Comparing PfGW456L13_2337 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 4 hits to proteins with known functional sites (download)
2x65B Crystal structure of t. Maritima gdp-mannose pyrophosphorylase in complex with mannose-1-phosphate. (see paper)
36% identity, 73% coverage: 5:355/480 of query aligns to 5:332/334 of 2x65B
2x65A Crystal structure of t. Maritima gdp-mannose pyrophosphorylase in complex with mannose-1-phosphate. (see paper)
36% identity, 73% coverage: 5:355/480 of query aligns to 5:332/334 of 2x65A
2x60A Crystal structure of t. Maritima gdp-mannose pyrophosphorylase in complex with gtp. (see paper)
36% identity, 73% coverage: 5:355/480 of query aligns to 5:332/333 of 2x60A
2x5zA Crystal structure of t. Maritima gdp-mannose pyrophosphorylase in complex with gdp-mannose. (see paper)
36% identity, 73% coverage: 5:355/480 of query aligns to 5:332/333 of 2x5zA
>PfGW456L13_2337 Mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22)
MLIPVILSGGAGTRLWPVSREGHPKPFMALPDGQSLLGKTYRRAADLLDGWGDIVTVTNR
EYYFQSKDHFRDAHLGRHRGHFLLEPTGRNTAPAIAAAALSLHALHGDDAIMLVMPADHL
IVNVDALKDAVEHAVALARRGHLVTFGVVPTAPETGFGYIEAGMPLDDKGAASVRRFVEK
PDLQTATHYLESGNFLWNSGMFCFSVATLLAELQTHAPDLLEQTQTCMAASAAVENAGSL
QQELSPALFGEIMDISIDYALMERSDKVVVVPARFDWSDIGSWGAVAALVPADAQNNRTV
GESIFIDSHNNFVQSENRLVATVGVDNLIIVDTADAVLVAHADRAQDVRRVARQLKDKEH
EAYRLHRTVSRPWGTYTVLEEGPRFKIKRIVVKPGAKLSLQMHHHRNEHWVVVEGMAKVT
NNGTGTHLVAKNESTFIAAGHKHRLENPGVIDLVIIEVQSGEYLGEDDIVRFEDQYGRTV
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory