Comparing Pf6N2E2_666 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_666 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3dv0D Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
44% identity, 98% coverage: 4:335/338 of query aligns to 2:324/324 of 3dv0D
3dv0B Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
44% identity, 98% coverage: 4:335/338 of query aligns to 2:324/324 of 3dv0B
3dufD Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
44% identity, 98% coverage: 4:335/338 of query aligns to 2:324/324 of 3dufD
1w85B The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2 (see paper)
44% identity, 98% coverage: 4:335/338 of query aligns to 2:324/324 of 1w85B
Q5SLR3 2-oxoisovalerate dehydrogenase subunit beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
44% identity, 97% coverage: 9:335/338 of query aligns to 8:324/324 of Q5SLR3
1umdD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate (see paper)
44% identity, 97% coverage: 9:335/338 of query aligns to 7:323/323 of 1umdD
1umcD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate (see paper)
44% identity, 97% coverage: 9:335/338 of query aligns to 7:323/323 of 1umcD
1umbD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
44% identity, 97% coverage: 9:335/338 of query aligns to 7:323/323 of 1umbD
P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Homo sapiens (Human) (see 6 papers)
40% identity, 96% coverage: 2:325/338 of query aligns to 30:349/359 of P11177
Sites not aligning to the query:
6cfoB Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate (see paper)
40% identity, 95% coverage: 4:325/338 of query aligns to 3:320/330 of 6cfoB
6cerD Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
40% identity, 95% coverage: 4:325/338 of query aligns to 4:321/331 of 6cerD
1qs0B Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
39% identity, 96% coverage: 9:334/338 of query aligns to 9:337/338 of 1qs0B
2j9fD Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase e1b (see paper)
40% identity, 99% coverage: 3:335/338 of query aligns to 6:329/329 of 2j9fD
1dtwB Human branched-chain alpha-keto acid dehydrogenase (see paper)
40% identity, 99% coverage: 3:335/338 of query aligns to 3:326/326 of 1dtwB
P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Homo sapiens (Human) (see 2 papers)
40% identity, 99% coverage: 3:335/338 of query aligns to 69:392/392 of P21953
6yakDDD C-terminal component of the split chain transketolase (see paper)
25% identity, 65% coverage: 52:271/338 of query aligns to 36:247/311 of 6yakDDD
Sites not aligning to the query:
Q9RUB5 1-deoxy-D-xylulose-5-phosphate synthase; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS; EC 2.2.1.7 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see paper)
25% identity, 63% coverage: 60:271/338 of query aligns to 363:561/629 of Q9RUB5
Sites not aligning to the query:
6ouvA 1-deoxy-d-xylulose 5-phosphate synthase (dxps) from deinococcus radiodurans with methylacetylphosphonate (map) bound (see paper)
25% identity, 63% coverage: 60:271/338 of query aligns to 329:527/595 of 6ouvA
Sites not aligning to the query:
6xxgAAA 1-deoxy-D-xylulose-5-phosphate synthase,1-deoxy-D-xylulose-5-phosphate synthase (see paper)
25% identity, 63% coverage: 60:271/338 of query aligns to 297:495/560 of 6xxgAAA
Sites not aligning to the query:
2o1xA 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from deinococcus radiodurans (see paper)
25% identity, 63% coverage: 60:271/338 of query aligns to 314:512/578 of 2o1xA
Sites not aligning to the query:
>Pf6N2E2_666 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_666
MARKISYQQAINEALAQEMRRDSSVFIMGEDVAGGAGAPGENDAWGGVLGVTKGLYDQFP
GRVLDTPLSEIGYVGAAVGAATCGVRPVCELMFVDFAGCCLDQILNQAAKFRYMFGGKAS
TPLVIRTMVGAGLRAAAQHSQMLTSLWTHIPGLKVVCPSSPYDAKGLLIQAIRDNDPVIF
CEHKLLYSMQGEVPEELYTIPFGEANFLRDGKDVTLVSYGRTVNTAMDAARSLAGRGIDC
EVIDLRTTSPLDEDSILESVEKTGRLVVIDEANPRCSMATDISALVAQKAFGALKAPIEM
VTAPHTPVPFSDSLEDLYIPDAAKIEQAVLNVIEWSKR
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory