SitesBLAST
Comparing Pf6N2E2_4388 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_4388 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 5 hits to proteins with known functional sites (download)
5i39A High resolution structure of l-amino acid deaminase from proteus vulgaris with the deletion of the specific insertion sequence (see paper)
25% identity, 83% coverage: 38:398/437 of query aligns to 25:370/383 of 5i39A
- active site: F66 (≠ N79), Q69 (= Q82), A70 (≠ L83), Q248 (= Q277), P267 (≠ D296)
- binding flavin-adenine dinucleotide: V30 (= V43), G31 (= G44), G33 (= G46), I34 (≠ F47), L35 (≠ S48), V53 (≠ L66), E54 (= E67), K55 (≠ A68), Q62 (≠ A75), S63 (= S76), F66 (≠ N79), Y67 (≠ G80), Q69 (= Q82), A196 (= A217), A197 (≠ V218), G226 (vs. gap), G227 (= G244), W229 (≠ N246), Q248 (= Q277), Q250 (= Q279), G321 (= G348), M323 (≠ I350), T348 (≠ S376), G349 (= G377), W350 (≠ H378), G351 (= G379), M352 (≠ V380), T353 (≠ N381)
1y56B Crystal structure of l-proline dehydrogenase from p.Horikoshii (see paper)
23% identity, 78% coverage: 55:395/437 of query aligns to 22:352/374 of 1y56B
- active site: F44 (≠ G77), G47 (= G80), T48 (≠ R85), H224 (vs. gap), P239 (vs. gap), G305 (= G348), M338 (≠ N381)
- binding flavin-adenine dinucleotide: I33 (≠ L66), E34 (= E67), K35 (≠ A68), S42 (≠ A75), T43 (≠ S76), R45 (= R78), C46 (≠ N79), G47 (= G80), G49 (= G86), E170 (≠ A217), V171 (= V218), T200 (≠ C245), N201 (= N246), W203 (≠ Y248), G305 (= G348), Y306 (≠ M349), Y307 (≠ I350), G334 (= G377), H335 (= H378), G336 (= G379), F337 (≠ V380), M338 (≠ N381)
- binding flavin mononucleotide: F44 (≠ G77), R45 (= R78), I260 (≠ A287), R301 (≠ Y344), W303 (= W346)
Sites not aligning to the query:
5hxwA L-amino acid deaminase from proteus vulgaris (see paper)
23% identity, 83% coverage: 38:398/437 of query aligns to 17:420/433 of 5hxwA
- active site: F58 (≠ N79), Q61 (= Q82), A62 (≠ L83), Q240 (vs. gap), V284 (≠ Q291), F288 (≠ L295)
- binding cetyl-trimethyl-ammonium: G291 (vs. gap), Y294 (vs. gap), N310 (≠ D303), E311 (≠ R304), F317 (= F308), M318 (≠ G309), S320 (≠ A311), M373 (≠ I350), E379 (≠ R356), G399 (= G377), W400 (≠ H378)
- binding flavin-adenine dinucleotide: V22 (= V43), G23 (= G44), G25 (= G46), I26 (≠ F47), L27 (≠ S48), E46 (= E67), K47 (≠ A68), E53 (≠ G74), Q54 (≠ A75), S55 (= S76), R57 (= R78), F58 (≠ N79), Y59 (≠ G80), G60 (= G81), Q61 (= Q82), A188 (= A217), A189 (≠ V218), G218 (vs. gap), G219 (vs. gap), W221 (vs. gap), Q240 (vs. gap), Q242 (vs. gap), F331 (vs. gap), G371 (= G348), M373 (≠ I350), T398 (≠ S376), G399 (= G377), W400 (≠ H378), G401 (= G379), M402 (≠ V380), T403 (≠ N381)
4pabB Crystal structure of the precursor form of rat dmgdh complexed with tetrahydrofolate (see paper)
25% identity, 62% coverage: 38:309/437 of query aligns to 6:266/824 of 4pabB
- active site: T53 (≠ I84), E102 (≠ G146), H226 (≠ S265), Y255 (= Y297)
- binding flavin-adenine dinucleotide: I11 (≠ V43), G12 (= G44), G14 (= G46), C15 (≠ F47), V16 (≠ S48), L35 (= L66), E36 (= E67), K37 (≠ A68), G43 (= G74), S44 (≠ A75), T45 (≠ S76), H47 (≠ R78), A48 (≠ N79), A49 (≠ G80), G50 (= G81), L51 (≠ Q82), V175 (= V218), A204 (≠ C245), G205 (≠ N246), W207 (≠ Y248), H226 (≠ S265), Y228 (≠ I267)
Sites not aligning to the query:
- active site: 536
- binding flavin-adenine dinucleotide: 326, 328, 353, 355, 356, 357, 358
- binding (6s)-5,6,7,8-tetrahydrofolate: 523, 536, 538, 550, 612, 613, 632, 639, 680, 700
Q63342 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 62% coverage: 38:309/437 of query aligns to 43:303/857 of Q63342
- CV 52:53 (≠ FS 47:48) binding FAD
- EK 73:74 (≠ EA 67:68) binding FAD
- 80:88 (vs. 74:82, 22% identical) binding FAD
- H84 (≠ R78) modified: Tele-8alpha-FAD histidine
- V212 (= V218) binding FAD
- W244 (≠ Y248) binding FAD
Sites not aligning to the query:
- 390:395 binding FAD
- 573:575 binding (6S)-5,6,7,8-tetrahydrofolate
- 669 binding (6S)-5,6,7,8-tetrahydrofolate
- 676:678 binding (6S)-5,6,7,8-tetrahydrofolate
- 737 binding (6S)-5,6,7,8-tetrahydrofolate
Query Sequence
>Pf6N2E2_4388 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_4388
MNARVQQPVPSHAHAASYYAASSLPQPDHPLLQGELLADVCVVGGGFSGLNTAIELAERG
MSVVLLEAHRIGWGASGRNGGQLIRGVGHGLDQFAPIIGADGVRQMKLMGLEAVEIVRQR
VERFQIPCDLTWGYCDLANKPSDLEGFAEDAEELRSLGYRHPTRLLQANEMHSVVGSDRY
VGGLIDMGSGHLHPLNLALGEAAAAQQLGVRLFEQSAVTRIDYGPEVKVHTQQGSVRAKT
LVLGCNAYLNGLNPQLGGKVLPAGSYIIATEPLSQAQAQALLPQNMAVCDQRVALDYYRL
SADRRLLFGGACHYSGRDPQDIGAYMRPKMLKVFPQLADVKIDYQWGGMIGIGANRLPQI
GRLKDQPNVYYAQAYSGHGVNATHLAGKLLAEAISGQHSSGFDLFAQVPHMTFPGGKHLR
SPLLALGMLWHRLKELV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory