SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Pf6N2E2_2230 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_2230 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 3 papers)
28% identity, 99% coverage: 2:397/402 of query aligns to 5:421/425 of O59010

query
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O59010

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S65 (≠ V55) mutation to V: Strongly decreased chloride conductance.
R276 (= R256) mutation to S: Increased rate of aspartate transport; when associated with R-395.
RSS 276:278 (= RSS 256:258) binding
M311 (= M291) mutation to A: Decreased dependence of aspartate binding on Na(+) concentration.
T314 (≠ A294) binding
V355 (= V335) binding
D394 (= D372) binding
M395 (≠ S373) mutation to R: Increased rate of aspartate transport; when associated with S-276.
R397 (≠ E375) mutation to A: Strongly decreased affinity for aspartate.
N401 (= N379) binding
D405 (= D383) mutation to N: Strongly decreased affinity for aspartate.

6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine (see paper)
28% identity, 94% coverage: 12:388/402 of query aligns to 7:402/409 of 6bavA

query
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6bavA

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binding benzylcysteine: R268 (= R256), S270 (= S258), T306 (≠ A294), Y309 (≠ T297), D382 (vs. gap), D386 (= D372), C389 (≠ E375), T390 (= T376)

6bauA Crystal structure of gltph r397c in complex with l-cysteine (see paper)
28% identity, 94% coverage: 12:388/402 of query aligns to 7:402/408 of 6bauA

query
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6bauA

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binding cysteine: S270 (= S258), M303 (= M291), T306 (≠ A294), A345 (≠ S333), G346 (= G334), V347 (= V335), G351 (≠ S339), D386 (= D372), C389 (≠ E375), T390 (= T376), N393 (= N379)

2nwwA Crystal structure of gltph in complex with tboa (see paper)
28% identity, 94% coverage: 12:388/402 of query aligns to 6:401/407 of 2nwwA

query
sites
2nwwA

Q

K

I

I

I

L

I

I

G

G

L

L

I

I

A

L

G

G

I

A

V

I

L

V

A

G

W

L

L

I

A

L

P

G

D

H

V

Y

A

G

K

Y

S

A

T

H

A

A

F

V

-

H

-

T

-

Y

-

V

-

K

-

P

I

F

G

G

K

D

V

L

F

F

V

V

S

R

A

L

L

L

K

K

A

M

-

L

V

V

A

M

P

P

I

I

L

V

V

F

F

A

V

S

L

L

V

V

M

V

-

G

-

A

A

A

S

S

I

I

A

S

N

P

H

A

K

R

H

L

G

G

Q

R

E

-

T

V

H

G

I

V

R

K

P

I

I

V

L

V

F

Y

L

-

Y

Y

L

L

G

T

T

S

F

A

T

F

A

A

A

V

V

T

V

L

A

G

V

I

A

M

S

A

T

R

L

L

F

F

-

N

P

P

S

G

S

A

-

G

-

I

-

H

L

L

V

A

L

V

S

G

T

G

Q

Q

D

Q

V

F

A

Q

V

-

T

-

A

-

P

P

G

H

G

Q

I

A

S

P

E

P

V

L

L

V

Q

H

S

I

L

L

L

D

S

I

V

V

V

P

D

T

N

N

P

P

V

F

R

G

A

A

L

L

M

A

D

N

G

G

N

Q

F

V

I

L

G

P

I

T

L

I

A

F

W

F

A

A

I

I

G

I

M

L

G

G

I

I

A

A

I

I

-

T

-

Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

-

V

R

R

H

K

A

S

G

A

Q

E

T

T

T

L

R

L

T

D

V

A

L

I

E

N

D

G

L

L

S

A

N

E

G

A

V

M

T

Y

V

K

I

I

V

V

R

N

V

G

V

V

I

M

R

Q

F

Y

A

A

P

P

L

I

G

G

I

V

F

F

G

A

L

L

V

I

A

A

S

Y

T

V

L

M

A

A

T

E

S

Q

G

G

F

V

G

-

A

H

L

V

G

G

Y

E

L

L

H

A

L

K

L

V

T

T

V

-

L

-

I

-

G

-

C

A

M

A

L

V

F

Y

V

V

A

G

L

L

V

T

V

L

N

Q

P

I

L

L

I

L

V

V

F

Y

W

F

K

V

L

L

R

L

R

K

-

I

-

Y

-

G

-

I

N

D

P

P

Y

I

P

S

L

F

V

I

F

K

T

H

C

A

L

-

R

K

E

D

S

A

G

M

I

L

T

T

A

A

F

F

F

V

T

T

R

R

S

S

S
|
S

A

S

A

G

N

T

I

L

P

P

V

V

N

T

L

M

E

R

L

V

S

A

K

K

R

E

L

M

G

G

L

I

H

S

E

E

D

G

T

I

Y

Y

S

S

V

F

S

T

I

L

P

P

L

L

G

G

A

A

T

T

I

I

N

N

M

M

A

D

G

G

A
x
T

A

A

I

L

T

Y

I

Q

T

G

V

V

L

C

T

T

L

F

A

F

A

I

V

A

H

N

T

A

L

L

G

G

I

S

A

H

V

L

D

T

I

V

P

G

T

Q

A

Q

V

L

L

T

L

I

S

V

V

L

V

T

A

A

A

V

I

L

C

A

A

S

C

I

G

G

A

T

S

A

G

G

V

V

A

P

G

G

G
x
A

S
x
G

L

A

L

I

L

M

I

L

P

A

L

M

A

V

C

L

S

H

L

S

F

V

G

G

I

L

P

P

S

L

E

T

I

D

A

P

M

N

Q

V

V

A

A

A

V

Y

G

A

F

M

I

I

I

L

G

G

V

I

-

D

-

A

L

I

Q

L

D
|
D

S

M

A

G

E
x
R

T
|
T

A

M

L

V

N
|
N

S

V

S

T

T

G

D

D

V

L

L

T

F

G

T

T

A

A

binding (3s)-3-(benzyloxy)-l-aspartic acid: S269 (= S258), T305 (≠ A294), A349 (≠ G338), G350 (≠ S339), D385 (= D372), R388 (≠ E375), T389 (= T376), N392 (= N379)

6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa (see paper)
27% identity, 96% coverage: 2:388/402 of query aligns to 2:407/413 of 6x14A

query
sites
6x14A

Q

R

R

K

L
x
Y

K

I

R

E

T

Y

S

P

L

V

V

L

T

Q

Q

K

I
|
I

I

L

I

I

G

G

L

L

I

I

A

L

G

G

I

A

V

I

L

V

A

G

W

L

L

I

A

L

P

G

D

H

V

Y

A

G

K

Y

S

A

T

H

A

A

F

V

-

H

-

T

-

Y

-

V

-

K

-

P

I

F

G

G

K

D

V

L

F

F

V

V

S

R

A

L

L

L

-

C

K

M

A

L

V

V

A

M

P

P

I

I

L

V

V

F

F

A

V

S

L

L

V

V

M

V

-
x
G

-

A

A

A

S

S

I

I

A

S

N

P

H

A

K

R

H

L

G

G

Q

R

E

-

T

V

H

G

I

V

R

K

P

I

I
x
V

L

V

F

Y

L

-

Y

Y

L

L

G

T

T

S

F

A

T

F

A

A

A

V

V

T

V

L

A

G

V

I

A

M

S

A

T

R

L

L

F

F

-

N

P

P

S

G

S

A

-

G

-

I

-

H

L

L

V

A

L

V

S

G

T

G

Q

Q

D

Q

V

F

A

Q

V

-

T

-

A

-

P

P

G

H

G

Q

I

A

S

P

E

P

V

L

L

V

Q

H

S

I

L

L

L

D

S

I

V

V

V

P

D

T

N

N

P

P

V

F

R

G

A

A

L

L

M

A

D

N

G

G

N

Q

F

V

I

L

G

P

I

T

L

I

A

F

W

F

A

A

I

I

G
x
I

M

L

G

G

I

I

A

A

I

I

-

T

-
x
Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

-

V

R

R

H

K

A

S

G

A

Q

E

T

T

T

L

R

L

T

D

V

A

L

I

E

N

D

G

L

L

S

A

N

E

G

A

V

M

T

Y

V
x
K

I

I

V

V

R

N

V

G

V

V

I
x
M

R

Q

F

Y

A

A

P

P

L

I

G

G

I

V

F

F

G

A

L

L

V

I

A

A

S

Y

T

V

L

M

A

A

T

E

S

Q

G

G

F

V

G

-

A

H

L

V

G

G

Y

E

L

L

H

A

L

K

L

V

T

T

V

-

L

-

I

-

G

-

C

A

M

A

L

V

F

Y

V

V

A

G

L

L

V

T

V

L

N

Q

P

I

L

L

I

L

V

V

F

Y

W

F

K

V

L

L

R

L

R

K

-

I

-

Y

-

G

-

I

N

D

P

P

Y

I

P

S

L

F

V

I

F

K

T

H

C

A

L

-

R

K

E

D

S

A

G

M

I

L

T

T

A

A

F

F

F

V

T

T

R

R

S

S

S
|
S

A

S

A

G

N

T

I

L

P

P

V

V

N

T

L

M

E

R

L

V

S

A

K

K

R

E

L

M

G

G

L

I

H

S

E

E

D

G

T

I

Y

Y

S

S

V

F

S

T

I

L

P

P

L

L

G

G

A

A

T
|
T

I
|
I

N

N

M

M

A

D

G

G

A
x
T

A

A

I

L

T

Y

I

Q

T

G

V

V

L

A

T

T

L

F

A

F

A

I

V

A

H

N

T

A

L

L

G

G

I

S

A

H

V

L

D

T

I

V

P

G

T

Q

A

Q

V

L

L

T

L

I

S

V

V

L

V

T

A

A

A

V

I

L

C

A

A

S

C
x
I

G

G

A

T

S

A

G

G

V

V

A

P

G

G

G

A

S
x
G

L

A

L

I

L

M

I

L

P

C

L

M

A

V

C

L

S

H

L

S

F

V

G

G

I

L

P

P

S

L

E

T

I

D

A

P

M

N

Q

V

V

A

A

A

V

Y

G

A

F

M

I

I

I
x
L

G

G

V

I

-

D

-

A

L

I

Q

L

D
|
D

S

M

A

G

E
x
R

T

T

A

M

L

V

N

N

S

V

S

T

T

G

D

D

V

L

L

T

F

G

T

T

A

A

binding [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate: Y4 (≠ L4), G66 (vs. gap), V83 (≠ I75), I157 (≠ G149), Y164 (vs. gap), K193 (≠ V174), T305 (= T288), I306 (= I289), I347 (≠ C330)
binding (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid: I13 (= I13), M199 (≠ I180), S275 (= S258), T311 (≠ A294), G356 (≠ S339), L384 (≠ I367), D391 (= D372), R394 (≠ E375)

6x15A Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
27% identity, 96% coverage: 2:388/402 of query aligns to 5:410/419 of 6x15A

query
sites
6x15A

Q

R

R

K

L
x
Y

K

I

R

E

T

Y

S

P

L

V

V

L

T

Q

Q

K

I

I

I

L

I

I

G

G

L

L

I

I

A

L

G

G

I

A

V

I

L

V

A

G

W

L

L

I

A

L

P

G

D

H

V

Y

A

G

K

Y

S

A

T

H

A

A

F

V

-

H

-

T

-

Y

-

V

-

K

-

P

I
x
F

G

G

K

D

V

L

F

F

V

V

S

R

A

L

L

L

-

C

K

M

A

L

V

V

A

M

P

P

I

I

L

V

V

F

F

A

V

S

L

L

V

V

M

V

-

G

-

A

A

A

S

S

I

I

A

S

N
x
P

H

A

K

R

H

L

G

G

Q

R

E

-

T

V

H

G

I

V

R

K

P

I

I

V

L

V

F

Y

L

-

Y
|
Y

L

L

L
|
L

G
x
T

T
x
S

F

A

T
x
F

A

A

A

V

V

T

V

L

A

G

V

I

A

M

S

A

T

R

L

L

F

F

-

N

P

P

S

G

S

A

-

G

-

I

-

H

L

L

V

A

L

V

S

G

T

G

Q

Q

D

Q

V

F

A

Q

V

-

T

-

A

-

P

P

G

H

G

Q

I

A

S

P

E

P

V
x
L

L

V

Q

H

S
x
I

L

L

L

D

S

I

V

V

V

P

D

T

N

N

P

P

V

F

R

G

A

A

L

L

M

A

D

N

G

G

N

Q

F

V

I

L

G

P

I

T

L

I

A

F

W

F

A

A

I
|
I

G

I

M

L

G

G

I

I

A

A

I

I

-

T

-
x
Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

-

V

R

R

H

K

A

S

G

A

Q

E

T

T

T

L

R

L

T

D

V

A

L

I

E

N

D

G

L

L

S

A

N

E

G

A

V

M

T

Y

V
x
K

I

I

V

V

R

N

V
x
G

V

V

I

M

R

Q

F

Y

A

A

P

P

L
x
I

G

G

I

V

F
|
F

G

A

L

L

V

I

A

A

S

Y

T

V

L

M

A

A

T

E

S

Q

G

G

F

V

G

-

A

H

L

V

G

G

Y

E

L

L

H

A

L

K

L

V

T

T

V

-

L

-

I

-

G

-

C

A

M

A

L

V

F

Y

V

V

A

G

L

L

V

T

V

L

N

Q

P

I

L

L

I

L

V

V

F

Y

W

F

K

V

L
|
L

R

L

R

K

-

I

-

Y

-

G

-

I

N

D

P

P

Y

I

P

S

L

F

V
x
I

F

K

T

H

C

A

L

-

R

K

E

D

S

A

G
x
M

I

L

T

T

A

A

F

F

F

V

T

T

R

R

S
|
S

A

S

A

G

N

T

I

L

P

P

V

V

N

T

L

M

E

R

L

V

S

A

K

K

R

E

L

M

G

G

L

I

H

S

E

E

D

G

T

I

Y

Y

S

S

V

F

S

T

I

L

P

P

L

L

G
|
G

A

A

T
|
T

I

I

N
|
N

M
|
M

A
x
D

G

G

A
x
T

A

A

I

L

T

Y

I

Q

T

G

V

V

L

A

T

T

L

F

A

F

A

I

V

A

H

N

T

A

L

L

G

G

I

S

A

H

V

L

D
x
T

I
x
V

P
x
G

T

Q

A

Q

V

L

L
x
T

L

I

S

V

V
x
L

V

T

A

A

A

V

I

L

C

A

A
x
S

C
x
I

G

G

A
x
T

S

A

G
|
G

V

V

A

P

G

G

G
x
A

S
x
G

L

A

L

I

L

M

I

L

P

C

L

M

A

V

C

L

S

H

L

S

F

V

G

G

I

L

P

P

S

L

E

T

I

D

A

P

M

N

Q

V

V

A

A

A

V

Y

G

A

F

M

I

I

I

L

G

G

V

I

-

D

-

A

L

I

Q

L

D
|
D

S

M

A

G

E
x
R

T
|
T

A
x
M

L

V

N
|
N

S
x
V

S

T

T

G

D
|
D

V

L

L

T

F

G

T

T

A

A

binding [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate: Y7 (≠ L4), F46 (≠ I37), F46 (≠ I37), P75 (≠ N63), L91 (= L81), F95 (≠ T85), L130 (≠ V119), I133 (≠ S122), I159 (= I148), Y167 (vs. gap), K196 (≠ V174), G200 (≠ V178), I207 (≠ L185), F210 (= F188), L250 (= L233), I262 (≠ V241), M269 (≠ G249), T334 (≠ D314), V335 (≠ I315), G336 (≠ P316), T340 (≠ L320), L343 (≠ V323), M399 (≠ A377)
binding aspartic acid: S277 (= S257), S278 (= S258), T314 (≠ A294), G354 (= G334), A358 (≠ G338), G359 (≠ S339), D394 (= D372), R397 (≠ E375), T398 (= T376)
binding sodium ion: Y89 (= Y79), T92 (≠ G82), S93 (≠ T83), G306 (= G286), T308 (= T288), N310 (= N290), N310 (= N290), M311 (= M291), D312 (≠ A292), S349 (≠ A329), I350 (≠ C330), T352 (≠ A332), N401 (= N379), V402 (≠ S380), D405 (= D383)

Sites not aligning to the query:

binding [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate: 4

6bmiA Crystal structure of gltph r397c in complex with l-serine (see paper)
30% identity, 74% coverage: 12:310/402 of query aligns to 7:322/396 of 6bmiA

query
sites
6bmiA

Q

K

I

I

I

L

I

I

G

G

L

L

I

I

A

L

G

G

I

A

V

I

L

V

A

G

W

L

L

I

-

L

-

G

-

H

-

Y

-

G

-

Y

A

A

P

D

D

A

V

V

A

K

K

T

S

Y

T

V

A

K

F

P

I

F

G

G

K

D

V

L

F

F

V

V

S

R

A

L

L

L

K

K

A

M

-

L

V

V

A

M

P

P

I

I

L

V

V

F

F

A

V

S

L

L

V

V

M

V

-

G

-

A

A

A

S

S

I

I

A

S

N

P

H

A

K

R

H

L

G

G

Q

R

E

-

T

V

H

G

I

V

R

K

P

I

I

V

L

V

F

Y

L

-

Y

Y

L

L

G

T

T

S

F

A

T

F

A

A

A

V

V

T

V

L

A

G

V

I

A

M

S

A

T

R

L

L

F

F

-

N

P

P

S

G

S

A

-

G

-

I

-

H

L

L

V

A

L

V

S

G

T

G

Q

Q

D

Q

V

F

A

Q

V

-

T

-

A

-

P

P

G

K

G

Q

I

A

S

P

E

P

V

L

L

V

Q

K

S

I

L

L

L

D

S

I

V

V

V

P

D

T

N

N

P

P

V

F

R

G

A

A

L

L

M

A

D

N

G

G

N

Q

F

V

I

L

G

P

I

T

L

I

A

F

W

F

A

A

I

I

G

I

M

L

G

G

I

I

A

A

I

I

-

T

-

Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

-

V

R

R

H

K

A

S

G

A

Q

E

T

T

T

L

R

L

T

D

V

A

L

I

E

N

D

G

L

L

S

A

N

E

G

A

V

M

T

Y

V

K

I

I

V

V

R

N

V

G

V

V

I

M

R

Q

F

Y

A

A

P

P

L

I

G

G

I

V

F

F

G

A

L

L

V

I

A

A

S

Y

T

V

L

M

A

A

T

E

S

Q

G

G

F

V

G

-

A

K

L

V

G

G

Y

E

L

L

H

A

L

K

L

V

T

T

V

-

L

-

I

-

G

-

C

A

M

A

L

V

F

Y

V

V

A

G

L

L

V

T

V

L

N

Q

P

I

L

L

I

L

V

V

F

Y

W

F

K

V

L

L

R

L

R

K

-

I

-

Y

-

G

-

I

N

D

P

P

Y

I

P

S

L

F

V

I

F

K

T

K

C

A

L

-

R

K

E

D

S

A

G

M

I

L

T

T

A

A

F

F

F

V

T

T

R
|
R

S

S

S
|
S

A

S

A

G

N

T

I

L

P

P

V

V

N

T

L

M

E

R

L

V

S

A

K

K

R

E

L

M

G

G

L

I

H

S

E

E

D

G

T

I

Y

Y

S

S

V

F

S

T

I

L

P

P

L

L

G

G

A

A

T

T

I

I

N

N

M

M

A

D

G

G

A
x
T

A

A

I

L

T

Y

I

Q

T

G

V

V

L

C

T

T

L

F

A

F

A

I

V

A

H

N

T

A

L

L

G

G

binding serine: R268 (= R256), S270 (= S258), T306 (≠ A294)

Sites not aligning to the query:

binding serine: 374, 378, 381

6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate (see paper)
26% identity, 96% coverage: 12:396/402 of query aligns to 6:407/416 of 6r7rA

query
sites
6r7rA

Q

K

I

I

I

L

I

W

G

G

L

L

I

V

A

L

G

G

I

A

V

V

L

F

A

G

W

L

L

I

A

A

P

G

D
x
H

V

F

A

G

K

Y

S

A

T

G

A

A

F

V

-

K

-

T

-

Y

-

I

-

K

-

P

I

F

G

G

K

D

V

L

F

F

V

V

S

R

A

L

L

L

K

K

A

M

-

L

V

V

A

M

P

P

I

I

L

V

V

L

F

A

V

S

L

L

V

V

M

V

-

G

-

A

A

A

S

S

I

I

A

S

N

P

H

A

K

R

H

L

G

G

Q

R

E

-

T

V

H

G

I

V

R

K

P

I

I

V

L

V

F

Y

L

-

Y

Y

L

L

L

A

G

T

T

S

F

A

T

M

A

A

A

V

V

F

A

G

V

L

V

I

A

V

S

G

T

R

L

L

F

F

P

N

S

V

S

G

L

A

V

N

L

V

S

N

T

L

Q

G

D

S

V

G

A

T

V

G

T

A

A

Q

P

P

G

-

I

-

S

P

E

S

V

L

L

V

Q

Q

S

T

L

L

L

N

S

I

V

V

V

P

D

T

N

N

P

P

V

F

R

A

A

S

L

L

M

A

D

K

G

G

N

E

F

V

I

L

G

P

I

V

L

I

A

F

W

F

A

A

I

I

G

I

M

L

G

G

I

I

A

A

I

I

-

T

-

Y

-

L

-

M

-

N

-

R

-

N

-

E

-

R

-

V

R

R

H

K

A

S

G

A

Q

E

T

T

T

L

R

L

T

R

V

V

L

F

E

D

D

G

L

L

S

A

N

E

G

A

V

M

T

Y

V

L

I

I

V

V

R

G

V

G

V

V

I

M

R

Q

F

Y

A

A

P

P

L

I

G

G

I

V

F

F

G

A

L

L

V

I

A

A

S

Y

T

V

L

M

A

A

T

E

S

Q

G

G

F

V

G

-

A

R

L

V

L
x
V

G

G

Y

P

L

L

H
x
A

L

K

L

V

T

V

V

G

L

A

I

V

G

Y

C

T

M

G

L

L

F

F

V

L

A

Q

L

I

V

V

V

I

N

T

P

Y

L

F

I

I

V

L

F

L

W

K

K

V

L

F

R

G

R

I

N

D

P

P

Y

I

P

K

L

F

V

I

F

R

T

K

C

A

L

-

R

K

E

D

S

A

G

M

I

I

T

T

A

A

F

F

F

V

T

T

R
|
R

S

S

S
|
S

A

S

A

G

N

T

I

L

P

P

V

V

N

T

L

M

E

R

L

V

S

A

K

E

R

E

-

E

L

M

G

G

L

V

H

D

E

K

D

G

T

I

Y

F

S

S

V

F

S

T

I

L

P

P

L

L

G

G

A

A

T

T

I

I

N

N

M
|
M

A

D

G

G

A
x
T

A

A

I

L

T

Y

I

Q

T

G

V

V

L

T

T

V

L

L

A

F

A

V

V

A

H

N

T

A

L

I

G

G

I

H

A

P

V

L

D

T

I

L

P

G

T

Q

A

Q

V

L

L

V

S

V

V

L

V

T

A

A

A

V

I

L

C

A

A

S

C

I

G

G

A
x
T

S

A

G
|
G

V
|
V

A

P

G

G

G

A

S
x
G

L

A

L

I

L

M

I

L

P

A

L

M

A

V

C

L

S

Q

L

S

F

V

G

G

I

L

P

D

-

L

-

T

-

P

-

G

S

S

E

P

I

V

A

A

M

L

Q

-

V

-

A

A

V

Y

G

A

F

M

I

I

I

L

G

G

V

I

-

D

-

A

L

I

Q

L

D
|
D

S

M

A

G

E
x
R

T
|
T

A

M

L

V

N
|
N

S

V

S

T

T

G

D

D

V

L

L

A

F

G

T

T

A

V

A

I

A

V

C

A

L

K

G

T

E

E

E

K

E

E

binding d-aspartic acid: R263 (= R256), S265 (= S258), M299 (= M291), T302 (≠ A294), T340 (≠ A332), G342 (= G334), V343 (= V335), G347 (≠ S339), D383 (= D372), R386 (≠ E375), T387 (= T376), N390 (= N379)
binding decyl-beta-d-maltopyranoside: H23 (≠ D29), V212 (≠ L204), A216 (≠ H208)

5e9sA Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
26% identity, 99% coverage: 1:396/402 of query aligns to 2:418/427 of 5e9sA

query
sites
5e9sA

M

L

Q

R

R

R

L

Y

K

L

R

D

T

Y

S

P

L

V

V

L

T

W

Q

K

I

I

I

L

I

W

G

G

L

L

I

V

A

L

G

G

I

A

V

V

L

F

A

G

W

L

L

I

A

A

P

G

D

H

V

F

A

G

K

Y

S

A

T

G

A

A

F

V

-

K

-

T

-

Y

-

I

-

K

-

P

I

F

G

G

K

D

V

L

F

F

V

V

S

R

A

L

L

L

K

K

A

M

-

L

V

V

A

M

P

P

I

I

L

V

V

L

F

A

V

S

L

L

V

V

M

V

-

G

-

A

A

A

S

S

I

I

A

S

N

P

H

A

K

R

H

L

G

G

Q

R

E

-

T

V

H

G

I

V

R

K

P

I

I

V

L

V

F

Y

L

-

Y
|
Y

L

L

L

A

G
x
T

T
x
S

F

A

T

M

A

A

A

V

V

F

A

G

V

L

V

I

A

V

S

G

T

R

L

L

F

F

P

N

S

V

-

G

-

A

-

N

-

V

S

N

L

L

V

G

L

S

S

G

T

T

Q

G

D

K

V

A

A

I

V

E

T

A

A

Q

P

P

G

-

I

-

S

P

E

S

V

L

L

V

Q

Q

S

T

L

L

L

N

S

I

V

V

V

P

D

T

N

N

P

P

V

F

R

A

A

S

L

L

M

A

D

K

G

G

N

E

F

V

I

L

G

P

I

V

L

I

A

F

W

F

A

A

I

I

G

I

M

L

G

G

I

I

A

A

I

I

-

T

-

Y

-

L

-

M

-

N

-

R

-

N

-

E

-

R

-

V

R

R

H

K

A

S

G

A

Q

E

T

T

T

L

R

L

T

R

V

V

L

F

E

D

D

G

L

L

S

A

N

E

G

A

V

M

T

Y

V
x
L

I

I

V

V

R

G

V
x
G

V

V

I

M

R

Q

F
x
Y

A

A

P

P

L

I

G

G

I

V

F

F

G

A

L

L

V

I

A

A

S

Y

T

V

L

M

A

A

T

E

S

Q

G

G

F

V

G

-

A

R

L

V

G

G

Y

P

L

L

H

A

L

K

L

V

T

V

V

G

L

A

I

V

G

Y

C

T

M

G

L

L

F

F

V

L

A

Q

L

I

V

V

V

I

N

T

P

Y

L

F

I

I

V

L

F

L

W

K

K

V

L

F

R

G

R

I

N

D

P

P

Y

I

P

K

L

F

V

I

F

R

T

K

C

A

L

-

R

K

E

D

S

A

G

M

I

I

T

T

A

A

F

F

F

V

T

T

R
|
R

S
|
S

A

S

A

G

N

T

I

L

P

P

V

V

N

T

L

M

E

R

L

V

S

A

K

E

R

E

-

E

L

M

G

G

L

V

H

D

E

K

D

G

T

I

Y

F

S

S

V

F

S

T

I

L

P

P

L

L

G
|
G

A
|
A

T
|
T

I

I

N
|
N

M
|
M

A
x
D

G

G

A
x
T

A

A

I

L

T

Y

I

Q

T

G

V

V

L

T

T

V

L

L

A

F

A

V

V

A

H

N

T

A

L

I

G

G

I

H

A

P

V

L

D

T

I

L

P

G

T

Q

A

Q

V

L

L

V

S

V

V

L

V

T

A

A

A

V

I

L

C

A

A
x
S

C
x
I

G
|
G

A
x
T

S

A

G
|
G

V
|
V

A

P

G

G

G
x
A

S
x
G

L

A

L

I

L

M

I

L

P

A

L

M

A

V

C

L

S

Q

L

S

F

V

G

G

I

L

P

D

-

L

-

T

-

P

-

G

S

S

E

P

I

V

A

A

M

L

Q

-

V

-

A

A

V

Y

G

A

F

M

I

I

I

L

G

G

V

I

-

D

-

A

L

I

Q

L

D
|
D

S

M

A

G

E
x
R

T
|
T

A

M

L

V

N
|
N

S
x
V

S

T

T

G

D
|
D

V

L

L

A

F

G

T

T

A

V

A

I

A

V

C

A

L

K

G

T

E

E

E

K

E

E

binding aspartic acid: R274 (= R256), S275 (= S257), S276 (= S258), T313 (≠ A294), G353 (= G334), V354 (= V335), A357 (≠ G338), G358 (≠ S339), D394 (= D372), R397 (≠ E375), T398 (= T376)
binding decyl-beta-d-maltopyranoside: L194 (≠ V174), G198 (≠ V178), Y202 (≠ F182)
binding sodium ion: Y87 (= Y79), T90 (≠ G82), S91 (≠ T83), S276 (= S258), G305 (= G286), A306 (= A287), T307 (= T288), N309 (= N290), N309 (= N290), M310 (= M291), D311 (≠ A292), S348 (≠ A329), I349 (≠ C330), G350 (= G331), T351 (≠ A332), N401 (= N379), V402 (≠ S380), D405 (= D383)

6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor (see paper)
26% identity, 99% coverage: 1:396/402 of query aligns to 2:418/426 of 6xwnB

query
sites
6xwnB

M

L

Q

R

R

R

L

Y

K

L

R

D

T

Y

S

P

L

V

V

L

T

W

Q

K

I

I

I

L

I

W

G

G

L

L

I

V

A

L

G

G

I

A

V

V

L

F

A

G

W

L

L

I

A

A

P

G

D

H

V

F

A

G

K

Y

S

A

T

G

A

A

F

V

-

K

-

T

-

Y

-

I

-

K

-

P

I

F

G

G

K

D

V

L

F

F

V

V

S

R

A

L

L

L

K

K

A

M

-

L

V

V

A

M

P

P

I

I

L

V

V

L

F

A

V

S

L

L

V

V

M

V

-

G

-

A

A

A

S

S

I

I

A

S

N

P

H

A

K

R

H

L

G

G

Q

R

E

-

T

V

H

G

I

V

R

K

P

I

I

V

L

V

F

Y

L

-

Y

Y

L

L

L

A

G

T

T

S

F

A

T

M

A

A

A

V

V

F

A

G

V

L

V

I

A

V

S

G

T

R

L

L

F

F

P

N

S

V

-

G

-

A

-

N

-

V

S

N

L

L

V

G

L

S

S

G

T

T

Q

G

D

K

V

A

A

I

V

E

T

A

A

Q

P

P

G

-

I

-

S

P

E

S

V

L

L

V

Q

Q

S

T

L

L

L

N

S

I

V

V

V

P

D

T

N

N

P

P

V

F

R

A

A

S

L

L

M

A

D

K

G

G

N

E

F

V

I

L

G

P

I

V

L

I

A

F

W

F

A

A

I

I

G

I

M

L

G

G

I

I

A

A

I

I

-

T

-

Y

-

L

-

M

-

N

-

R

-

N

-

E

-

R

-

V

R

R

H

K

A

S

G

A

Q

E

T

T

T

L

R

L

T

R

V

V

L

F

E

D

D

G

L

L

S

A

N

E

G

A

V

M

T

Y

V

L

I

I

V

V

R

G

V

G

V

V

I

M

R

Q

F

Y

A

A

P

P

L

I

G

G

I

V

F

F

G

A

L

L

V

I

A

A

S

Y

T

V

L

M

A

A

T

E

S

Q

G

G

F

V

G

-

A

R

L

V

G

G

Y

P

L

L

H

A

L

K

L

V

T

V

V

G

L

A

I

V

G

Y

C

T

M

G

L

L

F

F

V

L

A

Q

L

I

V

V

V

I

N

T

P

Y

L

F

I

I

V

L

F

L

W

K

K

V

L

F

R

G

R

I

N

D

P

P

Y

I

P

K

L

F

V

I

F

R

T

K

C

A

L

-

R

K

E

D

S

A

G

M

I

I

T

T

A

A

F

F

F

V

T

T

R

R

S
|
S

A

S

A

G

N

T

I

L

P

P

V

V

N

T

L

M

E

R

L

V

S

A

K

E

R

E

-

E

L

M

G

G

L

V

H

D

E

K

D

G

T

I

Y

F

S

S

V

F

S

T

I

L

P

P

L

L

G

G

A

A

T

T

I

I

N

N

M
|
M

A

D

G

G

A
x
T

A

A

I

L

T

Y

I

Q

T

G

V

V

L

T

T

V

L

L

A

F

A

V

V

A

H

N

T

A

L

I

G

G

I

H

A

P

V

L

D

T

I

L

P

G

T

Q

A

Q

V

L

L

V

S

V

V

L

V

T

A

A

A

V

I

L

C

A

A

S

C

I

G

G

A

T

S

A

G

G

V

V

A

P

G

G

G

A

S

G

L

A

L

I

L

M

I

L

P

A

L

M

A

V

C

L

S

Q

L

S

F

V

G

G

I

L

P

D

-

L

-

T

-

P

-

G

S

S

E

P

I

V

A

A

M

L

Q

-

V

-

A

A

V

Y

G

A

F

M

I

I

I

L

G

G

V

I

-

D

-

A

L

I

Q

L

D
|
D

S

M

A

G

E
x
R

T

T

A

M

L

V

N

N

S

V

S

T

T

G

D

D

V

L

L

A

F

G

T

T

A

V

A

I

A

V

C

A

L

K

G

T

E

E

E

K

E

E

binding (3s)-3-(benzyloxy)-l-aspartic acid: S275 (= S257), S276 (= S258), M310 (= M291), T313 (≠ A294), D394 (= D372), R397 (≠ E375)

6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis) (see paper)
27% identity, 69% coverage: 118:396/402 of query aligns to 124:415/424 of 6zl4A

query
sites
6zl4A

E

S

V

L

L

V

Q

Q

S

T

L

L

L

N

S

I

V

V

V

P

D

T

N

N

P

P

V

F

R

A

A

S

L

L

M

A

D

K

G

G

N

E

F

V

I

L

G

P

I

V

L

I

A

F

W

F

A

A

I

I

G

I

M

L

G

G

I

I

A

A

I

I

-

T

-

Y

-

L

-

M

-

N

-

R

-

N

-

E

-

R

-

V

R

R

H

K

A

S

G

A

Q

E

T

T

T

L

R

L

T

R

V

V

L

F

E

D

D

G

L

L

S

A

N

E

G

A

V

M

T

Y

V
x
L

I

I

V

V

R

G

V
x
G

V

V

I

M

R

Q

F

Y

A

A

P

P

L

I

G

G

I

V

F

F

G

A

L

L

V

I

A

A

S

Y

T

V

L

M

A

A

T

E

S

Q

G

G

F

V

G

-

A

R

L

V

G

G

Y

P

L

L

H

A

L

K

L

V

T

V

V

G

L

A

I

V

G

Y

C

T

M

G

L

L

F

F

V

L

A

Q

L

I

V

V

V

I

N

T

P

Y

L

F

I

I

V

L

F

L

W

K

K

V

L

F

R

G

R

I

N

D

P

P

Y

I

P

K

L

F

V

I

F

R

T

K

C

A

L

-

R

K

E

D

S

A

G

M

I

I

T

T

A

A

F

F

F

V

T

T

R
|
R

S
|
S

A

S

A

G

N

T

I

L

P

P

V

V

N

T

L

M

E
x
R

L

V

S

A

K

E

R

E

-

E

L

M

G

G

L

V

H

D

E

K

D

G

T

I

Y

F

S

S

V

F

S

T

I

L

P

P

L

L

G

G

A

A

T

T

I

I

N

N

M
|
M

A

D

G

G

A
x
T

A

A

I

L

T

Y

I

Q

T

G

V

V

L

T

T

V

L

L

A

F

A

V

V

A

H

N

T

A

L

I

G

G

I

H

A

P

V

L

D

T

I

L

P

G

T

Q

A

Q

V

L

L

V

S

V

V

L

V

T

A

A

A

V

I

L

C

A

A

S

C

I

G

G

A

T

S

A

G

G

V

V

A

P

G
|
G

G
x
A

S

G

L

A

L

I

L

M

I

L

P

A

L

M

A

V

C

L

S

Q

L

S

F

V

G

G

I

L

P

D

-

L

-

T

-

P

-

G

S

S

E

P

I

V

A

A

M

L

Q

-

V

-

A

A

V

Y

G

A

F

M

I

I

I

L

G

G

V

I

-

D

-

A

L

I

Q

L

D

D

S

M

A

G

E
x
R

T
|
T

A

M

L

V

N

N

S

V

S

T

T

G

D

D

V

L

L

A

F

G

T

T

A

V

A

I

A

V

C

A

L

K

G

T

E

E

E

K

E

E

binding decyl-beta-d-maltopyranoside: L191 (≠ V174), G195 (≠ V178), R282 (≠ E267)
binding (2~{S},3~{S})-2-azanyl-3-[[4-[2-(4-methoxyphenyl)hydrazinyl]phenyl]methoxy]butanedioic acid: R271 (= R256), S272 (= S257), S273 (= S258), M307 (= M291), T310 (≠ A294), G353 (= G337), A354 (≠ G338), R394 (≠ E375), T395 (= T376)

Sites not aligning to the query:

binding decyl-beta-d-maltopyranoside: 3

6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound (see paper)
27% identity, 69% coverage: 118:396/402 of query aligns to 125:416/425 of 6zgbA

query
sites
6zgbA

E

S

V

L

L

V

Q

Q

S

T

L

L

L

N

S

I

V

V

V

P

D

T

N

N

P

P

V

F

R

A

A

S

L

L

M

A

D

K

G

G

N

E

F

V

I

L

G

P

I

V

L

I

A

F

W

F

A

A

I

I

G

I

M

L

G

G

I

I

A

A

I

I

-

T

-

Y

-

L

-

M

-

N

-

R

-

N

-

E

-

R

-

V

R

R

H

K

A

S

G

A

Q

E

T

T

T

L

R

L

T

R

V

V

L

F

E

D

D

G

L

L

S

A

N

E

G

A

V

M

T

Y

V

L

I

I

V

V

R

G

V

G

V

V

I

M

R

Q

F

Y

A

A

P

P

L

I

G

G

I

V

F

F

G

A

L

L

V

I

A

A

S

Y

T

V

L

M

A

A

T

E

S

Q

G

G

F

V

G

-

A

R

L

V

G

G

Y

P

L

L

H

A

L

K

L

V

T

V

V

G

L

A

I

V

G

Y

C

T

M

G

L

L

F

F

V

L

A

Q

L

I

V

V

V

I

N

T

P

Y

L

F

I

I

V

L

F

L

W

K

K

V

L

F

R

G

R

I

N

D

P

P

Y

I

P

K

L

F

V

I

F

R

T

K

C

A

L

-

R

K

E

D

S

A

G

M

I

I

T

T

A

A

F

F

F

V

T

T

R
|
R

S
|
S

A

S

A

G

N

T

I

L

P

P

V

V

N

T

L

M

E

R

L

V

S

A

K

E

R

E

-

E

L

M

G

G

L

V

H

D

E

K

D

G

T

I

Y

F

S

S

V

F

S

T

I

L

P

P

L

L

G

G

A

A

T

T

I

I

N

N

M
|
M

A

D

G

G

A

T

A

A

I

L

T

Y

I

Q

T

G

V

V

L

T

T

V

L

L

A

F

A

V

V

A

H

N

T

A

L

I

G

G

I

H

A

P

V

L

D

T

I

L

P

G

T

Q

A

Q

V

L

L

V

S

V

V

L

V

T

A

A

A

V

I

L

C

A

A

S

C

I

G

G

A

T

S

A

G

G

V

V

A

P

G

G

G

A

S

G

L

A

L

I

L

M

I

L

P

A

L

M

A

V

C

L

S

Q

L

S

F

V

G

G

I

L

P

D

-

L

-

T

-

P

-

G

S

S

E

P

I

V

A

A

M

L

Q

-

V

-

A

A

V

Y

G

A

F

M

I

I

I

L

G

G

V

I

-

D

-

A

L

I

Q

L

D
|
D

S

M

A

G

E
x
R

T
|
T

A

M

L

V

N

N

S

V

S

T

T

G

D

D

V

L

L

A

F

G

T

T

A

V

A

I

A

V

C

A

L

K

G

T

E

E

E

K

E

E

binding (2~{S},3~{S})-2-azanyl-3-[(2-nitrophenyl)methoxy]butanedioic acid: R272 (= R256), S273 (= S257), S274 (= S258), M308 (= M291), D392 (= D372), R395 (≠ E375), T396 (= T376)

7awmA Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
25% identity, 95% coverage: 4:385/402 of query aligns to 17:393/412 of 7awmA

query
sites
7awmA

L

L

K

R

R

R

T

N

S

A

L

L

V

L

T

L

Q

L

I

T

I

V

I

L

G

A

L

V

I

I

A

L

G

G

I

V

V

V

L

L

A

G

W

F

L

L

-

L

-

R

-

P

-

Y

-

P

-

L

A

S

P

P

D

R

V

E

A

V

K

K

S

Y

T

F

A

A

F

F

I

P

G

G

K

E

V

L

F

L

V

M

S

R

A

M

L

L

K

K

A

M

-

L

V

I

A

L

P

P

I

L

L

I

V

V

F

S

V

S

L

L

V

I

-

T

-

G

M

L

A

A

S

S

I

L

A

D

N

A

H

K

K

A

H
x
S

G
|
G

Q

R

E

-

T

L

H
x
G

I

M

R

R

P
x
A

I
x
V

L

V

F

Y

L

-

Y
|
Y

L

M

L

S

G

T

T

T

F

I

T

I

A

A

A

V

V

V

V

L

A

G

V

I

-

L

-

V

-

L

-

I

-

H

-

P

-

E

-

V

-

L

-

D

-

C

-

F

-

L

-

D

-

L

A

A

S

R

T

N

L

I

F

F

P

P

S

S

S

N

L

L

V

V

-

S

-

A

-

F

-

R

-

S

L

Y

S

S

T

T

Q

Q

D

E

V

V

A

-

V

-

T

-

A

-

P

-

G

-

I

-

S

-

E

-

V

-

L

-

Q

-

S

-

L

-

S

-

V

-

D

-

N

-

P

-

V

-

R

-

A

-

L

-

M

-

D

E

G

G

-

M

N

N

F

I

I

L

G

G

I

L

L

V

A

V

W

F

A

S

I
x
M

G

V

M

F

G

G

I
x
F

A

A

I

L

R

G

H

K

A

M

G

G

Q

E

T

Q

T

G

R

Q

T

L

V

L

L

V

E

D

-

F

-

N

D

S

L

L

S

N

N

E

G

A

V

T

T

M

V

K

I

L

V

V

R

A

V

I

I

M

R

W

F

Y

A

A

P

P

L

L

G

G

I

I

F

L

G

F

L

L

V

I

A

A

S

G

T

K

L

I

A

V

T

-

S

-

G

-

F

-

G

G

A

G

L

Q

L

L

G

G

Y

-

L

M

H

Y

L

M

L

V

T

T

V

V

L

I

I

V

G

G

C

L

M

V

L

I

F

H

V

-

A

G

L

L

V

I

V

V

N

L

P

P

L

L

I

I

V

Y

F

F

W

L

K

I

L

T

R

R

R

K

N

N

P

P

Y

F

P

V

L

F

V

I

F

A

T

G

C

I

L

L

R

-

E

Q

S

A

G

L

I

I

T

T

A

A

F

L

F

G

T

T

R

S

S
|
S

A

S

A

A

N

T

I

L

P

P

V

I

N

T

L

F

E

K

-

C

L

L

S

E

K

E

R

N

L

N

G

G

L

V

H

D

E

K

D

R

T

I

Y

T

S

R

V
x
F

S

V

I

L

P

P

L
x
V

G

G

A

A

T

T

I

I

N

N

M

M

A

D

G

G

A
x
T

A

A

I

L

T

Y

I

E

T

A

V

V

L

A

T

A

L

I

A

F

A

I

V

A

H

Q

T

V

L

N

G

N

I

Y

A

E

V

L

D

D

I

F

P

G

T

Q

A

I

V

I

L

T

L

I

S

S

V

I

V

T

A

A

A

T

I

A

C

A

A

S

C

I

G

G

A

A

S

A

G
|
G

V
x
I

A

P

G

Q

G
x
A

S
x
G

L

L

L

V

L

T

I

M

P

V

L

I

A

V

C

L

S

T

L

A

F

V

G

G

I

L

P

P

S

T

E

D

I

D

A

I

M

T

Q

L

V

I

A

A

V

V

G

D

F

W

I

L

G

-

V

-

L

-

Q

-

D
|
D

S

R

A

F

E
x
R

T
|
T

A

M

L

V

N

N

S

V

S

L

T

G

D

D

V

A

L

L

binding 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile: S88 (≠ H66), G89 (= G67), G92 (≠ H71), A95 (≠ P74), V96 (≠ I75), Y99 (= Y79), M163 (≠ I148), F167 (≠ I152), F293 (≠ V281), V297 (≠ L285)
binding aspartic acid: S268 (= S257), S269 (= S258), T306 (≠ A294), G346 (= G334), I347 (≠ V335), A350 (≠ G338), G351 (≠ S339), D380 (= D372), R383 (≠ E375), T384 (= T376)

5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101 (see paper)
25% identity, 95% coverage: 4:385/402 of query aligns to 9:379/397 of 5mjuA

query
sites
5mjuA

L

L

K

R

R

R

T

N

S

A

L

L

V

L

T

L

Q

L

I

T

I

V

I

L

G

A

L

V

I

I

A

L

G

G

I

V

V

V

L

L

A

G

W

F

L

L

-

L

-

R

-

P

-

Y

-

P

-

L

A

S

P

P

D

R

V

E

A

V

K

K

S

Y

T

F

A

A

F

F

I

P

G

G

K

E

V

L

F

L

V

M

S

R

A

M

L

L

K

K

A

M

-

L

V

I

A

L

P

P

I

L

L
x
I

V

V

F

S

V

S

L

L

V

I

-

T

-

G

M
x
L

A

A

S

S

I

L

A

D

N

A

H

K

K

A

H
x
S

G
|
G

Q

R

E

-

T

L

H
x
G

I

M

R

R

P

A

I

V

L

V

F

Y

L

-

Y
|
Y

L

M

L

S

G

T

T

T

F

I

T

I

A

A

A

V

V

V

V

L

A

G

V

I

-

L

-

V

-

L

-

I

-

H

-

E

-

V

-

L

-

D

-

C

-

F

-

L

-

D

-

L

A

A

S

R

T

N

L

I

F

F

P

P

S

S

S

N

L

L

V

V

L

-

S

-

T

-

Q

-

D

-

V

-

A

-

V

-

T

-

A

-

P

-

G

-

I

-

S

S

E

A

V

A

L

F

Q

R

S

S

L

Y

L

-

S

S

V

T

D

G

N

Q

P

E

V

V

R

E

A

G

L

M

M

-

D

-

G

-

N

N

F
x
I

I

L

G

G

I

L

L

V

A

V

W

F

A

S

I
x
M

G

V

M

F

G

G

I
x
F

A

A

I

L

R

G

H

K

A

M

G

G

Q

E

T

Q

T

G

R

Q

T

L

V

L

L

V

E

D

-

F

-

N

D

S

L

L

S

N

N

E

G

A

V

T

T

M

V

K

I

L

V

V

R

A

V

I

I

M

R

W

F

Y

A

A

P

P

L

L

G

G

I

I

F

L

G

F

L

L

V

I

A

A

S

G

T

K

L

I

A

V

T

E

S

G

G

Q

F

L

G

G

A

-

L

-

G

-

Y

-

L

M

H

Y

L

M

L

V

T

T

V

V

L

I

I

V

G

G

C

L

M

V

L

I

F

H

V

-

A

G

L

L

V

I

V

V

N

L

P

P

L

L

I

I

V

Y

F

F

W

L

K

I

L

T

R

R

R

K

N

N

P

P

Y

F

P

V

L

F

V

I

F

A

T

G

C

I

L

L

R

-

E

Q

S

A

G

L

I

I

T

T

A

A

F

L

F

G

T

T

R

S

S

S

S
|
S

A
x
S

A

A

N

T

I

L

P

P

V

I

N

T

L

F

E

K

-

C

L

L

S

E

K

E

R

N

L

N

G

G

L

V

H

D

E

K

D

R

T

I

Y

T

S

R

V
x
F

S

V

I

L

P

P

L
x
V

G

G

A
|
A

T
|
T

I

I

N

N

M
|
M

A

D

G

G

A
x
T

A

A

I

L

T

-

I

-

T

-

V

-

L

-

T

-

L

Y

A

E

A

A

V

V

H

A

T

A

L

I

G

F

I

I

A

A

V

-

D

Q

I

V

P

N

T

Q

A

I

V

I

L

T

L

I

S

S

V

I

V

T

A

A

A

T

I

A

C

A

A

S

C

I

G
|
G

A

A

S

A

G

G

V

I

A

P

G

Q

G
x
A

S
x
G

L

L

L

V

L

T

I

M

P

V

L

I

A

V

C

L

S

T

L

A

F

V

G

G

I

L

P

P

S

T

E

D

I

D

A

I

M

T

Q

L

V

I

A

A

V

V

G

D

F

W

I

L

G

-

V

-

L

-

Q

-

D
|
D

S

R

A

F

E
x
R

T

T

A

M

L

V

N
|
N

S

V

S

L

T

G

D

D

V

A

L

L

binding 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile: L72 (≠ M58), S80 (≠ H66), G81 (= G67), G84 (≠ H71), Y91 (= Y79), M156 (≠ I148), F160 (≠ I152), F286 (≠ V281), V290 (≠ L285)
binding (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid: I64 (≠ L52), I148 (≠ F140), S262 (= S258), S263 (≠ A259), A292 (= A287), T293 (= T288), M296 (= M291), T299 (≠ A294), G329 (= G331), A336 (≠ G338), G337 (≠ S339), D366 (= D372), R369 (≠ E375), N373 (= N379)

P56564 Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Mus musculus (Mouse) (see paper)
27% identity, 60% coverage: 131:371/402 of query aligns to 233:479/543 of P56564

query
sites
P56564

P

P

V

V

R

P

A

G

L

S

M

V

D

N

G

G

-

V

N

N

F

A

I

L

G

G

I

L

L

V

A

V

W

F

A

S

I

M

G

C

M

F

G

G

I

F

A

V

I

I

-

G

-

N

-

M

R

K

H

E

A

Q

G

G

Q

Q

T

A

T

L

R

R

T

E

V

F

L

F

E

D

D

S

L

L

S

N

N

E

G

A

V

I

T

M

V

R

I

L

V

V

R

A

V

V

V

I

I

M

R

W

F

Y

A

A

P

P

L

L

G

G

I

I

F

L

G

F

L

L

V

I

A

A

S

G

T

K

L

I

A

V

T

E

-

M

S

E

G

D

F

M

G

G

A

V

L

I

L

G

G

G

Y

Q

L

L

-

A

-

M

H

Y

L

T

L

V

T

T

V

V

L

I

I

V

G

G

C

-

M

L

L

L

F

I

V

H

A

A

L

V

V

I

V

V

N

L

P

P

L

L

I

L

V

Y

F

F

W

L

K

V

L

T

R

R

R

K

N

N

P

P

Y

W

P

V

L

F

V

I

F

G

T

G

C

L

L

L

R

-

E

Q

S

A

G

L

I

I

T

T

A

A

F

L

F

G

T

T

R

S

S

S

A

S

A

A

N

T

I

L

P

P

V

I

N

T

L

F

E

K

-

C

L

L

S

E

K

E

R

N

L

N

G

G

L

V

H

D

E

K

D

R

T

I

Y

T

S

R

V

F

S

V

I

L

P

P

L

V

G

G

A

A

T

T

I

I

N

N

M

M

A

D

G

G

A

T

A

A

I

L

T

Y

I

E

T

A

V

L

L

A

T

A

L

I

A

F

A

I

V

A

H

Q

T

V

L

N

G

N

I

F

A

D

V

L

D

N

I

F

P

G

T

Q

A

I

V

I

L

T

L

I

S

S

V

I

V

T

A

A

A

T

I

A

C

A

A

S

C

I

G

G

A

A

S

A

G

G

V

I

A

P

G

Q

G

A

S

G

L

L

L

V

L

T

I

M

P

V

L

I

A

V

C

L

S

T

L

S

F

V

G

G

I

L

P

P

S

T

E

D

I

D

A

I

M

T

Q

L

V

I

A

A

V

V

G

D

F

W

I

F

I

L

G

D

V

R

L

L

Q

R

Sites not aligning to the query:

206 modified: carbohydrate, N-linked (GlcNAc...) asparagine
216 modified: carbohydrate, N-linked (GlcNAc...) asparagine

P43003 Excitatory amino acid transporter 1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Homo sapiens (Human) (see 3 papers)
26% identity, 60% coverage: 131:371/402 of query aligns to 233:479/542 of P43003

query
sites
P43003

P

P

V

V

R

P

A

G

L

S

M

V

D

N

G

G

-

V

N

N

F

A

I

L

G

G

I

L

L

V

A

V

W

F

A

S

I

M

G

C

M

F

G

G

I

F

A

V

I

I

-

G

-

N

-

M

R

K

H

E

A

Q

G

G

Q

Q

T

A

T

L

R

R

T

E

V

F

L

F

E

D

D

S

L

L

S

N

N

E

G

A

V

I

T

M

V

R

I

L

V

V

R

A

V

V

V

I

I

M

R

W

F

Y

A

A

P

P

L

V

G

G

I

I

F

L

G

F

L

L

V

I

A

A

S

G

T

K

L

I

A

V

T

E

-

M

S

E

G

D

F

M

G

G

A

V

L

I

L

G

G

G

Y

Q

L

L

-

A

-

M

H

Y

L

T

L

V

T

T

V

V

L

I

I

V

G

G

C

-

M

L

L

L

F

I

V

H

A

A

L

V

V

I

V

V

N

L

P

P

L

L

I

L

V

Y

F

F

W

L

K

V

L

T

R

R

R

K

N

N

P

P

Y

W

P

V

L

F

V

I

F

G

T

G

C

L

L

L

R

-

E

Q

S

A

G

L

I

I

T

T

A

A

F

L

F

G

T

T

R
x
S

S
|
S

A

S

A

A

N

T

I

L

P

P

V

I

N

T

L

F

E

K

-

C

L

L

S

E

K

E

R

N

L

N

G

G

L

V

H

D

E

K

D

R

T

V

Y

T

S

R

V

F

S

V

I

L

P

P

L

V

G

G

A

A

T
|
T

I

I

N

N

M

M

A

D

G

G

A
x
T

A

A

I

L

T

Y

I

E

T

A

V

L

L

A

T

A

L

I

A

F

A

I

V

A

H

Q

T

V

L

N

G

N

I

F

A

E

V

L

D

N

I

F

P

G

T

Q

A

I

V

I

L

T

L

I

S

S

V

I

V

T

A

A

A

T

I

A

C

A

A

S

C

I

G

G

A

A

S

A

G

G

V
x
I

A
x
P

G
x
Q

G
x
A

S
x
G

L

L

L

V

L

T

I

M

P

V

L

I

A

V

C

L

S

T

L

S

F

V

G

G

I

L

P

P

S

T

E

D

I

D

A

I

M

T

Q

L

V

I

A

A

V

V

G

D

F

W

I

F

I

L

G
x
D

V
x
R

L

L

Q

R

S363 (≠ R256) mutation to R: Loss of electrogenic glutamate transport. Strongly decreased L-aspartate and L-glutamate uptake combined with strongly increased permeability ot other ions; when associated with M-477.
SSS 363:365 (≠ RSS 256:258) binding
T396 (= T288) binding
T402 (≠ A294) binding
IPQAG 443:447 (≠ VAGGS 335:339) binding
D476 (≠ G368) binding
R477 (≠ V369) mutation to M: Strongly decreased L-aspartate and L-glutamate uptake combined with strongly increased permeability ot other ions; when associated with R-363.

Sites not aligning to the query:

483 binding
523 Y→F: No effect on activity.

Q10901 Excitatory amino acid transporter; Sodium-dependent glutamate/ aspartate transporter from Caenorhabditis elegans (see paper)
27% identity, 65% coverage: 139:401/402 of query aligns to 204:473/503 of Q10901

query
sites
Q10901

N

N

F

V

I

L

G

G

I

V

L

I

A

V

W

F

A

C

I

I

G

A

M

I

G

G

I

I

A

S

I

L

R

S

H

Q

A

L

G

G

Q

Q

T

E

T

A

R

H

T

V

V

M

L

V

E

Q

D

F

-

F

-

V

-

I

L

M

S

D

N

K

G

V

V

I

T

M

V

K

I

L

V

V

R

M

V

T

V

V

I

M

R

W

F

Y

A

S

P

P

L

F

G

G

I

I

F

F

G

C

L

L

V

I

A

M

-

G

-

K

-

I

-

L

-

E

-

I

S

H

T

D

L

L

A

A

T

D

S

T

G

-

F

-

G

-

A

A

L

R

L

M

G

L

Y

A

L

M

H

Y

L

M

L

V

T

T

V

V

L

L

I

S

G

G

C

L

M

A

L

I

F

H

V

-

A

S

L

L

V

I

V

S

N

L

P

P

L

L

I

I

V

F

F

F

W

V

K

T

L

T

R

K

N

N

P

P

Y

Y

P

-

L

V

V

F

F

M

T

R

C

G

L

L

R

F

E

Q

S

A

G

W

I

I

T

T

A

A

F

L

F

G

T

T

R

A

S

S

A

S

A

A

N

T

I

L

P

P

V

I

N

T

L

F

E

N

-

C

L

L

S

E

K

E

R

N

L

L

G

G

L

V

H

D

E

R

D

R

T

V

Y

T

S

R

V

F

S

V

I

L

P

P

L

V

G

G

A

A

T

T

I

I

N

N

M

M

A

D

G

G

A

T

A

A

I

L

T

Y

I

E

T

A

V

V

L

A

T

A

L

I

A

F

A

I

V

A

H

Q

T

I

L

N

G

G

I

V

A

H

V

L

D

S

I

F

P

G

T

Q

A

V

V

V

L

T

L

V

S

S

V

L

V

T

A

A

A

T

I

L

C

A

A

S

C

I

G

G

A

A

S

A

G

S

V

V

A

P

G

S

G

A

S

G

L

L

L

V

L

T

I

M

P

L

L

L

A

V

C

L

S

T

L

A

F

V

G

G

I

L

P

P

S

V

E

K

I

D

A

V

M

S

Q

L

V

I

V

V

A

A

V

V

G

D

F

W

I

L

G

-

V

-

L

-

Q

-

D

D

S

R

A

I

E

R

T

T

A

S

L

I

N

N

S

V

S

L

T

G

D

D

-

A

-

M

-

G

-

A

-

G

-

I

V

V

L

Y

F

H

T

Y

A

S

A

K

A

A

C

D

L

L

G

D

E

A

E

H

E

D

K

R

L

L

A

A

R

A

T

T

Sites not aligning to the query:

177 modified: carbohydrate, N-linked (GlcNAc...) asparagine
187 modified: carbohydrate, N-linked (GlcNAc...) asparagine

7xr4A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with glutamate (see paper)
25% identity, 95% coverage: 2:383/402 of query aligns to 3:404/425 of 7xr4A

query
sites
7xr4A

Q

D

R

K

L

L

K

G

R

K

T

N

S

L

L

L

V

L

T

T

Q

L

I

T

I

V

I

F

G

G

L

V

I

I

A

L

G

G

I

A

V

V

L

C

A

G

W

G

L

L

-

L

-

R

-

L

-

A

-

S

-

P

-

I

A

H

P

P

D

D

V

V

A

V

K

M

S

L

T

I

A

A

F

F

I

P

G

G

K

D

V

I

F

L

V

M

S

R

A

M

L

L

K

K

A

M

-

L

V

I

A

L

P

P

I

L

L

I

V

I

F

S

V

S

L

L

V

I

M

T

A

G

-

L

S

S

I

G

A

L

N

D

H

A

K

K

H

A

G

S

Q

G

E
x
R

T

L

H

G

I

T

R

R

P

A

I

M

L

V

F

Y

L

-

Y

Y

L

M

L

S

G

T

T

T

F

I

T

I

A

A

V

V

V

L

A

G

V

V

V

I

-

L

-

V

-

L

-

A

-

I

-

H

-

P

-

G

-

N

-

P

-

K

-

V

-

S

-

L

-

D

-

A

-

F

-

L

-

D

-

L

A

I

S

R

T

N

L

L

F

F

P

P

S

E

S

N

L

L

V

V

L

Q

S

A

T

C

Q

-

D

-

V

-

A

-

V

-

T

-

A

-

P

-

G

-

I

-

S

F

E

Q

V

Q

L

I

Q

Q

S

T

L

V

L

T

L

K

S

K

V

V

D

I

N

K

P

K

V

G

R

L

A

E

L

F

M

K

D

D

G

G

-

M

N

N

F

V

I

L

G

G

I

L

L

I

A

G

W

F

A

F

I

I

G

A

M

F

G

G

I

I

A

A

I

M

R

G

H

K

A

M

G

G

Q

D

T

Q

T

A

R

K

T

L

V

M

L

V

E

D

D

F

L

F

S

N

N

I

G

L

V

N

T

E

V

I

I

V

V

M

R

K

V

L

V

V

I

I

R

M

-

I

-

M

-

W

F

Y

A

S

P

P

L

L

G

G

I

I

F

A

G

C

L

L

V

I

-

C

A

G

S

K

T

I

L

I

A

A

T

I

S

K

G

D

F

L

G

E

A

V

L

V

-

A

-

R

-

Q

L

L

G

G

Y

-

L

M

H

Y

L

M

L

V

T

T

V

V

L

I

I

I

G

G

C

L

M

I

L

I

F

H

V

G

A

G

L

I

V

F

V

L

N

-

P

P

L

L

I
|
I

V

Y

F

F

W

V

K

V

L

T

R

R

R

K

N

N

P

P

Y

F

P

S

L

F

V

-

F

F

T

A

C

G

L

I

R

F

E

Q

S

A

G

W

I

I

T

T

A

A

F

L

F

G

T

T

R

A

S

S

S
|
S

A

A

A

G

N

T

I

L

P

P

V

V

N

T

L

F

E

R

-

C

L

L

S

E

K

E

R

N

L

L

G

G

L

I

H

D

E

K

D

R

T

V

Y

T

S

R

V

F

S

V

I

L

P

P

L

V

G

G

A

A

T

T

I

I

N

N

M
|
M

A

D

G

G

A
x
T

A

A

I

L

T

Y

I

E

T

A

V

V

L

A

T

A

L

I

A

F

A

I

V

A

H

Q

T

M

L

N

G

G

I

V

A

V

V

L

D

D

I

G

P

G

T

Q

A

I

V

V

L

T

L

V

S

S

V

L

V

T

A

A

A

T

I

L

C

A

A

S

C

V

G

G

A

A

S

A

G
x
S

V

I

A

P

G

S

G

A

S
x
G

L

L

L

V

L

T

I

M

P

L

L

L

A

I

C

L

S

T

L

A

F

V

G

G

I

L

P

P

S

T

E

E

I

D

A

I

M

S

Q

L

V

L

V

V

A

A

V

V

G

D

F

W

I

L

G

-

V

-

L

-

Q

-

D
|
D

S

R

A

M

E
x
R

T
|
T

A

S

L

V

N
|
N

S

V

T

G

D

D

binding glutamic acid: S282 (= S258), M316 (= M291), T319 (≠ A294), S359 (≠ G334), G364 (≠ S339), D393 (= D372), R396 (≠ E375), T397 (= T376), N400 (= N379)
binding cholesterol hemisuccinate: R79 (≠ E69), I253 (= I228)

P31596 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2 from Rattus norvegicus (Rat) (see paper)
28% identity, 61% coverage: 137:383/402 of query aligns to 237:485/573 of P31596

query
sites
P31596

D

D

G

G

-

M

N

N

F

V

I

L

G

G

I

L

L

I

A

G

W

F

A

F

I

I

G

A

M

F

G

G

I

I

A

A

I

M

R

G

H

K

A

M

G

G

Q

E

T

Q

T

A

R

K

T

L

V

M

L

V

E

E

D

F

L

F

S

N

N

I

G

L

V

N

T

E

V

I

I

V

V

M

R

K

V

L

V

V

I

I

R

M

-

I

-

M

-

W

F

Y

A

S

P

P

L

L

G

G

I

I

F

A

G

C

L

L

V

I

A

C

S

G

T
x
K

L

I

-

I

A

A

T

I

S

K

G

D

F

L

G

E

A

V

L

V

L

A

G

R

Y

Q

L

L

-

G

-

M

H

Y

L

M

L

I

T

T

V

V

L

I

I

V

G

G

C

L

M

I

L

I

F
x
H

V

G

A

G

L

I

V

F

V

L

N

-

P

P

L

L

I

I

V

Y

F

F

W

V

K

V

L

T

R

R

R

K

N

N

P

P

Y

F

P

S

L

F

V

-

F

F

T

A

C

G

L

I

R

F

E

Q

S

A

G

W

I

I

T

T

A

A

F

L

F

G

T

T

R

A

S

S

A

A

A

G

N

T

I

L

P

P

V

V

N

T

L

F

E

R

-

C

L

L

S

E

K

D

R

N

L

L

G

G

L

I

H

D

E

K

D

R

T

V

Y

T

S

R

V

F

S

V

I

L

P

P

L

V

G

G

A

A

T

T

I

I

N

N

M

M

A

D

G

G

A

T

A

A

I

L

T

Y

I

E

T

A

V

V

L

A

T

A

L

I

A

F

A

I

V

A

H

Q

T

M

L

N

G

G

I

V

A

I

V

L

D

D

I

G

P

G

T

Q

A

I

V

V

L

T

L

V

S

S

V

L

V

T

A

A

A

T

I

L

C

A

A

S

C

I

G

G

A

A

S

A

G

S

V

I

A

P

G

S

G

A

S

G

L

L

L

V

L

T

I

M

P

L

L

L

A

I

C

L

S

T

L

A

F

V

G

G

I

L

P

P

S

T

E

E

I

D

A

I

M

S

Q

L

V

L

V

V

A

A

V

V

G

D

F

W

I

L

G

-

V

-

L

-

Q

-

D

D

S

R

A

M

E

R

T

T

A

S

L

V

N

N

S

V

T

G

D

D

K298 (≠ T194) mutation K->H,R: Normal transporter activity.; mutation K->N,T: Reduced transporter activity.
H326 (≠ F219) mutation H->N,T,K,R: No transporter activity.

P43006 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 from Mus musculus (Mouse) (see paper)
28% identity, 61% coverage: 137:383/402 of query aligns to 237:485/572 of P43006

query
sites
P43006

D

D

G

G

-

M

N

N

F

V

I

L

G

G

I

L

L

I

A

G

W

F

A

F

I

I

G

A

M

F

G

G

I

I

A

A

I

M

R

G

H

K

A

M

G

G

Q

E

T

Q

T

A

R

K

T

L

V

M

L

V

E

E

D

F

L

F

S

N

N

I

G

L

V

N

T

E

V

I

I

V

V

M

R

K

V

L

V

V

I

I

R

M

-

I

-

M

-

W

F

Y

A

S

P

P

L

L

G

G

I

I

F

A

G

C

L

L

V

I

A

C

S

G

T

K

L

I

-

I

A

A

T

I

S

K

G

D

F

L

G

E

A

V

L

V

L

A

G

R

Y

Q

L

L

-

G

-

M

H

Y

L

M

L

I

T

T

V

V

L

I

I

V

G

G

C

L

M

I

L

I

F

H

V

G

A

G

L

I

V

F

V

L

N

-

P

P

L

L

I

I

V

Y

F

F

W

V

K

V

L

T

R

R

R

K

N

N

P

P

Y

F

P

S

L

F

V

-

F

F

T

A

C

G

L

I

R

F

E

Q

S

A

G

W

I

I

T

T

A

A

F

L

F

G

T

T

R

A

S

S

A

A

A

G

N

T

I

L

P

P

V

V

N

T

L

F

E

R

-

C

L

L

S

E

K

D

R

N

L

L

G

G

L

I

H

D

E

K

D

R

T

V

Y

T

S

R

V

F

S

V

I

L

P

P

L

V

G

G

A

A

T

T

I

I

N

N

M

M

A

D

G

G

A

T

A

A

I

L

T

Y

I

E

T

A

V

V

L

A

T

A

L

I

A

F

A

I

V

A

H

Q

T

M

L

N

G

G

I

V

A

I

V

L

D

D

I

G

P

G

T

Q

A

I

V

V

L

T

L

V

S

S

V

L

V

T

A

A

A

T

I

L

C

A

A

S

C

I

G

G

A

A

S

A

G

S

V

I

A

P

G

S

G

A

S

G

L

L

L

V

L

T

I

M

P

L

L

L

A

I

C

L

S

T

L

A

F

V

G

G

I

L

P

P

S

T

E

E

I

D

A

I

M

S

Q

L

V

L

V

V

A

A

V

V

G

D

F

W

I

L

G

-

V

-

L

-

Q

-

D

D

S

R

A

M

E

R

T

T

A

S

L

V

N

N

S

V

T

G

D

D

Sites not aligning to the query:

38 modified: S-palmitoyl cysteine; C→S: Severely impairs glutamate uptake activity.

Query Sequence

>Pf6N2E2_2230 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_2230
MQRLKRTSLVTQIIIGLIAGIVLAWLAPDVAKSTAFIGKVFVSALKAVAPILVFVLVMAS
IANHKHGQETHIRPILFLYLLGTFTAAVVAVVASTLFPSSLVLSTQDVAVTAPGGISEVL
QSLLLSVVDNPVRALMDGNFIGILAWAIGMGIAIRHAGQTTRTVLEDLSNGVTVIVRVVI
RFAPLGIFGLVASTLATSGFGALLGYLHLLTVLIGCMLFVALVVNPLIVFWKLRRNPYPL
VFTCLRESGITAFFTRSSAANIPVNLELSKRLGLHEDTYSVSIPLGATINMAGAAITITV
LTLAAVHTLGIAVDIPTAVLLSVVAAICACGASGVAGGSLLLIPLACSLFGIPSEIAMQV
VAVGFIIGVLQDSAETALNSSTDVLFTAAACLGEEEKLARTA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory