Comparing PfGW456L13_2432 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2432 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6aa8E Crystal structure of (s)-3-hydroxybutyryl-coenzymea dehydrogenase from clostridium acetobutylicum complexed with NAD+ (see paper)
40% identity, 56% coverage: 9:289/505 of query aligns to 2:281/281 of 6aa8E
P00348 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; L-3-hydroxyacyl CoA dehydrogenase; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Sus scrofa (Pig) (see paper)
41% identity, 55% coverage: 9:287/505 of query aligns to 29:313/314 of P00348
1f17A L-3-hydroxyacyl-coa dehydrogenase complexed with nadh (see paper)
41% identity, 55% coverage: 9:287/505 of query aligns to 6:290/293 of 1f17A
1f12A L-3-hydroxyacyl-coa dehydrogenase complexed with 3-hydroxybutyryl-coa (see paper)
41% identity, 55% coverage: 9:287/505 of query aligns to 6:290/293 of 1f12A
1f0yA L-3-hydroxyacyl-coa dehydrogenase complexed with acetoacetyl-coa and NAD+ (see paper)
41% identity, 55% coverage: 9:287/505 of query aligns to 6:290/291 of 1f0yA
4kugA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with NAD from clostridium butyricum
39% identity, 56% coverage: 9:289/505 of query aligns to 3:282/282 of 4kugA
Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Homo sapiens (Human) (see 7 papers)
41% identity, 55% coverage: 9:287/505 of query aligns to 29:313/314 of Q16836
4kuhA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with acetoacetyl-coa from clostridium butyricum
39% identity, 55% coverage: 9:287/505 of query aligns to 3:280/280 of 4kuhA
4pzeA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with acetoacetyl-coa (see paper)
35% identity, 55% coverage: 10:289/505 of query aligns to 5:283/283 of 4pzeA
4pzdA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with NAD+ (see paper)
35% identity, 55% coverage: 10:289/505 of query aligns to 5:283/283 of 4pzdA
P9WNP7 3-hydroxybutyryl-CoA dehydrogenase; Beta-hydroxybutyryl-CoA dehydrogenase; BHBD; EC 1.1.1.157 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
36% identity, 55% coverage: 9:287/505 of query aligns to 7:286/286 of P9WNP7
P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
30% identity, 63% coverage: 10:326/505 of query aligns to 364:699/763 of P40939
Sites not aligning to the query:
6iunB Crystal structure of enoyl-coa hydratase (ech) from ralstonia eutropha h16 in complex with NAD
33% identity, 61% coverage: 9:318/505 of query aligns to 293:594/692 of 6iunB
Sites not aligning to the query:
6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
32% identity, 56% coverage: 25:309/505 of query aligns to 324:620/707 of 6yswA
Sites not aligning to the query:
8oqlA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1
36% identity, 56% coverage: 9:290/505 of query aligns to 335:618/728 of 8oqlA
Sites not aligning to the query:
8oqsB Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-83
36% identity, 56% coverage: 9:290/505 of query aligns to 342:625/735 of 8oqsB
Sites not aligning to the query:
8oqvA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-109
36% identity, 56% coverage: 9:290/505 of query aligns to 334:617/726 of 8oqvA
Sites not aligning to the query:
4b3iA Crystal structure of mycobacterium tuberculosis fatty acid beta-oxidation complex with coenzymea bound at the hydratase active sites (see paper)
36% identity, 56% coverage: 9:290/505 of query aligns to 338:621/731 of 4b3iA
Sites not aligning to the query:
8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80
36% identity, 56% coverage: 9:290/505 of query aligns to 336:619/728 of 8oqrA
Sites not aligning to the query:
8pf8A Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
36% identity, 56% coverage: 9:290/505 of query aligns to 336:619/729 of 8pf8A
Sites not aligning to the query:
>PfGW456L13_2432 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2432
MTALNTSARIAVIGAGAMGAGIAQVAAQAGHPVLLLDNRPGAAAQAIEGIDRQLGKRVEN
GKLSAESRSATVARLQAVEVIETLADCDLIIEAIVENLEVKRALFRQLEGICGEHCILAS
NTSSLSITSIAAQLDHPQRLLGLHFFNPAPVMALVEVVSGLASDPALAECLYDTARAWGK
KPVHTRSTPGFIVNRVARPFYAESLRMLQEGAADCPTLDALMREAGGFAMGAFELTDLIG
HDVNYAVTCSVFDAYYQDTRFLPSLIQKELVDGGRLGRKSGQGFYCYAQGAERPQAGEIS
SSASVETCIAEGDLGIAQGLLARLSEQGVEVIRRDGRGLLRVGDAVLALSDGRMACQRAR
EDGLRNLILLDLAFDYGNAKRIAISHAAGIDPLALEQGVALLQRAGLMVSLLSDSPALAV
LRTVAMLANEAADALLQGVASAADIDLAMRAGVNYPQGPLAWADAIGLSHILETLENLQA
SYGEERYRPSLLLRRRVAEGRTFHD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory