SitesBLAST
Comparing Pf6N2E2_5839 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_5839 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8i01A Crystal structure of escherichia coli glyoxylate carboligase
74% identity, 100% coverage: 1:587/588 of query aligns to 5:591/594 of 8i01A
- binding flavin-adenine dinucleotide: R155 (= R151), G212 (= G208), G213 (= G209), G214 (= G210), N217 (= N213), T238 (= T234), L239 (= L235), M240 (= M236), V256 (= V252), G257 (= G253), Q259 (= Q255), T260 (= T256), G279 (= G275), N280 (= N276), R281 (= R277), A283 (= A279), R285 (= R281), H286 (= H282), D303 (= D299), I304 (= I300), Q308 (= Q304), D322 (= D318), A323 (= A319), G417 (= G413)
- binding magnesium ion: D447 (= D443), F452 (= F448), E455 (= E451), N474 (= N470), Y476 (= Y472)
- binding thiamine diphosphate: G395 (= G391), L396 (= L392), S397 (= S393), L422 (= L418), G446 (= G442), D447 (= D443), F448 (≠ Y444), D449 (= D445), N474 (= N470), Y476 (= Y472), L477 (= L473), G478 (= G474), L479 (= L475), I480 (= I476)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q354 (= Q350), C492 (= C488), Q494 (= Q490), C589 (≠ S585)
8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
74% identity, 100% coverage: 1:587/588 of query aligns to 3:589/592 of 8beoB
- binding methyl hydrogen (s)-acetylphosphonate: C490 (= C488), Q492 (= Q490)
- binding flavin-adenine dinucleotide: R153 (= R151), P154 (= P152), G210 (= G208), G211 (= G209), G212 (= G210), N215 (= N213), T236 (= T234), L237 (= L235), M238 (= M236), V254 (= V252), G255 (= G253), Q257 (= Q255), T258 (= T256), G277 (= G275), N278 (= N276), R279 (= R277), A281 (= A279), R283 (= R281), H284 (= H282), D301 (= D299), I302 (= I300), Q306 (= Q304), D320 (= D318), A321 (= A319), G415 (= G413)
- binding magnesium ion: D445 (= D443), F450 (= F448), L451 (≠ M449), E453 (= E451), N472 (= N470), Y474 (= Y472)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (= R281), G393 (= G391), L394 (= L392), S395 (= S393), L420 (= L418), G444 (= G442), D445 (= D443), F446 (≠ Y444), D447 (= D445), N472 (= N470), Y474 (= Y472), L475 (= L473), G476 (= G474), L477 (= L475), I478 (= I476)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q352 (= Q350), R356 (≠ A354), C587 (≠ S585)
8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
74% identity, 100% coverage: 1:587/588 of query aligns to 3:589/592 of 8beoA
- binding flavin-adenine dinucleotide: R153 (= R151), P154 (= P152), G210 (= G208), G211 (= G209), G212 (= G210), N215 (= N213), T236 (= T234), L237 (= L235), M238 (= M236), V254 (= V252), G255 (= G253), Q257 (= Q255), T258 (= T256), G277 (= G275), N278 (= N276), R279 (= R277), A281 (= A279), R283 (= R281), H284 (= H282), D301 (= D299), I302 (= I300), Q306 (= Q304), D320 (= D318), A321 (= A319), I397 (= I395), G415 (= G413)
- binding magnesium ion: R384 (≠ K382), V405 (= V403), F406 (≠ Y404), H410 (= H408), D445 (= D443), F450 (= F448), L451 (≠ M449), E453 (= E451), N472 (= N470), Y474 (= Y472)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (= R281), G393 (= G391), L394 (= L392), S395 (= S393), L420 (= L418), G444 (= G442), D445 (= D443), F446 (≠ Y444), D447 (= D445), N472 (= N470), Y474 (= Y472), L475 (= L473), G476 (= G474), L477 (= L475), I478 (= I476)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: E248 (≠ P246), Q352 (= Q350), C587 (≠ S585)
8i07D Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
74% identity, 100% coverage: 1:587/588 of query aligns to 5:591/594 of 8i07D
- binding 2-oxidanylethanal: R285 (= R281), I480 (= I476)
- binding flavin-adenine dinucleotide: R155 (= R151), P156 (= P152), G212 (= G208), G213 (= G209), G214 (= G210), N217 (= N213), T238 (= T234), L239 (= L235), M240 (= M236), V256 (= V252), G257 (= G253), Q259 (= Q255), T260 (= T256), G279 (= G275), N280 (= N276), R281 (= R277), R285 (= R281), H286 (= H282), D303 (= D299), I304 (= I300), Q308 (= Q304), D322 (= D318), A323 (= A319), I399 (= I395), G417 (= G413)
- binding magnesium ion: D447 (= D443), F452 (= F448), L453 (≠ M449), E455 (= E451), N474 (= N470), Y476 (= Y472)
- binding thiamine diphosphate: V52 (= V48), T76 (= T72), G395 (= G391), L396 (= L392), S397 (= S393), L422 (= L418), G446 (= G442), D447 (= D443), F448 (≠ Y444), D449 (= D445), N474 (= N470), Y476 (= Y472), L477 (= L473), G478 (= G474), L479 (= L475), I480 (= I476)
- binding ubiquinone-1: Q354 (= Q350), R358 (≠ A354), C492 (= C488), Q494 (= Q490), C589 (≠ S585)
8i07A Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
74% identity, 100% coverage: 1:587/588 of query aligns to 5:591/594 of 8i07A
- binding flavin-adenine dinucleotide: R155 (= R151), P156 (= P152), G212 (= G208), G213 (= G209), G214 (= G210), N217 (= N213), T238 (= T234), L239 (= L235), M240 (= M236), V256 (= V252), G257 (= G253), Q259 (= Q255), T260 (= T256), G279 (= G275), N280 (= N276), R281 (= R277), R285 (= R281), H286 (= H282), D303 (= D299), I304 (= I300), Q308 (= Q304), D322 (= D318), A323 (= A319), I394 (= I390), I399 (= I395), G417 (= G413)
- binding magnesium ion: D447 (= D443), F452 (= F448), L453 (≠ M449), E455 (= E451), N474 (= N470), Y476 (= Y472)
- binding thiamine diphosphate: I394 (= I390), G395 (= G391), L396 (= L392), S397 (= S393), L422 (= L418), G446 (= G442), D447 (= D443), F448 (≠ Y444), D449 (= D445), N474 (= N470), Y476 (= Y472), L477 (= L473), G478 (= G474), L479 (= L475), I480 (= I476)
- binding ubiquinone-1: Q354 (= Q350), C492 (= C488), Q494 (= Q490), C589 (≠ S585)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
33% identity, 93% coverage: 8:552/588 of query aligns to 101:638/667 of P09342
- C161 (= C69) modified: Disulfide link with 307
- P194 (= P102) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ I211) modified: Disulfide link with 161
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
33% identity, 93% coverage: 8:552/588 of query aligns to 98:635/664 of P09114
- P191 (= P102) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (≠ A479) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/583 of 5k3sA
- active site: Y33 (≠ I22), G35 (= G24), G36 (≠ A25), A37 (= A26), S38 (≠ I27), E59 (≠ V48), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (≠ A113), K171 (≠ F161), M266 (≠ L254), V293 (≠ H282), V400 (≠ I390), G426 (= G416), M428 (≠ L418), D453 (= D443), N480 (= N470), H482 (≠ Y472), L483 (= L473), M485 (≠ L475), V486 (≠ I476), W489 (≠ A479)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R281), M485 (≠ L475), W489 (≠ A479)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G208), G223 (= G209), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), L264 (≠ V252), M266 (≠ L254), G286 (= G275), R288 (= R277), D290 (≠ A279), V293 (≠ H282), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ I395), G423 (= G413)
- binding magnesium ion: D453 (= D443), N480 (= N470), H482 (≠ Y472)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ I390), G401 (= G391), Q402 (≠ L392), H403 (≠ S393), G426 (= G416), M428 (≠ L418), D453 (= D443), G454 (≠ Y444), S455 (≠ D445), N480 (= N470), H482 (≠ Y472), L483 (= L473), G484 (= G474), M485 (≠ L475), V486 (≠ I476)
Sites not aligning to the query:
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 18:492/582 of 3ea4A
- active site: Y32 (≠ I22), G34 (= G24), G35 (≠ A25), A36 (= A26), S37 (≠ I27), E58 (≠ V48), T81 (= T72), F120 (= F111), Q121 (= Q112), E122 (≠ A113), K170 (≠ F161), M265 (≠ L254), V292 (≠ H282), V399 (≠ I390), G425 (= G416), M427 (≠ L418), D452 (= D443), N479 (= N470), H481 (≠ Y472), L482 (= L473), M484 (≠ L475), V485 (≠ I476), W488 (≠ A479)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (≠ N280), R291 (= R281), W488 (≠ A479)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R151), G221 (= G208), G222 (= G209), G223 (= G210), T245 (= T234), L246 (= L235), M247 (= M236), L263 (≠ V252), G264 (= G253), M265 (≠ L254), H266 (≠ Q255), G285 (= G275), R287 (= R277), D289 (≠ A279), R291 (= R281), D309 (= D299), I310 (= I300), G327 (≠ S317), D328 (= D318), V329 (≠ A319), M404 (≠ I395), G422 (= G413)
- binding magnesium ion: D452 (= D443), N479 (= N470), H481 (≠ Y472)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ I390), G400 (= G391), Q401 (≠ L392), H402 (≠ S393), M427 (≠ L418), G451 (= G442), D452 (= D443), G453 (≠ Y444), S454 (≠ D445), N479 (= N470), H481 (≠ Y472), L482 (= L473), G483 (= G474), M484 (≠ L475), V485 (≠ I476)
Sites not aligning to the query:
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 18:492/582 of 3e9yA
- active site: Y32 (≠ I22), G34 (= G24), G35 (≠ A25), A36 (= A26), S37 (≠ I27), E58 (≠ V48), T81 (= T72), F120 (= F111), Q121 (= Q112), E122 (≠ A113), K170 (≠ F161), M265 (≠ L254), V292 (≠ H282), V399 (≠ I390), G425 (= G416), M427 (≠ L418), D452 (= D443), N479 (= N470), H481 (≠ Y472), L482 (= L473), M484 (≠ L475), V485 (≠ I476), W488 (≠ A479)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (≠ N280), R291 (= R281), W488 (≠ A479)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R151), G221 (= G208), G222 (= G209), G223 (= G210), T245 (= T234), L246 (= L235), M247 (= M236), L263 (≠ V252), G285 (= G275), R287 (= R277), D289 (≠ A279), R291 (= R281), D309 (= D299), I310 (= I300), G327 (≠ S317), D328 (= D318), V329 (≠ A319), M404 (≠ I395), G422 (= G413)
- binding magnesium ion: D452 (= D443), N479 (= N470), H481 (≠ Y472)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ I390), G400 (= G391), Q401 (≠ L392), H402 (≠ S393), M427 (≠ L418), G451 (= G442), G453 (≠ Y444), S454 (≠ D445), N479 (= N470), H481 (≠ Y472), L482 (= L473), G483 (= G474), M484 (≠ L475), V485 (≠ I476)
Sites not aligning to the query:
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ I390), G401 (= G391), Q402 (≠ L392), H403 (≠ S393), G426 (= G416), M428 (≠ L418), G452 (= G442), D453 (= D443), G454 (≠ Y444), S455 (≠ D445), M458 (≠ F448), N480 (= N470), H482 (≠ Y472), L483 (= L473), G484 (= G474), M485 (≠ L475), V486 (≠ I476)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G208), G223 (= G209), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), L264 (≠ V252), M266 (≠ L254), H267 (≠ Q255), G286 (= G275), V287 (≠ N276), R288 (= R277), D290 (≠ A279), R292 (= R281), V293 (≠ H282), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ I395), G423 (= G413)
- binding magnesium ion: F370 (≠ R358), D453 (= D443), M458 (≠ F448), Q461 (≠ E451), N480 (= N470), H482 (≠ Y472)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ L254), R292 (= R281), M485 (≠ L475), W489 (≠ A479)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/582 of 5wj1A
- active site: Y33 (≠ I22), G35 (= G24), G36 (≠ A25), A37 (= A26), S38 (≠ I27), E59 (≠ V48), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (≠ A113), K171 (≠ F161), M266 (≠ L254), V293 (≠ H282), V400 (≠ I390), G426 (= G416), M428 (≠ L418), D453 (= D443), N480 (= N470), H482 (≠ Y472), L483 (= L473), M485 (≠ L475), V486 (≠ I476), W489 (≠ A479)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G208), G223 (= G209), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), M263 (= M251), L264 (≠ V252), G286 (= G275), R288 (= R277), V293 (≠ H282), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ I395), G423 (= G413), G424 (≠ Q414)
- binding magnesium ion: D453 (= D443), N480 (= N470), H482 (≠ Y472)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ L254), D291 (≠ N280), R292 (= R281), M485 (≠ L475), W489 (≠ A479)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ I390), G401 (= G391), Q402 (≠ L392), H403 (≠ S393), M428 (≠ L418), D453 (= D443), G454 (≠ Y444), S455 (≠ D445), M458 (≠ F448), N480 (= N470), H482 (≠ Y472), L483 (= L473), G484 (= G474), M485 (≠ L475), V486 (≠ I476)
Sites not aligning to the query:
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/582 of 5k6tA
- active site: Y33 (≠ I22), G35 (= G24), G36 (≠ A25), A37 (= A26), S38 (≠ I27), E59 (≠ V48), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (≠ A113), K171 (≠ F161), M266 (≠ L254), V293 (≠ H282), V400 (≠ I390), G426 (= G416), M428 (≠ L418), D453 (= D443), N480 (= N470), H482 (≠ Y472), L483 (= L473), M485 (≠ L475), V486 (≠ I476), W489 (≠ A479)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ Q255), R292 (= R281), M485 (≠ L475), W489 (≠ A479)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G208), G223 (= G209), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), L264 (≠ V252), G286 (= G275), R288 (= R277), D290 (≠ A279), R292 (= R281), V293 (≠ H282), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), Q404 (= Q394), M405 (≠ I395), G423 (= G413)
- binding magnesium ion: D453 (= D443), N480 (= N470), H482 (≠ Y472)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ I390), G401 (= G391), Q402 (≠ L392), H403 (≠ S393), G426 (= G416), M428 (≠ L418), G452 (= G442), G454 (≠ Y444), S455 (≠ D445), N480 (= N470), H482 (≠ Y472), L483 (= L473), G484 (= G474)
Sites not aligning to the query:
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/582 of 5k6rA
- active site: Y33 (≠ I22), G35 (= G24), G36 (≠ A25), A37 (= A26), S38 (≠ I27), E59 (≠ V48), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (≠ A113), K171 (≠ F161), M266 (≠ L254), V293 (≠ H282), V400 (≠ I390), G426 (= G416), M428 (≠ L418), D453 (= D443), N480 (= N470), H482 (≠ Y472), L483 (= L473), M485 (≠ L475), V486 (≠ I476), W489 (≠ A479)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R281), W489 (≠ A479)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G208), G223 (= G209), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), L264 (≠ V252), M266 (≠ L254), G286 (= G275), R288 (= R277), R292 (= R281), V293 (≠ H282), D310 (= D299), I311 (= I300), G328 (≠ S317), D329 (= D318), V330 (≠ A319), M405 (≠ I395), G423 (= G413)
- binding magnesium ion: D453 (= D443), N480 (= N470), H482 (≠ Y472)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ I390), G401 (= G391), Q402 (≠ L392), H403 (≠ S393), G426 (= G416), M428 (≠ L418), D453 (= D443), G454 (≠ Y444), S455 (≠ D445), M458 (≠ F448), N480 (= N470), H482 (≠ Y472), L483 (= L473), G484 (= G474), M485 (≠ L475), V486 (≠ I476)
Sites not aligning to the query:
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/582 of 1z8nA
- active site: Y33 (≠ I22), G35 (= G24), G36 (≠ A25), A37 (= A26), S38 (≠ I27), E59 (≠ V48), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (≠ A113), K171 (≠ F161), M266 (≠ L254), V293 (≠ H282), V400 (≠ I390), G426 (= G416), M428 (≠ L418), D453 (= D443), N480 (= N470), H482 (≠ Y472), L483 (= L473), M485 (≠ L475), V486 (≠ I476), W489 (≠ A479)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K125), R161 (= R151), Y191 (vs. gap), R194 (vs. gap), D291 (≠ N280), R292 (= R281), D312 (≠ E301), W489 (≠ A479)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G208), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), L264 (≠ V252), G265 (= G253), M266 (≠ L254), H267 (≠ Q255), G286 (= G275), V287 (≠ N276), R288 (= R277), D290 (≠ A279), R292 (= R281), V293 (≠ H282), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ I395), G423 (= G413), G424 (≠ Q414)
- binding magnesium ion: D453 (= D443), N480 (= N470)
- binding thiamine diphosphate: V400 (≠ I390), G401 (= G391), Q402 (≠ L392), H403 (≠ S393), G426 (= G416), M428 (≠ L418), G452 (= G442), G454 (≠ Y444), S455 (≠ D445), N480 (= N470), H482 (≠ Y472), L483 (= L473), G484 (= G474), M485 (≠ L475), V486 (≠ I476)
Sites not aligning to the query:
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/582 of 1yi1A
- active site: Y33 (≠ I22), G35 (= G24), G36 (≠ A25), A37 (= A26), S38 (≠ I27), E59 (≠ V48), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (≠ A113), K171 (≠ F161), M266 (≠ L254), V293 (≠ H282), V400 (≠ I390), G426 (= G416), M428 (≠ L418), D453 (= D443), N480 (= N470), H482 (≠ Y472), L483 (= L473), M485 (≠ L475), V486 (≠ I476), W489 (≠ A479)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (≠ N280), R292 (= R281), W489 (≠ A479)
- binding flavin-adenine dinucleotide: R161 (= R151), G223 (= G209), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), M263 (= M251), L264 (≠ V252), G265 (= G253), M266 (≠ L254), H267 (≠ Q255), G286 (= G275), V287 (≠ N276), R288 (= R277), D290 (≠ A279), V293 (≠ H282), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ I395), G423 (= G413), G424 (≠ Q414)
- binding magnesium ion: D453 (= D443), N480 (= N470), H482 (≠ Y472)
Sites not aligning to the query:
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/582 of 1yi0A
- active site: Y33 (≠ I22), G35 (= G24), G36 (≠ A25), A37 (= A26), S38 (≠ I27), E59 (≠ V48), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (≠ A113), K171 (≠ F161), M266 (≠ L254), V293 (≠ H282), V400 (≠ I390), G426 (= G416), M428 (≠ L418), D453 (= D443), N480 (= N470), H482 (≠ Y472), L483 (= L473), M485 (≠ L475), V486 (≠ I476), W489 (≠ A479)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ N280), R292 (= R281), W489 (≠ A479)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G208), G223 (= G209), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), L264 (≠ V252), G265 (= G253), M266 (≠ L254), H267 (≠ Q255), G286 (= G275), V287 (≠ N276), R288 (= R277), D290 (≠ A279), R292 (= R281), V293 (≠ H282), D310 (= D299), I311 (= I300), G328 (≠ S317), D329 (= D318), V330 (≠ A319), M405 (≠ I395), G423 (= G413), G424 (≠ Q414)
- binding magnesium ion: D453 (= D443), N480 (= N470), H482 (≠ Y472)
Sites not aligning to the query:
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/582 of 1yhzA
- active site: Y33 (≠ I22), G35 (= G24), G36 (≠ A25), A37 (= A26), S38 (≠ I27), E59 (≠ V48), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (≠ A113), K171 (≠ F161), M266 (≠ L254), V293 (≠ H282), V400 (≠ I390), G426 (= G416), M428 (≠ L418), D453 (= D443), N480 (= N470), H482 (≠ Y472), L483 (= L473), M485 (≠ L475), V486 (≠ I476), W489 (≠ A479)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (≠ N280), R292 (= R281), M485 (≠ L475), W489 (≠ A479)
- binding flavin-adenine dinucleotide: R161 (= R151), G223 (= G209), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), L264 (≠ V252), M266 (≠ L254), H267 (≠ Q255), G286 (= G275), V287 (≠ N276), R288 (= R277), D290 (≠ A279), V293 (≠ H282), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), Q404 (= Q394), M405 (≠ I395), G423 (= G413), G424 (≠ Q414)
- binding magnesium ion: D453 (= D443), N480 (= N470), H482 (≠ Y472)
Sites not aligning to the query:
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/582 of 1yhyA
- active site: Y33 (≠ I22), G35 (= G24), G36 (≠ A25), A37 (= A26), S38 (≠ I27), E59 (≠ V48), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (≠ A113), K171 (≠ F161), M266 (≠ L254), V293 (≠ H282), V400 (≠ I390), G426 (= G416), M428 (≠ L418), D453 (= D443), N480 (= N470), H482 (≠ Y472), L483 (= L473), M485 (≠ L475), V486 (≠ I476), W489 (≠ A479)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ N280), R292 (= R281), V486 (≠ I476), W489 (≠ A479)
- binding flavin-adenine dinucleotide: R161 (= R151), G222 (= G208), G223 (= G209), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), L264 (≠ V252), G265 (= G253), M266 (≠ L254), H267 (≠ Q255), G286 (= G275), V287 (≠ N276), R288 (= R277), D290 (≠ A279), V293 (≠ H282), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), Q404 (= Q394), M405 (≠ I395), G423 (= G413), G424 (≠ Q414)
- binding magnesium ion: D453 (= D443), N480 (= N470), H482 (≠ Y472)
Sites not aligning to the query:
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
34% identity, 81% coverage: 8:483/588 of query aligns to 19:493/582 of 1ybhA
- active site: Y33 (≠ I22), G35 (= G24), G36 (≠ A25), A37 (= A26), S38 (≠ I27), E59 (≠ V48), T82 (= T72), F121 (= F111), Q122 (= Q112), E123 (≠ A113), K171 (≠ F161), M266 (≠ L254), V293 (≠ H282), V400 (≠ I390), G426 (= G416), M428 (≠ L418), D453 (= D443), N480 (= N470), H482 (≠ Y472), L483 (= L473), M485 (≠ L475), V486 (≠ I476), W489 (≠ A479)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (≠ L254), D291 (≠ N280), R292 (= R281), M485 (≠ L475), W489 (≠ A479)
- binding flavin-adenine dinucleotide: R161 (= R151), G223 (= G209), G224 (= G210), T246 (= T234), L247 (= L235), M248 (= M236), L264 (≠ V252), M266 (≠ L254), H267 (≠ Q255), G286 (= G275), V287 (≠ N276), R288 (= R277), D290 (≠ A279), V293 (≠ H282), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), Q404 (= Q394), M405 (≠ I395), G423 (= G413), G424 (≠ Q414)
- binding magnesium ion: D453 (= D443), N480 (= N470), H482 (≠ Y472)
Sites not aligning to the query:
Query Sequence
>Pf6N2E2_5839 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_5839
MRAIEAAVLVMRREGVDTAFGIPGAAINPLYSALQKVGGIDHVLARHVEGASHMAEGYTR
TKAGNIGVCIGTSGPAGTDMVTGLYSASADSIPILCITGQAPRARLHKEDFQAVDITSIV
KPVTKWATTVLEPGQVPYAFQKAFFEMRSGRPGPVLIDLPFDVQMAEIEFDIDAYQPLPL
AKPAANRVQIEKALAMLNQAERPLLVAGGGIINADASELLVAFAELTGIPVIPTLMGWGT
IPDDHPLMVGMVGLQTSHRYGNATLLKSDVVLGIGNRWANRHTGSVDVYTEGRTFIHVDI
EPTQIGRVFTPDLGIVSDAASALTVFIEVAREWQAAGKLKNRDAWLQDCQQRKASLQRKT
HFDNVPVKPQRVYEEMNQVFGKDTCYVSTIGLSQIAGAQFLHVYKPRHWINCGQAGPLGW
TIPAALGVVKADPSRKVVALSGDYDFQFMIEELAVGAQFKLPYIHVVVNNSYLGLIRQAQ
RGFDMDYCVQLSFDNLNAPELNGYGVDHIAVAEGLGCKALRVFEPSQIAPALRQAEKMIE
EFKVPVIVEIILERVTNISMGTEINAVNEFEDLALVGNDAPTAISLLD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory