Comparing Pf6N2E2_5558 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_5558 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 10 hits to proteins with known functional sites (download)
4lhdA Crystal structure of synechocystis sp. Pcc 6803 glycine decarboxylase (p-protein), holo form with pyridoxal-5'-phosphate and glycine, closed flexible loop (see paper)
61% identity, 99% coverage: 4:946/953 of query aligns to 12:949/952 of 4lhdA
Sites not aligning to the query:
Q94B78 Glycine dehydrogenase (decarboxylating) 1, mitochondrial; Glycine cleavage system P protein 1; Glycine decarboxylase 1; Glycine decarboxylase P-protein 1; AtGLDP1; Glycine dehydrogenase (aminomethyl-transferring) 1; EC 1.4.4.2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
57% identity, 98% coverage: 8:944/953 of query aligns to 76:1022/1037 of Q94B78
6i35A Crystal structure of human glycine decarboxylase (p-protein) bound with pyridoxyl-glycine-5'-monophosphate
55% identity, 99% coverage: 9:949/953 of query aligns to 13:953/953 of 6i35A
6i34B Crystal structure of neanderthal glycine decarboxylase (p-protein)
55% identity, 99% coverage: 9:947/953 of query aligns to 11:953/954 of 6i34B
6i33A Crystal structure of human glycine decarboxylase (p-protein)
55% identity, 99% coverage: 9:949/953 of query aligns to 13:950/950 of 6i33A
P15505 Glycine dehydrogenase (decarboxylating), mitochondrial; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring); EC 1.4.4.2 from Gallus gallus (Chicken) (see paper)
54% identity, 99% coverage: 9:952/953 of query aligns to 51:992/1004 of P15505
6i33B Crystal structure of human glycine decarboxylase (p-protein)
54% identity, 99% coverage: 9:947/953 of query aligns to 11:924/925 of 6i33B
1wyuB Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in holo form (see paper)
43% identity, 43% coverage: 484:897/953 of query aligns to 46:450/473 of 1wyuB
1wyvA Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in inhibitor-bound form (see paper)
39% identity, 36% coverage: 18:364/953 of query aligns to 5:359/437 of 1wyvA
1wyuA Crystal structure of glycine decarboxylase (p-protein) of the glycine cleavage system, in holo form (see paper)
39% identity, 36% coverage: 18:364/953 of query aligns to 5:359/437 of 1wyuA
>Pf6N2E2_5558 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_5558
MTVNLGTANEFIARHIGPRASDEQAMLERLGYDSLEALSASVIPESIKGTSVLDMGDGQS
EADALASIKAIAAKNQLFKTYIGQGYYNCHTPAPILRNLLENPAWYTAYTPYQPEISQGR
LEALLNFQTLISDLTGLPIANASLLDEATAAAEAMTFCKRLSKNKGSNAFFASVHSHPQT
LDVLRTRAEPLGIDVVVGDERELSDVSGFFGALLQYPASNGDLFDYRELTERFHTANALV
AVAADLLALTLLTPPGEFGADVAIGSAQRFGVPLGFGGPHAAYFSTKDAFKRDMPGRLVG
VSVDRFGKPALRLAMQTREQHIRREKATSNICTAQVLLANIASMYAVYHGPKGLVQIANR
IHHLTAILAKGLGALGLSVEQESFFDTLTLRTGAQTAALHDKARAQRINLRVVDAERLGL
SLDETTSQADVEALLRLIGNLMADGKAVPDFAALAASVQSHIPAELVRQSAILSHPVFNR
YHSETELMRYLRKLADKDLALDRTMIPLGSCTMKLNAASEMIPVTWAEFGALHPFAPAEQ
SAGYQQLTDELEAMLCAATGYDAVSLQPNAGSQGEYAGLLAIRAYHQSRGEDRRDICLIP
SSAHGTNPATAHMAGMRVVVTACDARGNVDIEDLRAKAIEHREHLAALMITYPSTHGVFE
EGIREICGIIHDNGGQVYIDGANMNAMVGLCAPGKFGGDVSHLNLHKTFCIPHGGGGPGV
GPIGVKSHLAPFLPGHASMERKQGAVCAAPFGSASILPITWMYIRMMGGAGLKRASQLAI
LNANYIARRLEEHYPVLYSGSNGLVAHECILDLRPLKDSSGISVDDVAKRLIDFGFHAPT
MSFPVAGTLMIEPTESESKEELDRFCDAMICIREEIRAVENGSLDKDDNPLKNAPHTAAE
IVGEWTHPYSREQAVYPVASLIDGKYWPPVGRVDNVFGDRNLVCACPSIESYA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory