SitesBLAST
Comparing PfGW456L13_2690 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2690 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
46% identity, 96% coverage: 19:501/502 of query aligns to 10:490/491 of 5gtlA
- active site: N165 (= N176), K188 (= K199), E263 (= E274), C297 (= C308), E394 (= E405), E471 (≠ D482)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I172), P163 (= P174), K188 (= K199), A190 (= A201), E191 (= E202), Q192 (≠ L203), G221 (= G232), G225 (= G236), G241 (= G252), S242 (= S253), T245 (≠ V256), L264 (= L275), C297 (= C308), E394 (= E405), F396 (= F407)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
46% identity, 96% coverage: 19:501/502 of query aligns to 10:490/491 of 5gtkA
- active site: N165 (= N176), K188 (= K199), E263 (= E274), C297 (= C308), E394 (= E405), E471 (≠ D482)
- binding nicotinamide-adenine-dinucleotide: I161 (= I172), I162 (≠ V173), P163 (= P174), W164 (= W175), K188 (= K199), E191 (= E202), G221 (= G232), G225 (= G236), A226 (= A237), F239 (= F250), G241 (= G252), S242 (= S253), T245 (≠ V256), Y248 (≠ T259), L264 (= L275), C297 (= C308), Q344 (= Q355), R347 (= R358), E394 (= E405), F396 (= F407)
O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 6 papers)
44% identity, 95% coverage: 24:502/502 of query aligns to 36:514/518 of O94788
- E50 (≠ S38) to G: in dbSNP:rs34266719
- A110 (= A97) to V: in dbSNP:rs35365164
- Q182 (≠ A171) to K: in DIH4; decreased retinoic acid biosynthetic process
- IPW 184:186 (≠ VPW 173:175) binding
- KPAE 210:213 (= KPAE 199:202) binding
- STE 264:266 (≠ STP 253:255) binding
- C320 (= C308) active site, Nucleophile
- R347 (≠ L335) to H: in DIH4; decreased expression; dbSNP:rs141245344
- V348 (≠ K336) to I: in dbSNP:rs4646626
- KQYNK 366:370 (≠ LQKQR 354:358) binding
- A383 (= A371) to T: in DIH4; uncertain significance; dbSNP:rs749124508
- E417 (= E405) binding
- E436 (≠ A424) to K: in dbSNP:rs34744827
- S461 (≠ I449) to Y: in DIH4; decreased retinoic acid biosynthetic process
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121) (see paper)
44% identity, 95% coverage: 24:502/502 of query aligns to 10:488/492 of 6b5hA
- active site: N161 (= N176), E260 (= E274), C294 (= C308), E468 (≠ D482)
- binding 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1H-pyrazole-4-carboxamide: V112 (= V125), G116 (= G129), F162 (= F177), W169 (= W184), Q284 (≠ N298), F288 (= F302), T295 (≠ D309), N449 (≠ G463), L451 (= L465), N452 (≠ D466), F457 (= F471)
- binding nicotinamide-adenine-dinucleotide: I157 (= I172), I158 (≠ V173), W160 (= W175), N161 (= N176), K184 (= K199), G217 (= G232), G221 (= G236), F235 (= F250), T236 (= T251), G237 (= G252), S238 (= S253), V241 (= V256), E260 (= E274), L261 (= L275), C294 (= C308), F393 (= F407)
6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118) (see paper)
44% identity, 95% coverage: 24:502/502 of query aligns to 10:488/492 of 6b5gA
- active site: N161 (= N176), E260 (= E274), C294 (= C308), E468 (≠ D482)
- binding (3-ethoxythiophen-2-yl){4-[4-nitro-3-(pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone: F162 (= F177), L165 (≠ Q180), W169 (= W184), F288 (= F302), C293 (≠ V307), C294 (= C308), T295 (≠ D309), N449 (≠ G463), L451 (= L465)
- binding nicotinamide-adenine-dinucleotide: I157 (= I172), I158 (≠ V173), P159 (= P174), W160 (= W175), N161 (= N176), M166 (≠ T181), K184 (= K199), E187 (= E202), G217 (= G232), G221 (= G236), F235 (= F250), T236 (= T251), G237 (= G252), S238 (= S253), V241 (= V256), E260 (= E274), L261 (= L275), C294 (= C308), E391 (= E405), F393 (= F407)
6aljA Aldh1a2 liganded with NAD and compound win18,446 (see paper)
44% identity, 95% coverage: 24:502/502 of query aligns to 10:488/492 of 6aljA
- active site: N161 (= N176), E260 (= E274), C294 (= C308), E468 (≠ D482)
- binding N,N'-(octane-1,8-diyl)bis(2,2-dichloroacetamide): G116 (= G129), F162 (= F177), L165 (≠ Q180), M166 (≠ T181), W169 (= W184), E260 (= E274), C293 (≠ V307), C294 (= C308), L451 (= L465), N452 (≠ D466), A453 (≠ P467)
- binding nicotinamide-adenine-dinucleotide: I157 (= I172), I158 (≠ V173), P159 (= P174), W160 (= W175), N161 (= N176), K184 (= K199), E187 (= E202), G217 (= G232), G221 (= G236), F235 (= F250), G237 (= G252), S238 (= S253), V241 (= V256), Q341 (= Q355), K344 (≠ R358), E391 (= E405), F393 (= F407)
Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
44% identity, 95% coverage: 24:502/502 of query aligns to 36:514/518 of Q63639
O14293 Putative aldehyde dehydrogenase-like protein C9E9.09c; EC 1.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
46% identity, 94% coverage: 28:501/502 of query aligns to 25:497/503 of O14293
- S248 (= S253) modified: Phosphoserine
Sites not aligning to the query:
- 501 modified: Phosphoserine
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
46% identity, 94% coverage: 24:497/502 of query aligns to 9:484/494 of 4pz2B
- active site: N159 (= N176), K182 (= K199), E258 (= E274), C292 (= C308), E392 (= E405), D469 (= D482)
- binding nicotinamide-adenine-dinucleotide: I155 (= I172), I156 (≠ V173), P157 (= P174), W158 (= W175), N159 (= N176), M164 (≠ T181), K182 (= K199), A184 (= A201), E185 (= E202), G215 (= G232), G219 (= G236), F233 (= F250), T234 (= T251), G235 (= G252), S236 (= S253), V239 (= V256), E258 (= E274), L259 (= L275), C292 (= C308), E392 (= E405), F394 (= F407)
7radA Crystal structure analysis of aldh1b1
45% identity, 95% coverage: 26:502/502 of query aligns to 13:489/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I172), I159 (≠ V173), P160 (= P174), W161 (= W175), N162 (= N176), M167 (≠ T181), K185 (= K199), E188 (= E202), G218 (= G232), G222 (= G236), A223 (= A237), T237 (= T251), G238 (= G252), S239 (= S253), V242 (= V256), E261 (= E274), L262 (= L275), C295 (= C308), E392 (= E405), F394 (= F407)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (≠ V125), E117 (≠ G129), F163 (= F177), E285 (≠ N298), F289 (= F302), N450 (≠ G463), V452 (≠ L465)
7mjdA Crystal structure analysis of aldh1b1
45% identity, 95% coverage: 26:502/502 of query aligns to 13:489/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I172), I159 (≠ V173), P160 (= P174), W161 (= W175), N162 (= N176), M167 (≠ T181), K185 (= K199), E188 (= E202), G218 (= G232), G222 (= G236), F236 (= F250), T237 (= T251), G238 (= G252), S239 (= S253), V242 (= V256), E261 (= E274), L262 (= L275), C295 (= C308), E392 (= E405), F394 (= F407)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ G129), E285 (≠ N298), F289 (= F302), N450 (≠ G463), V452 (≠ L465)
7mjcA Crystal structure analysis of aldh1b1
45% identity, 95% coverage: 26:502/502 of query aligns to 13:489/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I172), I159 (≠ V173), P160 (= P174), W161 (= W175), N162 (= N176), K185 (= K199), E188 (= E202), G218 (= G232), G222 (= G236), T237 (= T251), G238 (= G252), S239 (= S253), V242 (= V256), E261 (= E274), L262 (= L275), C295 (= C308), E392 (= E405), F394 (= F407)
7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
44% identity, 95% coverage: 24:501/502 of query aligns to 12:489/489 of 7a6qB
- active site: N163 (= N176), E262 (= E274), C296 (= C308), E470 (≠ D482)
- binding nicotinamide-adenine-dinucleotide: I159 (= I172), W162 (= W175), K186 (= K199), E189 (= E202), G219 (= G232), G223 (= G236), S240 (= S253), V243 (= V256), K342 (≠ L354)
- binding (3-oxidanylidene-3-sodiooxy-propanoyl)oxysodium: A32 (≠ D44), T33 (≠ V45), C34 (≠ V46), P36 (= P48), D103 (= D114), E189 (= E202), Q190 (≠ L203), F218 (≠ R231), I339 (≠ V351), D340 (≠ S352)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (= G129), D141 (≠ S152), N143 (= N156), N451 (≠ G463), L453 (= L465), A455 (≠ P467)
7a6qA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
44% identity, 95% coverage: 24:501/502 of query aligns to 12:489/489 of 7a6qA
- active site: N163 (= N176), E262 (= E274), C296 (= C308), E470 (≠ D482)
- binding nicotinamide-adenine-dinucleotide: I159 (= I172), T160 (≠ V173), W162 (= W175), K186 (= K199), A188 (= A201), E189 (= E202), G219 (= G232), G223 (= G236), S240 (= S253), V243 (= V256), K342 (≠ L354), K346 (≠ R358)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (= G129), D141 (≠ S152), N143 (= N156), N451 (≠ G463), L453 (= L465), Y454 (≠ D466)
5fhzA Human aldehyde dehydrogenase 1a3 complexed with NAD(+) and retinoic acid (see paper)
44% identity, 95% coverage: 24:501/502 of query aligns to 12:489/489 of 5fhzA
- active site: N163 (= N176), K186 (= K199), E262 (= E274), C296 (= C308), E393 (= E405), E470 (≠ D482)
- binding nicotinamide-adenine-dinucleotide: I159 (= I172), T160 (≠ V173), W162 (= W175), K186 (= K199), E189 (= E202), G219 (= G232), G223 (= G236), F237 (= F250), G239 (= G252), S240 (= S253), T241 (= T254), V243 (= V256), G264 (= G276), Q343 (= Q355), E393 (= E405)
- binding retinoic acid: G118 (= G129), R121 (≠ D132), F164 (= F177), M168 (≠ T181), W171 (= W184), C295 (≠ V307), C296 (= C308), L453 (= L465)
7qk9A Crystal structure of the aldh1a3-atp complex (see paper)
44% identity, 95% coverage: 24:501/502 of query aligns to 11:488/489 of 7qk9A
- binding adenosine-5'-triphosphate: I158 (= I172), T159 (≠ V173), P160 (= P174), W161 (= W175), K185 (= K199), E188 (= E202), G218 (= G232), G222 (= G236), F236 (= F250), S239 (= S253), V242 (= V256)
P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 2 papers)
44% identity, 95% coverage: 24:501/502 of query aligns to 30:507/512 of P47895
- R89 (= R82) to C: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514652
- K204 (= K199) binding
- E207 (= E202) binding
- GSTEVG 257:262 (≠ GSTPVG 252:257) binding
- Q361 (= Q355) binding
- E411 (= E405) binding
- A493 (≠ Q487) to P: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514653
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylalanine
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
45% identity, 94% coverage: 24:497/502 of query aligns to 4:476/486 of 4pxlA
- active site: N154 (= N176), K177 (= K199), E253 (= E274), C287 (= C308), E384 (= E405), D461 (= D482)
- binding nicotinamide-adenine-dinucleotide: I150 (= I172), V151 (= V173), P152 (= P174), W153 (= W175), K177 (= K199), E180 (= E202), G210 (= G232), G214 (= G236), A215 (= A237), F228 (= F250), G230 (= G252), S231 (= S253), V234 (= V256), E253 (= E274), G255 (= G276), C287 (= C308), Q334 (= Q355), K337 (≠ R358), E384 (= E405), F386 (= F407)
5teiA Structure of human aldh1a1 with inhibitor cm039
44% identity, 95% coverage: 24:501/502 of query aligns to 9:488/493 of 5teiA
- active site: N162 (= N176), K185 (= K199), E261 (= E274), C295 (= C308), E392 (= E405), E469 (≠ D482)
- binding 6-{[(3-fluorophenyl)methyl]sulfanyl}-5-(2-methylphenyl)-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: S113 (≠ V125), F163 (= F177), H285 (≠ N298), G286 (= G299), Y289 (≠ F302), C295 (= C308), G450 (= G463), V452 (≠ L465), F458 (= F471)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I158 (= I172), I159 (≠ V173), P160 (= P174), W161 (= W175), N162 (= N176), K185 (= K199), E188 (= E202), G218 (= G232), G222 (= G236), A223 (= A237), F236 (= F250), T237 (= T251), G238 (= G252), S239 (= S253), V242 (= V256), C295 (= C308), Q342 (= Q355), K345 (≠ R358), E392 (= E405), F394 (= F407)
4x4lA Structure of human aldh1a1 with inhibitor cm037 (see paper)
44% identity, 95% coverage: 24:501/502 of query aligns to 9:488/493 of 4x4lA
- active site: N162 (= N176), K185 (= K199), E261 (= E274), C295 (= C308), E392 (= E405), E469 (≠ D482)
- binding ethyl ({4-oxo-3-[3-(pyrrolidin-1-yl)propyl]-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetate: S113 (≠ V125), M167 (≠ T181), W170 (= W184), Y289 (≠ F302), G450 (= G463), F458 (= F471)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I158 (= I172), I159 (≠ V173), P160 (= P174), W161 (= W175), K185 (= K199), E188 (= E202), G218 (= G232), G222 (= G236), F236 (= F250), T237 (= T251), G238 (= G252), S239 (= S253), V242 (= V256), C295 (= C308), Q342 (= Q355), K345 (≠ R358), E392 (= E405), F394 (= F407)
Query Sequence
>PfGW456L13_2690 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2690
MDTIVKSYLQKFGVSEATQTFLGKVQKMFIGGAWVEASDGQTSDVVEPSTEGLITRIPMG
TTDDLDRAVQAARAQFDGGAWRQAKPAERERMMQRLADLIEQNAAELAQIESIDMGKSVA
FAKDVDIQGTVDTLRYFAGWATKLHGRTVEPSLPGNYLAYTRKEAVGVVGAIVPWNFPLQ
TMAWKLGAALATGCTVVVKPAELTSLSALRFAELVQEAGIPDGVINIVTGRGSVVGAAMA
THPGIDKLTFTGSTPVGQTVGRAALDDMKRLTLELGGKSPVIVCADADIPAAAQAVANGV
FFNSGQVCDAGTRAYIHSSVYDEFLRELITYTRTLKMAPGLDPDCFIGPLVSALQKQRVT
EYIETGKAEGAELVYGGQPVDGPGFFVEPTIFANCRNDMRIVQEEIFGPVLVTAPFDDEE
EALALANDSPYGLAAALYSNDLGKVHSLIPRLKAGSVYVNAHGTLDPSMPFGGYKQSGFG
KDLGAEQLDYLLETKAVWITLP
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory