Comparing Pf6N2E2_3299 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_3299 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5hwnB Crystal structure of keto-deoxy-d-galactarate dehydratase complexed with pyruvate (see paper)
51% identity, 100% coverage: 1:303/303 of query aligns to 1:302/310 of 5hwnB
4ur8A Crystal structure of keto-deoxy-d-galactarate dehydratase complexed with 2-oxoadipic acid (see paper)
51% identity, 100% coverage: 1:303/303 of query aligns to 1:302/304 of 4ur8A
7mjfA Crystal structure of candidatus liberibacter solanacearum dihydrodipicolinate synthase with pyruvate and succinic semi-aldehyde bound in active site
28% identity, 89% coverage: 19:289/303 of query aligns to 10:279/296 of 7mjfA
Sites not aligning to the query:
7lvlA Dihydrodipicolinate synthase bound with allosteric inhibitor (s)- lysine from candidatus liberibacter solanacearum
28% identity, 89% coverage: 19:289/303 of query aligns to 10:279/296 of 7lvlA
Q07607 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; Protein MosA; EC 4.3.3.7 from Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
29% identity, 85% coverage: 37:293/303 of query aligns to 27:281/292 of Q07607
Q8UGL3 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
28% identity, 90% coverage: 19:292/303 of query aligns to 10:281/294 of Q8UGL3
4i7wA Agrobacterium tumefaciens dhdps with lysine and pyruvate
29% identity, 72% coverage: 19:235/303 of query aligns to 10:227/294 of 4i7wA
4dxvA Crystal structure of dihydrodipicolinate synthase from acinetobacter baumannii complexed with mg and cl ions at 1.80 a resolution
31% identity, 72% coverage: 19:236/303 of query aligns to 10:228/291 of 4dxvA
3u8gA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with oxalic acid at 1.80 a resolution
31% identity, 72% coverage: 19:236/303 of query aligns to 10:228/291 of 3u8gA
Sites not aligning to the query:
3tdfA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 2-ketobutanoic acid at 1.99 a resolution
31% identity, 72% coverage: 19:236/303 of query aligns to 10:228/291 of 3tdfA
Sites not aligning to the query:
3tceA Crystal structure of the complex of dihydrodipicolinate synthase from acinetobacter baumannii with 5-hydroxylysine at 2.6 a resolution
31% identity, 72% coverage: 19:236/303 of query aligns to 10:228/291 of 3tceA
3rk8A Crystal structure of the chloride inhibited dihydrodipicolinate synthase from acinetobacter baumannii complexed with pyruvate at 1.8 a resolution
31% identity, 72% coverage: 19:236/303 of query aligns to 10:228/291 of 3rk8A
Sites not aligning to the query:
3pueB Crystal structure of the complex of dhydrodipicolinate synthase from acinetobacter baumannii with lysine at 2.6a resolution
31% identity, 72% coverage: 19:236/303 of query aligns to 10:228/291 of 3pueB
Sites not aligning to the query:
3na8A Crystal structure of a putative dihydrodipicolinate synthetase from pseudomonas aeruginosa
27% identity, 95% coverage: 13:299/303 of query aligns to 5:289/291 of 3na8A
3di1B Crystal structure of the staphylococcus aureus dihydrodipicolinate synthase-pyruvate complex (see paper)
27% identity, 86% coverage: 36:295/303 of query aligns to 29:291/291 of 3di1B
Sites not aligning to the query:
Q5HG25 4-hydroxy-tetrahydrodipicolinate synthase; HTPA synthase; EC 4.3.3.7 from Staphylococcus aureus (strain COL) (see paper)
27% identity, 86% coverage: 36:295/303 of query aligns to 29:291/295 of Q5HG25
3s8hA Structure of dihydrodipicolinate synthase complexed with 3- hydroxypropanoic acid(hpa)at 2.70 a resolution
29% identity, 93% coverage: 19:301/303 of query aligns to 10:289/292 of 3s8hA
Sites not aligning to the query:
3puoA Crystal structure of dihydrodipicolinate synthase from pseudomonas aeruginosa(psdhdps)complexed with l-lysine at 2.65a resolution (see paper)
29% identity, 93% coverage: 19:301/303 of query aligns to 10:289/292 of 3puoA
4m19A Dihydrodipicolinate synthase from c. Jejuni with pyruvate bound to the active site and lysine bound to allosteric site (see paper)
27% identity, 77% coverage: 13:246/303 of query aligns to 6:239/296 of 4m19A
5ud6C Crystal structure of dhdps from cyanidioschyzon merolae with lysine bound
29% identity, 81% coverage: 40:285/303 of query aligns to 34:280/299 of 5ud6C
>Pf6N2E2_3299 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_3299
MNPQELKSILSSGLLSFPVTDFTAQGDFNRASYIKRLEWLAPYGASALFAAGGTGEFFSL
AASEYSQVIKTAVDTCATSVPILAGVGGATRQAIEYAQEAERLGAKGLLLLPHYLTEASQ
DGVAAHVEAVCKSVKIGVVVYNRNVCRLNATQLERLAERCPNLIGYKDGLGDIELMVSIR
RRLGDRFSYLGGLPTAEVYAAAYKALGVPVYSSAVFNFIPKTAMDFYHAIARDDHETVGK
IIDDFFLPYLDIRNRKAGYAVSIVKAGAKIVGYDAGPVRTPLTDLLPEEYEALAALIDKQ
GKQ
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory