SitesBLAST
Comparing Pf1N1B4_4765 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_4765 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2dcnA Crystal structure of 2-keto-3-deoxygluconate kinase from sulfolobus tokodaii complexed with 2-keto-6-phosphogluconate (alpha-furanose form)
32% identity, 88% coverage: 6:303/339 of query aligns to 3:297/308 of 2dcnA
- active site: G252 (= G258), A253 (= A259), G254 (= G260), D255 (= D261)
- binding adenosine-5'-diphosphate: D193 (≠ G197), K223 (= K228), G225 (= G230), P226 (= P231), G228 (= G233), V247 (= V250), G254 (= G260), I279 (≠ N285), S282 (≠ G288), V286 (= V292)
- binding 6-O-phosphono-beta-D-psicofuranosonic acid: G33 (= G36), F89 (= F91), Y105 (= Y107), R107 (= R109), I136 (= I137), R165 (= R170), T251 (≠ V257), G252 (= G258), D255 (= D261), D291 (= D297)
1v1bA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound atp (see paper)
33% identity, 90% coverage: 4:307/339 of query aligns to 2:297/300 of 1v1bA
- active site: G248 (= G258), A249 (= A259), G250 (= G260), D251 (= D261)
- binding adenosine-5'-triphosphate: K219 (= K228), G221 (= G230), A238 (vs. gap), F239 (vs. gap), V241 (vs. gap), G248 (= G258), A249 (= A259), G250 (= G260), N275 (= N285), A279 (≠ S289)
1v1aA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound 2- keto-3-deoxygluconate and adp (see paper)
33% identity, 90% coverage: 4:307/339 of query aligns to 2:297/301 of 1v1aA
- active site: G248 (= G258), A249 (= A259), G250 (= G260), D251 (= D261)
- binding adenosine-5'-diphosphate: K219 (= K228), G221 (= G230), A222 (≠ P231), A249 (= A259), G250 (= G260), N275 (= N285), A279 (≠ S289)
- binding 2-keto-3-deoxygluconate: L11 (≠ M13), G34 (= G36), A35 (= A37), N38 (= N40), Y89 (≠ Q92), R105 (= R109), R167 (= R170), G248 (= G258), D251 (= D261), D287 (= D297)
Q53W83 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
33% identity, 90% coverage: 4:307/339 of query aligns to 2:297/309 of Q53W83
- GAEVN 34:38 (≠ GADSN 36:40) binding substrate
- YYR 103:105 (≠ YFR 107:109) binding substrate
- R167 (= R170) binding substrate
- S193 (≠ F207) binding ATP
- 219:225 (vs. 228:234, 57% identical) binding ATP
- GAGD 248:251 (= GAGD 258:261) binding ATP
- D251 (= D261) binding substrate
- N275 (= N285) binding ATP
- D287 (= D297) binding substrate
5eynA Crystal structure of fructokinase from vibrio cholerae o395 in fructose, adp, beryllium trifluoride and calcium ion bound form
32% identity, 84% coverage: 29:312/339 of query aligns to 21:306/306 of 5eynA
- active site: G246 (= G258), A247 (= A259), G248 (= G260), D249 (= D261)
- binding adenosine-5'-diphosphate: H91 (≠ G100), T217 (≠ K228), G219 (= G230), A220 (≠ P231), A238 (≠ P249), V239 (= V250), T244 (= T256), G246 (= G258), A247 (= A259), G248 (= G260), F251 (= F263), N279 (= N285), G282 (= G288), A283 (≠ S289)
- binding beryllium trifluoride ion: G246 (= G258), G248 (= G260), D249 (= D261)
- binding beta-D-fructofuranose: G28 (= G36), A29 (= A37), N32 (= N40), F96 (≠ V105), F98 (≠ Y107), R159 (= R170), D249 (= D261)
Sites not aligning to the query:
5yggA Crystal structure of fructokinase double-mutant (t261c-h108c) from vibrio cholerae o395 in fructose, adp and potassium ion bound form (see paper)
32% identity, 84% coverage: 29:312/339 of query aligns to 25:310/310 of 5yggA
- binding adenosine-5'-diphosphate: K188 (≠ L195), T221 (≠ K228), G223 (= G230), A242 (≠ P249), V243 (= V250), F255 (= F263), N283 (= N285), G286 (= G288), A287 (≠ S289)
- binding beta-D-fructofuranose: G32 (= G36), A33 (= A37), F100 (≠ V105), F102 (≠ Y107), R163 (= R170), D253 (= D261)
Sites not aligning to the query:
Q97U29 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase; 2-dehydro-3-deoxyglucono/galactono-kinase; 2-keto-3-deoxy-galactonokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; KDGal kinase; EC 2.7.1.178 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
30% identity, 88% coverage: 4:303/339 of query aligns to 2:300/313 of Q97U29
2varA Crystal structure of sulfolobus solfataricus 2-keto-3-deoxygluconate kinase complexed with 2-keto-3-deoxygluconate (see paper)
30% identity, 88% coverage: 4:303/339 of query aligns to 1:299/311 of 2varA
- active site: G254 (= G258), A255 (= A259), G256 (= G260), D257 (= D261)
- binding adenosine monophosphate: G227 (= G230), G230 (= G233), M259 (≠ F263), S284 (≠ G288), I288 (≠ V292)
- binding phosphoaminophosphonic acid-adenylate ester: K225 (= K228), G227 (= G230), S228 (≠ P231), G230 (= G233), G254 (= G258), A255 (= A259), G256 (= G260), D257 (= D261), M259 (≠ F263), I281 (≠ N285), S284 (≠ G288), I288 (≠ V292)
- binding 3-deoxy-alpha-D-erythro-hex-2-ulofuranosonic acid: L10 (≠ M13), G33 (= G36), S34 (≠ A37), Y89 (≠ Q92), Y105 (= Y107), R107 (= R109), I136 (= I137), R165 (= R170), G254 (= G258), D257 (= D261)
- binding 2-keto-3-deoxygluconate: G33 (= G36), S34 (≠ A37), Y89 (≠ Q92), L103 (≠ V105), Y105 (= Y107), R107 (= R109), I136 (= I137), R165 (= R170), T253 (≠ V257), G254 (= G258), D257 (= D261), D293 (= D297)
Q8ZKR2 Aminoimidazole riboside kinase; AIRs kinase; EC 2.7.1.223 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
31% identity, 81% coverage: 28:302/339 of query aligns to 23:298/319 of Q8ZKR2
- G31 (= G36) binding 5-amino-1-(beta-D-ribosyl)imidazole
- Y101 (= Y107) binding 5-amino-1-(beta-D-ribosyl)imidazole
- R162 (= R170) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A180 (= A188) binding K(+)
- A181 (= A189) binding K(+)
- A183 (= A191) binding K(+)
- G213 (= G221) binding K(+)
- D246 (= D255) binding K(+)
- T248 (≠ V257) binding K(+)
- D252 (= D261) binding 5-amino-1-(beta-D-ribosyl)imidazole
- A287 (= A291) binding K(+)
- A290 (≠ S294) binding K(+)
- G292 (= G296) binding K(+)
Sites not aligning to the query:
- 16 binding 5-amino-1-(beta-D-ribosyl)imidazole
3in1A Crystal structure of a putative ribokinase in complex with adp from e.Coli
29% identity, 85% coverage: 26:312/339 of query aligns to 25:312/312 of 3in1A
- active site: R106 (≠ D102), G255 (= G258), A256 (= A259), G257 (= G260), D258 (= D261)
- binding adenosine-5'-diphosphate: N194 (≠ G197), K225 (= K228), G227 (= G230), G230 (= G233), A244 (≠ G247), T253 (= T256), N282 (= N285), A285 (≠ G288)
1tz6A Crystal structure of aminoimidazole riboside kinase from salmonella enterica complexed with aminoimidazole riboside and atp analog (see paper)
30% identity, 81% coverage: 28:302/339 of query aligns to 19:287/297 of 1tz6A
- active site: C24 (≠ R33), F88 (≠ V105), G238 (= G258), A239 (= A259), G240 (= G260), D241 (= D261)
- binding phosphomethylphosphonic acid adenylate ester: N149 (= N168), K176 (≠ L195), E181 (= E200), S209 (≠ K228), G211 (= G230), A212 (≠ P231), G214 (= G233), A239 (= A259), G240 (= G260), F243 (= F263), N270 (= N285), G273 (= G288), A274 (≠ S289)
- binding 5-aminoimidazole ribonucleoside: G27 (= G36), F88 (≠ V105), Y90 (= Y107), R151 (= R170), M154 (≠ L173), D241 (= D261)
Sites not aligning to the query:
1tz3A Crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside (see paper)
30% identity, 81% coverage: 28:302/339 of query aligns to 19:287/299 of 1tz3A
- active site: C24 (≠ R33), F88 (≠ V105), G238 (= G258), A239 (= A259), G240 (= G260), D241 (= D261)
- binding 5-aminoimidazole ribonucleoside: G27 (= G36), L83 (≠ Q92), F88 (≠ V105), Y90 (= Y107), R151 (= R170), M154 (≠ L173), D241 (= D261)
Sites not aligning to the query:
3ih0A Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with amp-pnp
29% identity, 86% coverage: 6:296/339 of query aligns to 3:283/304 of 3ih0A
3gbuA Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with atp
29% identity, 86% coverage: 6:296/339 of query aligns to 2:282/302 of 3gbuA
- active site: G242 (= G258), A243 (= A259), G244 (= G260), D245 (= D261)
- binding adenosine-5'-triphosphate: K188 (≠ L195), T213 (≠ K228), G215 (= G230), V235 (= V253), P237 (vs. gap), A243 (= A259), G244 (= G260), A274 (≠ G288)
3iq0B Crystal structure of a putative ribokinase ii in complex with atp and mg+2 from e.Coli
28% identity, 78% coverage: 45:307/339 of query aligns to 45:301/308 of 3iq0B