SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing PfGW456L13_2828 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2828 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

P68183 Maltose/maltodextrin transport system permease protein MalG from Escherichia coli (strain K12) (see 2 papers)
27% identity, 75% coverage: 8:203/262 of query aligns to 12:229/296 of P68183

query
sites
P68183

K

R

L

L

P

F

L

I

T

T

R

H

E

L

V

L

S

L

L

L

L

L

M

F

L

I

A

A

Y

A

L

I

Y

M

L

F

P

P

I

L

F

L

V

M

L

V

I

V

A

A

Y

I

S

S

F

L

N

R

A

Q

N

G

R

N

S

F

A

A

T

T

-

G

-

S

-

L

V

I

W

P

T

E

E

Q

F

I

S

S

F

W

D

D

W

H

Y

W

-

K

-

L

-

A

-

L

-

G

-

F

-

S

-

V

-

E

-

Q

-

A

-

D

G

G

R

R

I

I

L

T

A

P

N

P

P

P

-

F

-

P

-

V

-

L

-

L

-

W

-

L

-

W

-

N

S

S

I

V

Q

K

T

V

A

A

A

G

L

I

N

S

S

A

I

I

I

G

V

I

A

V

S

A

I

L

A

S

T

T

V

T

C

C

A

A

T

Y

A

A

I

F

A

A

L

R

L

M

A

R

A

-

L

-

A

-

T

-

Y

-

R

-

P

-

F

F

Y

P

G

G

Q

K

K

A

M

T

V

L

E

L

G

K

G

G

I

M

N

L

L

I

P

F

L

Q

I

M

L

F

P

P

E

A

I

V

V

L

T

S

A

L

V

V

A

A

T

L

L

Y

L

A

L

L

F

F

M

D

A

R

L

L

G

G

I

E

K

Y

L

I

-

P

-

F

-

I

G

G

L

L

L

N

T

T

-

H

-

G

-

G

V

V

I

I

V

F

A

A

H

Y

I

L

G

G

F

-

C

G

I

I

P

A

F

L

A

H

Y

V

L

W

P

T

I

I

R

K

A

G

R

Y

L

F

N

E

D

T

L

I

D

D

K

S

S

S

L

L

L

E

E
|
E

A

A

A
|
A

N

A

D

L

L

D

Y
x
G

A

A

N

T

P

P

W

W

Q

Q

V

A

F

F

R

R

R

L

V

V

T

L

L

L

P
|
P

L

L

L

S

W

V

P

P

A

I

V

L

L

A

S

V

G

V

S

F

V

I

L

L

A

S

F

F

V

I

V

A

S

A

L

I

D

T

D

E

E190 (= E164) mutation E->A,C,K,L: Reduction of transport rate.
A192 (= A166) mutation A->D,S,L: Loss of transport and MalK dissociation from the membrane.
G196 (≠ Y170) mutation to A: No effect.; mutation to P: Loss of transport and MalK dissociation from the membrane.
P209 (= P183) mutation to A: No effect.

Query Sequence

>PfGW456L13_2828 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2828
MIALHLKKLPLTREVSLLMLAYLYLPIFVLIAYSFNANRSATVWTEFSFDWYGRILANPS
IQTAALNSIIVASIATVCATAIALLAALATYRPFYGQKMVEGGINLPLILPEIVTAVATL
LLFMALGIKLGLLTVIVAHIGFCIPFAYLPIRARLNDLDKSLLEAANDLYANPWQVFRRV
TLPLLWPAVLSGSVLAFVVSLDDFIMTFFVAGPGSTTLPVYIFSAIKAGVTPEINAISTL
MLVISIVLVVLAFWLGQRGKQQ

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory