SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Pf1N1B4_5938 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_5938 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P61887 Glucose-1-phosphate thymidylyltransferase 2; G1P-TT 2; dTDP-glucose pyrophosphorylase 2; dTDP-glucose synthase 2; EC 2.7.7.24 from Escherichia coli (strain K12) (see paper)
71% identity, 100% coverage: 1:292/292 of query aligns to 1:292/293 of P61887

query
sites
P61887

M

M

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

I

T

T

R

R

G

G

V

V

S

S

K

K

Q

Q

L

L

P

P

V

I

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

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V

L

L

M

M

L

L

A

A

G

G

I

I

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R

E

E

I

I

L

L

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I

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T

T

T

P

P

Q

E

D

D

L

K

P

G

N

Y

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F

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R

L

L

G

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D

D

G

G

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S

E

F

F

G

G

I

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E

Q

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L

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E

Y

Y

A

A

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E

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Q

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P

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S

P

P

D

D

G

G

L

L

A

A

Q

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A

A

F

F

L

I

I

I

G

G

E

E

D

T

F

F

I

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N

D

G

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E

N

P

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S

A

C

L

L

I

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L

L

G

G

D
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D

N

N

I

I

F

F

Y

F

G

G

Y

Q

G

G

F

F

S

S

A

P

L

K

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E

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A

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A

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A

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T

T

E

G

G

A

A

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T

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V

F

F

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G

Y

Y

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M

D

D

P

P

D

E

R

R

F

F

G

G

V

V

E

E

F

F

D

D

N

N

G

F

K

R

A

A

I

I

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S

I

L

E

E

K

K

P

P

K

K

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P

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K

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D

N

H

W

A

A

V

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T

G

G

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L

Y

Y

F

F

Y

Y

D

D

N

S

D

K

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A

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K

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G

G

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E

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E

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S

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I

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N

N

Q

A

M

Y

Y

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L

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E

R

A

G

G

D

N

L

L

H

T

V

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S

E

V

L

L

L

G

G

R

R

G

G

F

F

A

A

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W

L

L

D
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D

T

T

G

G

T

T

H

H

D

D

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S

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L

M

I

E

E

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A

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S

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F

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E

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C

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N

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G

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W

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A

D

A

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E

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L

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D

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K

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A

A

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A

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L

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A

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K

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T

G

G

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Y

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Y

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N

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A

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K

Q

D108 (= D108) binding
D223 (= D223) binding

4b5bA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 4:289/293 of 4b5bA

query
sites
4b5bA

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

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L

P

P

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V

Y

Y

D

D

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K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
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S

V

T

L

L

M

M

L
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L

A

A

G

G

I

I

R

R

E

E

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I

L

L

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I

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S

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T

P

P

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Q

D

D

L

T

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P

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R

F

F

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N

Q

L

L

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D

D

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Y

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D

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A

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A

A

F

F

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L

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I

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G

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E

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F

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I

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G

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D

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A

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L

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D

D

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N

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x
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Y

Y

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Y

H

G

D

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F

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H

A

E

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L

R

G

E

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A

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S

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G

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P

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E

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F

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D

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G

G

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K

A

A

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E

E

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P

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E

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P

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K

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S

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N

H

Y

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A

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V

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T

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G

L

L

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Y

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F

Y

Y

D

D

N

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D

Q

V

V

S

D

I

I

A

A

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R

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D

V

L

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K

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P

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S

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P

R

R

G

G

E

E

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E

E

I

I

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D

V

V

N

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N

R

A

A

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Y

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L

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E

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R

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G

D

Q

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L

H

S

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V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
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V

A
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A

C

C

L

P

E

E

E
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E

V
x
I

A

A

Y

Y

H

R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

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L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

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A

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R

R

V

L

L

L

N

T

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N,3-dimethylbenzenesulfonamide: S41 (= S39), L45 (= L43), Y113 (≠ F111), G115 (= G113), V250 (= V248), A251 (= A249), E255 (= E253), I256 (≠ V254)

4b4gA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 4:289/293 of 4b4gA

query
sites
4b4gA

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

V

T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

Y

H

G

D

F
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F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

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D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A
|
A

C

C

L

P

E

E

E
|
E

V
x
I

A

A

Y

Y

H
x
R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbutane-1-sulfonamide: L45 (= L43), Y113 (≠ F111), G115 (= G113), F118 (= F116), V250 (= V248), A251 (= A249), E255 (= E253), I256 (≠ V254), R259 (≠ H257)

4b42A Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 4:289/293 of 4b42A

query
sites
4b42A

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

V
x
T

L

L

M

M

L

L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G

G

Y

H

G

D

F
|
F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A

A

C

C

L

P

E

E

E
|
E

V
x
I

A

A

Y

Y

H

R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding N-[6-azanyl-1-butyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-N-methyl-benzamide: S41 (= S39), T42 (≠ V40), Y113 (≠ F111), F118 (= F116), V250 (= V248), E255 (= E253), I256 (≠ V254)

4b3uA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 10:295/299 of 4b3uA

query
sites
4b3uA

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

V

T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F

Y

Y

Y

G

G

Y

H

G

D

F

F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V

V

A

A

C

C

L

P

E

E

E
|
E

V
x
I

A

A

Y

Y

H
x
R

Q
|
Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding 6-amino-1-benzyl-5-(ethylamino)pyrimidine-2,4(1H,3H)-dione: L51 (= L43), E261 (= E253), I262 (≠ V254), R265 (≠ H257), Q266 (= Q258)

4asyA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 4:289/293 of 4asyA

query
sites
4asyA

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

V
x
T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

Y

H

G

D

F

F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A

A

C

C

L

P

E

E

E
|
E

V

I

A

A

Y

Y

H

R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzamide: S41 (= S39), T42 (≠ V40), L45 (= L43), Y113 (≠ F111), G115 (= G113), V250 (= V248), E255 (= E253)

4asjA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 3:288/292 of 4asjA

query
sites
4asjA

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

V

T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

Y

H

G

D

F
|
F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A
|
A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V
|
V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A

A

C

C

L

P

E

E

E
|
E

V

I

A

A

Y

Y

H

R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: S40 (= S39), L44 (= L43), Y112 (≠ F111), G114 (= G113), F117 (= F116), V249 (= V248), E254 (= E253)
binding phosphate ion: A155 (= A154), V213 (= V212)

1g3lA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Tdp-l-rhamnose complex. (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 3:288/292 of 1g3lA

query
sites
1g3lA

K

K

G

G

I

I

L
|
L

A

A

G
|
G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

V

T

L

L

M

M

L

L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

Y
x
H

G
x
D

F
|
F

S
x
H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F
x
Y

G
|
G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

E
|
E

K
|
K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V
|
V

T
|
T

G
|
G

L

L

Y
|
Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R
|
R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G
|
G

R
|
R

G
|
G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V

V

A

A

C

C

L

P

E

E

E
|
E

V
x
I

A

A

Y

Y

H
x
R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding 2'-deoxy-thymidine-beta-l-rhamnose: L7 (= L6), G9 (= G8), G10 (= G9), Q81 (= Q80), P84 (= P83), D109 (= D108), Y113 (= Y112), G114 (= G113), H115 (≠ Y114), D116 (≠ G115), F117 (= F116), H118 (≠ S117), Y144 (≠ F143), G145 (= G144), E160 (= E159), K161 (= K160), V171 (= V170), T172 (= T171), G173 (= G172), Y175 (= Y174), R193 (= R192), G217 (= G216), R218 (= R217), G219 (= G218), E254 (= E253), I255 (≠ V254), R258 (≠ H257)

1g2vA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Ttp complex. (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 3:288/292 of 1g2vA

query
sites
1g2vA

K

K

G

G

I

I

L
|
L

A
|
A

G
|
G

S

S

G
|
G

T
|
T

R
|
R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q
|
Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

V

T

L

L

M

M

L

L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G

G

L
|
L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

Y
x
H

G
x
D

F
|
F

S
x
H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G
|
G

R
|
R

G
|
G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V

V

A

A

C

C

L

P

E

E

E
|
E

V
x
I

A

A

Y

Y

H

R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding thymidine-5'-triphosphate: L7 (= L6), A8 (= A7), G9 (= G8), G10 (= G9), G12 (= G11), T13 (= T12), R14 (= R13), Q25 (= Q24), Q81 (= Q80), P84 (= P83), L87 (= L86), D109 (= D108), Y113 (= Y112), G114 (= G113), H115 (≠ Y114), D116 (≠ G115), F117 (= F116), H118 (≠ S117), G217 (= G216), R218 (= R217), G219 (= G218), E254 (= E253), I255 (≠ V254)

1g1lA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Tdp-glucose complex. (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 3:288/292 of 1g1lA

query
sites
1g1lA

K

K

G

G

I

I

L
|
L

A

A

G
|
G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q
|
Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

V

T

L

L

M

M

L

L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G
|
G

L
|
L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L
|
L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

Y
x
H

G
x
D

F
|
F

S
x
H

A
x
E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F
x
Y

G
|
G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

E
|
E

K
|
K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V
|
V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G
|
G

R
|
R

G
|
G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A
|
A

C

C

L

P

E

E

E
|
E

V
x
I

A

A

Y

Y

H
x
R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding 2'deoxy-thymidine-5'-diphospho-alpha-d-glucose: L7 (= L6), G9 (= G8), G10 (= G9), Q25 (= Q24), Q81 (= Q80), P84 (= P83), G86 (= G85), L87 (= L86), L107 (= L106), D109 (= D108), Y113 (= Y112), G114 (= G113), H115 (≠ Y114), D116 (≠ G115), F117 (= F116), H118 (≠ S117), E119 (≠ A118), Y144 (≠ F143), G145 (= G144), E160 (= E159), K161 (= K160), V171 (= V170), G217 (= G216), R218 (= R217), G219 (= G218), V249 (= V248), A250 (= A249), E254 (= E253), I255 (≠ V254), R258 (≠ H257)

Sites not aligning to the query:

binding 2'deoxy-thymidine-5'-diphospho-alpha-d-glucose: 292

1g0rA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Thymidine/glucose- 1-phosphate complex. (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 3:288/292 of 1g0rA

query
sites
1g0rA

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

V

T

L

L

M

M

L

L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L
|
L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F

Y

Y

Y

G

G

Y

H

G

D

F

F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F
x
Y

G
|
G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

E
|
E

K
|
K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V
|
V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V

V

A

A

C

C

L

P

E

E

V

I

A

A

Y

Y

H

R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding 1-O-phosphono-alpha-D-glucopyranose: L87 (= L86), Y144 (≠ F143), G145 (= G144), E160 (= E159), K161 (= K160), V171 (= V170)

1fxoA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Tmp complex. (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 3:288/292 of 1fxoA

query
sites
1fxoA

K

K

G

G

I

I

L
|
L

A

A

G
|
G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q
|
Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

V

T

L

L

M

M

L

L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G
|
G

L
|
L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

Y
x
H

G
x
D

F

F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G
|
G

R
|
R

G
|
G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A

A

C

C

L

P

E

E

E
|
E

V
x
I

A

A

Y

Y

H
x
R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding thymidine-5'-phosphate: L7 (= L6), G9 (= G8), G10 (= G9), Q25 (= Q24), Q81 (= Q80), P84 (= P83), G86 (= G85), L87 (= L86), D109 (= D108), Y113 (= Y112), G114 (= G113), H115 (≠ Y114), D116 (≠ G115), G217 (= G216), R218 (= R217), G219 (= G218), V249 (= V248), E254 (= E253), I255 (≠ V254), R258 (≠ H257)

1mc3A Crystal structure of rffh (see paper)
72% identity, 99% coverage: 1:290/292 of query aligns to 2:291/291 of 1mc3A

query
sites
1mc3A

M

M

K

K

G

G

I

I

L
|
L

A

A

G
|
G

S

S

G
|
G

T
|
T

R
|
R

L

L

H

H

P

P

I

I

T

T

R

R

G

G

V

V

S

S

K
|
K

Q
|
Q

L

L

P

P

V

I

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

V

V

L

L

M

M

L

L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

T

T

T

P

P

Q

E

D

D

L

K

P

G

N

Y

F

F

Q

Q

N

R

L

L

G

G

D

D

G

G

S

S

S

E

F

F

G

G

I

I

E

Q

L

L

S

E

Y

Y

A

A

E

E

Q
|
Q

P

P

S

S

P
|
P

D

D

G

G

L
|
L

A

A

Q

Q

A

A

F

F

L

I

I

I

G

G

E

E

D

T

F

F

I

L

G

N

D

G

S

E

N

P

V

S

A

C

L

L

I

V

L

L

G

G

D
|
D

N

N

I

I

F

F

Y

F

G

G

Y

Q

G

G

F

F

S

S

A

P

L

K

L

L

R

R

E

H

A

V

S

A

Q

A

R

R

Q

T

T

E

G

G

A

A

T

T

V

V

F

F

G

G

Y

Y

R

Q

V

V

S

M

D

D

P

P

D

E

R

R

F

F

G

G

V

V

E

E

F

F

D

D

N

N

G

F

K

R

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

K

H

Q

P

P

K

K

S

S

D

N

H

W

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

S

D

K

V

V

S

E

I

Y

A

A

K

K

Q

Q

V

V

K

K

P

P

S

S

I

E

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

S

V

I

N

N

N

Q

A

M

Y

Y

L

L

Q

E

R

A

G

G

D

N

L

L

H

T

V

V

S

E

V

L

L

L

G

G

R

R

G

G

F

F

A

A

W

W

L

L

D
|
D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

I

E

E

A

A

G

S

H

T

F

F

V

V

Q

Q

T

T

I

V

E

E

A

K

R

R

Q

Q

G

G

L

F

K

K

V

I

A

A

C

C

L

L

E

E

V

I

A

A

Y

W

H

R

Q

N

G

G

W

W

L

L

S

D

A

D

A

E

E

G

L

V

D

K

K

R

Q

A

A

A

T

S

A

S

L

L

H

A

K

K

T

T

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

L

R

E

V

L

L

L

N

R

T

A

E

R

P

P

binding magnesium ion: D109 (= D108), D224 (= D223)
binding thymidine-5'-triphosphate: L7 (= L6), G9 (= G8), G10 (= G9), G12 (= G11), T13 (= T12), R14 (= R13), K24 (= K23), Q25 (= Q24), Q81 (= Q80), P84 (= P83), L87 (= L86), D109 (= D108)

4b4mA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 7:292/296 of 4b4mA

query
sites
4b4mA

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

V
x
T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

Y

H

G

D

F

F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A
|
A

C

C

L

P

E

E

E
|
E

V
x
I

A

A

Y

Y

H
x
R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-fluoro-N-methylbenzenesulfonamide: S44 (= S39), T45 (≠ V40), L48 (= L43), Y116 (≠ F111), G118 (= G113), V253 (= V248), A254 (= A249), E258 (= E253), I259 (≠ V254), R262 (≠ H257)

4b2xB Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 13:298/302 of 4b2xB

query
sites
4b2xB

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

V

T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G

G

Y

H

G

D

F

F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V

V

A

A

C

C

L

P

E

E

E
|
E

V

I

A

A

Y

Y

H

R

Q
|
Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding 6-amino-1-butyl-5-(cyclopentylamino)pyrimidine-2,4(1H,3H)-dione: L54 (= L43), Y122 (≠ F111), E264 (= E253), Q269 (= Q258)

4arwA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
73% identity, 98% coverage: 2:287/292 of query aligns to 5:290/294 of 4arwA

query
sites
4arwA

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

V

T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y
|
Y

G
|
G

Y

H

G

D

F

F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A
|
A

C

C

L

P

E

E

E
|
E

V

I

A

A

Y

Y

H

R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding n-(6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-n-methyl-benzenesulfonamide: S42 (= S39), L46 (= L43), Y114 (≠ F111), Y115 (= Y112), G116 (= G113), V251 (= V248), A252 (= A249), E256 (= E253)

5fyeA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
73% identity, 98% coverage: 2:287/292 of query aligns to 7:292/296 of 5fyeA

query
sites
5fyeA

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

V

T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

Y

H

G

D

F

F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A
|
A

C

C

L

P

E

E

E
|
E

V

I

A

A

Y

Y

H
x
R

Q

Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding N-(6-Amino-1-(3-fluorobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: S44 (= S39), L48 (= L43), Y116 (≠ F111), G118 (= G113), V253 (= V248), A254 (= A249), E258 (= E253), R262 (≠ H257)

5fu8A Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
73% identity, 98% coverage: 2:287/292 of query aligns to 8:293/297 of 5fu8A

query
sites
5fu8A

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

V

T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y
|
Y

G
|
G

Y

H

G

D

F

F

S
x
H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A

A

C

C

L

P

E

E

E
|
E

V

I

A

A

Y

Y

H
x
R

Q
|
Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding N-(6-amino-1-(4-bromo-3-methylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: S45 (= S39), L49 (= L43), Y117 (≠ F111), Y118 (= Y112), G119 (= G113), H123 (≠ S117), V254 (= V248), E259 (= E253), R263 (≠ H257), Q264 (= Q258)

5fu0A Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
73% identity, 98% coverage: 2:287/292 of query aligns to 7:292/296 of 5fu0A

query
sites
5fu0A

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

V

T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y
|
Y

G
|
G

Y

H

G

D

F

F

S
x
H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A
|
A

C

C

L

P

E

E

E
|
E

V

I

A

A

Y

Y

H

R

Q
|
Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding n-(6-amino-1-(3-methylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-n-methylbenzenesulfonamide: S44 (= S39), L48 (= L43), Y116 (≠ F111), Y117 (= Y112), G118 (= G113), H122 (≠ S117), V253 (= V248), A254 (= A249), E258 (= E253), Q263 (= Q258)

5ftvA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
73% identity, 98% coverage: 2:287/292 of query aligns to 7:292/296 of 5ftvA

query
sites
5ftvA

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

H

H

P

P

I

A

T

T

R

L

G

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

V

T

L

L

M

M

L
|
L

A

A

G

G

I

I

R

R

E

E

I

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

L

T

P

P

N

R

F

F

Q

Q

N

Q

L

L

G

G

D

D

G

G

S

S

S

N

F

W

G

G

I

L

E

D

L

L

S

Q

Y

Y

A

A

E

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

E

E

D

S

F

F

I

I

G

G

D

N

S

D

N

L

V

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y
|
Y

G
|
G

Y

H

G

D

F
|
F

S

H

A

E

L

L

R

G

E

S

A

A

S

S

Q

Q

R

R

Q

Q

T

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

R

H

V

V

S

L

D

D

P

P

D

E

R

R

F

Y

G

G

V

V

E

E

F

F

D

D

D

Q

N

G

G

G

K

K

A

A

I

I

S

S

I

L

E

E

K

K

P

P

K

L

H

E

P

P

K

K

S

S

D

N

H

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

D

Q

V

V

S

D

I

I

A

A

K

R

Q

D

V

L

K

K

P

P

S

S

I

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

N

R

A

A

Y

Y

L

L

Q

E

R

R

G

G

D

Q

L

L

H

S

V

V

S

E

V

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

M

L

E

E

A

A

G

G

H

Q

F

F

V

I

Q

A

T

T

I

L

E

E

A

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

A
|
A

C

C

L

P

E

E

E
|
E

V

I

A

A

Y

Y

H
x
R

Q
|
Q

G

K

W

W

L

I

S

D

A

A

E

Q

L

L

D

E

K

K

Q

L

A

A

T

A

A

P

L

L

H

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

A

K

R

R

V

L

L

L

N

T

binding n-(6-amino-1-(4-bromobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-n-methylbenzenesulfonamide: S44 (= S39), L48 (= L43), Y116 (≠ F111), Y117 (= Y112), G118 (= G113), F121 (= F116), V253 (= V248), A254 (= A249), E258 (= E253), R262 (≠ H257), Q263 (= Q258)

Query Sequence

>Pf1N1B4_5938 FitnessBrowser__pseudo1_N1B4:Pf1N1B4_5938
MKGIILAGGSGTRLHPITRGVSKQLLPVYDKPMIYYPLSVLMLAGIREILIISTPQDLPN
FQNLLGDGSSFGIELSYAEQPSPDGLAQAFLIGEDFIGDSNVALILGDNIFYGYGFSALL
REASQRQTGATVFGYRVSDPDRFGVVEFDDNGKAISIEEKPKHPKSDHAVTGLYFYDNDV
VSIAKQVKPSIRGELEITDVNNAYLQRGDLHVSVLGRGFAWLDTGTHDSLMEAGHFVQTI
EARQGLKVACLEEVAYHQGWLSAAELDKQATALHKTGYGQYLARVLNTEPAK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory