SitesBLAST
Comparing Pf1N1B4_4393 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_4393 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3lxdA Crystal structure of ferredoxin reductase arr from novosphingobium aromaticivorans (see paper)
38% identity, 98% coverage: 6:411/413 of query aligns to 4:408/409 of 3lxdA
- active site: H13 (= H15), R44 (= R46), P45 (= P47), N302 (≠ E301)
- binding flavin-adenine dinucleotide: V9 (= V11), G10 (= G12), G12 (= G14), H13 (= H15), G14 (≠ A16), R36 (≠ D38), E37 (= E39), R44 (= R46), P45 (= P47), S48 (= S50), K49 (= K51), E81 (≠ P83), V82 (= V84), T109 (= T111), I157 (= I158), G278 (= G278), D279 (= D279), S297 (≠ T296), V298 (≠ W297), F325 (= F324), W326 (= W325)
3fg2P Crystal structure of ferredoxin reductase for the cyp199a2 system from rhodopseudomonas palustris (see paper)
44% identity, 81% coverage: 5:340/413 of query aligns to 1:336/404 of 3fg2P
- binding flavin-adenine dinucleotide: G8 (= G12), G10 (= G14), H11 (= H15), A12 (= A16), D34 (= D38), E35 (= E39), R42 (= R46), P43 (= P47), S46 (= S50), K47 (= K51), R78 (≠ P83), M79 (≠ V84), T106 (= T111), R127 (= R132), I153 (= I158), D275 (= D279), S292 (≠ T296), V293 (≠ W297), W321 (= W325)
P16640 Putidaredoxin reductase CamA; Pdr; Putidaredoxin--NAD(+) reductase; EC 1.18.1.5 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 2 papers)
37% identity, 100% coverage: 1:411/413 of query aligns to 1:412/422 of P16640
- A15 (= A16) binding
- D37 (= D38) binding
- K50 (= K51) binding
- V83 (= V84) binding
- R134 (= R132) binding
- D284 (= D279) binding
- V302 (≠ W297) binding
1q1wA Crystal structure of putidaredoxin reductase from pseudomonas putida (see paper)
37% identity, 99% coverage: 4:411/413 of query aligns to 2:411/422 of 1q1wA
- active site: L13 (≠ H15), L44 (≠ R46), P45 (= P47), L305 (≠ E301)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), L13 (≠ H15), A14 (= A16), G35 (= G37), D36 (= D38), L44 (≠ R46), P45 (= P47), K49 (= K51), V82 (= V84), A108 (= A110), T109 (= T111), G110 (= G112), R133 (= R132), I159 (= I158), D283 (= D279), S300 (≠ T296), V301 (≠ W297), W329 (= W325)
1f3pA Ferredoxin reductase (bpha4)-nadh complex (see paper)
37% identity, 98% coverage: 5:410/413 of query aligns to 3:398/401 of 1f3pA
- active site: L13 (≠ H15), R44 (= R46), P45 (= P47), Q291 (≠ E301)
- binding flavin-adenine dinucleotide: A14 (= A16), V34 (≠ I36), D36 (= D38), E37 (= E39), R44 (= R46), P45 (= P47), A78 (≠ V84), T105 (= T111), G106 (= G112), R126 (= R132), G268 (= G278), D269 (= D279), E285 (= E295), T286 (= T296), W287 (= W297), A290 (= A300), W316 (= W325)
- binding nicotinamide-adenine-dinucleotide: V147 (≠ I153), G148 (= G154), G150 (= G156), V151 (≠ F157), I152 (= I158), E155 (= E161), E171 (= E177), T172 (≠ A178), R179 (= R185), G230 (= G240), I231 (= I241), G232 (= G242), V233 (≠ M243), E285 (= E295), W316 (= W325), S317 (= S326)
2yvjA Crystal structure of the ferredoxin-ferredoxin reductase (bpha3-bpha4)complex (see paper)
37% identity, 98% coverage: 5:410/413 of query aligns to 3:398/402 of 2yvjA
- active site: L13 (≠ H15), R44 (= R46), P45 (= P47), Q291 (≠ E301)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), G35 (= G37), D36 (= D38), E37 (= E39), R44 (= R46), P45 (= P47), A78 (≠ V84), T105 (= T111), G106 (= G112), R126 (= R132), G268 (= G278), D269 (= D279), T286 (= T296), W287 (= W297), A290 (= A300), W316 (= W325)
- binding 1,4-dihydronicotinamide adenine dinucleotide: V147 (≠ I153), G148 (= G154), G149 (= G155), G150 (= G156), I152 (= I158), V170 (≠ L176), E171 (= E177), T172 (≠ A178), R179 (= R185), G230 (= G240), I231 (= I241), G232 (= G242), V233 (≠ M243), E285 (= E295)
8pxkA Structure of nadh-dependent ferredoxin reductase, bpha4, solved at wavelength 5.76 a (see paper)
37% identity, 98% coverage: 5:410/413 of query aligns to 4:399/403 of 8pxkA
- binding flavin-adenine dinucleotide: G13 (= G14), A15 (= A16), D37 (= D38), E38 (= E39), R45 (= R46), P46 (= P47), K50 (= K51), A79 (≠ V84), T106 (= T111), G107 (= G112), R127 (= R132), I153 (= I158), G269 (= G278), D270 (= D279), E286 (= E295), T287 (= T296), W288 (= W297), A291 (= A300), W317 (= W325)
2gr2A Crystal structure of ferredoxin reductase, bpha4 (oxidized form)
37% identity, 98% coverage: 5:410/413 of query aligns to 2:397/401 of 2gr2A
- active site: L12 (≠ H15), R43 (= R46), P44 (= P47), Q290 (≠ E301)
- binding adenosine-5-diphosphoribose: R109 (= R116), V146 (≠ I153), G147 (= G154), G149 (= G156), V150 (≠ F157), I151 (= I158), E170 (= E177), T171 (≠ A178), R178 (= R185), G229 (= G240), I230 (= I241), G231 (= G242), E284 (= E295)
- binding flavin-adenine dinucleotide: G11 (= G14), A13 (= A16), D35 (= D38), E36 (= E39), R43 (= R46), P44 (= P47), K48 (= K51), A77 (≠ V84), T104 (= T111), G105 (= G112), R125 (= R132), G267 (= G278), D268 (= D279), T285 (= T296), W286 (= W297), A289 (= A300), W315 (= W325)
2gr0A Crystal structure of ferredoxin reductase, bpha4 (oxidized form, NAD+ complex) (see paper)
37% identity, 98% coverage: 5:410/413 of query aligns to 2:397/401 of 2gr0A
- active site: L12 (≠ H15), R43 (= R46), P44 (= P47), Q290 (≠ E301)
- binding adenosine-5'-diphosphate: V146 (≠ I153), G147 (= G154), G149 (= G156), I151 (= I158), E170 (= E177), T171 (≠ A178), R178 (= R185), G229 (= G240), I230 (= I241), G231 (= G242)
- binding flavin-adenine dinucleotide: G11 (= G14), A13 (= A16), D35 (= D38), E36 (= E39), R43 (= R46), P44 (= P47), K48 (= K51), T76 (≠ P83), A77 (≠ V84), T104 (= T111), G105 (= G112), R125 (= R132), I151 (= I158), G267 (= G278), D268 (= D279), E284 (= E295), T285 (= T296), W286 (= W297), A289 (= A300), W315 (= W325)
4h4uA Crystal structure of ferredoxin reductase, bpha4 t176r mutant (reduced form)
37% identity, 98% coverage: 5:410/413 of query aligns to 3:398/401 of 4h4uA
- active site: L13 (≠ H15), R44 (= R46), P45 (= P47), Q291 (≠ E301)
- binding flavin-adenine dinucleotide: G12 (= G14), A14 (= A16), D36 (= D38), R44 (= R46), P45 (= P47), A78 (≠ V84), T105 (= T111), G106 (= G112), L125 (= L131), R126 (= R132), I152 (= I158), E155 (= E161), G268 (= G278), D269 (= D279), E285 (= E295), T286 (= T296), W287 (= W297), A290 (= A300), W316 (= W325)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: V151 (≠ F157), I152 (= I158), E171 (= E177), R172 (≠ A178), Q173 (≠ G179), G230 (= G240), I231 (= I241), G232 (= G242), I284 (≠ Q294), E285 (= E295), Y315 (≠ F324)
4h4wA Crystal structure of ferredoxin reductase, bpha4 e175c/t176r/q177g mutant (reduced form)
37% identity, 98% coverage: 5:410/413 of query aligns to 2:397/399 of 4h4wA
- active site: L12 (≠ H15), R43 (= R46), P44 (= P47), Q290 (≠ E301)
- binding flavin-adenine dinucleotide: G11 (= G14), A13 (= A16), D35 (= D38), R43 (= R46), P44 (= P47), A77 (≠ V84), T104 (= T111), G105 (= G112), R125 (= R132), I151 (= I158), E154 (= E161), G267 (= G278), D268 (= D279), T285 (= T296), W286 (= W297), A289 (= A300), W315 (= W325)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G148 (= G155), I151 (= I158), R171 (≠ A178), S177 (≠ G184), R178 (= R185), G229 (= G240), I230 (= I241), G231 (= G242)
4emiA Toluene dioxygenase reductase in reduced state in complex with NAD+ (see paper)
35% identity, 98% coverage: 8:412/413 of query aligns to 4:402/402 of 4emiA
- binding flavin-adenine dinucleotide: G10 (= G14), V11 (≠ H15), G12 (≠ A16), D34 (= D38), E35 (= E39), R42 (= R46), P43 (= P47), K47 (= K51), E78 (≠ P83), V79 (= V84), T106 (= T111), G107 (= G112), G273 (= G278), D274 (= D279), T290 (= T296), Y291 (≠ W297), W319 (= W325)
- binding nicotinamide-adenine-dinucleotide: R111 (= R116), G149 (= G154), L152 (≠ F157), I153 (= I158), E156 (= E161), E172 (= E177), A173 (= A178), R180 (= R185), V236 (≠ I241), G237 (= G242), A238 (≠ M243), E289 (= E295), W319 (= W325), T320 (≠ S326)
4emjA Complex between the reductase and ferredoxin components of toluene dioxygenase (see paper)
35% identity, 98% coverage: 8:412/413 of query aligns to 5:403/406 of 4emjA
- binding flavin-adenine dinucleotide: G11 (= G14), V12 (≠ H15), G13 (≠ A16), D35 (= D38), E36 (= E39), R43 (= R46), P44 (= P47), S47 (= S50), K48 (= K51), V80 (= V84), T107 (= T111), G108 (= G112), R128 (= R132), G274 (= G278), D275 (= D279), T291 (= T296), Y292 (≠ W297), S319 (≠ F324), W320 (= W325)
6tukB Crystal structure of fdr9 (see paper)
37% identity, 80% coverage: 8:337/413 of query aligns to 4:324/393 of 6tukB
- binding flavin-adenine dinucleotide: V7 (= V11), G8 (= G12), G9 (≠ A13), G10 (= G14), A12 (= A16), A34 (≠ D38), E35 (= E39), R42 (= R46), P43 (= P47), K47 (= K51), A75 (≠ P83), A76 (≠ V84), T102 (= T111), G103 (= G112), V118 (= V128), R119 (= R132), G259 (= G278), D260 (= D279), H277 (≠ T296), W278 (= W297), F311 (= F324), W312 (= W325)
8d3kA Crystal structure of human apoptosis-inducing factor (aif) complexed with 8-fluoro-2-methylquinolin-4-amine
30% identity, 98% coverage: 3:405/413 of query aligns to 3:434/437 of 8d3kA
- binding flavin-adenine dinucleotide: G12 (= G12), G13 (≠ A13), A16 (= A16), E38 (≠ D38), D39 (≠ E39), R46 (= R46), P47 (= P47), K51 (= K51), K104 (≠ P83), V105 (= V84), T132 (= T111), F156 (≠ D135), R157 (≠ E136), G309 (= G278), D310 (= D279), E325 (= E295), H326 (≠ T296), H327 (≠ W297), A330 (= A300), W355 (= W325)
- binding 8-fluoro-2-methylquinolin-4-amine: F182 (= F157), L183 (≠ I158), E186 (= E161), H326 (≠ T296), F354 (= F324), W355 (= W325), S356 (= S326)
8d3jA Crystal structure of human apoptosis-inducing factor (aif) complexed with 6-fluoro-2-methylquinolin-4-amine
30% identity, 98% coverage: 3:405/413 of query aligns to 3:433/436 of 8d3jA
- binding flavin-adenine dinucleotide: G12 (= G12), A16 (= A16), E38 (≠ D38), D39 (≠ E39), R46 (= R46), P47 (= P47), K51 (= K51), K103 (≠ P83), V104 (= V84), T131 (= T111), F155 (≠ D135), R156 (≠ E136), G308 (= G278), D309 (= D279), E324 (= E295), H325 (≠ T296), H326 (≠ W297), W354 (= W325)
- binding 6-fluoro-2-methylquinolin-4-amine: F181 (= F157), L182 (≠ I158), E185 (= E161), H325 (≠ T296), F353 (= F324), W354 (= W325), S355 (= S326)
8d3iA Crystal structure of human apoptosis-inducing factor (aif) w196a mutant complexed with quinolin-4-amine
30% identity, 98% coverage: 3:405/413 of query aligns to 3:436/439 of 8d3iA
- binding quinolin-4-amine: F184 (= F157), L185 (≠ I158), E188 (= E161), W357 (= W325)
- binding flavin-adenine dinucleotide: G12 (= G12), A16 (= A16), E38 (≠ D38), D39 (≠ E39), R46 (= R46), P47 (= P47), K51 (= K51), K106 (≠ P83), V107 (= V84), T134 (= T111), F158 (≠ D135), G311 (= G278), D312 (= D279), E327 (= E295), H328 (≠ T296), H329 (≠ W297), W357 (= W325)
8d3oA Crystal structure of human apoptosis-inducing factor (aif) complexed with 8-methoxyquinolin-4-amine
30% identity, 98% coverage: 3:405/413 of query aligns to 3:433/436 of 8d3oA
- binding flavin-adenine dinucleotide: G12 (= G12), A16 (= A16), E38 (≠ D38), D39 (≠ E39), R46 (= R46), P47 (= P47), K51 (= K51), K104 (≠ P83), V105 (= V84), T132 (= T111), G133 (= G112), F156 (≠ D135), R157 (≠ E136), G309 (= G278), D310 (= D279), E325 (= E295), H326 (≠ T296), H327 (≠ W297), A330 (= A300)
- binding 8-methoxyquinolin-4-amine: F182 (= F157), L183 (≠ I158), E186 (= E161), E325 (= E295), H326 (≠ T296), F354 (= F324)
8d3hA Crystal structure of human apoptosis-inducing factor (aif) w196a mutant complexed with 7-chloroquinolin-4-amine
29% identity, 97% coverage: 3:402/413 of query aligns to 1:430/432 of 8d3hA
- binding flavin-adenine dinucleotide: G10 (= G12), G11 (≠ A13), T13 (≠ H15), A14 (= A16), E36 (≠ D38), D37 (≠ E39), R44 (= R46), P45 (= P47), S48 (= S50), K49 (= K51), K104 (≠ P83), V105 (= V84), T132 (= T111), G133 (= G112), F156 (≠ D135), R157 (≠ E136), G309 (= G278), D310 (= D279), H326 (≠ T296), H327 (≠ W297), A330 (= A300), W355 (= W325)
- binding 7-chloroquinolin-4-amine: F182 (= F157), L183 (≠ I158), E186 (= E161), W355 (= W325)
8d3eA Crystal structure of human apoptosis-inducing factor (aif) w196a mutant complexed with 6-fluoroquinolin-4-amine
29% identity, 97% coverage: 3:402/413 of query aligns to 2:431/433 of 8d3eA
- binding flavin-adenine dinucleotide: G11 (= G12), G12 (≠ A13), A15 (= A16), E37 (≠ D38), D38 (≠ E39), R45 (= R46), P46 (= P47), K50 (= K51), K105 (≠ P83), V106 (= V84), T133 (= T111), F157 (≠ D135), R158 (≠ E136), G310 (= G278), D311 (= D279), E326 (= E295), H327 (≠ T296), H328 (≠ W297), A331 (= A300), W356 (= W325)
- binding 6-fluoroquinolin-4-amine: F183 (= F157), L184 (≠ I158), E187 (= E161), E326 (= E295), H327 (≠ T296), F355 (= F324)
Query Sequence
>Pf1N1B4_4393 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_4393
MNPANAPLVIVGAGHAGGRAALTLRGEGYSGRLILIGDESHAPYERPPLSKGLLQGTVEL
AGYSLCDTAQLAELGIEHLAGNPVKCLDPQQHRLQLADGSWLHYARLLLATGGRSRRLAS
VPEHLLNVLYLRTHDEALALRASLQPDTRVVIIGGGFIGLEVAATARALGCTVTLLEAGP
RLAGRVLPEQLSSVLLELHRSRGVDVRLNVAIEAVQGTTHVESVQLVDGELLPCDLVVVG
IGMQPNTELAAAAGLEVGQGIRVDAQLRTSAPDIFAAGDVCEFRLHPQGVFQRQETWRNA
ETQGRHAALNLLGGELPFEVIPGFWSDQYDWGLQTVGVIANTQPTASRTTPGGGFLLFYL
DAEQCLQGACGWGQGNSIAKDIKLCERLIAHRNLLSVDALADADVPLKQLLRN
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory