Comparing PfGW456L13_1866 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_1866 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P48728 Aminomethyltransferase, mitochondrial; Glycine cleavage system T protein; GCVT; EC 2.1.2.10 from Homo sapiens (Human) (see 4 papers)
46% identity, 99% coverage: 4:372/374 of query aligns to 31:400/403 of P48728
1wsvA Crystal structure of human t-protein of glycine cleavage system (see paper)
46% identity, 98% coverage: 6:372/374 of query aligns to 2:369/371 of 1wsvA
1worA Crystal structure of t-protein of the glycine cleavage system (see paper)
36% identity, 98% coverage: 8:374/374 of query aligns to 3:358/362 of 1worA
1wopA Crystal structure of t-protein of the glycine cleavage system (see paper)
36% identity, 98% coverage: 8:374/374 of query aligns to 3:358/362 of 1wopA
Sites not aligning to the query:
1wooA Crystal structure of t-protein of the glycine cleavage system (see paper)
36% identity, 98% coverage: 8:374/374 of query aligns to 3:358/362 of 1wooA
Sites not aligning to the query:
3a8iA Crystal structure of et-ehred-5-ch3-thf complex (see paper)
35% identity, 96% coverage: 8:367/374 of query aligns to 3:356/363 of 3a8iA
2gagA Heteroteterameric sarcosine: structure of a diflavin metaloenzyme at 1.85 a resolution (see paper)
28% identity, 91% coverage: 9:347/374 of query aligns to 577:915/965 of 2gagA
Sites not aligning to the query:
Q50LF0 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain U-96) (see 2 papers)
28% identity, 70% coverage: 9:270/374 of query aligns to 577:858/965 of Q50LF0
Sites not aligning to the query:
3ad7A Heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with methylthio acetate (see paper)
28% identity, 70% coverage: 9:270/374 of query aligns to 576:857/963 of 3ad7A
Sites not aligning to the query:
1vrqA Crystal structure of heterotetrameric sarcosine oxidase from corynebacterium sp. U-96 in complex with folinic acid (see paper)
28% identity, 70% coverage: 9:270/374 of query aligns to 576:857/963 of 1vrqA
Sites not aligning to the query:
Q46337 Sarcosine oxidase subunit alpha; Sarcosine oxidase subunit A; Sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) subunit alpha; Tetrameric sarcosine oxidase subunit alpha; TSOX subunit alpha; EC 1.5.3.24 from Corynebacterium sp. (strain P-1) (see 2 papers)
25% identity, 95% coverage: 9:364/374 of query aligns to 579:955/967 of Q46337
Sites not aligning to the query:
4pabB Crystal structure of the precursor form of rat dmgdh complexed with tetrahydrofolate (see paper)
25% identity, 88% coverage: 38:367/374 of query aligns to 474:804/824 of 4pabB
Sites not aligning to the query:
Q63342 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 88% coverage: 38:367/374 of query aligns to 511:841/857 of Q63342
Sites not aligning to the query:
Q9UI17 Dimethylglycine dehydrogenase, mitochondrial; ME2GLYDH; EC 1.5.8.4 from Homo sapiens (Human) (see 4 papers)
24% identity, 88% coverage: 38:367/374 of query aligns to 518:848/866 of Q9UI17
Sites not aligning to the query:
1pj7A Structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folinic acid (see paper)
24% identity, 90% coverage: 1:337/374 of query aligns to 422:789/827 of 1pj7A
Sites not aligning to the query:
1pj6A Crystal structure of dimethylglycine oxidase of arthrobacter globiformis in complex with folic acid (see paper)
24% identity, 90% coverage: 1:337/374 of query aligns to 423:790/828 of 1pj6A
Sites not aligning to the query:
Q9AGP8 Dimethylglycine oxidase; DMGO; EC 1.5.3.10 from Arthrobacter globiformis (see 2 papers)
24% identity, 90% coverage: 1:337/374 of query aligns to 425:792/830 of Q9AGP8
Sites not aligning to the query:
3gsiA Crystal structure of d552a dimethylglycine oxidase mutant of arthrobacter globiformis in complex with tetrahydrofolate (see paper)
24% identity, 90% coverage: 1:337/374 of query aligns to 422:789/827 of 3gsiA
Sites not aligning to the query:
Q8GAI3 4-methylaminobutanoate oxidase (formaldehyde-forming); MABO; Demethylating gamma-N-methylaminobutyrate oxidase; Gamma-N-methylaminobutyrate oxidase 1; EC 1.5.3.19 from Paenarthrobacter nicotinovorans (Arthrobacter nicotinovorans) (see paper)
27% identity, 96% coverage: 8:366/374 of query aligns to 439:814/824 of Q8GAI3
Sites not aligning to the query:
3tfjA Dmsp-dependent demethylase from p. Ubique - with cofactor thf (see paper)
19% identity, 87% coverage: 42:367/374 of query aligns to 48:369/369 of 3tfjA
Sites not aligning to the query:
>PfGW456L13_1866 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_1866
MSTEQLLKTPLHALHIELGARMVPFAGYDMPVQYPLGVMKEHQHTRDQAGLFDVSHMGQI
RLTGANAAKALETLVPVDIIDLPVGMQRYAMFTNATGGILDDLMVANLGNDELFLVVNAA
CKDQDLAHLRKHIGDQCTIEPLFEERALLALQGPAAVTVLARLAPEVAKMTFMQFARVKL
LGVDCFVSRSGYTGEDGFEISVPATNAEALARALLAEAEVAAIGLGARDSLRLEAGLCLY
GHDMNTDTTPIEASLLWAISKPRRADGARAGGFPGAETVFAQQQAGVSRKRVGLLPQERT
PVREGAEIVNEAGDIIGSVCSGGFGPTLGGPLAMGYVDSAYIALDTPVWAIVRGKKVPLL
VSKMPFVPQRYYRG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory