SitesBLAST
Comparing Pf1N1B4_405 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_405 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4xckA Vibrio cholerae o395 ribokinase complexed with adp, ribose and cesium ion. (see paper)
31% identity, 98% coverage: 1:303/309 of query aligns to 1:302/306 of 4xckA
- active site: A249 (≠ G251), A250 (= A252), G251 (= G253), D252 (= D254)
- binding adenosine-5'-diphosphate: T220 (≠ R222), G222 (= G224), S223 (= S225), V242 (= V244), T247 (≠ S249), A250 (= A252), F254 (≠ H256), H276 (≠ N278), A279 (= A281), V283 (= V285)
- binding alpha-D-ribofuranose: N11 (≠ M11), D13 (= D13), G39 (= G39), K40 (vs. gap), N43 (= N42), A95 (≠ C93), I107 (≠ F105), I109 (= I109), E140 (≠ D153), T248 (≠ N250), D252 (= D254)
6a8cA Ribokinase from leishmania donovani with adp (see paper)
28% identity, 97% coverage: 2:301/309 of query aligns to 14:324/327 of 6a8cA
- binding adenosine-5'-diphosphate: G245 (= G224), A246 (≠ S225), T271 (≠ S249), A274 (= A252), G275 (= G253), N300 (= N278), A303 (= A281)
- binding glycerol: D25 (= D13), S42 (≠ A30), S44 (= S32), G50 (= G38), G51 (= G39), N55 (= N42)
6a8bA Ribokinase from leishmania donovani with amppcp (see paper)
28% identity, 97% coverage: 2:301/309 of query aligns to 14:324/327 of 6a8bA
- binding phosphomethylphosphonic acid adenylate ester: G245 (= G224), A246 (≠ S225), T271 (≠ S249), A274 (= A252), G275 (= G253), N300 (= N278), A303 (= A281), V307 (= V285)
- binding glycerol: D25 (= D13), G50 (= G38), G51 (= G39), N55 (= N42), N157 (≠ W150), I159 (≠ L152), E190 (≠ D172)
6a8aA Ribokinase from leishmania donovani with atp (see paper)
28% identity, 97% coverage: 2:301/309 of query aligns to 14:324/327 of 6a8aA
- binding adenosine-5'-triphosphate: N207 (= N189), T243 (≠ R222), G245 (= G224), A246 (≠ S225), G248 (= G227), T271 (≠ S249), G273 (= G251), A274 (= A252), G275 (= G253), N300 (= N278), A303 (= A281), V307 (= V285)
- binding glycerol: D25 (= D13), G50 (= G38), G51 (= G39), N55 (= N42)
8cqxA Ribokinase from t.Sp mutant a92g
31% identity, 97% coverage: 4:303/309 of query aligns to 2:298/300 of 8cqxA
- binding adenosine-5'-diphosphate: N179 (= N189), T217 (≠ R222), G219 (= G224), A220 (≠ S225), G222 (= G227), F250 (≠ H256), N272 (= N278), G275 (≠ A281), A276 (= A282), T279 (≠ V285)
- binding magnesium ion: D242 (= D248), T244 (≠ N250), A278 (= A284), S287 (= S293)
1rk2A E. Coli ribokinase complexed with ribose and adp, solved in space group p212121 (see paper)
28% identity, 97% coverage: 3:303/309 of query aligns to 3:302/305 of 1rk2A
- active site: A249 (≠ G251), A250 (= A252), G251 (= G253), D252 (= D254)
- binding adenosine-5'-diphosphate: T220 (≠ R222), G222 (= G224), S223 (= S225), A250 (= A252), G251 (= G253), H276 (≠ N278), A279 (= A281)
- binding tetrafluoroaluminate ion: G213 (≠ T215), R215 (≠ A217)
- binding magnesium ion: D246 (= D248), A282 (= A284), R285 (= R287), S291 (= S293)
- binding alpha-D-ribofuranose: N11 (≠ M11), D13 (= D13), G38 (= G38), G39 (= G39), K40 (vs. gap), N43 (= N42), E140 (≠ H140), D252 (= D254)
1gqtB Activation of ribokinase by monovalent cations (see paper)
28% identity, 97% coverage: 3:303/309 of query aligns to 5:304/307 of 1gqtB
- active site: A251 (≠ G251), A252 (= A252), G253 (= G253), D254 (= D254)
- binding phosphomethylphosphonic acid adenylate ester: N186 (= N189), T222 (≠ R222), G224 (= G224), S225 (= S225), A252 (= A252), G253 (= G253), H278 (≠ N278), A281 (= A281)
- binding cesium ion: D248 (= D248), I250 (≠ N250), A284 (= A284), R287 (= R287), S293 (= S293)
- binding alpha-D-ribofuranose: N13 (≠ M11), D15 (= D13), G41 (= G39), N45 (= N42), E142 (≠ H140), D254 (= D254)
P0A9J6 Ribokinase; RK; EC 2.7.1.15 from Escherichia coli (strain K12) (see 3 papers)
28% identity, 97% coverage: 3:303/309 of query aligns to 6:305/309 of P0A9J6
5byfA Crystal structure of human ribokinase in complex with amp
28% identity, 93% coverage: 8:293/309 of query aligns to 10:298/313 of 5byfA
Q9H477 Ribokinase; RK; EC 2.7.1.15 from Homo sapiens (Human)
28% identity, 93% coverage: 8:293/309 of query aligns to 22:310/322 of Q9H477
6wjzA Crystal structure of human ribokinase in complex with ampcp
28% identity, 93% coverage: 8:293/309 of query aligns to 9:297/315 of 6wjzA
- binding phosphomethylphosphonic acid adenosyl ester: N186 (= N189), T222 (≠ R222), G224 (= G224), A225 (≠ S225), G227 (= G227), T243 (≠ G241), V246 (= V244), A254 (= A252), G255 (= G253), N282 (= N278), A285 (= A281), A286 (= A282), V289 (= V285)
5c3yA Structure of human ribokinase crystallized with amppnp
28% identity, 93% coverage: 8:293/309 of query aligns to 8:296/306 of 5c3yA
- active site: G252 (= G251), A253 (= A252), G254 (= G253), D255 (= D254)
- binding amp phosphoramidate: T221 (≠ R222), G223 (= G224), V245 (= V244), T250 (≠ S249), G254 (= G253), N281 (= N278), A284 (= A281), A285 (= A282)
2fv7A Crystal structure of human ribokinase
28% identity, 93% coverage: 8:293/309 of query aligns to 8:296/308 of 2fv7A
- active site: G252 (= G251), A253 (= A252), G254 (= G253), D255 (= D254)
- binding adenosine-5'-diphosphate: N185 (= N189), T221 (≠ R222), G223 (= G224), G226 (= G227), T242 (≠ G241), V245 (= V244), A253 (= A252), G254 (= G253), N281 (= N278), A284 (= A281), A285 (= A282), V288 (= V285)
6wk0B Crystal structure of human ribokinase in complex with amppcp and ribose
28% identity, 93% coverage: 8:293/309 of query aligns to 9:297/311 of 6wk0B
- binding phosphomethylphosphonic acid adenylate ester: N186 (= N189), T222 (≠ R222), G224 (= G224), A225 (≠ S225), G227 (= G227), T243 (≠ G241), V246 (= V244), A254 (= A252), G255 (= G253), N282 (= N278), A285 (= A281), A286 (= A282), V289 (= V285)
- binding alpha-D-ribofuranose: D14 (= D13), G40 (= G39), K41 (vs. gap), N44 (= N42), A96 (≠ C93), E141 (≠ H140), D256 (= D254)
5c41A Crystal structure of human ribokinase in complex with amppcp in p21 spacegroup and with 4 protomers
28% identity, 93% coverage: 8:293/309 of query aligns to 9:297/317 of 5c41A
- active site: G253 (= G251), A254 (= A252), G255 (= G253), D256 (= D254)
- binding phosphomethylphosphonic acid adenylate ester: N186 (= N189), T222 (≠ R222), G224 (= G224), A225 (≠ S225), G227 (= G227), V246 (= V244), G255 (= G253), N282 (= N278), A285 (= A281), A286 (= A282)
6znxC Ribokinase from thermus species
29% identity, 97% coverage: 4:303/309 of query aligns to 2:263/265 of 6znxC
3iq0B Crystal structure of a putative ribokinase ii in complex with atp and mg+2 from e.Coli
27% identity, 83% coverage: 49:304/309 of query aligns to 47:306/308 of 3iq0B
- active site: G252 (= G251), A253 (= A252), G254 (= G253), D255 (= D254)
- binding adenosine-5'-triphosphate: S192 (≠ N189), K223 (≠ R222), G225 (= G224), E247 (≠ A246), A253 (= A252), G254 (= G253), F257 (≠ H256), N279 (= N278), G282 (≠ A281)
3i3yD Crystal structure of ribokinase in complex with d-ribose from klebsiella pneumoniae
26% identity, 96% coverage: 7:303/309 of query aligns to 6:284/285 of 3i3yD
3ikhA Crystal structure of ribokinase in complex with atp and glycerol in the active site from klebsiella pneumoniae
26% identity, 96% coverage: 7:303/309 of query aligns to 7:285/286 of 3ikhA
6ilsB Structure of arabidopsis thaliana ribokinase complexed with ribose and atp (see paper)
25% identity, 93% coverage: 2:289/309 of query aligns to 3:294/313 of 6ilsB
- binding adenosine-5'-triphosphate: N189 (= N189), K225 (≠ R222), G227 (= G224), I246 (≠ V239), A248 (≠ G241), A257 (= A252), G258 (= G253), F261 (≠ H256), A286 (= A281), S287 (≠ A282)
- binding alpha-D-ribofuranose: N12 (≠ M11), D14 (= D13), G40 (= G39), K41 (vs. gap), N44 (= N42), E144 (≠ G142), D259 (= D254)
Query Sequence
>Pf1N1B4_405 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_405
MPNLLHTGQVMIDLVMAVDKLPQSGGDVLAQSARFEAGGGFNVMAAARRNGLPVVYLGGH
GKGRFGDMAREAMTAEGIRIGIDQSTERDTGLCVALTEASAERTFISCIGAEGELTAEDL
ASVPAEAGDFVYVSGYSLLHGGKAQALVNWVLDLPDGIKVVFDPGPLVDSPDAPLMKALF
PRIDLWTSNRVEALRFTGASDIAEALNGLADHLPTDALMVVRDGSQGCWISQHGDRQHVP
GFKVTAVDSNGAGDAHAGVLVAGLAQGLSAIDAARRANAAAALAVTRWGPATSPGAAELD
AFIRDTFGA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory