SitesBLAST
Comparing PfGW456L13_2692 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2692 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8b7sA Crystal structure of the chloramphenicol-inactivating oxidoreductase from novosphingobium sp (see paper)
38% identity, 93% coverage: 8:534/567 of query aligns to 2:451/458 of 8b7sA
- binding flavin-adenine dinucleotide: G11 (= G17), G13 (= G19), S14 (= S20), A15 (= A21), E35 (= E41), A36 (≠ F42), W47 (= W68), P65 (= P86), G67 (= G88), V180 (≠ T226), A214 (≠ S260), G215 (= G261), A218 (≠ G264), T270 (≠ L316), Y391 (= Y474), A424 (≠ S507), I435 (≠ L518), N436 (= N519)
5nccA Structure of fatty acid photodecarboxylase in complex with fad and palmitic acid (see paper)
34% identity, 94% coverage: 2:535/567 of query aligns to 15:571/578 of 5nccA
- active site: R347 (≠ L326), L420 (vs. gap), I421 (vs. gap), S507 (≠ T473), A509 (≠ H475), G552 (= G516), Q553 (≠ N517)
- binding flavin-adenine dinucleotide: G30 (= G17), G32 (= G19), T33 (≠ S20), A34 (= A21), L53 (= L40), E54 (= E41), A55 (≠ F42), F74 (≠ N62), W80 (= W68), A98 (≠ P86), G100 (= G88), G105 (= G93), S106 (= S94), N110 (= N98), A111 (≠ G99), T112 (≠ L100), L113 (≠ V101), V238 (≠ T226), A278 (≠ S260), H282 (≠ G264), L286 (= L268), N508 (≠ Y474), Q553 (≠ N517), T554 (≠ L518), G555 (≠ N519), V558 (≠ T522)
A0A248QE08 Fatty acid photodecarboxylase, chloroplastic; CvFAP; EC 4.1.1.106 from Chlorella variabilis (Green alga) (see paper)
34% identity, 94% coverage: 2:535/567 of query aligns to 75:638/654 of A0A248QE08
- TA 93:94 (≠ SA 20:21) binding
- E114 (= E41) binding
- L162 (≠ V90) binding
- S166 (= S94) binding
- NATL 170:173 (≠ NGLV 98:101) binding
- V298 (≠ T226) binding
- C432 (≠ F345) binding
- R451 (≠ H365) binding
- Y466 (vs. gap) binding
- Q486 (vs. gap) binding
- G622 (≠ N519) binding
6yrvAAA structure of fap after illumination at 100k (see paper)
34% identity, 93% coverage: 6:535/567 of query aligns to 3:562/573 of 6yrvAAA
- binding carbon dioxide: R375 (≠ H365), N499 (≠ Y474)
- binding flavin-adenine dinucleotide: G14 (= G17), G16 (= G19), T17 (≠ S20), A18 (= A21), L37 (= L40), E38 (= E41), A39 (≠ F42), F58 (≠ N62), W64 (= W68), A82 (≠ P86), G89 (= G93), S90 (= S94), N94 (= N98), A95 (≠ G99), T96 (≠ L100), L97 (≠ V101), M191 (≠ T195), V222 (≠ T226), C264 (≠ S259), A265 (≠ S260), G266 (= G261), H269 (≠ G264), N499 (≠ Y474), A534 (≠ S507), Q544 (≠ N517), T545 (≠ L518), G546 (≠ N519)
- binding heptadecane: V377 (≠ L367), G379 (≠ A369), M380 (vs. gap), G386 (= G375), T389 (vs. gap), Y390 (vs. gap), F393 (vs. gap), T408 (≠ N391), Q410 (vs. gap)
4mjwA Crystal structure of choline oxidase in complex with the reaction product glycine betaine (see paper)
34% identity, 94% coverage: 4:537/567 of query aligns to 7:530/532 of 4mjwA
- active site: I333 (≠ A347), P377 (≠ T388), N378 (≠ G389), V464 (≠ T473), H466 (= H475), V509 (≠ G516), N510 (= N517)
- binding flavin-adenine dinucleotide: G20 (= G17), G22 (= G19), S23 (= S20), E44 (= E41), A45 (≠ F42), W71 (= W68), R89 (= R87), A90 (≠ G88), G95 (= G93), C96 (≠ S94), H99 (≠ I97), N100 (= N98), S101 (≠ G99), I103 (≠ V101), R231 (≠ M225), A232 (≠ T226), T269 (≠ S260), G270 (= G261), D273 (≠ G264), Y465 (= Y474), H466 (= H475), A500 (≠ S507), N510 (= N517), P511 (≠ L518), N512 (= N519), V515 (≠ T522)
3ljpA Crystal structure of choline oxidase v464a mutant (see paper)
34% identity, 94% coverage: 4:537/567 of query aligns to 7:530/530 of 3ljpA
- active site: I333 (≠ A347), P377 (≠ T388), N378 (≠ G389), A464 (≠ T473), H466 (= H475), V509 (≠ G516), N510 (= N517)
- binding dihydroflavine-adenine dinucleotide: G22 (= G19), S23 (= S20), E44 (= E41), A45 (≠ F42), W71 (= W68), R89 (= R87), A90 (≠ G88), G95 (= G93), C96 (≠ S94), H99 (≠ I97), N100 (= N98), S101 (≠ G99), I103 (≠ V101), A232 (≠ T226), T269 (≠ S260), D273 (≠ G264), Y465 (= Y474), H466 (= H475), D499 (= D506), A500 (≠ S507), N510 (= N517), P511 (≠ L518), N512 (= N519), V515 (≠ T522)
2jbvA Crystal structure of choline oxidase reveals insights into the catalytic mechanism (see paper)
35% identity, 94% coverage: 4:534/567 of query aligns to 7:527/527 of 2jbvA
- active site: I333 (≠ A347), P377 (≠ T388), N378 (≠ G389), V464 (≠ T473), H466 (= H475), V509 (≠ G516), N510 (= N517)
- binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(4aS,10aR)-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate: G22 (= G19), S23 (= S20), E44 (= E41), A45 (≠ F42), W71 (= W68), A90 (≠ G88), G95 (= G93), C96 (≠ S94), H99 (≠ I97), N100 (= N98), S101 (≠ G99), I103 (≠ V101), R231 (≠ M225), A232 (≠ T226), T269 (≠ S260), G270 (= G261), D273 (≠ G264), V464 (≠ T473), Y465 (= Y474), H466 (= H475), D499 (= D506), A500 (≠ S507), N510 (= N517), P511 (≠ L518), N512 (= N519), V515 (≠ T522)
4ha6A Crystal structure of pyridoxine 4-oxidase - pyridoxamine complex (see paper)
34% identity, 91% coverage: 12:527/567 of query aligns to 3:498/508 of 4ha6A
- active site: F360 (≠ T388), G361 (= G389), H444 (≠ T473), H446 (= H475), G487 (= G516), P488 (≠ N517)
- binding flavin-adenine dinucleotide: G8 (= G17), G10 (= G19), S11 (= S20), A12 (= A21), E32 (= E41), A33 (≠ F42), W58 (= W68), R77 (= R87), G78 (= G88), G83 (= G93), S84 (= S94), L87 (≠ I97), H88 (≠ N98), A89 (≠ G99), M90 (≠ L100), G91 (≠ V101), V218 (≠ T226), A251 (≠ S260), G252 (= G261), E255 (≠ G264), H445 (≠ Y474), A478 (≠ S507), P488 (≠ N517), I489 (≠ L518), H490 (≠ N519)
- binding 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol: A89 (≠ G99), S314 (≠ G329), H444 (≠ T473), H446 (= H475)
3t37A Crystal structure of pyridoxine 4-oxidase from mesorbium loti
34% identity, 91% coverage: 12:527/567 of query aligns to 3:498/509 of 3t37A
- active site: F360 (≠ T388), G361 (= G389), H444 (≠ T473), H446 (= H475), G487 (= G516), P488 (≠ N517)
- binding flavin-adenine dinucleotide: G8 (= G17), G10 (= G19), S11 (= S20), A12 (= A21), E32 (= E41), A33 (≠ F42), W58 (= W68), R77 (= R87), G78 (= G88), R79 (≠ K89), G83 (= G93), S84 (= S94), H88 (≠ N98), A89 (≠ G99), G91 (≠ V101), R217 (≠ M225), V218 (≠ T226), A251 (≠ S260), E255 (≠ G264), H445 (≠ Y474), A478 (≠ S507), P488 (≠ N517), I489 (≠ L518), H490 (≠ N519)
5oc1A Crystal structure of aryl-alcohol oxidase from pleurotus eryngii in complex with p-anisic acid (see paper)
30% identity, 93% coverage: 11:537/567 of query aligns to 2:565/565 of 5oc1A
- active site: V339 (vs. gap), N413 (≠ T388), A414 (≠ G389), I499 (≠ T473), H501 (= H475), A544 (≠ G516), H545 (≠ N517)
- binding 4-methoxybenzoic acid: Y91 (≠ G99), I356 (≠ M327), I390 (≠ R358), F396 (= F364), T412 (≠ L387), I499 (≠ T473), H501 (= H475), H545 (≠ N517)
- binding flavin-adenine dinucleotide: G8 (= G17), G10 (= G19), N11 (≠ S20), A12 (= A21), E32 (= E41), A33 (≠ F42), W60 (= W68), P78 (= P86), G80 (= G88), G85 (= G93), S86 (= S94), H90 (≠ N98), Y91 (≠ G99), V93 (= V101), V230 (≠ T226), S270 (= S259), A271 (≠ S260), G272 (= G261), F500 (≠ Y474), H545 (≠ N517), T546 (≠ L518), Q547 (≠ N519), I550 (≠ T522)
E4QP00 5-(hydroxymethyl)furfural oxidase; 5-hydroxymethylfurfural oxidase; HMFO; Thiol oxidase; EC 1.1.3.47; EC 1.8.3.- from Methylovorus sp. (strain MP688) (see paper)
31% identity, 93% coverage: 6:533/567 of query aligns to 1:527/531 of E4QP00
- V101 (≠ I97) mutation to H: Abolishes activity.
- M103 (≠ G99) mutation to A: 16-fold reduction in catalytic efficiency on vanillyl alcohol.
- V367 (= V386) mutation to K: 1.6-fold reduction in catalytic efficiency on vanillyl alcohol. Shows significantly improved activity on the aldehyde 5-formyl-2-furancarboxylate, which results in a better 5-hydroxymethylfurfural to 2,5-furandicarboxylate conversion.; mutation to R: 1.4-fold reduction in catalytic efficiency on vanillyl alcohol. Shows significantly improved activity on the aldehyde 5-formyl-2-furancarboxylate, which results in a better 5-hydroxymethylfurfural to 2,5-furandicarboxylate conversion. Displays a catalytic efficiency toward 5-formyl-2-furancarboxylate that is over 1000-fold higher than that for wild-type; when associated with F-466.
- W369 (≠ T388) mutation to A: 7.5-fold reduction in catalytic efficiency on vanillyl alcohol.
- V465 (≠ T473) mutation to A: 18-fold reduction in catalytic efficiency on vanillyl alcohol.
- W466 (≠ Y474) mutation to A: 39-fold reduction in catalytic efficiency on vanillyl alcohol. In contrast to wild-type, is active on secondary alcohols, such as (S)-1-phenylethanol, and is strictly enantionselective as this mutant has no activity on (R)-1-phenylethanol. Shows increased activity on the aldehyde 5-formyl-2-furancarboxylate.; mutation to F: 3.4-fold reduction in catalytic efficiency on vanillyl alcohol. In contrast to wild-type, is active on secondary alcohols, such as (S)-1-phenylethanol, and is strictly enantionselective as this mutant has no activity on (R)-1-phenylethanol. Shows increased activity on the aldehyde 5-formyl-2-furancarboxylate. Displays a catalytic efficiency toward 5-formyl-2-furancarboxylate that is over 1000-fold higher than that for wild-type; when associated with R-367.
- H467 (= H475) mutation to A: Abolishes activity.
- N511 (= N517) mutation to A: 53-fold reduction in catalytic efficiency on vanillyl alcohol.
3fimB Crystal structure of aryl-alcohol-oxidase from pleurotus eryingii (see paper)
30% identity, 93% coverage: 11:537/567 of query aligns to 2:565/565 of 3fimB
- active site: V339 (vs. gap), N413 (≠ T388), A414 (≠ G389), I499 (≠ T473), H501 (= H475), A544 (≠ G516), H545 (≠ N517)
- binding flavin-adenine dinucleotide: G8 (= G17), N11 (≠ S20), A12 (= A21), E32 (= E41), A33 (≠ F42), W60 (= W68), P78 (= P86), G80 (= G88), G85 (= G93), S86 (= S94), H90 (≠ N98), Y91 (≠ G99), V93 (= V101), V230 (≠ T226), S270 (= S259), A271 (≠ S260), F500 (≠ Y474), H501 (= H475), H545 (≠ N517), T546 (≠ L518), Q547 (≠ N519), I550 (≠ T522)
4udqA Crystal structure of 5-hydroxymethylfurfural oxidase (hmfo) in the reduced state
31% identity, 92% coverage: 11:533/567 of query aligns to 2:523/525 of 4udqA
- active site: L331 (≠ A347), F364 (≠ L387), W365 (≠ T388), V461 (≠ T473), H463 (= H475), A506 (≠ G516), N507 (= N517)
- binding flavin-adenine dinucleotide: G8 (= G17), G10 (= G19), T11 (≠ S20), A12 (= A21), E32 (= E41), A33 (≠ F42), W64 (= W68), G88 (= G80), G93 (= G93), G94 (≠ S94), N98 (= N98), M99 (≠ G99), V101 (= V101), V229 (≠ T226), T261 (≠ S259), A262 (≠ S260), W462 (≠ Y474), H463 (= H475), A497 (≠ S507), N507 (= N517), T508 (≠ L518), N509 (= N519), T512 (= T522)
4yntA Crystal structure of aspergillus flavus fad glucose dehydrogenase (see paper)
31% identity, 93% coverage: 8:534/567 of query aligns to 2:564/570 of 4yntA
- active site: V342 (≠ P322), F413 (≠ G383), W414 (≠ F384), N502 (≠ T473), H504 (= H475), G546 (= G516), H547 (≠ N517)
- binding dihydroflavine-adenine dinucleotide: G13 (= G19), T14 (≠ S20), S15 (≠ A21), E35 (= E41), A36 (≠ F42), F56 (vs. gap), W62 (= W68), R80 (≠ P86), G82 (= G88), G87 (= G93), T88 (≠ S94), N92 (= N98), G93 (= G99), M94 (≠ L100), A95 (≠ V101), A234 (≠ T226), A274 (≠ S260), R278 (≠ G264), F503 (≠ Y474), A537 (≠ S507), H547 (≠ N517), L548 (= L518), V549 (≠ N519), L552 (≠ T522)
4ynuA Crystal structure of aspergillus flavus fadgdh in complex with d- glucono-1,5-lactone (see paper)
31% identity, 93% coverage: 8:534/567 of query aligns to 1:563/569 of 4ynuA
- active site: V341 (≠ P322), F412 (≠ G383), W413 (≠ F384), N501 (≠ T473), H503 (= H475), G545 (= G516), H546 (≠ N517)
- binding flavin-adenine dinucleotide: G12 (= G19), T13 (≠ S20), S14 (≠ A21), E34 (= E41), A35 (≠ F42), Y51 (= Y66), F55 (vs. gap), W61 (= W68), R79 (≠ P86), G81 (= G88), G86 (= G93), T87 (≠ S94), N91 (= N98), G92 (= G99), T232 (≠ M225), A233 (≠ T226), A273 (≠ S260), G274 (= G261), R277 (≠ G264), F502 (≠ Y474), A536 (≠ S507), H546 (≠ N517), L547 (= L518), V548 (≠ N519), L551 (≠ T522)
- binding D-glucono-1,5-lactone: Y51 (= Y66), E411 (≠ H382), A496 (≠ D468), N497 (= N469), R499 (≠ E471), R499 (≠ E471), N501 (≠ T473), H503 (= H475), H546 (≠ N517)
7vzsA Fad-dpendent glucose dehydrogenase complexed with an inhibitor at ph7.56
31% identity, 93% coverage: 8:534/567 of query aligns to 1:563/566 of 7vzsA
- binding D-glucal: Y6 (= Y13), L22 (= L29), N25 (≠ D32), Y51 (= Y66), I349 (≠ L326), Q356 (≠ L333), E411 (≠ H382), E444 (= E420), W445 (≠ E421), K448 (≠ E424), R499 (≠ E471), N501 (≠ T473), H546 (≠ N517), K563 (≠ R534)
- binding flavin-adenine dinucleotide: G10 (= G17), G12 (= G19), T13 (≠ S20), S14 (≠ A21), E34 (= E41), A35 (≠ F42), Y51 (= Y66), F55 (vs. gap), W61 (= W68), R79 (≠ P86), G81 (= G88), G86 (= G93), T87 (≠ S94), N91 (= N98), G92 (= G99), M93 (≠ L100), A94 (≠ V101), T232 (≠ M225), A233 (≠ T226), A273 (≠ S260), G274 (= G261), R277 (≠ G264), F502 (≠ Y474), A536 (≠ S507), H546 (≠ N517), L547 (= L518), V548 (≠ N519), L551 (≠ T522)
Sites not aligning to the query:
8bxlB Patulin synthase from penicillium expansum
29% identity, 93% coverage: 9:535/567 of query aligns to 12:588/590 of 8bxlB
- binding flavin-adenine dinucleotide: G20 (= G17), G22 (= G19), T23 (≠ S20), A24 (= A21), E44 (= E41), A45 (≠ F42), W80 (= W68), G100 (= G88), G105 (= G93), S106 (= S94), R109 (≠ I97), N110 (= N98), Y111 (≠ G99), A113 (≠ V101), L253 (≠ M225), A254 (≠ T226), A288 (≠ S260), Q292 (≠ G264), F525 (≠ Y474), D559 (= D506), A560 (≠ S507), H570 (≠ N517), P571 (≠ L518), Q572 (≠ N519), L575 (≠ T522)
Q3L245 Pyranose dehydrogenase 1; PDH 1; Pyranose:quinone oxidoreductase 1; EC 1.1.99.29 from Leucoagaricus meleagris (Western flat-topped agaric) (Agaricus meleagris) (see 2 papers)
30% identity, 92% coverage: 11:533/567 of query aligns to 41:597/602 of Q3L245
- N100 (≠ R69) modified: carbohydrate, N-linked (GlcNAc...) asparagine
- H128 (≠ I97) modified: Tele-8alpha-FAD histidine
- N344 (= N297) modified: carbohydrate, N-linked (GlcNAc...) asparagine
- H537 (= H475) active site, Proton acceptor
- H581 (≠ N517) active site
Sites not aligning to the query:
4h7uA Crystal structure of pyranose dehydrogenase from agaricus meleagris, wildtype (see paper)
30% identity, 92% coverage: 11:533/567 of query aligns to 16:572/577 of 4h7uA
- active site: A343 (vs. gap), V426 (≠ P390), Y510 (≠ T473), H512 (= H475), A555 (≠ G516), H556 (≠ N517)
- binding [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aR)-4a-hydroxy-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate (non-preferred name): G22 (= G17), G24 (= G19), T25 (≠ S20), A26 (= A21), E46 (= E41), A47 (≠ F42), W74 (= W68), G99 (= G93), C100 (≠ S94), H103 (≠ I97), N104 (= N98), G105 (= G99), V107 (= V101), L242 (≠ A224), V243 (≠ M225), G282 (≠ S260), G283 (= G261), A286 (≠ G264), H512 (= H475), A546 (≠ S507), H556 (≠ N517), T557 (≠ L518), Q558 (≠ N519), V561 (≠ T522)
6xuuA Crystallographic structure of oligosaccharide dehydrogenase from pycnoporus cinnabarinus, glucose-bound form (see paper)
27% identity, 93% coverage: 9:537/567 of query aligns to 13:589/589 of 6xuuA
- binding beta-D-glucopyranose: E35 (= E31), N67 (≠ S58), H83 (= H84), N104 (≠ A107), D108 (= D111), S139 (≠ E137), A140 (≠ S138), N142 (≠ G140), T166 (= T153), D169 (≠ N156), T188 (≠ A173), W213 (vs. gap), A225 (= A207), Y226 (= Y208), Q329 (≠ E303), N330 (vs. gap), A331 (vs. gap), Q357 (≠ I306), F414 (≠ R372), K474 (≠ E435), N517 (vs. gap), G520 (≠ N469), A522 (≠ E471), V524 (≠ T473), H526 (= H475), H569 (≠ N517)
- binding flavin-adenine dinucleotide: G21 (= G17), G23 (= G19), L24 (≠ S20), T25 (≠ A21), E45 (= E41), A46 (≠ F42), F66 (= F57), W72 (= W68), H83 (= H84), G85 (= G88), G90 (= G93), S91 (= S94), N95 (= N98), G96 (= G99), A97 (≠ L100), A98 (≠ V101), M244 (= M225), A245 (≠ T226), A286 (≠ S260), Q290 (≠ G264), A525 (≠ Y474), A559 (≠ S507), H569 (≠ N517), L570 (= L518), S571 (≠ N519), L574 (≠ T522)
- binding alpha-D-glucopyranose: G96 (= G99), F414 (≠ R372), W428 (≠ G389)
Query Sequence
>PfGW456L13_2692 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2692
MTTQKMATQKYDYIIIGAGSAGCVLANRLSEDPATSVLVLEFGGSDKSVVIQMPSAFSIP
MNTKKYNWRYETEPETHLNGRRIHCPRGKVLGGSSSINGLVYIRGHALDFDEWESLGAEG
WGYRNCLPYFKRAESYESGGDSYRGQTGPLHTTNGNHMKNPLYGAWVEAGAEAGYIKTED
CNGYMQEGFGAMHMTVKNGVRCSTANAYLRPAMGRPNLTVITHAMTRQVILEGKRAVGVM
YDHGGQTHQVYCNREVLISSGPIGSPHLLQRSGIGPADVLRKAGIGVRHDLPGVGENLQD
HAEVYIQFGCKEPVTLNSKMDPLSKLMIGLRWLLFKDGLGATNHFEAGGFIRSEKGLRWP
DIQFHFLPAAMRYDGNKPIKGHGFMVLTGPNKPKSRGYVRVRSADPYEHPEIRFNYLERE
EDREGFRRCIRLTREIIGQKAMDRFRDGEIAPGAQVTSDEDLDAFVRDNLESTYHPCGSC
RMGEDEMAVVDSELRVRGIAGLRVIDSSVFPTEPNGNLNAPTIMLAERASDLVRGVQMLP
SADVPVGLVEGWESSQRTSLPGRNVRV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory