SitesBLAST
Comparing PfGW456L13_1538 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_1538 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 27:583/597 of 6demA
- active site: Y33 (= Y17), G35 (= G19), G36 (= G20), A37 (= A21), I38 (≠ L22), E59 (= E43), T82 (= T66), F121 (= F105), Q122 (= Q106), E123 (= E107), K171 (= K155), K228 (vs. gap), M264 (= M252), V291 (= V279), V407 (= V389), L432 (= L414), G433 (= G415), M435 (= M417), D460 (≠ E442), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), M492 (= M474), V493 (= V475), W496 (= W478), L518 (= L501), N523 (≠ G506), V524 (≠ H507)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M252), D289 (= D277), R290 (= R278), M492 (= M474), W496 (= W478), A567 (≠ K551)
- binding flavin-adenine dinucleotide: R161 (= R145), G217 (= G206), A218 (≠ G207), G219 (= G208), N222 (≠ G212), T244 (= T232), L245 (= L233), Q246 (≠ M234), L262 (= L250), G284 (= G272), A285 (= A273), R286 (= R274), D288 (= D276), R290 (= R278), V291 (= V279), E317 (≠ D296), I318 (= I297), N322 (≠ S301), D336 (≠ P315), V337 (= V316), M412 (= M394), G430 (= G412)
- binding magnesium ion: D460 (≠ E442), N487 (= N469), E489 (≠ V471)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V389), G408 (= G390), Q409 (= Q391), H410 (= H392), M435 (= M417), G459 (= G441), D460 (≠ E442), A461 (≠ G443), S462 (= S444), M465 (= M447), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), G491 (= G473), M492 (= M474), V493 (= V475)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 27:583/597 of 6delA
- active site: Y33 (= Y17), G35 (= G19), G36 (= G20), A37 (= A21), I38 (≠ L22), E59 (= E43), T82 (= T66), F121 (= F105), Q122 (= Q106), E123 (= E107), K171 (= K155), K228 (vs. gap), M264 (= M252), V291 (= V279), V407 (= V389), L432 (= L414), G433 (= G415), M435 (= M417), D460 (≠ E442), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), M492 (= M474), V493 (= V475), W496 (= W478), L518 (= L501), N523 (≠ G506), V524 (≠ H507)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D277), R290 (= R278), W496 (= W478)
- binding flavin-adenine dinucleotide: R161 (= R145), G217 (= G206), A218 (≠ G207), G219 (= G208), N222 (≠ G212), T244 (= T232), L245 (= L233), Q246 (≠ M234), L262 (= L250), G284 (= G272), A285 (= A273), R286 (= R274), D288 (= D276), R290 (= R278), V291 (= V279), E317 (≠ D296), I318 (= I297), N322 (≠ S301), D336 (≠ P315), V337 (= V316), M412 (= M394), G430 (= G412)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V389), G408 (= G390), Q409 (= Q391), H410 (= H392), G433 (= G415), M435 (= M417), G459 (= G441), D460 (≠ E442), A461 (≠ G443), S462 (= S444), M465 (= M447), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), G491 (= G473), M492 (= M474), V493 (= V475)
- binding magnesium ion: D460 (≠ E442), N487 (= N469), E489 (≠ V471)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V389), G408 (= G390), Q409 (= Q391), H410 (= H392), G433 (= G415), M435 (= M417), G459 (= G441), D460 (≠ E442), A461 (≠ G443), S462 (= S444), M465 (= M447), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), G491 (= G473), M492 (= M474), V493 (= V475)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
43% identity, 98% coverage: 11:565/566 of query aligns to 29:585/599 of 6denA
- active site: Y35 (= Y17), G37 (= G19), G38 (= G20), A39 (= A21), I40 (≠ L22), E61 (= E43), T84 (= T66), F123 (= F105), Q124 (= Q106), E125 (= E107), K173 (= K155), K230 (vs. gap), M266 (= M252), V293 (= V279), V409 (= V389), L434 (= L414), G435 (= G415), M437 (= M417), D462 (≠ E442), N489 (= N469), E491 (≠ V471), Q492 (≠ L472), M494 (= M474), V495 (= V475), W498 (= W478), L520 (= L501), N525 (≠ G506), V526 (≠ H507)
- binding flavin-adenine dinucleotide: R163 (= R145), G219 (= G206), A220 (≠ G207), G221 (= G208), N224 (≠ G212), T246 (= T232), L247 (= L233), Q248 (≠ M234), L264 (= L250), G286 (= G272), A287 (= A273), R288 (= R274), D290 (= D276), R292 (= R278), V293 (= V279), E319 (≠ D296), I320 (= I297), N324 (≠ S301), D338 (≠ P315), V339 (= V316), M414 (= M394), G432 (= G412)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M252), D291 (= D277), R292 (= R278), W498 (= W478)
- binding magnesium ion: D462 (≠ E442), N489 (= N469), E491 (≠ V471)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V389), G410 (= G390), Q411 (= Q391), H412 (= H392), G435 (= G415), M437 (= M417), G461 (= G441), D462 (≠ E442), A463 (≠ G443), S464 (= S444), N489 (= N469), E491 (≠ V471), Q492 (≠ L472), G493 (= G473), M494 (= M474), V495 (= V475)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 29:587/601 of 6deqA
- active site: Y35 (= Y17), G37 (= G19), G38 (= G20), A39 (= A21), I40 (≠ L22), E61 (= E43), T84 (= T66), F123 (= F105), Q124 (= Q106), E125 (= E107), K173 (= K155), K232 (vs. gap), M268 (= M252), V295 (= V279), V411 (= V389), L436 (= L414), G437 (= G415), M439 (= M417), D464 (≠ E442), N491 (= N469), E493 (≠ V471), Q494 (≠ L472), M496 (= M474), V497 (= V475), W500 (= W478), L522 (= L501), N527 (≠ G506), V528 (≠ H507)
- binding flavin-adenine dinucleotide: R163 (= R145), G221 (= G206), A222 (≠ G207), G223 (= G208), N226 (≠ G212), T248 (= T232), L249 (= L233), Q250 (≠ M234), L266 (= L250), G288 (= G272), A289 (= A273), R290 (= R274), D292 (= D276), R294 (= R278), V295 (= V279), E321 (≠ D296), I322 (= I297), D340 (≠ P315), V341 (= V316), M416 (= M394), G434 (= G412)
- binding magnesium ion: D464 (≠ E442), N491 (= N469), E493 (≠ V471)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M252), R294 (= R278), M496 (= M474), V497 (= V475), W500 (= W478), A571 (≠ K551)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V389), G412 (= G390), Q413 (= Q391), H414 (= H392), M439 (= M417), G463 (= G441), D464 (≠ E442), A465 (≠ G443), S466 (= S444), N491 (= N469), E493 (≠ V471), Q494 (≠ L472), G495 (= G473), M496 (= M474), V497 (= V475)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 29:586/600 of 6derA
- active site: Y35 (= Y17), G37 (= G19), G38 (= G20), A39 (= A21), I40 (≠ L22), E61 (= E43), T84 (= T66), F123 (= F105), Q124 (= Q106), E125 (= E107), K173 (= K155), K231 (vs. gap), M267 (= M252), V294 (= V279), V410 (= V389), L435 (= L414), G436 (= G415), M438 (= M417), D463 (≠ E442), N490 (= N469), E492 (≠ V471), Q493 (≠ L472), M495 (= M474), V496 (= V475), W499 (= W478), L521 (= L501), N526 (≠ G506), V527 (≠ H507)
- binding flavin-adenine dinucleotide: R163 (= R145), G220 (= G206), A221 (≠ G207), G222 (= G208), N225 (≠ G212), T247 (= T232), L248 (= L233), Q249 (≠ M234), L265 (= L250), H268 (= H253), G287 (= G272), A288 (= A273), R289 (= R274), D291 (= D276), R293 (= R278), V294 (= V279), E320 (≠ D296), I321 (= I297), N325 (≠ S301), G338 (= G314), D339 (≠ P315), V340 (= V316), Q414 (= Q393), M415 (= M394), G433 (= G412)
- binding Metosulam: R293 (= R278), M495 (= M474), W499 (= W478), A570 (≠ K551)
- binding magnesium ion: D463 (≠ E442), N490 (= N469), E492 (≠ V471)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V389), G411 (= G390), Q412 (= Q391), H413 (= H392), G436 (= G415), M438 (= M417), G462 (= G441), D463 (≠ E442), A464 (≠ G443), S465 (= S444), N490 (= N469), E492 (≠ V471), Q493 (≠ L472), G494 (= G473), M495 (= M474), V496 (= V475)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V389), G411 (= G390), Q412 (= Q391), H413 (= H392), G436 (= G415), M438 (= M417), G462 (= G441), D463 (≠ E442), A464 (≠ G443), S465 (= S444), M468 (= M447), N490 (= N469), E492 (≠ V471), Q493 (≠ L472), G494 (= G473), V496 (= V475)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 27:584/598 of 6desA
- active site: Y33 (= Y17), G35 (= G19), G36 (= G20), A37 (= A21), I38 (≠ L22), E59 (= E43), T82 (= T66), F121 (= F105), Q122 (= Q106), E123 (= E107), K171 (= K155), K229 (vs. gap), M265 (= M252), V292 (= V279), V408 (= V389), L433 (= L414), G434 (= G415), M436 (= M417), D461 (≠ E442), N488 (= N469), E490 (≠ V471), Q491 (≠ L472), M493 (= M474), V494 (= V475), W497 (= W478), L519 (= L501), N524 (≠ G506), V525 (≠ H507)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M252), D290 (= D277), R291 (= R278), W497 (= W478)
- binding flavin-adenine dinucleotide: R161 (= R145), G218 (= G206), A219 (≠ G207), G220 (= G208), N223 (≠ G212), T245 (= T232), L246 (= L233), Q247 (≠ M234), L263 (= L250), G285 (= G272), A286 (= A273), R287 (= R274), D289 (= D276), R291 (= R278), V292 (= V279), E318 (≠ D296), I319 (= I297), N323 (≠ S301), D337 (≠ P315), V338 (= V316), Q412 (= Q393), M413 (= M394), G431 (= G412)
- binding magnesium ion: D461 (≠ E442), N488 (= N469), E490 (≠ V471)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V389), G409 (= G390), Q410 (= Q391), H411 (= H392), G434 (= G415), M436 (= M417), G460 (= G441), D461 (≠ E442), A462 (≠ G443), S463 (= S444), N488 (= N469), E490 (≠ V471), Q491 (≠ L472), G492 (= G473), M493 (= M474), V494 (= V475)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 27:584/598 of 6depA
- active site: Y33 (= Y17), G35 (= G19), G36 (= G20), A37 (= A21), I38 (≠ L22), E59 (= E43), T82 (= T66), F121 (= F105), Q122 (= Q106), E123 (= E107), K171 (= K155), K229 (vs. gap), M265 (= M252), V292 (= V279), V408 (= V389), L433 (= L414), G434 (= G415), M436 (= M417), D461 (≠ E442), N488 (= N469), E490 (≠ V471), Q491 (≠ L472), M493 (= M474), V494 (= V475), W497 (= W478), L519 (= L501), N524 (≠ G506), V525 (≠ H507)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D277), R291 (= R278), M493 (= M474), W497 (= W478)
- binding flavin-adenine dinucleotide: R161 (= R145), G218 (= G206), A219 (≠ G207), G220 (= G208), N223 (≠ G212), T245 (= T232), L246 (= L233), Q247 (≠ M234), L263 (= L250), G264 (= G251), G285 (= G272), A286 (= A273), R287 (= R274), D289 (= D276), R291 (= R278), V292 (= V279), E318 (≠ D296), I319 (= I297), N323 (≠ S301), D337 (≠ P315), V338 (= V316), M413 (= M394), G431 (= G412)
- binding magnesium ion: D461 (≠ E442), N488 (= N469), E490 (≠ V471)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V389), G409 (= G390), Q410 (= Q391), H411 (= H392), G434 (= G415), M436 (= M417), G460 (= G441), D461 (≠ E442), A462 (≠ G443), S463 (= S444), M466 (= M447), N488 (= N469), E490 (≠ V471), Q491 (≠ L472), G492 (= G473), M493 (= M474), V494 (= V475)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V389), G409 (= G390), Q410 (= Q391), H411 (= H392), G434 (= G415), M436 (= M417), G460 (= G441), D461 (≠ E442), A462 (≠ G443), S463 (= S444), M466 (= M447), N488 (= N469), E490 (≠ V471), Q491 (≠ L472), G492 (= G473), M493 (= M474), V494 (= V475)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
44% identity, 98% coverage: 11:565/566 of query aligns to 25:579/593 of 6deoA
- active site: Y31 (= Y17), G33 (= G19), G34 (= G20), A35 (= A21), I36 (≠ L22), E57 (= E43), T80 (= T66), F119 (= F105), Q120 (= Q106), E121 (= E107), K169 (= K155), K224 (vs. gap), M260 (= M252), V287 (= V279), V403 (= V389), L428 (= L414), G429 (= G415), M431 (= M417), D456 (≠ E442), N483 (= N469), E485 (≠ V471), Q486 (≠ L472), M488 (= M474), V489 (= V475), W492 (= W478), L514 (= L501), N519 (≠ G506), V520 (≠ H507)
- binding flavin-adenine dinucleotide: R159 (= R145), G213 (= G206), A214 (≠ G207), G215 (= G208), N218 (≠ G212), T240 (= T232), L241 (= L233), Q242 (≠ M234), L258 (= L250), G280 (= G272), A281 (= A273), R282 (= R274), D284 (= D276), R286 (= R278), V287 (= V279), E313 (≠ D296), I314 (= I297), N318 (≠ S301), D332 (≠ P315), V333 (= V316), M408 (= M394), G426 (= G412)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M252), D285 (= D277), R286 (= R278), M488 (= M474), W492 (= W478)
- binding magnesium ion: D456 (≠ E442), N483 (= N469), E485 (≠ V471)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V389), G404 (= G390), Q405 (= Q391), H406 (= H392), G429 (= G415), M431 (= M417), G455 (= G441), D456 (≠ E442), A457 (≠ G443), S458 (= S444), M461 (= M447), N483 (= N469), E485 (≠ V471), Q486 (≠ L472), G487 (= G473), M488 (= M474), V489 (= V475)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
44% identity, 99% coverage: 4:561/566 of query aligns to 18:578/599 of 1n0hA
- active site: Y31 (= Y17), G33 (= G19), G34 (= G20), A35 (= A21), I36 (≠ L22), E57 (= E43), T80 (= T66), F119 (= F105), Q120 (= Q106), E121 (= E107), K169 (= K155), R230 (≠ A216), M266 (= M252), V293 (= V279), V409 (= V389), L434 (= L414), G435 (= G415), M437 (= M417), D462 (≠ E442), N489 (= N469), E491 (≠ V471), Q492 (≠ L472), M494 (= M474), V495 (= V475), W498 (= W478), L520 (= L501), G525 (= G506), L526 (≠ H507), K559 (≠ T541)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V389), G410 (= G390), Q411 (= Q391), H412 (= H392), G435 (= G415), M437 (= M417), G461 (= G441), D462 (≠ E442), A463 (≠ G443), S464 (= S444), M467 (= M447), N489 (= N469), E491 (≠ V471), Q492 (≠ L472), G493 (= G473), V495 (= V475)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G20), A35 (= A21), V109 (= V95), P110 (= P96), F119 (= F105), K169 (= K155), M266 (= M252), D291 (= D277), R292 (= R278), V495 (= V475), W498 (= W478)
- binding flavin-adenine dinucleotide: R159 (= R145), G219 (= G206), A220 (≠ G207), G221 (= G208), N224 (vs. gap), T246 (= T232), L247 (= L233), Q248 (≠ M234), L264 (= L250), G265 (= G251), M266 (= M252), H267 (= H253), G286 (= G272), A287 (= A273), R288 (= R274), D290 (= D276), R292 (= R278), V293 (= V279), E319 (≠ D296), V320 (≠ I297), N324 (≠ S301), G337 (= G314), D338 (≠ P315), A339 (≠ V316), M414 (= M394), G432 (= G412), G433 (= G413)
- binding magnesium ion: D462 (≠ E442), N489 (= N469), E491 (≠ V471)
- binding thiamine diphosphate: Y31 (= Y17), E57 (= E43), P83 (= P69)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
44% identity, 99% coverage: 4:561/566 of query aligns to 16:575/596 of 1t9cA
- active site: Y29 (= Y17), G31 (= G19), G32 (= G20), A33 (= A21), I34 (≠ L22), E55 (= E43), T78 (= T66), F117 (= F105), Q118 (= Q106), E119 (= E107), K167 (= K155), R227 (vs. gap), M263 (= M252), V290 (= V279), V406 (= V389), L431 (= L414), G432 (= G415), M434 (= M417), D459 (≠ E442), N486 (= N469), E488 (≠ V471), Q489 (≠ L472), M491 (= M474), V492 (= V475), W495 (= W478), L517 (= L501), G522 (= G506), L523 (≠ H507), K556 (≠ T541)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G20), V107 (= V95), P108 (= P96), F117 (= F105), K167 (= K155), D288 (= D277), R289 (= R278), W495 (= W478)
- binding flavin-adenine dinucleotide: R157 (= R145), G216 (= G206), A217 (≠ G207), G218 (= G208), N221 (≠ G212), T243 (= T232), L244 (= L233), Q245 (≠ M234), L261 (= L250), M263 (= M252), H264 (= H253), G283 (= G272), A284 (= A273), R285 (= R274), D287 (= D276), R289 (= R278), V290 (= V279), E316 (≠ D296), V317 (≠ I297), N321 (≠ S301), G334 (= G314), D335 (≠ P315), A336 (≠ V316), M411 (= M394), G429 (= G412), G430 (= G413)
- binding magnesium ion: D459 (≠ E442), N486 (= N469), E488 (≠ V471)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
44% identity, 99% coverage: 4:561/566 of query aligns to 16:575/596 of 1t9dA
- active site: Y29 (= Y17), G31 (= G19), G32 (= G20), A33 (= A21), I34 (≠ L22), E55 (= E43), T78 (= T66), F117 (= F105), Q118 (= Q106), E119 (= E107), K167 (= K155), R227 (vs. gap), M263 (= M252), V290 (= V279), V406 (= V389), L431 (= L414), G432 (= G415), M434 (= M417), D459 (≠ E442), N486 (= N469), E488 (≠ V471), Q489 (≠ L472), M491 (= M474), V492 (= V475), W495 (= W478), L517 (= L501), G522 (= G506), L523 (≠ H507), K556 (≠ T541)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G20), A33 (= A21), V107 (= V95), P108 (= P96), F117 (= F105), K167 (= K155), M263 (= M252), D288 (= D277), R289 (= R278), W495 (= W478)
- binding flavin-adenine dinucleotide: R157 (= R145), G216 (= G206), A217 (≠ G207), G218 (= G208), N221 (≠ G212), T243 (= T232), L244 (= L233), Q245 (≠ M234), M260 (= M249), L261 (= L250), H264 (= H253), G283 (= G272), A284 (= A273), R285 (= R274), D287 (= D276), R289 (= R278), V290 (= V279), E316 (≠ D296), V317 (≠ I297), N321 (≠ S301), G334 (= G314), D335 (≠ P315), A336 (≠ V316), Q410 (= Q393), M411 (= M394), G429 (= G412), G430 (= G413)
- binding magnesium ion: D459 (≠ E442), N486 (= N469), E488 (≠ V471)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E43), P81 (= P69), Q118 (= Q106), G432 (= G415), M434 (= M417), M464 (= M447)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
44% identity, 99% coverage: 4:561/566 of query aligns to 17:576/597 of 1t9aA
- active site: Y30 (= Y17), G32 (= G19), G33 (= G20), A34 (= A21), I35 (≠ L22), E56 (= E43), T79 (= T66), F118 (= F105), Q119 (= Q106), E120 (= E107), K168 (= K155), R228 (vs. gap), M264 (= M252), V291 (= V279), V407 (= V389), L432 (= L414), G433 (= G415), M435 (= M417), D460 (≠ E442), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), M492 (= M474), V493 (= V475), W496 (= W478), L518 (= L501), G523 (= G506), L524 (≠ H507), K557 (≠ T541)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G20), V108 (= V95), P109 (= P96), F118 (= F105), K168 (= K155), M264 (= M252), D289 (= D277), R290 (= R278), M492 (= M474), V493 (= V475), W496 (= W478)
