SitesBLAST
Comparing PfGW456L13_3207 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_3207 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
32% identity, 99% coverage: 4:530/535 of query aligns to 4:518/539 of 6lpiB
- active site: I27 (= I27), G29 (= G29), G30 (≠ V30), S31 (≠ H31), I32 (≠ T32), E53 (= E52), C76 (≠ I75), F115 (≠ L116), Q116 (≠ H117), E117 (= E118), K165 (≠ L167), M256 (≠ S256), A283 (≠ D283), V375 (≠ M383), G401 (= G409), M403 (≠ L411), D428 (= D436), N455 (= N464), A457 (= A466), L458 (= L467), L460 (≠ Q469), V461 (≠ I470), Q464 (≠ D473)
- binding flavin-adenine dinucleotide: R155 (= R157), G212 (= G214), G213 (= G215), G214 (= G216), T236 (≠ S238), L237 (≠ V239), M238 (≠ A240), L254 (vs. gap), M256 (≠ S256), H257 (≠ L257), G276 (= G276), A277 (≠ T277), R278 (≠ E278), D280 (≠ A280), R282 (≠ T282), A283 (≠ D283), D300 (= D299), I301 (= I300), D319 (= D318), V320 (≠ A319), M380 (≠ Y388), G398 (≠ T406)
- binding magnesium ion: D428 (= D436), N455 (= N464)
- binding thiamine diphosphate: E53 (= E52), C76 (≠ I75), P79 (= P78), G376 (≠ T384), Q377 (= Q385), H378 (≠ L386), G401 (= G409), M403 (≠ L411), G427 (= G435), D428 (= D436), G429 (= G437), S430 (≠ G438), M433 (≠ Y441), N455 (= N464), A457 (= A466), L458 (= L467), G459 (= G468), L460 (≠ Q469), V461 (≠ I470)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 7:539/582 of 1t9dB
- active site: Y28 (≠ I27), G30 (= G29), G31 (≠ V30), A32 (≠ H31), I33 (≠ T32), E54 (= E52), T77 (≠ I75), F116 (≠ L116), Q117 (≠ H117), E118 (= E118), K166 (≠ L167), R213 (vs. gap), M249 (≠ S255), V276 (vs. gap), V392 (≠ M383), L417 (≠ Y408), G418 (= G409), M420 (≠ L411), D445 (= D436), N472 (= N464), E474 (≠ A466), Q475 (≠ L467), M477 (≠ Q469), V478 (≠ I470), W481 (vs. gap), L503 (= L494), G508 (= G499), L509 (≠ C500)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (≠ V30), A32 (≠ H31), V106 (≠ N104), P107 (≠ H105), F116 (≠ L116), K166 (≠ L167), M249 (≠ S255), D274 (= D281), R275 (vs. gap), W481 (vs. gap)
- binding flavin-adenine dinucleotide: R156 (= R157), G202 (= G214), A203 (≠ G215), G204 (= G216), N207 (= N219), T229 (≠ S238), L230 (≠ V239), Q231 (≠ A240), L247 (≠ A253), M249 (≠ S255), H250 (≠ S256), G269 (= G276), A270 (≠ T277), R271 (≠ E278), D273 (≠ A280), R275 (vs. gap), V276 (vs. gap), E302 (≠ D299), V303 (≠ I300), N307 (≠ K304), G320 (= G317), D321 (= D318), A322 (= A319), Q396 (≠ A387), M397 (≠ Y388), G415 (≠ T406), G416 (= G407)
- binding magnesium ion: D445 (= D436), N472 (= N464), E474 (≠ A466)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E52), P80 (= P78), G418 (= G409), M420 (≠ L411), M450 (≠ Y441)
Sites not aligning to the query:
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 8:540/583 of 1t9bA
- active site: Y29 (≠ I27), G31 (= G29), G32 (≠ V30), A33 (≠ H31), I34 (≠ T32), E55 (= E52), T78 (≠ I75), F117 (≠ L116), Q118 (≠ H117), E119 (= E118), K167 (≠ L167), R214 (vs. gap), M250 (≠ S255), V277 (vs. gap), V393 (≠ M383), L418 (≠ Y408), G419 (= G409), M421 (≠ L411), D446 (= D436), N473 (= N464), E475 (≠ A466), Q476 (≠ L467), M478 (≠ Q469), V479 (≠ I470), W482 (vs. gap), L504 (= L494), G509 (= G499), L510 (≠ C500)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ N104), P108 (≠ H105), F117 (≠ L116), D275 (= D281), R276 (vs. gap), M478 (≠ Q469), W482 (vs. gap)
- binding flavin-adenine dinucleotide: R157 (= R157), G203 (= G214), A204 (≠ G215), G205 (= G216), N208 (= N219), T230 (≠ S238), L231 (≠ V239), Q232 (≠ A240), M247 (vs. gap), L248 (≠ A253), M250 (≠ S255), H251 (≠ S256), G270 (= G276), A271 (≠ T277), R272 (≠ E278), D274 (≠ A280), R276 (vs. gap), V277 (vs. gap), E303 (≠ D299), V304 (≠ I300), N308 (≠ K304), D322 (= D318), A323 (= A319), Q397 (≠ A387), M398 (≠ Y388), G416 (≠ T406), G417 (= G407)
- binding magnesium ion: D446 (= D436), N473 (= N464), E475 (≠ A466)
Sites not aligning to the query:
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 8:548/591 of 5wkcA
- active site: Y29 (≠ I27), G31 (= G29), G32 (≠ V30), A33 (≠ H31), I34 (≠ T32), E55 (= E52), T78 (≠ I75), F117 (≠ L116), Q118 (≠ H117), E119 (= E118), K167 (≠ L167), R222 (vs. gap), M258 (≠ S255), V285 (vs. gap), V401 (≠ M383), L426 (≠ Y408), G427 (= G409), M429 (≠ L411), D454 (= D436), N481 (= N464), E483 (≠ A466), Q484 (≠ L467), M486 (≠ Q469), V487 (≠ I470), W490 (vs. gap), L512 (= L494), G517 (= G499), L518 (≠ C500)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ M383), G402 (≠ T384), Q403 (= Q385), H404 (≠ L386), G427 (= G409), M429 (≠ L411), G453 (= G435), D454 (= D436), A455 (≠ G437), S456 (≠ G438), M459 (≠ Y441), N481 (= N464), E483 (≠ A466), Q484 (≠ L467), G485 (= G468), M486 (≠ Q469), V487 (≠ I470)
- binding ethaneperoxoic acid: G32 (≠ V30), Q118 (≠ H117)
- binding flavin-adenine dinucleotide: R157 (= R157), G211 (= G214), A212 (≠ G215), G213 (= G216), N216 (= N219), T238 (≠ S238), L239 (≠ V239), Q240 (≠ A240), L256 (≠ A253), M258 (≠ S255), G278 (= G276), A279 (≠ T277), R280 (≠ E278), R284 (vs. gap), V285 (vs. gap), E311 (≠ D299), V312 (≠ I300), N316 (≠ K304), D330 (= D318), A331 (= A319), M406 (≠ Y388), G424 (≠ T406)
- binding magnesium ion: D454 (= D436), N481 (= N464), E483 (≠ A466)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (≠ V30), A33 (≠ H31), V107 (≠ N104), F117 (≠ L116), K167 (≠ L167), M258 (≠ S255), R284 (vs. gap), M486 (≠ Q469), W490 (vs. gap)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P28), E55 (= E52)
Sites not aligning to the query:
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
32% identity, 87% coverage: 8:470/535 of query aligns to 13:485/582 of 3ea4A
- active site: Y32 (≠ I27), G34 (= G29), G35 (≠ V30), A36 (≠ H31), S37 (≠ T32), E58 (= E52), T81 (≠ I75), F120 (≠ L116), Q121 (≠ H117), E122 (= E118), K170 (≠ L167), M265 (≠ S255), V292 (≠ D283), V399 (≠ M383), G425 (= G409), M427 (≠ L411), D452 (= D436), N479 (= N464), H481 (≠ A466), L482 (= L467), M484 (≠ Q469), V485 (≠ I470)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D281), R291 (≠ T282)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R157), G221 (= G214), G222 (= G215), G223 (= G216), T245 (≠ S238), L246 (≠ V239), M247 (≠ A240), L263 (≠ A253), G264 (= G254), M265 (≠ S255), H266 (≠ S256), G285 (= G276), R287 (≠ E278), D289 (≠ A280), R291 (≠ T282), D309 (= D299), I310 (= I300), G327 (= G317), D328 (= D318), V329 (≠ A319), M404 (≠ Y388), G422 (≠ T406)
- binding magnesium ion: D452 (= D436), N479 (= N464), H481 (≠ A466)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ M383), G400 (≠ T384), Q401 (= Q385), H402 (≠ L386), M427 (≠ L411), G451 (= G435), D452 (= D436), G453 (= G437), S454 (≠ G438), N479 (= N464), H481 (≠ A466), L482 (= L467), G483 (= G468), M484 (≠ Q469), V485 (≠ I470)
Sites not aligning to the query:
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
32% identity, 87% coverage: 8:470/535 of query aligns to 13:485/582 of 3e9yA
- active site: Y32 (≠ I27), G34 (= G29), G35 (≠ V30), A36 (≠ H31), S37 (≠ T32), E58 (= E52), T81 (≠ I75), F120 (≠ L116), Q121 (≠ H117), E122 (= E118), K170 (≠ L167), M265 (≠ S255), V292 (≠ D283), V399 (≠ M383), G425 (= G409), M427 (≠ L411), D452 (= D436), N479 (= N464), H481 (≠ A466), L482 (= L467), M484 (≠ Q469), V485 (≠ I470)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D281), R291 (≠ T282)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R157), G221 (= G214), G222 (= G215), G223 (= G216), T245 (≠ S238), L246 (≠ V239), M247 (≠ A240), L263 (≠ A253), G285 (= G276), R287 (≠ E278), D289 (≠ A280), R291 (≠ T282), D309 (= D299), I310 (= I300), G327 (= G317), D328 (= D318), V329 (≠ A319), M404 (≠ Y388), G422 (≠ T406)
- binding magnesium ion: D452 (= D436), N479 (= N464), H481 (≠ A466)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ M383), G400 (≠ T384), Q401 (= Q385), H402 (≠ L386), M427 (≠ L411), G451 (= G435), G453 (= G437), S454 (≠ G438), N479 (= N464), H481 (≠ A466), L482 (= L467), G483 (= G468), M484 (≠ Q469), V485 (≠ I470)
Sites not aligning to the query:
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 8:552/595 of 1t9bB
- active site: Y29 (≠ I27), G31 (= G29), G32 (≠ V30), A33 (≠ H31), I34 (≠ T32), E55 (= E52), T78 (≠ I75), F117 (≠ L116), Q118 (≠ H117), E119 (= E118), K167 (≠ L167), R226 (vs. gap), M262 (≠ S255), V289 (vs. gap), V405 (≠ M383), L430 (≠ Y408), G431 (= G409), M433 (≠ L411), D458 (= D436), N485 (= N464), E487 (≠ A466), Q488 (≠ L467), M490 (≠ Q469), V491 (≠ I470), W494 (vs. gap), L516 (= L494), G521 (= G499), L522 (≠ C500)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ N104), P108 (≠ H105), D287 (= D281), R288 (vs. gap), M490 (≠ Q469), W494 (vs. gap)
- binding flavin-adenine dinucleotide: R157 (= R157), G215 (= G214), A216 (≠ G215), G217 (= G216), N220 (= N219), T242 (≠ S238), L243 (≠ V239), Q244 (≠ A240), M259 (vs. gap), L260 (≠ A253), M262 (≠ S255), H263 (≠ S256), G282 (= G276), A283 (≠ T277), R284 (≠ E278), D286 (≠ A280), R288 (vs. gap), V289 (vs. gap), E315 (≠ D299), V316 (≠ I300), N320 (≠ K304), G333 (= G317), D334 (= D318), A335 (= A319), Q409 (≠ A387), M410 (≠ Y388), G428 (≠ T406), G429 (= G407)
- binding magnesium ion: D458 (= D436), N485 (= N464), E487 (≠ A466)
Sites not aligning to the query:
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (≠ S255), R292 (≠ T282)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ M383), G401 (≠ T384), Q402 (= Q385), H403 (≠ L386), G426 (= G409), M428 (≠ L411), G452 (= G435), D453 (= D436), G454 (= G437), S455 (≠ G438), L483 (= L467), G484 (= G468), M485 (≠ Q469), V486 (≠ I470)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), M263 (vs. gap), L264 (≠ A253), M266 (≠ S255), H267 (≠ S256), G286 (= G276), R288 (≠ E278), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406)
- binding magnesium ion: A37 (≠ H31), T82 (≠ I75), S83 (≠ T76), Q122 (≠ H117), Y381 (≠ I365), D453 (= D436), M458 (≠ Y441), Q461 (= Q444), N480 (= N464), H482 (≠ A466)
Sites not aligning to the query:
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
29% identity, 98% coverage: 6:530/535 of query aligns to 10:556/599 of 1n0hA
- active site: Y31 (≠ I27), G33 (= G29), G34 (≠ V30), A35 (≠ H31), I36 (≠ T32), E57 (= E52), T80 (≠ I75), F119 (≠ L116), Q120 (≠ H117), E121 (= E118), K169 (≠ L167), R230 (vs. gap), M266 (≠ S255), V293 (vs. gap), V409 (≠ M383), L434 (≠ Y408), G435 (= G409), M437 (≠ L411), D462 (= D436), N489 (= N464), E491 (≠ A466), Q492 (≠ L467), M494 (≠ Q469), V495 (≠ I470), W498 (vs. gap), L520 (= L494), G525 (= G499), L526 (≠ C500)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ M383), G410 (≠ T384), Q411 (= Q385), H412 (≠ L386), G435 (= G409), M437 (≠ L411), G461 (= G435), D462 (= D436), A463 (≠ G437), S464 (≠ G438), M467 (≠ Y441), N489 (= N464), E491 (≠ A466), Q492 (≠ L467), G493 (= G468), V495 (≠ I470)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ V30), A35 (≠ H31), V109 (≠ N104), P110 (≠ H105), F119 (≠ L116), K169 (≠ L167), M266 (≠ S255), D291 (= D281), R292 (vs. gap), V495 (≠ I470), W498 (vs. gap)
- binding flavin-adenine dinucleotide: R159 (= R157), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (= N219), T246 (≠ S238), L247 (≠ V239), Q248 (≠ A240), L264 (≠ A253), G265 (= G254), M266 (≠ S255), H267 (≠ S256), G286 (= G276), A287 (≠ T277), R288 (≠ E278), D290 (≠ A280), R292 (vs. gap), V293 (vs. gap), E319 (≠ D299), V320 (≠ I300), N324 (≠ K304), G337 (= G317), D338 (= D318), A339 (= A319), M414 (≠ Y388), G432 (≠ T406), G433 (= G407)
- binding magnesium ion: D462 (= D436), N489 (= N464), E491 (≠ A466)
- binding thiamine diphosphate: Y31 (≠ I27), E57 (= E52), P83 (= P78)
Sites not aligning to the query:
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/583 of 5k3sA
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ S255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (≠ T282), M485 (≠ Q469)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), L264 (≠ A253), M266 (≠ S255), G286 (= G276), R288 (≠ E278), D290 (≠ A280), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406)
- binding magnesium ion: D453 (= D436), N480 (= N464), H482 (≠ A466)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ M383), G401 (≠ T384), Q402 (= Q385), H403 (≠ L386), G426 (= G409), M428 (≠ L411), D453 (= D436), G454 (= G437), S455 (≠ G438), N480 (= N464), H482 (≠ A466), L483 (= L467), G484 (= G468), M485 (≠ Q469), V486 (≠ I470)
Sites not aligning to the query:
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ M383), G401 (≠ T384), Q402 (= Q385), H403 (≠ L386), G426 (= G409), M428 (≠ L411), G452 (= G435), D453 (= D436), G454 (= G437), S455 (≠ G438), M458 (≠ Y441), N480 (= N464), H482 (≠ A466), L483 (= L467), G484 (= G468), M485 (≠ Q469), V486 (≠ I470)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), L264 (≠ A253), M266 (≠ S255), H267 (≠ S256), G286 (= G276), V287 (≠ T277), R288 (≠ E278), D290 (≠ A280), R292 (≠ T282), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406)
- binding magnesium ion: F370 (vs. gap), D453 (= D436), M458 (≠ Y441), Q461 (= Q444), N480 (= N464), H482 (≠ A466)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ S255), R292 (≠ T282), M485 (≠ Q469)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 5wj1A
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ S255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), M263 (vs. gap), L264 (≠ A253), G286 (= G276), R288 (≠ E278), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406), G424 (= G407)
- binding magnesium ion: D453 (= D436), N480 (= N464), H482 (≠ A466)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ S255), D291 (= D281), R292 (≠ T282), M485 (≠ Q469)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ M383), G401 (≠ T384), Q402 (= Q385), H403 (≠ L386), M428 (≠ L411), D453 (= D436), G454 (= G437), S455 (≠ G438), M458 (≠ Y441), N480 (= N464), H482 (≠ A466), L483 (= L467), G484 (= G468), M485 (≠ Q469), V486 (≠ I470)
Sites not aligning to the query:
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 5k6tA
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ S255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ S256), R292 (≠ T282), M485 (≠ Q469)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), L264 (≠ A253), G286 (= G276), R288 (≠ E278), D290 (≠ A280), R292 (≠ T282), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), Q404 (≠ A387), M405 (≠ Y388), G423 (≠ T406)
- binding magnesium ion: D453 (= D436), N480 (= N464), H482 (≠ A466)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ M383), G401 (≠ T384), Q402 (= Q385), H403 (≠ L386), G426 (= G409), M428 (≠ L411), G452 (= G435), G454 (= G437), S455 (≠ G438), N480 (= N464), H482 (≠ A466), L483 (= L467), G484 (= G468)
Sites not aligning to the query:
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 5k6rA
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ S255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (≠ T282)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), L264 (≠ A253), M266 (≠ S255), G286 (= G276), R288 (≠ E278), R292 (≠ T282), V293 (≠ D283), D310 (= D299), I311 (= I300), G328 (= G317), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406)
- binding magnesium ion: D453 (= D436), N480 (= N464), H482 (≠ A466)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ M383), G401 (≠ T384), Q402 (= Q385), H403 (≠ L386), G426 (= G409), M428 (≠ L411), D453 (= D436), G454 (= G437), S455 (≠ G438), M458 (≠ Y441), N480 (= N464), H482 (≠ A466), L483 (= L467), G484 (= G468), M485 (≠ Q469), V486 (≠ I470)
Sites not aligning to the query:
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 1z8nA
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ S255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (≠ A131), R161 (= R157), Y191 (≠ R188), R194 (vs. gap), D291 (= D281), R292 (≠ T282), D312 (= D301)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), L264 (≠ A253), G265 (= G254), M266 (≠ S255), H267 (≠ S256), G286 (= G276), V287 (≠ T277), R288 (≠ E278), D290 (≠ A280), R292 (≠ T282), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406), G424 (= G407)
- binding magnesium ion: D453 (= D436), N480 (= N464)
- binding thiamine diphosphate: V400 (≠ M383), G401 (≠ T384), Q402 (= Q385), H403 (≠ L386), G426 (= G409), M428 (≠ L411), G452 (= G435), G454 (= G437), S455 (≠ G438), N480 (= N464), H482 (≠ A466), L483 (= L467), G484 (= G468), M485 (≠ Q469), V486 (≠ I470)
Sites not aligning to the query:
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 1yi1A
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ S255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D281), R292 (≠ T282)
- binding flavin-adenine dinucleotide: R161 (= R157), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), M263 (vs. gap), L264 (≠ A253), G265 (= G254), M266 (≠ S255), H267 (≠ S256), G286 (= G276), V287 (≠ T277), R288 (≠ E278), D290 (≠ A280), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406), G424 (= G407)
- binding magnesium ion: D453 (= D436), N480 (= N464), H482 (≠ A466)
Sites not aligning to the query:
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 1yi0A
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ S255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D281), R292 (≠ T282)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), L264 (≠ A253), G265 (= G254), M266 (≠ S255), H267 (≠ S256), G286 (= G276), V287 (≠ T277), R288 (≠ E278), D290 (≠ A280), R292 (≠ T282), V293 (≠ D283), D310 (= D299), I311 (= I300), G328 (= G317), D329 (= D318), V330 (≠ A319), M405 (≠ Y388), G423 (≠ T406), G424 (= G407)
- binding magnesium ion: D453 (= D436), N480 (= N464), H482 (≠ A466)
Sites not aligning to the query:
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 1yhzA
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ S255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D281), R292 (≠ T282), M485 (≠ Q469)
- binding flavin-adenine dinucleotide: R161 (= R157), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), L264 (≠ A253), M266 (≠ S255), H267 (≠ S256), G286 (= G276), V287 (≠ T277), R288 (≠ E278), D290 (≠ A280), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), Q404 (≠ A387), M405 (≠ Y388), G423 (≠ T406), G424 (= G407)
- binding magnesium ion: D453 (= D436), N480 (= N464), H482 (≠ A466)
Sites not aligning to the query:
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 1yhyA
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ S255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D281), R292 (≠ T282), V486 (≠ I470)
- binding flavin-adenine dinucleotide: R161 (= R157), G222 (= G214), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), L264 (≠ A253), G265 (= G254), M266 (≠ S255), H267 (≠ S256), G286 (= G276), V287 (≠ T277), R288 (≠ E278), D290 (≠ A280), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), Q404 (≠ A387), M405 (≠ Y388), G423 (≠ T406), G424 (= G407)
- binding magnesium ion: D453 (= D436), N480 (= N464), H482 (≠ A466)
Sites not aligning to the query:
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
31% identity, 87% coverage: 8:470/535 of query aligns to 14:486/582 of 1ybhA
- active site: Y33 (≠ I27), G35 (= G29), G36 (≠ V30), A37 (≠ H31), S38 (≠ T32), E59 (= E52), T82 (≠ I75), F121 (≠ L116), Q122 (≠ H117), E123 (= E118), K171 (≠ L167), M266 (≠ S255), V293 (≠ D283), V400 (≠ M383), G426 (= G409), M428 (≠ L411), D453 (= D436), N480 (= N464), H482 (≠ A466), L483 (= L467), M485 (≠ Q469), V486 (≠ I470)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (≠ S255), D291 (= D281), R292 (≠ T282), M485 (≠ Q469)
- binding flavin-adenine dinucleotide: R161 (= R157), G223 (= G215), G224 (= G216), T246 (≠ S238), L247 (≠ V239), M248 (≠ A240), L264 (≠ A253), M266 (≠ S255), H267 (≠ S256), G286 (= G276), V287 (≠ T277), R288 (≠ E278), D290 (≠ A280), V293 (≠ D283), D310 (= D299), I311 (= I300), D329 (= D318), V330 (≠ A319), Q404 (≠ A387), M405 (≠ Y388), G423 (≠ T406), G424 (= G407)
- binding magnesium ion: D453 (= D436), N480 (= N464), H482 (≠ A466)
Sites not aligning to the query:
Query Sequence
>PfGW456L13_3207 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_3207
MQSKTLTGGQALVRLLANYGVDTVFGIPGVHTLELYRGLPGSGIRHVLTRHEQGASFMAD
GYARVSGKPGVCFVITGPGVTNAATGIGQAYADSIPMLVISSVNHSASLGKGWGSLHECQ
DQRAMTAPITAFSAVALTAEDLPELIARAYAVFDSERPRPVHISVPLDVLSAPIARDWSN
EVVRRPGRGPASTTAIDQAVAKLNAAKRPMIIAGGGALNATSELQEVSTRLAAPLFTSVA
GKGLLPPDAPLNAGSSLCVEPGWNLIAEADVVLAVGTEMADTDFWRERLPLNGELLRVDI
DPRKFNDFYPCAVALHGDAQQTLSGLLERLPTDVREASAAIASVAALRKAVKASHGPLQS
IHQSILDRIAAELPDNAFISTDMTQLAYTGNYAFDSLAIRSWLHPTGYGTLGYGLPAGIG
AKFGAPQRPGLVLVGDGGFLYTAQELATSVEELDSPLVVLLWNNDALGQIRDDMLGLDIE
PIGVLPRNPDFAALARAFGCTVTQPQSLAELQTDLRHGFKRNGVTLIELKHACAH
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory