Comparing Pf6N2E2_512 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_512 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q53W83 2-dehydro-3-deoxygluconokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; EC 2.7.1.45 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
28% identity, 52% coverage: 11:344/645 of query aligns to 1:309/309 of Q53W83
1v1aA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound 2- keto-3-deoxygluconate and adp (see paper)
29% identity, 51% coverage: 11:336/645 of query aligns to 1:301/301 of 1v1aA
1v1bA 2-keto-3-deoxygluconate kinase from thermus thermophilus with bound atp (see paper)
29% identity, 50% coverage: 11:335/645 of query aligns to 1:300/300 of 1v1bA
2varA Crystal structure of sulfolobus solfataricus 2-keto-3-deoxygluconate kinase complexed with 2-keto-3-deoxygluconate (see paper)
27% identity, 49% coverage: 12:328/645 of query aligns to 1:299/311 of 2varA
Q97U29 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase; 2-dehydro-3-deoxyglucono/galactono-kinase; 2-keto-3-deoxy-galactonokinase; 2-keto-3-deoxygluconokinase; 3-deoxy-2-oxo-D-gluconate kinase; KDG kinase; KDGal kinase; EC 2.7.1.178 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
27% identity, 49% coverage: 12:328/645 of query aligns to 2:300/313 of Q97U29
5eynA Crystal structure of fructokinase from vibrio cholerae o395 in fructose, adp, beryllium trifluoride and calcium ion bound form
25% identity, 46% coverage: 39:336/645 of query aligns to 22:304/306 of 5eynA
Sites not aligning to the query:
5yggA Crystal structure of fructokinase double-mutant (t261c-h108c) from vibrio cholerae o395 in fructose, adp and potassium ion bound form (see paper)
25% identity, 46% coverage: 39:336/645 of query aligns to 26:308/310 of 5yggA
Sites not aligning to the query:
2dcnA Crystal structure of 2-keto-3-deoxygluconate kinase from sulfolobus tokodaii complexed with 2-keto-6-phosphogluconate (alpha-furanose form)
26% identity, 50% coverage: 14:337/645 of query aligns to 3:306/308 of 2dcnA
3in1A Crystal structure of a putative ribokinase in complex with adp from e.Coli
28% identity, 51% coverage: 11:337/645 of query aligns to 1:309/312 of 3in1A
3ih0A Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with amp-pnp
27% identity, 44% coverage: 14:295/645 of query aligns to 3:255/304 of 3ih0A
Sites not aligning to the query:
3gbuA Crystal structure of an uncharacterized sugar kinase ph1459 from pyrococcus horikoshii in complex with atp
27% identity, 44% coverage: 14:295/645 of query aligns to 2:254/302 of 3gbuA
Sites not aligning to the query:
Q8ZKR2 Aminoimidazole riboside kinase; AIRs kinase; EC 2.7.1.223 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
24% identity, 47% coverage: 38:338/645 of query aligns to 24:309/319 of Q8ZKR2
Sites not aligning to the query:
1tz3A Crystal structure of aminoimidazole riboside kinase complexed with aminoimidazole riboside (see paper)
24% identity, 47% coverage: 38:338/645 of query aligns to 20:298/299 of 1tz3A
Sites not aligning to the query:
3iq0B Crystal structure of a putative ribokinase ii in complex with atp and mg+2 from e.Coli
23% identity, 47% coverage: 14:319/645 of query aligns to 4:288/308 of 3iq0B
1tz6A Crystal structure of aminoimidazole riboside kinase from salmonella enterica complexed with aminoimidazole riboside and atp analog (see paper)
24% identity, 47% coverage: 38:337/645 of query aligns to 20:297/297 of 1tz6A
Sites not aligning to the query:
3lkiB Crystal structure of fructokinase with bound atp from xylella fastidiosa
24% identity, 49% coverage: 14:332/645 of query aligns to 5:313/322 of 3lkiB
3uboA The crystal structure of adenosine kinase from sinorhizobium meliloti
24% identity, 43% coverage: 44:319/645 of query aligns to 57:310/338 of 3uboA
Sites not aligning to the query:
6a8cA Ribokinase from leishmania donovani with adp (see paper)
23% identity, 50% coverage: 13:332/645 of query aligns to 15:322/327 of 6a8cA
6a8bA Ribokinase from leishmania donovani with amppcp (see paper)
23% identity, 50% coverage: 13:332/645 of query aligns to 15:322/327 of 6a8bA
8cqxA Ribokinase from t.Sp mutant a92g
25% identity, 46% coverage: 39:336/645 of query aligns to 31:298/300 of 8cqxA
>Pf6N2E2_512 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_512
MGQTRFASGRQLDVICLGRLGVDLYAQQVGARLEDVASFAKYLGGSSANIAFGTARLGLR
SAMLSRVGDDHMGRFLVESLAREGCDVSGIKVDPERLTAMVLLGIKDRETFPLVFYRENC
ADMALRVEDIDETFIASSKALLITGTHFSTDGVYKASTQALDYAEKHNVKCVLDIDYRPV
LWGLAGKADGETRFVADQKVSQHVQGILPRFDLIVGTEEEFLIAGGSEDLLSALRTVRSL
TAATLVVKLGAQGCTVIHGAIPARLEDGALYPGVRVEVLNVLGAGDAFMSGFLAGWLEDA
SDERCCQLANACGGLVVSRHACAPAMPTRAELDYLFKSPVPITRPDQDAVLQRLHQVSVP
RKTWKQLFIFAFDHRWQLVELAQKGGRDLNCIGDLKQLFIQAVERVEADLQRQGIEADVG
LLADQRFGQDSLNAATGRGWWVARPVEVQNSRPLAFEHGRSIGSNLIAWPQEQIIKCLVQ
FHPDDEPLLRLEQEAQLMGLYKASQVSGHELLLEVIPPKDHPSPHPDVLYRALKRLYNLG
IFPAWWKIEAQSAQEWKQLDELIQQRDPYCRGVVLLGLNAPAAALAEGFRQASQSTTCRG
FAVGRTIFQEPSRAWLAGEIDDETLIRQVQGRFVELIEAWRSARA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory