Comparing Pf6N2E2_4148 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_4148 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound (see paper)
38% identity, 92% coverage: 10:418/443 of query aligns to 10:421/425 of 6zgbA
6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis) (see paper)
38% identity, 92% coverage: 10:418/443 of query aligns to 9:420/424 of 6zl4A
Sites not aligning to the query:
5e9sA Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
38% identity, 92% coverage: 10:418/443 of query aligns to 12:423/427 of 5e9sA
6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor (see paper)
38% identity, 92% coverage: 10:418/443 of query aligns to 12:423/426 of 6xwnB
6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate (see paper)
37% identity, 92% coverage: 10:418/443 of query aligns to 5:412/416 of 6r7rA
O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 3 papers)
36% identity, 91% coverage: 10:412/443 of query aligns to 14:417/425 of O59010
6x15A Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
36% identity, 91% coverage: 11:412/443 of query aligns to 15:417/419 of 6x15A
Sites not aligning to the query:
2nwwA Crystal structure of gltph in complex with tboa (see paper)
36% identity, 91% coverage: 11:411/443 of query aligns to 6:407/407 of 2nwwA
6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa (see paper)
36% identity, 91% coverage: 11:411/443 of query aligns to 12:413/413 of 6x14A
Sites not aligning to the query:
6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine (see paper)
35% identity, 91% coverage: 10:412/443 of query aligns to 6:409/409 of 6bavA
6bauA Crystal structure of gltph r397c in complex with l-cysteine (see paper)
35% identity, 91% coverage: 10:411/443 of query aligns to 6:408/408 of 6bauA
6bmiA Crystal structure of gltph r397c in complex with l-serine (see paper)
34% identity, 91% coverage: 10:411/443 of query aligns to 6:396/396 of 6bmiA
7awmA Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
30% identity, 84% coverage: 45:418/443 of query aligns to 57:412/412 of 7awmA
7xr6A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with way-213613 (see paper)
31% identity, 87% coverage: 15:401/443 of query aligns to 18:404/424 of 7xr6A
Sites not aligning to the query:
Q10901 Excitatory amino acid transporter; Sodium-dependent glutamate/ aspartate transporter from Caenorhabditis elegans (see paper)
27% identity, 94% coverage: 16:433/443 of query aligns to 29:501/503 of Q10901
7xr4A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with glutamate (see paper)
30% identity, 87% coverage: 15:401/443 of query aligns to 17:405/425 of 7xr4A
P31596 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2 from Rattus norvegicus (Rat) (see paper)
27% identity, 93% coverage: 15:425/443 of query aligns to 53:533/573 of P31596
5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101 (see paper)
29% identity, 84% coverage: 45:417/443 of query aligns to 49:397/397 of 5mjuA
P43006 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 from Mus musculus (Mouse) (see paper)
27% identity, 93% coverage: 15:425/443 of query aligns to 53:532/572 of P43006
Sites not aligning to the query:
P56564 Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Mus musculus (Mouse) (see paper)
28% identity, 88% coverage: 12:403/443 of query aligns to 58:490/543 of P56564
>Pf6N2E2_4148 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_4148
MKKARLSLAWQILIGLVLGIALGALLNHFSAEKAWWISNVLQPAGDIFIRLIKMIVIPIV
ISSLIVGIAGVGDAKKLGRIGLKTILYFEVVTTIAIVVGLLLANFFQPGSGIDMSTLGTV
DISKYQATAAEVQHEHAFIQTILNLIPSNIFAAVARGEMLPIIFFSVLFGLGLSSLQSDL
RDPLVKMFQGVSESMFKVTHMIMQYAPIGVFALIAVTVANFGFASLLPLAKLVILVYVAI
AFFAFVVLGVIARLFGFSVLKLMRIFKDELVLAYSTASSETVLPRVIEKMEAYGAPKAIC
SFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSISQQLLLVLTLMVTSKGIAGVPGVS
FVVLLATLGSVGIPLEGLAFIAGVDRIMDMARTALNVIGNALAVLVIARWEGMYDDAKGQ
RYWNSLPHWRSKEPLPAGEPSSH
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory