P

P

V

I

L

I

Y

Y

S

A

G
|
G

G
x
A

G
|
G

V

-

I

I

L

L

G
x
N

G

N

G

E

S

Q

A

G

P

P

-
x
K

-

L

L

L

T

K

E

E

L

L

A

A

K

D

M

K

L

A

N

N

L

I

P

P

V

V

T

T

N

T

T
|
T

L
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L

M
x
Q

G

G

L

L

G

G

A

A

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F

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D

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F

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I

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M

M

L
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L

G

G

M
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M

H
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H

G

G

S

S

Y

A

T

A

A

A

N

N

L

T

A

A

M

I

H

Q

H

N

A

A

D

D

V

C

I

I

L

I

A

A

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G

A
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A

R
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R

F

F

D
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D

D

D

R
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R

V
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V

I

T

N

G

G

N

P

I

A

S

K

K

F

F

C

A

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P

N

E

A

A

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K

-

L

-

A

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I

I

I

L

H

H

I

F

D
x
E

I
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I

D

S

P

P

A

K

S
x
N

I

I

S

N

K

K

T

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I

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E

A

A

D

T

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A

I

I

V

E

G
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G

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x
D

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V

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A

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N

L

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F

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I

L

L

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G

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N

T

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N

-

K

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A

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W

W

W

F

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N

Q

K

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N

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W

W

R

K

G

K

D

K

R

-

G

-

L

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P

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Y

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Y

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L

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H

Q
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Q

M
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M

F

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A

A

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Y

F

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T

F

W

N

T

K

Q

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P

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R

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W

M

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I

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S

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G
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G

G

G

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L

G
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G

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M

G

G

F

Y

G

G

L

L

P

P

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A

M

I

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G

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A

F

K

P

P

D

D

D

A

D

I

V

V

A

I

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V

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D

G
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x
D

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active site: Y35 (= Y17), G37 (= G19), G38 (= G20), A39 (= A21), I40 (≠ L22), E61 (= E43), T84 (= T66), F123 (= F105), Q124 (= Q106), E125 (= E107), K173 (= K155), K231 (vs. gap), M267 (= M252), V294 (= V279), V410 (= V389), L435 (= L414), G436 (= G415), M438 (= M417), D463 (≠ E442), N490 (= N469), E492 (≠ V471), Q493 (≠ L472), M495 (= M474), V496 (= V475), W499 (= W478), L521 (= L501), N526 (≠ G506), V527 (≠ H507)
binding flavin-adenine dinucleotide: R163 (= R145), G220 (= G206), A221 (≠ G207), G222 (= G208), N225 (≠ G212), T247 (= T232), L248 (= L233), Q249 (≠ M234), L265 (= L250), H268 (= H253), G287 (= G272), A288 (= A273), R289 (= R274), D291 (= D276), R293 (= R278), V294 (= V279), E320 (≠ D296), I321 (= I297), N325 (≠ S301), G338 (= G314), D339 (≠ P315), V340 (= V316), Q414 (= Q393), M415 (= M394), G433 (= G412)
binding Metosulam: R293 (= R278), M495 (= M474), W499 (= W478), A570 (≠ K551)
binding magnesium ion: D463 (≠ E442), N490 (= N469), E492 (≠ V471)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V389), G411 (= G390), Q412 (= Q391), H413 (= H392), G436 (= G415), M438 (= M417), G462 (= G441), D463 (≠ E442), A464 (≠ G443), S465 (= S444), N490 (= N469), E492 (≠ V471), Q493 (≠ L472), G494 (= G473), M495 (= M474), V496 (= V475)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V389), G411 (= G390), Q412 (= Q391), H413 (= H392), G436 (= G415), M438 (= M417), G462 (= G441), D463 (≠ E442), A464 (≠ G443), S465 (= S444), M468 (= M447), N490 (= N469), E492 (≠ V471), Q493 (≠ L472), G494 (= G473), V496 (= V475)

6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 27:584/598 of 6depA

query
sites
6depA

V

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