SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Pf1N1B4_6034 Ribose ABC transport system, ATP-binding protein RbsA (TC 3.A.1.2.1) to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
40% identity, 95% coverage: 8:497/517 of query aligns to 3:491/501 of P04983

query
sites
P04983

A

A

V

L

L

L

S

Q

V

L

S

K

G

G

I

I

G

D

K

K

T

A

Y

F

-

P

A

G

Q

V

P

K

V

A

L

L

T

S

G

G

I

A

D

A

L

L

T

N

L

V

M

Y

R

P

G

G

E

R

V

V

L

M

A

A

L

L

T

V

G

G

E

E

N

N

G

G

A

A

G

G

K
|
K

S

S

T

T

L

M

S

M

K

K

I

V

I

L

G

T

G

G

L

I

V

Y

A

T

P

R

T

D

T

A

G

G

Q

T

M

L

R

L

F

W

Q

L

G

G

R

K

D

E

Y

T

R

T

P

F

G

T

S

G

R

P

S

K

Q

S

A

S

E

Q

E

E

L

A

G

G

I

I

R

G

M

I

V

I

M

H

Q

Q

E

E

L

L

N

N

L

L

L

I

P

P

T

Q

L

L

S

T

V

I

A

A

E

E

N

N

L

I

F

F

L

L

D

G

-

R

N

E

L

F

P

V

S

N

H

R

G

F

G

G

W

K

I

I

S

D

R

W

K

K

Q

T

L

M

R

Y

K

A

A

E

A

A

I

D

E

K

A

L

M

L

A

A

Q

K

V

L

G

N

L

L

D

-

A

R

I

F

D

K

P

S

D

D

T

K

L

L

V

V

G

G

E

D

L

L

G

S

I

I

G

G

H

D

Q

Q

M

M

V

V

E

E

I

I

A

A

R

K

N

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L

L

I

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G

F

D

E

C

S

H

K

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V

L

I

I

I

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M

D

D

E

E

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P

T

T

A

D

M

A

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T

A

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T

E

E

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E

M

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L

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F

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R

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I

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R

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L

L

Q

K

A

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R

Q

G

G

V

R

S

G

I

I

I

V

Y

Y

I

I

S

S

H

H

R

R

L

M

E

K

E

E

L

I

A

F

R

E

V

I

A

C

Q

D

R

D

I

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A

T

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L

F

R

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D

D

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G

N

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C

A

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E

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E

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A

A

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Y

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E

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L

M

M

M

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V

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G

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R

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E

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D

-

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Y

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H

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A

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R

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K

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I

-

G

G

A

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A

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V

K

D

G

N

L

L

T

C

R

-

S

G

D

P

K

G

V

V

R

N

D

D

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S

F

F

E

T

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L

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R

A

K

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G

E

E

I

I

F

L

G

G

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S

G

G

L

L

I

M

G

G

A

A

G

G

R

R

T

T

E

E

L

L

L

M

R

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L

V

I

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F

Y

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G

A

A

D

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P

A

R

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S

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G

T

Y

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V

A

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L

G

-

A

-

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D

A

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Q

H

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E

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S

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I

T

R

R

S

S

P

P

A

Q

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D

A

G

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L

G

A

H

N

G

G

I

I

A

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Y

I

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E

E

D

D

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R

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K

G

R

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D

G

G

L

L

L

V

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G

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M

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S

I

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K

A

E

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N

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M

A

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L

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R

V

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I

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-

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A

G

G

F

S

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L

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K

N

H

G

A

D

D

E

E

M

Q

S

Q

L

A

A

V

Q

S

R

D

Q

F

I

I

N

R

A

L

M

F

R

N

I

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R

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T

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P

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S

P

M

T

E

Q

Q

L

A

V

I

S

G

E

L

L

L

S

S

G

G

N

N

Q

Q

K

K

V

V

V

A

I

I

G

A

R

R

W

G

L

L

E

M

R

T

D

R

C

P

T

K

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V

M

L

L

I

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L

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D

E

E

P

P

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T

R

R

G

G

I

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D

D

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V

G

G

A

A

K

K

F

K

D

E

I

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Y

A

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L

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E

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A

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D

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G

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A

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E

L

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R

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E

E

L

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M

L

L

G

I

M

C

S

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D

R

R

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I

G

I

V

V

L

M

S

H

A

E

G

G

R

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L

L

I

S

D

G

T

E

F

F

E

T

R

R

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E

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Q

W

A

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T

Q

Q

D

E

D

V

L

L

L

M

A

A

K43 (= K47) mutation to R: Loss of transport.

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
31% identity, 46% coverage: 9:248/517 of query aligns to 6:243/353 of 1oxvD

query
sites
1oxvD

V

V

L

K

S

N

V

V

S

S

G

K

I

V

G
x
F

K

K

T

K

Y

G

A

K

Q
x
V

P

V

V
x
A

L

L

T

D

G

N

I

V

D

N

L

I

T

N

L

I

M

E

R

N

G

G

E

E

V

R

L

F

A

G

L

I

T

L

G

G

E
x
P

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T
|
T

L

F

S

M

K

R

I

I

G

A

G

G

L

L

V

D

A

V

P

P

T

S

T

T

G

G

Q

E

M

L

R

Y

F

F

Q

D

G

D

R

R

D

L

Y

V

R

A

P

S

G

N

S

G

R

K

-

L

-

I

S

V

Q

P

A

P

E

E

E

D

L

R

G

K

I

I

R

G

M

M

V

V

M

F

Q
|
Q

E

T

L

W

N

A

L

L

L

Y

P

P

T

N

L

L

S

T

V

A

A

F

E

E

N

N

L

I

F

-

L

-

D

-

N

A

L

F

P

P

S

L

H

T

G

N

G

M

W

K

I

M

S

S

R

K

K

E

Q

E

L

I

R

R

K

K

A

R

A

V

I

E

E

E

A

V

M

A

A

K

Q

I

V

L

G

D

L

I

D

H

A

H

I

V

D

-

P

L

D

N

T

H

L

F

V

P

G

R

E

E

L

L

G

S

I

G

G

G

H

Q

Q

Q

M

R

V

V

E

A

I

L

A

A

R

R

N

A

L

L

I

V

G

K

D

D

C

P

H

S

V

L

L

L

I

L

L

L

D

D

E
|
E

P

P

T

F

A

S

M

N

L

L

T

D

A

A

R

R

E

M

V

R

E

D

M

S

L

A

F

R

E

A

Q

L

I

V

T

K

R

E

L

V

Q

Q

A

S

R

R

-

L

G

G

V

V

S

T

I

L

Y

V

I

V

S

S

H

H

R

D

L

P

E

A

E

D

L

I

A

F

R

A

V

I

A

A

Q

D

R

R

I

V

A

G

V

V

L

L

R

V

D

K

G

G

N

K

L

L

V

V

C

Q

V

V

-

G

E

K

P

P

M

E

A

D

N

L

Y

Y

N

D

S

N

E

P

Q

-

L

-

V

V

T

S

L

I

M

Q

V

V

G

A

R

S

E

L

L

I

G

G

E

E

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ G16), V18 (≠ Q21), A20 (≠ V23), P39 (≠ E42), S40 (≠ N43), G41 (= G44), A42 (= A45), G43 (= G46), K44 (= K47), T45 (≠ S48), T46 (= T49), Q89 (= Q90), E166 (= E171)
binding magnesium ion: T45 (≠ S48), Q89 (= Q90)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
31% identity, 46% coverage: 9:248/517 of query aligns to 6:243/353 of 1oxvA

query
sites
1oxvA

V

V

L

K

S

N

V

V

S

S

G

K

I

V

G
x
F

K

K

T

K

Y

G

A

K

Q
x
V

P

V

V
x
A

L

L

T

D

G

N

I

V

D

N

L

I

T

N

L

I

M

E

R

N

G

G

E

E

V

R

L

F

A

G

L

I

T

L

G

G

E
x
P

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T
|
T

L

F

S

M

K

R

I

I

G

A

G

G

L

L

V

D

A

V

P

P

T

S

T

T

G

G

Q

E

M

L

R

Y

F

F

Q

D

G

D

R

R

D

L

Y

V

R

A

P

S

G

N

S

G

R

K

-

L

-

I

S

V

Q

P

A

P

E

E

E

D

L

R

G

K

I

I

R

G

M

M

V

V

M

F

Q

Q

E

T

L

W

N

A

L

L

L

Y

P

P

T

N

L

L

S

T

V

A

A

F

E

E

N

N

L

I

F

-

L

-

D

-

N

A

L

F

P

P

S

L

H

T

G

N

G

M

W

K

I

M

S

S

R

K

K

E

Q

E

L

I

R

R

K

K

A

R

A

V

I

E

E

E

A

V

M

A

A

K

Q

I

V

L

G

D

L

I

D

H

A

H

I

V

D

-

P

L

D

N

T

H

L

F

V

P

G

R

E

E

L

L

G

S

I

G

G

G

H

Q

Q

Q

M

R

V

V

E

A

I

L

A

A

R

R

N

A

L

L

I

V

G

K

D

D

C

P

H

S

V

L

L

L

I

L

L

L

D

D

E
|
E

P

P

T

F

A

S

M

N

L

L

T

D

A

A

R

R

E

M

V

R

E

D

M

S

L

A

F

R

E

A

Q

L

I

V

T

K

R

E

L

V

Q

Q

A

S

R

R

-

L

G

G

V

V

S

T

I

L

Y

V

I

V

S

S

H

H

R

D

L

P

E

A

E

D

L

I

A

F

R

A

V

I

A

A

Q

D

R

R

I

V

A

G

V

V

L

L

R

V

D

K

G

G

N

K

L

L

V

V

C

Q

V

V

-

G

E

K

P

P

M

E

A

D

N

L

Y

Y

N

D

S

N

E

P

Q

-

L

-

V

V

T

S

L

I

M

Q

V

V

G

A

R

S

E

L

L

I

G

G

E

E

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ G16), V18 (≠ Q21), A20 (≠ V23), P39 (≠ E42), S40 (≠ N43), G41 (= G44), A42 (= A45), G43 (= G46), K44 (= K47), T45 (≠ S48), T46 (= T49), E166 (= E171)

1oxuA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
31% identity, 46% coverage: 9:248/517 of query aligns to 6:243/353 of 1oxuA

query
sites
1oxuA

V

V

L

K

S

N

V

V

S

S

G

K

I

V

G
x
F

K

K

T

K

Y

G

A

K

Q

V

P

V

V
x
A

L

L

T

D

G

N

I

V

D

N

L

I

T

N

L

I

M

E

R

N

G

G

E

E

V

R

L

F

A

G

L

I

T

L

G

G

E

P

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T
|
T

L

F

S

M

K

R

I

I

G

A

G

G

L

L

V

D

A

V

P

P

T

S

T

T

G

G

Q

E

M

L

R

Y

F

F

Q

D

G

D

R

R

D

L

Y

V

R

A

P

S

G

N

S

G

R

K

-

L

-

I

S

V

Q

P

A

P

E

E

E

D

L

R

G

K

I

I

R

G

M

M

V

V

M

F

Q

Q

E

T

L

W

N

A

L

L

L

Y

P

P

T

N

L

L

S

T

V

A

A

F

E

E

N

N

L

I

F

-

L

-

D

-

N

A

L

F

P

P

S

L

H

T

G

N

G

M

W

K

I

M

S

S

R

K

K

E

Q

E

L

I

R

R

K

K

A

R

A

V

I

E

E

E

A

V

M

A

A

K

Q

I

V

L

G

D

L

I

D

H

A

H

I

V

D

-

P

L

D

N

T

H

L

F

V

P

G

R

E

E

L

L

G

S

I

G

G

G

H

Q

Q

Q

M

R

V

V

E

A

I

L

A

A

R

R

N

A

L

L

I

V

G

K

D

D

C

P

H

S

V

L

L

L

I

L

L

L

D

D

E

E

P

P

T

F

A

S

M

N

L

L

T

D

A

A

R

R

E

M

V

R

E

D

M

S

L

A

F

R

E

A

Q

L

I

V

T

K

R

E

L

V

Q

Q

A

S

R

R

-

L

G

G

V

V

S

T

I

L

Y

V

I

V

S

S

H

H

R

D

L

P

E

A

E

D

L

I

A

F

R

A

V

I

A

A

Q

D

R

R

I

V

A

G

V

V

L

L

R

V

D

K

G

G

N

K

L

L

V

V

C

Q

V

V

-

G

E

K

P

P

M

E

A

D

N

L

Y

Y

N

D

S

N

E

P

Q

-

L

-

V

V

T

S

L

I

M

Q

V

V

G

A

R

S

E

L

L

I

G

G

E

E

binding adenosine-5'-diphosphate: F13 (≠ G16), A20 (≠ V23), S40 (≠ N43), G41 (= G44), A42 (= A45), G43 (= G46), K44 (= K47), T45 (≠ S48), T46 (= T49)

Q97UY8 Glucose import ATP-binding protein GlcV; EC 7.5.2.- from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
31% identity, 46% coverage: 9:248/517 of query aligns to 6:243/353 of Q97UY8

query
sites
Q97UY8

V

V

L

K

S

N

V

V

S

S

G

K

I

V

G

F

K

K

T

K

Y

G

A

K

Q

V

P

V

V

A

L

L

T

D

G

N

I

V

D

N

L

I

T

N

L

I

M

E

R

N

G

G

E

E

V

R

L

F

A

G

L

I

T

L

G

G

E

P

N

S

G

G

A

A

G

G

K

K

S

T

T

T

L

F

S

M

K

R

I

I

G

A

G

G

L

L

V

D

A

V

P

P

T

S

T

T

G

G

Q

E

M

L

R

Y

F

F

Q

D

G

D

R

R

D

L

Y

V

R

A

P

S

G

N

S

G

R

K

-

L

-

I

S

V

Q

P

A

P

E

E

E

D

L

R

G

K

I

I

R

G

M

M

V

V

M

F

Q

Q

E

T

L

W

N

A

L

L

L

Y

P

P

T

N

L

L

S

T

V

A

A

F

E

E

N

N

L

I

F

-

L

-

D

-

N

A

L

F

P

P

S

L

H

T

G

N

G

M

W

K

I

M

S

S

R

K

K

E

Q

E

L

I

R

R

K

K

A

R

A

V

I

E

E

E

A

V

M

A

A

K

Q

I

V

L

G

D

L

I

D

H

A

H

I

V

D

-

P

L

D

N

T

H

L

F

V

P

G

R

E

E

L

L

G
x
S

I

G

G
|
G

H

Q

Q

Q

M

R

V

V

E

A

I

L

A

A

R

R

N

A

L

L

I

V

G

K

D

D

C

P

H

S

V

L

L

L

I

L

L

L

D

D

E
|
E

P

P

T

F

A

S

M

N

L

L

T

D

A

A

R

R

E

M

V

R

E

D

M

S

L

A

F

R

E

A

Q

L

I

V

T

K

R

E

L

V

Q

Q

A

S

R

R

-

L

G

G

V

V

S

T

I

L

Y

V

I

V

S

S

H

H

R

D

L

P

E

A

E

D

L

I

A

F

R

A

V

I

A

A

Q

D

R

R

I

V

A

G

V

V

L

L

R

V

D

K

G

G

N

K

L

L

V

V

C

Q

V

V

-

G

E

K

P

P

M

E

A

D

N

L

Y

Y

N

D

S

N

E

P

Q

-

L

-

V

V

T

S

L

I

M

Q

V

V

G

A

R

S

E

L

L

I

G

G

E

E

S142 (≠ G147) mutation to A: Decrease in ATPase activity. Can form dimers.
G144 (= G149) mutation to A: Loss of ATPase activity. Cannot form dimers. Forms an active heterodimer; when associated with A-166.
E166 (= E171) mutation to A: Loss of ATPase activity. Can form dimers in the presence of ATP-Mg(2+). Forms an active heterodimer; when associated with A-144.; mutation to Q: Strong decrease in ATPase activity. Can form dimers in the presence of ATP alone, without Mg(2+).

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
28% identity, 41% coverage: 9:221/517 of query aligns to 1:221/232 of 1f3oA

query
sites
1f3oA

V

M

L

I

S

K

V

L

S

K

G

N

I

V

G

T

K

K

T

T

Y
|
Y

A

K

Q

M

-

G

-

E

-

I

P

Y

V
x
A

L

L

T

K

G

N

I

V

D

N

L

L

T

N

L

I

M

K

R

E

G

G

E

E

V

F

L

V

A

S

L

I

T

M

G

G

E

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

S

L

K

N

I

I

G

G

G

C

L

L

V

D

A

K

P

P

T

T

T

E

G

G

Q

E

M

V

-

Y

-

I

-

D

R

N

F

I

Q

K

G

T

R

N

D

D

Y

L

R

D

P

D

G

D

S

E

R

L

S

T

Q

K

A

I

E

R

L

D

G

K

I

I

R

G

M

F

V

V

M

F

Q

Q

E

Q

L

F

N

N

L

L

L

I

P

P

T

L

L

L

S

T

V

A

A

L

E

E

N

N

L

V

F

E

L

L

D

P

N

L

L

I

P

F

S

K

H

Y

G

R

G

G

W

A

I

M

S

S

R

G

K

E

Q

E

L

R

R

R

K

K

A

R

A

A

I

L

E

E

A

C

M

L

A

K

Q

M

V

A

G

E

L

L

D

E

A

E

I

R

D

F

P

A

D

N

T

H

L

K

V

P

G

N

E

Q

L

L

G

S

I

G

G

G

H

Q

Q

Q

M

R

V

V

E

A

I

I

A

A

R

R

N

A

L

L

I

A

G

N

D

N

C

P

H

P

V

I

L

I

I

L

L

A

D

D

E

E

P

P

T

T

A

G

M

A

L

L

T

D

A

S

R

K

E

T

V

G

E

E

M

K

L

I

F

M

E

Q

Q

L

I

L

T

K

R

K

L

L

-

N

Q

E

A

E

R

D

G

G

V

K

S

T

I

V

Y

V

I

V

S

T

H

H

R

D

L

I

E

-

E

N

L

V

A

A

R

R

V

F

A

G

Q

E

R

R

I

I

A

I

V

Y

L

L

R

K

D

D

G

G

binding adenosine-5'-diphosphate: Y11 (= Y19), A20 (≠ V23), S40 (≠ N43), G41 (= G44), S42 (≠ A45), G43 (= G46), K44 (= K47), S45 (= S48), T46 (= T49)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
28% identity, 41% coverage: 9:221/517 of query aligns to 1:221/230 of 1l2tA

query
sites
1l2tA

V

M

L

I

S

K

V

L

S

K

G

N

I

V

G

T

K

K

T

T

Y
|
Y

A

K

Q
x
M

-

G

-

E

-

I

-
x
I

P

Y

V
x
A

L

L

T

K

G

N

I

V

D

N

L

L

T

N

L

I

M

K

R

E

G

G

E

E

V

F

L

V

A

S

L

I

T

M

G

G

E
x
P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

M

S

L

K

N

I

I

G

G

G

C

L

L

V

D

A

K

P

P

T

T

T

E

G

G

Q

E

M

V

-

Y

-

I

-

D

R

N

F

I

Q

K

G

T

R

N

D

D

Y

L

R

D

P

D

G

D

S

E

R

L

S

T

Q

K

A

I

E

R

L

D

G

K

I

I

R

G

M

F

V

V

M

F

Q

Q

E

Q

L

F

N

N

L

L

L

I

P

P

T

L

L

L

S

T

V

A

A

L

E

E

N

N

L

V

F

E

L

L

D

P

N

L

L

I

P

F

S

K

H

Y

G

R

G

G

W

A

I

M

S

S

R

G

K

E

Q

E

L

R

R

R

K

K

A

R

A

A

I

L

E

E

A

C

M

L

A

K

Q

M

V

A

G

E

L

L

D

E

A

E

I

R

D
x
F

P

A

D

N

T
x
H

L

K

V

P

G

N

E
x
Q

L

L

G
x
S

I
x
G

G
|
G

H
x
Q

Q

Q

M

R

V

V

E

A

I

I

A

A

R

R

N

A

L

L

I

A

G

N

D

N

C

P

H

P

V

I

L

I

I

L

L

A

D

D

E

Q

P

P

T

T

A

G

M
x
A

L

L

T

D

A

S

R

K

E

T

V

G

E

E

M

K

L

I

F

M

E

Q

Q

L

I

L

T

K

R

K

L

L

-

N

Q

E

A

E

R

D

G

G

V

K

S

T

I

V

Y

V

I

V

S

T

H
|
H

R

D

L

I

E

-

E

N

L

V

A

A

R

R

V

F

A

G

Q

E

R

R

I

I

A

I

V

Y

L

L

R

K

D

D

G

G

binding adenosine-5'-triphosphate: Y11 (= Y19), M13 (≠ Q21), I18 (vs. gap), A20 (≠ V23), P39 (≠ E42), S40 (≠ N43), G41 (= G44), S42 (≠ A45), G43 (= G46), K44 (= K47), S45 (= S48), T46 (= T49), F138 (≠ D138), H141 (≠ T141), Q145 (≠ E145), S147 (≠ G147), G148 (≠ I148), G149 (= G149), Q150 (≠ H150), A175 (≠ M175), H204 (= H203)

7arlD Lolcde in complex with lipoprotein and adp (see paper)
32% identity, 39% coverage: 23:225/517 of query aligns to 21:222/222 of 7arlD

query
sites
7arlD

V

V

L

L

T

H

G

N

I

V

D

S

L

F

T

S

L

V

M

G

R

E

G

G

E

E

V

M

L

M

A

A

L

I

T

V

G

G

E

S

N

S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

S

L

K

H

I

L

G

G

L

L

V

D

A

T

P

P

T

T

T

S

G

G

Q

D

M

V

R

I

F

F

Q

N

G

G

R

Q

D

P

Y

M

R

S

P

K

G

L

S

S

R

S

S

A

Q

A

A

K

E

A

E

E

L

L

-

R

-

N

-

Q

G

K

I

L

R

G

M

F

V

I

M

Y

Q

Q

E

F

L

H

N

H

L

L

P

P

T

D

L

F

S

T

V

A

A

L

E

E

N

N

L

V

F

-

L

-

D

-

N

A

L

M

P

P

S

L

H

L

G

I

G

G

W

K

I

K

S

K

R

P

K

A

Q

E

L

I

R

N

K

S

A

R

A

A

I

L

E

E

A

M

M

L

A

K

Q

A

V

V

G

G

L

L

D

D

A

H

I

-

D

R

P

A

D

N

T

H

L

R

V

P

G

S

E

E

L

L

G

S

I

G

G

G

H

E

Q

R

Q

Q

M

R

V

V

E

A

I

I

A

A

R

R

N

A

L

L

I

V

G

N

D

N

C

P

H

R

V

L

L

V

I

L

L

A

D

D

E

E

P

P

T

T

A

G

M

N

L

L

T

D

A

A

R

R

E

N

V

A

E

D

M

S

L

I

F

F

E

Q

-

L

-

G

Q

E

I

L

T

N

R

R

L

L

Q

Q

A

-

R

-

G

G

V

T

S

A

I

F

I

L

Y

V

I

V

S

T

H

H

R

D

L

L

E

-

E

Q

L

L

A

A

R

K

V

R

A

M

Q

S

R

R

I

Q

A

L

V

E

L

M

R

R

D

D

G

G

N

R

L

L

V

T

C

A

binding adenosine-5'-diphosphate: G42 (= G44), G44 (= G46), K45 (= K47), S46 (= S48), T47 (= T49)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 12

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
32% identity, 39% coverage: 23:225/517 of query aligns to 24:225/233 of P75957

query
sites
P75957

V

V

L

L

T

H

G

N

I

V

D

S

L

F

T

S

L

V

M

G

R

E

G

G

E

E

V

M

L

M

A

A

L

I

T

V

G
|
G

E

S

N

S

G

G

A

S

G

G

K

K

S

S

T

T

L

L

S

L

K

H

I

L

G

G

L

L

V

D

A

T

P

P

T

T

T

S

G

G

Q

D

M

V

R

I

F

F

Q

N

G

G

R

Q

D

P

Y

M

R

S

P

K

G

L

S

S

R

S

S

A

Q

A

A

K

E

A

E

E

L

L

-

R

-

N

-

Q

G

K

I

L

R

G

M

F

V

I

M

Y

Q

Q

E

F

L

H

N

H

L

L

P

P

T

D

L

F

S

T

V

A

A

L

E

E

N

N

L

V

F

A

L

-

D

-

N

-

L

M

P

P

S

L

H

L

G

I

G

G

W

K

I

K

S

K

R

P

K

A

Q

E

L

I

R

N

K

S

A

R

A

A

I

L

E

E

A

M

M

L

A

K

Q

A

V

V

G

G

L

L

D

D

A

H

I

-

D

R

P

A

D

N

T

H

L

R

V

P

G

S

E

E

L

L

G

S

I

G

G

G

H

E

Q

R

Q

Q

M

R

V

V

E

A

I

I

A

A

R

R

N

A

L

L

I

V

G

N

D

N

C

P

H

R

V

L

L

V

I

L

L

A

D

D

E

E

P

P

T

T

A

G

M

N

L

L

T

D

A

A

R

R

E

N

V

A

E

D

M

S

L

I

F

F

E

Q

-

L

-

G

Q

E

I

L

T

N

R

R

L

L

Q

Q

A

-

R

-

G

G

V

T

S

A

I

F

I

L

Y

V

I

V

S

T

H

H

R

D

L

L

E

-

E

Q

L

L

A

A

R

K

V

R

A

M

Q

S

R

R

I

Q

A

L

V

E

L

M

R

R

D

D

G

G

N

R

L

L

V

T

C

A

G42 (= G41) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
32% identity, 39% coverage: 23:225/517 of query aligns to 21:222/226 of 7mdyC

query
sites
7mdyC

V
|
V

L

L

T

H

G

N

I

V

D

S

L

F

T

S

L

V

M

G

R

E

G

G

E

E

V

M

L

M

A

A

L

I

T

V

G

G

E
x
S

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

S

L

K

H

I

L

G

G

L

L

V

D

A

T

P

P

T

T

T

S

G

G

Q

D

M

V

R

I

F

F

Q

N

G

G

R

Q

D

P

Y

M

R

S

P

K

G

L

S

S

R

S

S

A

Q

A

A

K

E

A

E

E

L

L

-

R

-

N

-

Q

G

K

I

L

R

G

M

F

V

I

M

Y

Q
|
Q

E

F

L

H

N

H

L

L

P

P

T

D

L

F

S

T

V

A

A

L

E

E

N

N

L

V

F

-

L

-

D

-

N

A

L

M

P

P

S

L

H

L

G

I

G

G

W

K

I

K

S

K

R

P

K

A

Q

E

L

I

R

N

K

S

A

R

A

A

I

L

E

E

A

M

M

L

A

K

Q

A

V

V

G

G

L

L

D

D

A

H

I

-

D
x
R

P

A

D

N

T
x
H

L

R

V

P

G

S

E
|
E

L

L

G
x
S

I
x
G

G
|
G

H
x
E

Q

R

Q

Q

M

R

V

V

E

A

I

I

A

A

R

R

N

A

L

L

I

V

G

N

D

N

C

P

H

R

V

L

L

V

I

L

L

A

D

D

E
|
E

P

P

T

T

A

G

M
x
N

L

L

T

D

A

A

R

R

E

N

V

A

E

D

M

S

L

I

F

F

E

Q

-

L

-

G

Q

E

I

L

T

N

R

R

L

L

Q

Q

A

-

R

-

G

G

V

T

S

A

I

F

I

L

Y

V

I

V

S

T

H
|
H

R

D

L

L

E

-

E

Q

L

L

A

A

R

K

V

R

A

M

Q

S

R

R

I

Q

A

L

V

E

L

M

R

R

D

D

G

G

N

R

L

L

V

T

C

A

binding adp orthovanadate: V21 (= V23), S40 (≠ E42), S41 (≠ N43), G42 (= G44), S43 (≠ A45), G44 (= G46), K45 (= K47), S46 (= S48), T47 (= T49), Q91 (= Q90), R135 (≠ D138), H138 (≠ T141), E142 (= E145), S144 (≠ G147), G145 (≠ I148), G146 (= G149), E147 (≠ H150), E168 (= E171), N172 (≠ M175), H201 (= H203)
binding magnesium ion: S46 (= S48), Q91 (= Q90)

Sites not aligning to the query:

binding adp orthovanadate: 12, 19

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs
32% identity, 39% coverage: 23:225/517 of query aligns to 23:224/229 of 7v8iD

query
sites
7v8iD

V
|
V

L

L

T

H

G

N

I

V

D

S

L

F

T

S

L

V

M

G

R

E

G

G

E

E

V

M

L

M

A

A

L

I

T

V

G

G

E

S

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

S

L

K

H

I

L

G

G

L

L

V

D

A

T

P

P

T

T

T

S

G

G

Q

D

M

V

R

I

F

F

Q

N

G

G

R

Q

D

P

Y

M

R

S

P

K

G

L

S

S

R

S

S

A

Q

A

A

K

E

A

E

E

L

L

-

R

-

N

-

Q

G

K

I

L

R

G

M

F

V

I

M

Y

Q
|
Q

E

F

L

H

N

H

L

L

P

P

T

D

L

F

S

T

V

A

A

L

E

E

N

N

L

V

F

A

L

-

D

-

N

-

L

M

P

P

S

L

H

L

G

I

G

G

W

K

I

K

S

K

R

P

K

A

Q

E

L

I

R

N

K

S

A

R

A

A

I

L

E

E

A

M

M

L

A

K

Q

A

V

V

G

G

L

L

D

D

A

H

I

-

D
x
R

P

A

D

N

T
x
H

L

R

V

P

G

S

E
|
E

L
|
L

G
x
S

I
x
G

G
|
G

H
x
E

Q

R

Q

Q

M

R

V

V

E

A

I

I

A

A

R

R

N

A

L

L

I

V

G

N

D

N

C

P

H

R

V

L

L

V

I

L

L

A

D

D

E

Q

P

P

T

T

A

G

M
x
N

L

L

T

D

A

A

R

R

E

N

V

A

E

D

M

S

L

I

F

F

E

Q

-

L

-

G

Q

E

I

L

T

N

R

R

L

L

Q

Q

A

-

R

-

G

G

V

T

S

A

I

F

I

L

Y

V

I

V

S

T

H
|
H

R

D

L

L

E

-

E

Q

L

L

A

A

R

K

V

R

A

M

Q

S

R

R

I

Q

A

L

V

E

L

M

R

R

D

D

G

G

N

R

L

L

V

T

C

A

binding phosphoaminophosphonic acid-adenylate ester: V23 (= V23), S43 (≠ N43), G44 (= G44), S45 (≠ A45), G46 (= G46), K47 (= K47), S48 (= S48), T49 (= T49), Q93 (= Q90), R137 (≠ D138), H140 (≠ T141), E144 (= E145), L145 (= L146), S146 (≠ G147), G147 (≠ I148), G148 (= G149), E149 (≠ H150), N174 (≠ M175), H203 (= H203)
binding magnesium ion: S48 (= S48), Q93 (= Q90)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
31% identity, 39% coverage: 23:224/517 of query aligns to 16:215/240 of 4ymuJ

query
sites
4ymuJ

V
|
V

L

L

T

K

G

G

I

V

D

T

L

L

T

K

L

V

M

N

R

K

G

G

E

E

V

V

L

V

A

V

L

I

T

I

G

G

E

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

S

L

K

R

I

C

I

I

G

N

G

L

L

L

V
x
E

A

E

P

P

T

T

T

K

G

G

Q

E

M

V

R

F

F

I

Q

D

G

G

R

V

D

K

Y

I

R

N

P

N

G

G

S

K

R

V

S

N

-

I

Q

N

A

K

E

V

E

R

L

Q

G

K

I

V

R

G

M

M

V

V

M

F

Q

Q

E

H

L

F

N

N

L

L

L

F

P

P

T

H

L

L

S

T

V

A

A

I

E

E

N

N

L

I

F

T

L

L

D

-

N

-

L

A

P

P

S

V

H

K

G

V

G

K

W

K

I

M

S

N

R

K

K

K

Q

E

L

A

R

E

K

E

A

L

A

A

I

V

E

D

A

L

M

L

A

A

Q

K

V

V

G

G

L

L

-

L

D

D

A

K

I

K

D

D

-

Q

-

Y

P

P

D

I

T

K

L

L

V

S

G

G

E

-

L

-

G

-

I

-

G

G

H

Q

Q

K

Q

Q

M

R

V

L

E

A

I

I

A

A

R

R

N

A

L

L

I

A

G

M

D

Q

C

P

H

E

V

V

L

M

I

L

L

F

D

D

E
|
E

P

P

T

T

A

S

M

A

L

L

T

D

A

P

R

E

E

M

V

V

E

K

M

E

L

V

F

L

E

N

Q

V

I

M

T

K

R

Q

L

L

Q

A

A

N

R

E

G

G

V

M

S

T

I

M

I

V

Y

V

I

V

S

T

H
|
H

R

E

L

M

E

G

E

F

L

A

A

R

R

E

V

V

A

G

Q

D

R

R

I

V

A

I

V

F

L

M

R

D

D

D

G

G

N

V

L

I

V

V

binding adenosine-5'-triphosphate: V16 (= V23), S36 (≠ N43), G37 (= G44), S38 (≠ A45), G39 (= G46), K40 (= K47), S41 (= S48), T42 (= T49), E51 (≠ V58), E162 (= E171), H194 (= H203)
binding magnesium ion: S41 (= S48), E162 (= E171)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 11, 14

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
30% identity, 40% coverage: 23:228/517 of query aligns to 23:226/650 of 5ws4A

query
sites
5ws4A

V
x
I

L

L

T

K

G

G

I

I

D

D

L

L

T

T

L

I

M

Y

R

E

G

G

E

E

V

L

L

V

A

A

L

I

T

V

G

G

E

Q

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

S

M

K

N

I

I

I

L

G

G

G

C

L

L

V

D

A

R

P

P

T

T

T

S

G

G

Q

S

M

Y

R

K

F

V

Q

N

G

G

R

Q

D

E

-

T

-

G

-

K

Y

L

R

E

P

P

G

D

S

Q

R

L

S

A

Q

Q

A

L

E

R

L

E

G

Y

I

F

R

G

M

F

V

I

M

F

Q

Q

E

R

L

Y

N

H

L

L

P

G

T

D

L

L

S

S

V

A

A

E

E

G

N

N

L

V

F

-

L

-

D

-

N

E

L

V

P

P

S

A

H

V

G

Y

G

A

W

G

I

V

S

T

R

P

K

A

Q

D

L

R

R

K

K

Q

A

R

A

A

I

T

E

A

A

L

M

L

A

T

Q

E

V

L

G

G

L

L

D

-

A

G

I

T

D

K

P

T

D

Q

T

N

L

R

V

P

G

S

E

Q

L

L

G

S

I

G

G

G

H

Q

Q

Q

M

R

V

V

E

S

I

I

A

A

R

R

N

A

L

L

I

M

G

N

D

G

C

G

H

D

V

V

L

I

I

L

L

A

D

D

E

E

P

P

T

T

A

G

M

A

L

L

T

D

A

S

R

H

E

S

V

G

E

V

M

E

L

V

F

M

E

R

Q

I

I

L

T

R

R

E

L

L

Q

N

A

A

R

A

G

G

V

H

S

T

I

I

Y

L

I

V

S

T

H

H

R

D

L

M

E

-

E

Q

L

V

A

A

R

K

V

N

A

A

Q

T

R

R

I

I

A

I

V

E

L

I

R

S

D

D

G

G

N

E

L

I

V

I

C

S

V

D

E

R

P

P

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: I23 (≠ V23), S43 (≠ N43), G44 (= G44), S45 (≠ A45), G46 (= G46), K47 (= K47), S48 (= S48), T49 (= T49)

Sites not aligning to the query:

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: 14

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
30% identity, 41% coverage: 9:221/517 of query aligns to 3:218/226 of 5xu1B

query
sites
5xu1B

V

L

L

I

S

S

V

L

S

K

G

N

I

I

G

F

K

R

T

S

Y

Y

A

R

Q

N

-

G

-

D

-

Q

-

E

-

L

P

Q

V

V

L

L

T

K

G

N

I

I

D

N

L

L

T

E

L

V

M

N

R

E

G

G

E

E

V

F

L

V

A

A

L

I

T

M

G

G

E

P

N

S

G

G

A

S

G
|
G

K
|
K

S
|
S

T

T

L

L

S

M

K

N

I

T

I

I

G

G

G

M

L

L

V

D

A

T

P

P

T

T

T

S

G

G

Q

E

M

Y

R

Y

F

L

Q

E

G

G

R

Q

D

E

Y

V

-

A

-

G

-

L

-

G

-

E

R

K

P

Q

G

L

S

A

R

K

S

V

Q

R

A

N

E

Q

L

I

G

G

I

-

R

-

M

F

V

V

M

F

Q

Q

E

Q

L

F

N

F

L

L

P

S

T

K

L

L

S

N

V

A

A

L

E

Q

N

N

L

V

F

-

L

-

D

-

N

E

L

L

P

P

S

L

H

I

G

Y

G

A

W

G

I

V

S

S

R

S

K

S

Q

K

L

R

R

R

K

K

A

L

A

A

I

E

E

E

A

Y

M

L

A

D

Q

K

V

V

G

E

L

L

D

T

A

E

I

-

D

R

P

S

D

H

T

H

L

L

V

P

G

S

E

E

L

L

G

S

I

G

G

G

H

Q

Q

K

Q

Q

M

R

V

V

E

A

I

I

A

A

R

R

N

A

L

L

I

V

G

N

D

N

C

P

H

S

V

I

L

I

I

L

L

A

D

D

E

E

P

P

T

T

A

G

M

A

L

L

T

D

A

T

R

K

E

T

V

G

E

N

M

Q

L

I

F

M

E

Q

Q

L

I

L

T

V

R

D

L

L

Q

N

A

K

R

E

G

G

V

K

S

T

I

I

Y

M

I

V

S

T

H

H

R

E

L

-

E

P

E

E

L

I

A

A

R

A

V

Y

A

A

Q

K

R

R

I

Q

A

I

V

V

L

I

R

R

D

D

G

G

binding magnesium ion: G45 (= G46), K46 (= K47), S47 (= S48)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
31% identity, 39% coverage: 23:225/517 of query aligns to 22:222/615 of 5lilA

query
sites
5lilA

V
|
V

L

L

T

K

G

D

I

I

D

S

L

L

T

S

L

I

M

E

R

R

G

G

E

D

V

F

L

V

A

A

L

I

T

M

G

G

E

Q

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

S

M

K

N

I

I

G

G

G

C

L

L

V

D

A

T

P

A

T

T

T

G

G

G

Q

S

M

S

R

K

F

I

Q

D

G

G

R

K

D

E

Y

T

R

I

P

E

G

L

S

T

R

N

S

D

Q

Q

A

L

E

S

E

D

L

L

-

R

-

S

-

Q

G

K

I

F

R

G

M

F

V

I

M

F

Q
|
Q

E

R

L

Y

N

N

L

L

P

S

T

S

L

L

S

T

V

A

A

A

E

E

N

N

L

V

F

-

L

-

D

-

N

A

L

L

P

P

S

A

H

I

G

Y

G

A

W

G

I

M

S

P

R

Q

K

S

Q

Q

L

R

R

L

K

E

A

R

A

A

I

K

E

Q

A

L

M

L

A

E

Q

K

V

L

G

G

L

L

D

G

-

D

-
x
K

-

W

A

Q

I
x
N

D

K

P

P

D

N

T
x
Q

L
|
L

V
x
S

G
|
G

E

-

L

-

G

-

I

-

G
|
G

H
x
Q

Q

Q

M

R

V

V

E

S

I

I

A

A

R

R

N

A

L

L

I

M

G

N

D

G

C

G

H

E

V

I

L

I

I

L

L

A

D
|
D

E
x
Q

P

P

T

T

A

G

M
x
A

L

L

T

D

A

S

R

H

E

S

V

G

E

E

M

N

L

V

F

M

E

E

Q

I

I

L

T

R

R

Q

L

L

Q

H

A

E

R

E

G

G

V

H

S

T

I

I

Y

M

I

V

S

T

H
|
H

R

D

L

-

E

K

E

H

L

I

A

A

R

A

V

S

A

A

Q

N

R

R

I

I

A

I

V

E

L

I

R

K

D

D

G

G

N

E

L

I

V

I

C

S

binding adenosine-5'-triphosphate: V22 (= V23), S42 (≠ N43), G43 (= G44), S44 (≠ A45), G45 (= G46), K46 (= K47), S47 (= S48), T48 (= T49), Q92 (= Q90), K136 (vs. gap), N139 (≠ I137), Q143 (≠ T141), L144 (= L142), S145 (≠ V143), G146 (= G144), G147 (= G149), Q148 (≠ H150), Q169 (≠ E171), A173 (≠ M175), H201 (= H203)
binding magnesium ion: S47 (= S48), Q92 (= Q90), D168 (= D170)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 13

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
25% identity, 42% coverage: 9:225/517 of query aligns to 4:230/253 of 1g9xB

query
sites
1g9xB

V

I

L

L

S

R

V

T

S

E

G

N

I

I

G

V

K

K

T

Y

Y
x
F

A

G

Q

E

-
x
F

P

K

V

A

L

L

T

D

G

G

I

V

D

S

L

I

T

S

L

V

M

C

R

K

G

G

E

D

V

V

L

T

A

L

L

I

T

I

G

G

E

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

S

I

K

N

I

V

I

I

G

T

G

G

L

F

V

L

A

K

P

A

T

D

T

E

G

G

Q

R

M

V

R

Y

F

F

Q

E

G

N

R

K

D

D

Y

I

R

T

P

N

G

K

S

E

R

P

S

A

Q

E

A

L

E

Y

E

H

L

Y

G

G

I

I

R

V

M

R

V

T

M

F

Q

Q

E

T

L

P

N

Q

L

P

L

L

P

K

T

E

L

M

S

T

V

V

A

L

E

E

N

N

L

L

F

L

L

I

D

G

N

E

L

I

P

N

S

P

-

G

-

E

-

S

-

P

-

L

-

N

-

S

-

L

-

F

H

Y

G

K

W

W

I

I

S

P

R

K

K

E

Q

E

-

E

L

M

R

V

K

E

A

K

A

A

I

F

E

K

A

I

M

L

A

E

Q

F

V

L

G

K

L

L

D

S

A

H

I

L

D

Y

P

-

D

D

T

R

L

K

V

A

G

G

E

E

L

L

G

S

I

G

G

G

H

Q

Q

M

Q

K

M

L

V

V

E

E

I

I

A

G

R

R

N

A

L

L

I

M

G

T

D

N

C

P

H

K

V

M

L

I

I

V

L

M

D

D

E
|
E

P

P

T

I

A

A

M

G

L

V

T

A

A

P

R

G

E

L

V

A

E

H

M

D

L

I

F

F

E

N

Q

H

I

V

T

L

R

E

L

L

Q

K

A

A

R

K

G

G

V

I

S

T

I

F

I

L

Y

I

I

I

S

E

H

H

R

R

L

L

E

D

E

I

L

V

A

L

R

N

V

Y

A

I

Q

D

R

H

I

L

A

Y

V

V

L

M

R

F

D

N

G

G

N

Q

L

I

V

I

C

A

binding adenosine-5'-diphosphate: F14 (≠ Y19), F17 (vs. gap), N39 (= N43), G40 (= G44), S41 (≠ A45), G42 (= G46), K43 (= K47), S44 (= S48), T45 (= T49)
binding magnesium ion: S44 (= S48), E176 (= E171)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
31% identity, 39% coverage: 23:225/517 of query aligns to 22:222/592 of 5lj7A

query
sites
5lj7A

V
|
V

L

L

T

K

G

D

I

I

D

S

L

L

T

S

L

I

M

E

R

R

G

G

E

D

V

F

L

V

A

A

L

I

T

M

G

G

E

Q

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

S

M

K

N

I

I

G

G

G

C

L

L

V

D

A

T

P

A

T

T

T

G

G

G

Q

S

M

S

R

K

F

I

Q

D

G

G

R

K

D

E

Y

T

R

I

P

E

G

L

S

T

R

N

S

D

Q

Q

A

L

E

S

E

D

L

L

-

R

-

S

-

Q

G

K

I

F

R

G

M

F

V

I

M

F

Q
|
Q

E

R

L

Y

N

N

L

L

P

S

T

S

L

L

S

T

V

A

A

A

E

E

N

N

L

V

F

-

L

-

D

-

N

A

L

L

P

P

S

A

H

I

G

Y

G

A

W

G

I

M

S

P

R

Q

K

S

Q

Q

L

R

R

L

K

E

A

R

A

A

I

K

E

Q

A

L

M

L

A

E

Q

K

V

L

G

G

L

L

D

G

-

D

-
x
K

-

W

A

Q

I

N

D

K

P

P

D
x
N

T
x
Q

L
|
L

V
x
S

G
|
G

E

-

L

-

G

-

I

-

G
|
G

H
x
Q

Q

Q

M

R

V

V

E

S

I

I

A

A

R

R

N

A

L

L

I

M

G

N

D

G

C

G

H

E

V

I

L

I

I

L

L

A

D
|
D

E
x
Q

P

P

T

T

A

G

M
x
A

L

L

T

D

A

S

R

H

E

S

V

G

E

E

M

N

L

V

F

M

E

E

Q

I

I

L

T

R

R

Q

L

L

Q

H

A

E

R

E

G

G

V

H

S

T

I

I

Y

M

I

V

S

T

H
|
H

R

D

L

-

E

K

E

H

L

I

A

A

R

A

V

S

A

A

Q

N

R

R

I

I

A

I

V

E

L

I

R

K

D

D

G

G

N

E

L

I

V

I

C

S

binding adenosine-5'-triphosphate: V22 (= V23), S42 (≠ N43), G43 (= G44), S44 (≠ A45), G45 (= G46), K46 (= K47), S47 (= S48), T48 (= T49), Q92 (= Q90), K136 (vs. gap), N142 (≠ D140), Q143 (≠ T141), L144 (= L142), S145 (≠ V143), G146 (= G144), G147 (= G149), Q148 (≠ H150), Q169 (≠ E171), A173 (≠ M175), H201 (= H203)
binding magnesium ion: S47 (= S48), Q92 (= Q90), D168 (= D170)

Sites not aligning to the query:

binding adenosine-5'-triphosphate: 13

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
32% identity, 40% coverage: 23:228/517 of query aligns to 23:226/648 of P75831

query
sites
P75831

V

V

L

L

T

K

G

G

I

I

D

S

L

L

T

D

L

I

M

Y

R

A

G

G

E

E

V

M

L

V

A

A

L

I

T

V

G

G

E

A

N

S

G

G

A

S

G

G

K
|
K

S

S

T

T

L

L

S

M

K

N

I

I

I

L

G

G

G

C

L

L

V

D

A

K

P

A

T

T

T

S

G

G

Q

T

M

Y

R

R

F

V

Q

A

G

G

R

Q

D

D

Y

V

R

A

-

T

-

L

-

D

P

A

G

D

S

A

R

L

S

A

Q

Q

A

L

E

R

L

E

G

H

I

F

R

G

M

F

V

I

M

F

Q

Q

E

R

L

Y

N

H

L

L

P

S

T

H

L

L

S

T

V

A

A

E

E

Q

N

N

L

V

F

-

L

-

D

-

N

E

L

V

P

P

S

A

H

V

G

Y

G

A

W

G

I

L

S

E

R

R

K

K

Q

Q

L

R

R

L

K

L

A

R

A

A

I

Q

E

E

A

L

M

L

A

Q

Q

R

V

L

G

G

L

L

D

E

A

D

I

-

D

R

P

T

D

E

T

Y

L

Y

V

P

G

A

E

Q

L

L

G

S

I

G

G

G

H

Q

Q

Q

M

R

V

V

E

S

I

I

A

A

R

R

N

A

L

L

I

M

G

N

D

G

C

G

H

Q

V

V

L

I

I

L

L

A

D
|
D

E

E

P

P

T

T

A

G

M

A

L

L

T

D

A

S

R

H

E

S

V

G

E

E

M

E

L

V

F

M

E

A

Q

I

I

L

T

H

R

Q

L

L

Q

R

A

D

R

R

G

G

V

H

S

T

I

V

I

I

Y

I

I

V

S

T

H

H

R

D

L

-

E

P

E

Q

L

V

A

A

R

A

V

Q

A

A

Q

E

R

R

I

V

A

I

V

E

L

I

R

R

D

D

G

G

N

E

L

I

V

V

C

R

V

N

E

P

P

P

K47 (= K47) mutation to L: Lack of activity.
D169 (= D170) mutation to N: Lack of activity.

1g6hA Crystal structure of the adp conformation of mj1267, an atp- binding cassette of an abc transporter (see paper)
25% identity, 42% coverage: 9:225/517 of query aligns to 4:230/254 of 1g6hA

query
sites
1g6hA

V

I

L

L

S

R

V

T

S

E

G

N

I

I

G

V

K

K

T

Y

Y
x
F

A

G

Q

E

-
x
F

P

K

V

A

L

L

T

D

G

G

I

V

D

S

L

I

T

S

L

V

M

N

R

K

G

G

E

D

V

V

L

T

A

L

L

I

T

I

G

G

E

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

S

I

K

N

I

V

I

I

G

T

G

G

L

F

V

L

A

K

P

A

T

D

T

E

G

G

Q

R

M

V

R

Y

F

F

Q

E

G

N

R

K

D

D

Y

I

R

T

P

N

G

K

S

E

R

P

S

A

Q

E

A

L

E

Y

E

H

L

Y

G

G

I

I

R

V

M

R

V

T

M

F

Q

Q

E

T

L

P

N

Q

L

P

L

L

P

K

T

E

L

M

S

T

V

V

A

L

E

E

N

N

L

L

F

L

L

I

D

G

-

E

-

I

-

C

-

P

-

G

-

E

-

S

-

P