- binding flavin-adenine dinucleotide: R158 (= R145), G217 (= G206), A218 (≠ G207), G219 (= G208), N222 (≠ G212), T244 (= T232), L245 (= L233), Q246 (≠ M234), L262 (= L250), M264 (= M252), H265 (= H253), G284 (= G272), A285 (= A273), R286 (= R274), D288 (= D276), R290 (= R278), V291 (= V279), E317 (≠ D296), V318 (≠ I297), N322 (≠ S301), G335 (= G314), D336 (≠ P315), A337 (≠ V316), Q411 (= Q393), M412 (= M394), G430 (= G412), G431 (= G413)
- binding magnesium ion: D460 (≠ E442), N487 (= N469), E489 (≠ V471)
- binding propyl trihydrogen diphosphate: V407 (= V389), G408 (= G390), Q409 (= Q391), H410 (= H392), M435 (= M417), G459 (= G441), D460 (≠ E442), A461 (≠ G443), S462 (= S444), N487 (= N469), E489 (≠ V471), Q490 (≠ L472), G491 (= G473), M492 (= M474)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G415), M435 (= M417), M465 (= M447)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
44% identity, 98% coverage: 9:561/566 of query aligns to 105:666/687 of P07342
- R241 (= R145) binding
- 355:376 (vs. 253:274, 68% identical) binding
- 407:426 (vs. 296:315, 20% identical) binding
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
44% identity, 99% coverage: 4:561/566 of query aligns to 20:586/607 of 6u9dB
- active site: Y33 (= Y17), G35 (= G19), G36 (= G20), A37 (= A21), I38 (≠ L22), E59 (= E43), T82 (= T66), F121 (= F105), Q122 (= Q106), E123 (= E107), K171 (= K155), M274 (= M252), V301 (= V279), V417 (= V389), G443 (= G415), M445 (= M417), D470 (≠ E442), N497 (= N469), E499 (≠ V471), Q500 (≠ L472), M502 (= M474), V503 (= V475), W506 (= W478)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G20), V111 (= V95), P112 (= P96), F121 (= F105), K171 (= K155), D299 (= D277), R300 (= R278), M502 (= M474), W506 (= W478)
- binding flavin-adenine dinucleotide: R161 (= R145), A228 (≠ G207), G229 (= G208), N232 (≠ G212), T254 (= T232), L255 (= L233), Q256 (≠ M234), L272 (= L250), M274 (= M252), G294 (= G272), R296 (= R274), D298 (= D276), R300 (= R278), V301 (= V279), E327 (≠ D296), V328 (≠ I297), N332 (≠ S301), D346 (≠ P315), A347 (≠ V316), M422 (= M394), G440 (= G412), G441 (= G413)
- binding magnesium ion: D470 (≠ E442), N497 (= N469)
- binding thiamine diphosphate: E59 (= E43), P85 (= P69), V417 (= V389), G418 (= G390), Q419 (= Q391), H420 (= H392), G443 (= G415), M445 (= M417), A471 (≠ G443), S472 (= S444), N497 (= N469), E499 (≠ V471), Q500 (≠ L472), G501 (= G473), M502 (= M474), V503 (= V475)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
44% identity, 99% coverage: 4:561/566 of query aligns to 16:574/595 of 1t9bB
- active site: Y29 (= Y17), G31 (= G19), G32 (= G20), A33 (= A21), I34 (≠ L22), E55 (= E43), T78 (= T66), F117 (= F105), Q118 (= Q106), E119 (= E107), K167 (= K155), R226 (vs. gap), M262 (= M252), V289 (= V279), V405 (= V389), L430 (= L414), G431 (= G415), M433 (= M417), D458 (≠ E442), N485 (= N469), E487 (≠ V471), Q488 (≠ L472), M490 (= M474), V491 (= V475), W494 (= W478), L516 (= L501), G521 (= G506), L522 (≠ H507), K555 (≠ T541)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V95), P108 (= P96), D287 (= D277), R288 (= R278), M490 (= M474), W494 (= W478)
- binding flavin-adenine dinucleotide: R157 (= R145), G215 (= G206), A216 (≠ G207), G217 (= G208), N220 (≠ G212), T242 (= T232), L243 (= L233), Q244 (≠ M234), M259 (= M249), L260 (= L250), M262 (= M252), H263 (= H253), G282 (= G272), A283 (= A273), R284 (= R274), D286 (= D276), R288 (= R278), V289 (= V279), E315 (≠ D296), V316 (≠ I297), N320 (≠ S301), G333 (= G314), D334 (≠ P315), A335 (≠ V316), Q409 (= Q393), M410 (= M394), G428 (= G412), G429 (= G413)
- binding magnesium ion: D458 (≠ E442), N485 (= N469), E487 (≠ V471)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
44% identity, 99% coverage: 4:561/566 of query aligns to 15:561/582 of 1t9dB
- active site: Y28 (= Y17), G30 (= G19), G31 (= G20), A32 (= A21), I33 (≠ L22), E54 (= E43), T77 (= T66), F116 (= F105), Q117 (= Q106), E118 (= E107), K166 (= K155), R213 (vs. gap), M249 (= M252), V276 (= V279), V392 (= V389), L417 (= L414), G418 (= G415), M420 (= M417), D445 (≠ E442), N472 (= N469), E474 (≠ V471), Q475 (≠ L472), M477 (= M474), V478 (= V475), W481 (= W478), L503 (= L501), G508 (= G506), L509 (≠ H507), K542 (≠ T541)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G20), A32 (= A21), V106 (= V95), P107 (= P96), F116 (= F105), K166 (= K155), M249 (= M252), D274 (= D277), R275 (= R278), W481 (= W478)
- binding flavin-adenine dinucleotide: R156 (= R145), G202 (= G206), A203 (≠ G207), G204 (= G208), N207 (≠ G212), T229 (= T232), L230 (= L233), Q231 (≠ M234), L247 (= L250), M249 (= M252), H250 (= H253), G269 (= G272), A270 (= A273), R271 (= R274), D273 (= D276), R275 (= R278), V276 (= V279), E302 (≠ D296), V303 (≠ I297), N307 (≠ S301), G320 (= G314), D321 (≠ P315), A322 (≠ V316), Q396 (= Q393), M397 (= M394), G415 (= G412), G416 (= G413)
- binding magnesium ion: D445 (≠ E442), N472 (= N469), E474 (≠ V471)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E43), P80 (= P69), G418 (= G415), M420 (= M417), M450 (= M447)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
44% identity, 99% coverage: 4:561/566 of query aligns to 16:562/583 of 1t9bA
- active site: Y29 (= Y17), G31 (= G19), G32 (= G20), A33 (= A21), I34 (≠ L22), E55 (= E43), T78 (= T66), F117 (= F105), Q118 (= Q106), E119 (= E107), K167 (= K155), R214 (vs. gap), M250 (= M252), V277 (= V279), V393 (= V389), L418 (= L414), G419 (= G415), M421 (= M417), D446 (≠ E442), N473 (= N469), E475 (≠ V471), Q476 (≠ L472), M478 (= M474), V479 (= V475), W482 (= W478), L504 (= L501), G509 (= G506), L510 (≠ H507), K543 (≠ T541)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V95), P108 (= P96), F117 (= F105), D275 (= D277), R276 (= R278), M478 (= M474), W482 (= W478)
- binding flavin-adenine dinucleotide: R157 (= R145), G203 (= G206), A204 (≠ G207), G205 (= G208), N208 (≠ G212), T230 (= T232), L231 (= L233), Q232 (≠ M234), M247 (= M249), L248 (= L250), M250 (= M252), H251 (= H253), G270 (= G272), A271 (= A273), R272 (= R274), D274 (= D276), R276 (= R278), V277 (= V279), E303 (≠ D296), V304 (≠ I297), N308 (≠ S301), D322 (≠ P315), A323 (≠ V316), Q397 (= Q393), M398 (= M394), G416 (= G412), G417 (= G413)
- binding magnesium ion: D446 (≠ E442), N473 (= N469), E475 (≠ V471)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
43% identity, 99% coverage: 4:561/566 of query aligns to 16:570/591 of 5wkcA
- active site: Y29 (= Y17), G31 (= G19), G32 (= G20), A33 (= A21), I34 (≠ L22), E55 (= E43), T78 (= T66), F117 (= F105), Q118 (= Q106), E119 (= E107), K167 (= K155), R222 (vs. gap), M258 (= M252), V285 (= V279), V401 (= V389), L426 (= L414), G427 (= G415), M429 (= M417), D454 (≠ E442), N481 (= N469), E483 (≠ V471), Q484 (≠ L472), M486 (= M474), V487 (= V475), W490 (= W478), L512 (= L501), G517 (= G506), L518 (≠ H507), K551 (≠ T541)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V389), G402 (= G390), Q403 (= Q391), H404 (= H392), G427 (= G415), M429 (= M417), G453 (= G441), D454 (≠ E442), A455 (≠ G443), S456 (= S444), M459 (= M447), N481 (= N469), E483 (≠ V471), Q484 (≠ L472), G485 (= G473), M486 (= M474), V487 (= V475)
- binding ethaneperoxoic acid: G32 (= G20), Q118 (= Q106)
- binding flavin-adenine dinucleotide: R157 (= R145), G211 (= G206), A212 (≠ G207), G213 (= G208), N216 (≠ G212), T238 (= T232), L239 (= L233), Q240 (≠ M234), L256 (= L250), M258 (= M252), G278 (= G272), A279 (= A273), R280 (= R274), R284 (= R278), V285 (= V279), E311 (≠ D296), V312 (≠ I297), N316 (≠ S301), D330 (≠ P315), A331 (≠ V316), M406 (= M394), G424 (= G412)
- binding magnesium ion: D454 (≠ E442), N481 (= N469), E483 (≠ V471)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G20), A33 (= A21), V107 (= V95), F117 (= F105), K167 (= K155), M258 (= M252), R284 (= R278), M486 (= M474), W490 (= W478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P18), E55 (= E43)
6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit (see paper)
43% identity, 98% coverage: 11:565/566 of query aligns to 28:581/595 of 6dekA
- active site: Y34 (= Y17), G36 (= G19), G37 (= G20), A38 (= A21), I39 (≠ L22), E60 (= E43), T83 (= T66), Q118 (= Q106), E119 (= E107), K167 (= K155), K226 (vs. gap), M262 (= M252), V289 (= V279), V405 (= V389), L430 (= L414), G431 (= G415), M433 (= M417), D458 (≠ E442), N485 (= N469), E487 (≠ V471), Q488 (≠ L472), M490 (= M474), V491 (= V475), W494 (= W478), L516 (= L501), N521 (≠ G506), V522 (≠ H507)
- binding flavin-adenine dinucleotide: R157 (= R145), G215 (= G206), A216 (≠ G207), G217 (= G208), N220 (≠ G212), T242 (= T232), L243 (= L233), Q244 (≠ M234), L260 (= L250), M262 (= M252), G282 (= G272), A283 (= A273), R284 (= R274), D286 (= D276), R288 (= R278), V289 (= V279), E315 (≠ D296), I316 (= I297), N320 (≠ S301), D334 (≠ P315), V335 (= V316), M410 (= M394), G428 (= G412)
- binding magnesium ion: D458 (≠ E442), N485 (= N469), E487 (≠ V471)
- binding thiamine diphosphate: V405 (= V389), G406 (= G390), Q407 (= Q391), H408 (= H392), M433 (= M417), G457 (= G441), D458 (≠ E442), A459 (≠ G443), S460 (= S444), N485 (= N469), E487 (≠ V471), Q488 (≠ L472), G489 (= G473), M490 (= M474), V491 (= V475)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
41% identity, 99% coverage: 1:558/566 of query aligns to 99:657/667 of P09342
- C161 (≠ V63) modified: Disulfide link with 307
- P194 (= P96) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ V209) modified: Disulfide link with 161
Query Sequence
>PfGW456L13_1538 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_1538
MLVRFLRDEGVKYIYGYPGGALLHVYDALFKEPEVTHILVRHEQAATHMADGYARATGKA
GVVLVTSGPGATNAITGIATAYMDSIPMVIISGQVPSTMVGTDAFQETDMIGISRPIVKH
SFMIKHASEIPEVMKKAFYLAQSGRPGPVVVDIPKDMTNPAEKFEYVFPKKAKLRSYSPA
VRGHSGQIRKAAEMLLAAKRPVLYSGGGVILGGGSAPLTELAKMLNLPVTNTLMGLGGYP
GTDRQFIGMLGMHGSYTANLAMHHADVILAVGARFDDRVINGASKFCPNAKIIHIDIDPA
SISKTIKADVPIVGPVESVLTEMVAILKEIGETPNKESVASWWKQVDEWRGDRGLFPYDK
GDGSKIKPQTVIETLCEVTNGDAFVTSDVGQHQMFAAQYYKFNKPNRWINSGGLGTMGFG
FPAAMGIQLSYPDADVACVTGEGSIQMNIQELSTCLQYGLPVKIVILNNGVLGMVRQWQD
MSYGSRHSHSYMESLPDFVKLAEAYGHVGVRITESKDLKSKMEEAFAMKDRLVVIDISVD
TSEHVYPMQIKDGSMRDMWLSKTERT
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory