SitesBLAST
Comparing Pf6N2E2_1381 Aldehyde dehydrogenase (EC 1.2.1.3) to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P37685 Aldehyde dehydrogenase B; Acetaldehyde dehydrogenase; EC 1.2.1.4 from Escherichia coli (strain K12) (see paper)
66% identity, 99% coverage: 5:506/506 of query aligns to 11:512/512 of P37685
- R197 (≠ E191) mutation to E: Less than 10% of wild-type acetaldehyde dehydrogenase activity.
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
43% identity, 95% coverage: 22:501/506 of query aligns to 7:482/489 of 4o6rA
- active site: N150 (= N165), K173 (= K188), E248 (= E262), C282 (= C301), E383 (= E402), E460 (= E479)
- binding adenosine monophosphate: I146 (= I161), V147 (≠ I162), K173 (= K188), G206 (= G220), G210 (= G224), Q211 (≠ E225), F224 (= F238), G226 (= G240), S227 (= S241), T230 (≠ I244), R233 (≠ H247)
O14293 Putative aldehyde dehydrogenase-like protein C9E9.09c; EC 1.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
44% identity, 94% coverage: 20:497/506 of query aligns to 24:496/503 of O14293
- S248 (= S241) modified: Phosphoserine
Sites not aligning to the query:
- 501 modified: Phosphoserine
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
42% identity, 95% coverage: 22:502/506 of query aligns to 23:499/501 of Q56YU0
- G152 (≠ A148) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A419) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
41% identity, 94% coverage: 22:496/506 of query aligns to 43:513/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
5l13A Structure of aldh2 in complex with 2p3 (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 5l13A
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F166), M168 (= M170), W171 (= W173), F290 (= F295), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 4kwgA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F166), M168 (= M170), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 4kwfA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F166), M168 (= M170), W171 (= W173), E262 (= E262), C295 (≠ V300), C296 (= C301), C297 (≠ T302), D451 (≠ H460), F453 (≠ Y462), F459 (= F468)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 3sz9A
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F166), C295 (≠ V300), C296 (= C301), D451 (≠ H460), F453 (≠ Y462), F459 (= F468)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 3injA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ L120), F164 (= F166), L167 (= L169), F286 (≠ L292), F290 (= F295), D451 (≠ H460), F453 (≠ Y462)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 2vleA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding daidzin: M118 (≠ L120), F164 (= F166), M168 (= M170), W171 (= W173), F286 (≠ L292), F290 (= F295), C295 (≠ V300), C296 (= C301), D451 (≠ H460), V452 (≠ L461), F453 (≠ Y462)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 1o01B
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding (2e)-but-2-enal: C296 (= C301), C297 (≠ T302), F453 (≠ Y462)
- binding nicotinamide-adenine-dinucleotide: I159 (= I161), I160 (= I162), P161 (= P163), W162 (= W164), K186 (= K188), E189 (= E191), G219 (= G220), G223 (= G224), A224 (≠ E225), F237 (= F238), G239 (= G240), S240 (= S241), I243 (= I244), L263 (= L263), G264 (= G264), C296 (= C301), Q343 (= Q348), E393 (= E402), F395 (= F404)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 1cw3A
- active site: N163 (= N165), K186 (= K188), E262 (= E262), C296 (= C301), E393 (= E402), E470 (= E479)
- binding magnesium ion: V34 (≠ T39), D103 (= D105), Q190 (= Q192)
- binding nicotinamide-adenine-dinucleotide: I159 (= I161), I160 (= I162), P161 (= P163), W162 (= W164), K186 (= K188), G219 (= G220), G223 (= G224), A224 (≠ E225), F237 (= F238), G239 (= G240), S240 (= S241), I243 (= I244), L263 (= L263), G264 (= G264), C296 (= C301), Q343 (= Q348), K346 (= K351), E393 (= E402), F395 (= F404)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 19:489/496 of 4fr8C
- active site: N165 (= N165), K188 (= K188), Q264 (≠ E262), C298 (= C301), E395 (= E402), E472 (= E479)
- binding nicotinamide-adenine-dinucleotide: I161 (= I161), I162 (= I162), W164 (= W164), K188 (= K188), G221 (= G220), G225 (= G224), A226 (≠ E225), F239 (= F238), G241 (= G240), S242 (= S241), I245 (= I244), Q345 (= Q348), E395 (= E402), F397 (= F404)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 16:486/493 of 4fr8A
- active site: N162 (= N165), K185 (= K188), Q261 (≠ E262), C295 (= C301), E392 (= E402), E469 (= E479)
- binding nicotinamide-adenine-dinucleotide: I158 (= I161), I159 (= I162), W161 (= W164), K185 (= K188), G218 (= G220), G222 (= G224), A223 (≠ E225), F236 (= F238), G238 (= G240), S239 (= S241), I242 (= I244), Q342 (= Q348), K345 (= K351), E392 (= E402), F394 (= F404)
- binding propane-1,2,3-triyl trinitrate: F163 (= F166), L166 (= L169), W170 (= W173), F289 (= F295), S294 (≠ V300), C295 (= C301), D450 (≠ H460), F452 (≠ Y462)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
42% identity, 94% coverage: 22:499/506 of query aligns to 6:478/487 of 4go4A
- active site: N149 (= N165), K172 (= K188), E247 (= E262), C281 (= C301), E381 (= E402), E458 (= E479)
- binding nicotinamide-adenine-dinucleotide: I145 (= I161), V146 (≠ I162), W148 (= W164), N149 (= N165), F154 (≠ M170), K172 (= K188), G205 (= G220), G209 (= G224), Q210 (≠ E225), F223 (= F238), T224 (= T239), G225 (= G240), S226 (= S241), T229 (≠ I244), E247 (= E262), G249 (= G264), C281 (= C301), E381 (= E402), F383 (= F404)
7radA Crystal structure analysis of aldh1b1
41% identity, 94% coverage: 22:497/506 of query aligns to 16:487/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I161), I159 (= I162), P160 (= P163), W161 (= W164), N162 (= N165), M167 (= M170), K185 (= K188), E188 (= E191), G218 (= G220), G222 (= G224), A223 (≠ E225), T237 (= T239), G238 (= G240), S239 (= S241), V242 (≠ I244), E261 (= E262), L262 (= L263), C295 (= C301), E392 (= E402), F394 (= F404)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (≠ A116), E117 (≠ L120), F163 (= F166), E285 (= E288), F289 (= F295), N450 (≠ H460), V452 (≠ Y462)
7mjdA Crystal structure analysis of aldh1b1
41% identity, 94% coverage: 22:497/506 of query aligns to 16:487/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I161), I159 (= I162), P160 (= P163), W161 (= W164), N162 (= N165), M167 (= M170), K185 (= K188), E188 (= E191), G218 (= G220), G222 (= G224), F236 (= F238), T237 (= T239), G238 (= G240), S239 (= S241), V242 (≠ I244), E261 (= E262), L262 (= L263), C295 (= C301), E392 (= E402), F394 (= F404)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ L120), E285 (= E288), F289 (= F295), N450 (≠ H460), V452 (≠ Y462)
7mjcA Crystal structure analysis of aldh1b1
41% identity, 94% coverage: 22:497/506 of query aligns to 16:487/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I161), I159 (= I162), P160 (= P163), W161 (= W164), N162 (= N165), K185 (= K188), E188 (= E191), G218 (= G220), G222 (= G224), T237 (= T239), G238 (= G240), S239 (= S241), V242 (≠ I244), E261 (= E262), L262 (= L263), C295 (= C301), E392 (= E402), F394 (= F404)
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+ (see paper)
42% identity, 94% coverage: 22:496/506 of query aligns to 17:487/494 of 1nzwA
- active site: N163 (= N165), K186 (= K188), E262 (= E262), S296 (≠ T302), E393 (= E402), E470 (= E479)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (= I161), I160 (= I162), P161 (= P163), K186 (= K188), E189 (= E191), G219 (= G220), P220 (≠ R221), G223 (= G224), A224 (≠ E225), F237 (= F238), G239 (= G240), S240 (= S241), I243 (= I244), E262 (= E262), G264 (= G264), S296 (≠ T302), Q343 (= Q348), E393 (= E402), F395 (= F404)
Query Sequence
>Pf6N2E2_1381 Aldehyde dehydrogenase (EC 1.2.1.3)
MIYAQPGTPGAVVSFKPRYGNFIGGEFVAPVNGEYFTNTSPVNGEVIAEFPRSSAADIDK
ALDAAHAAADAWGKTSVQDRSLVLLKIADRIEQNLEILAVSETWDNGKAVRETLNADVPL
AADHFRYFAGCIRAQEGGAAEINELTTAYHFHEPLGVVGQIIPWNFPLLMAAWKLAPALA
AGNCIVLKPAEQTPLSIMVFIELVADLLPPGVLNIVHGFGREAGEALATSKRIAKIAFTG
STPIGSHIMKCAAENIIPSTVELGGKSPNIFFEDIMQAEPAFIEKAAEGLVLAFFNQGEV
CTCPSRALVQESIYAPFMAEVMKKIAKIKRGNPLDTETMVGAQASEQQFDKILSYLEIAQ
QEGAELLTGGAAERLEGDLSSGYYIQPTLLKGHNKMRVFQEEIFGPVVGVTTFKDEAEAL
AIANDTEFGLGAGLWTRDINRAYRMGRAIKAGRVWTNCYHLYPAHAAFGGYKKSGVGRET
HKMMLDHYQQTKNLLVSYDINPLGFF
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory