SitesBLAST

Q9JI12 Vesicular glutamate transporter 2; VGluT2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6 from Rattus norvegicus (Rat) (see 2 papers)
26% identity, 83% coverage: 38:424/467 of query aligns to 70:465/582 of Q9JI12

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Q9JI12

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R88 (= R56) mutation to A: Impairs synaptic transmission. Abolishes the chloride ion conductance.
H128 (≠ F81) mutation to A: Greatly lowers L-glutamate transport.
R184 (= R139) mutation R->A,E,K: Greatly lowers L-glutamate transport.
E191 (= E146) mutation to A: Greatly lowers L-glutamate transport.; mutation E->D,Q: Lowers L-glutamate transport.
R322 (≠ I283) mutation to A: Loss of L-glutamate release. Abolishes the chloride ion conductance.

Q8BN82 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Mus musculus (Mouse) (see paper)
26% identity, 78% coverage: 57:422/467 of query aligns to 88:443/495 of Q8BN82

query
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Q8BN82

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H183 (≠ G154) mutation to R: Abolishes sialic acid transporter activity. Does not affect L-aspartate and L-glutamate transporter activity.

Sites not aligning to the query:

39 R→C: Completely abolishes L-aspartate and L-glutamate transporter activity. Retains appreciable H(+)-coupled sialic acid transporter activity.

Q9NRA2 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Membrane glycoprotein HP59; Solute carrier family 17 member 5; Vesicular excitatory amino acid transporter; VEAT from Homo sapiens (Human) (see 8 papers)
26% identity, 78% coverage: 57:422/467 of query aligns to 88:443/495 of Q9NRA2

query
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Q9NRA2

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K136 (= K105) to E: in SD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; completely devoid of L-aspartate and L-glutamate transporter activity, but retains appreciable H(+)-coupled sialic acid transporter activity; dbSNP:rs80338795
H183 (≠ G154) to R: in ISSD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; abolishes H(+)-coupled sialic acid transporter activity; has normal L-aspartate and L-glutamate transporter activity; dbSNP:rs119491109
LL 198:199 (≠ AG 169:170) mutation to AA: Localizes in vesicular structures mainly concentrated in the perinuclear region.
I--------L 266:267 (≠ IRAGDGLVDL 236:245) mutation to LA: Localizes in vesicular structures mainly concentrated in the perinuclear region.
SSLRN 268:272 (≠ ESLKS 246:250) natural variant: Missing (in ISSD; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; abolishes H(+)-coupled sialic acid transporter activity; has normal L-aspartate and L-glutamate transporter activity)
G328 (= G310) to E: in ISSD; some patients may manifest a milder phenotype consistent with Salla disease; markedly decreases H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs386833996
P334 (= P316) to R: in ISSD; does not affect intracellular localization, targeted to lysosomes; abolishes H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs119491110
G371 (= G352) to V: in ISSD; abolishes H(+)-coupled sialic acid transporter activity; abolishes L-aspartate and L-glutamate transporter activity; dbSNP:rs777862172

Sites not aligning to the query:

22:23 Dileucine internalization motif; LL→AA: Targeted to plasma membrane.; LL→GG: Targeted to plasma membrane; sialic acid uptake strongly activated at acidic pH.
39 R → C: in SD; frequent variant in Finland; alters intracellular localization, only partially targeted to lysosomes and mainly detected in LAMP1-negative vesicles and in the Golgi apparatus; completely devoid of L-aspartate and L-glutamate transport activity, but retains appreciable H(+)-coupled sialic acid and nitrate transporter activity; dbSNP:rs80338794

7t3nA R184q/e191q mutant of rat vesicular glutamate transporter 2 (vglut2)
25% identity, 83% coverage: 38:424/467 of query aligns to 12:407/452 of 7t3nA

query
sites
7t3nA

R
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R

F
x
Y

L

I

I

I

L

A

A

I

L

M

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A

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A

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V

A

A

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D

M

M

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N

E

N

L

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I

I

-

H

-

R

-

G

-

K

-

V

-

I

-

K

-

E

-

K

-

A

-

K

-

F

-

N

-

W

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S

P

V

E

E

T

M

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G

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M

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Y

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G

G

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Y

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M

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A

A

A

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S

C

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G

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x
Y

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I

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A

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A

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W

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E
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E

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A

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x
G

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Y
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Y

L

A

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A

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I

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A

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P

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Y

Y

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G

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W

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F

I

Y

I

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M

Y

G

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A

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I

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G

G

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-

G

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A

-

I

-

W

W

W

Y

K

M

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Y

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Y

L

L

L

-

V

-

S

-

Y

-

E

-

S

P

P

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A

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T

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A

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-

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x
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Y

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A

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L

C

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Q

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A

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-

S

K

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R

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G

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M

S

E

A

A

S

T

I

L

L

L

-

V

C

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N

G

Y

Y

A

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E

H

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A

R

A

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A

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M

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A

A

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F

K

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N

A

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-

L

D

D

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A

A

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P

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R

E

-

L

Y

I

A

G

S

T

I

T

L

G

M

G

G

V

I

F

S

N

N

A

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N

T

T

L

A

S

G

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M

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V

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C

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P

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I

V

G

G

binding (1s,3r)-1-aminocyclopentane-1,3-dicarboxylic acid: Y77 (= Y88), Y137 (≠ G150), Y165 (= Y178), R264 (≠ I283), F268 (≠ T287), Y269 (≠ W288)
binding (2R)-2-(methoxymethyl)-4-{[(25R)-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside: R12 (= R38), Y13 (≠ F39), E152 (= E165), G163 (≠ A176)

Q5Q0U0 Sialin; H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; AST; Solute carrier family 17 (Anion/sugar transporter), member 5; Vesicular excitatory amino acid transporter; VEAT from Rattus norvegicus (Rat) (see 2 papers)
26% identity, 78% coverage: 57:422/467 of query aligns to 88:443/495 of Q5Q0U0

query
sites
Q5Q0U0

A

A

A

P

L

V

S

K

V

V

A

H

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H

T

N

D

H

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T

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K

E

K

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Y

G

Q

I

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D

S

A

V

E

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T

M

Q

G

G

Y

W

L

I

F

L

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A

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F

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A

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Y

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I

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A

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K
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K

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A

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A

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-

L

-

L

L

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A

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L

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R
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R

F

A

L

L

L
x
E

G
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G

A

L

A

G

E
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E

S
x
G

P

V

V

T

G
x
F

P
|
P

A

A

S

M

G
x
H

R

A

I

M

I
x
W

A

S

W

W

F

A

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P

S

P

S

L

E

E

R

R

G

S

I

K

A

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G

L

A

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I

I

F

S

N

Y

S

A

A

G

Q

A

Y

Q

L

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A

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V

I

F

S

T

L

P

P

V

L

M

S

G

G

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I

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I

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C

Y

Y

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Y

Y

M

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N

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W

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Y

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F

I

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M

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G

G

A

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G

G

L

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G

F

A

I

I

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W

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M

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E

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-

A

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-

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D

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x
S

S
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S

L
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L

K
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K

S
x
N

K

Q

A

L

A

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N

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-

G

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G

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M

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P

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K

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R

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G

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M

-

V

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A

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F

L

L

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A

A

A

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C

C

N

D

Y

Y

A

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L

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A

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A

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-

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-

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S

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I

A

G

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N

N

A

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G

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I

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G

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P

V

I

K136 (= K105) mutation to E: Markedly decreases H(+)-coupled sialic acid transporter activity.
R168 (= R139) mutation to C: Abolishes H(+)-coupled sialic acid transporter activity.
E171 (≠ L142) mutation to C: Decreases H(+)-coupled sialic acid transporter activity; when associated with C-175.
G172 (= G143) mutation to C: Decreases protein levels and alters subcellular localization.
E175 (= E146) mutation to C: Decreases H(+)-coupled sialic acid transporter activity; when associated with C-171.
G176 (≠ S147) mutation to C: Decreases protein levels and alters subcellular localization.
F179 (≠ G150) mutation to C: Decreases the affinity and transport rate for D-glucuronate. Does not affect H(+)-coupled sialic acid transporter activity.
P180 (= P151) mutation to C: Decreases protein levels and alters subcellular localization.
H183 (≠ G154) mutation to R: Abolishes H(+)-coupled sialic acid transporter activity.
W186 (≠ I157) mutation to C: Abolishes H(+)-coupled sialic acid transporter activity.
SSLKN 268:272 (≠ ESLKS 246:250) mutation Missing: Abolishes H(+)-coupled sialic acid transporter activity.
P334 (= P316) mutation to R: Abolishes H(+)-coupled sialic acid transporter activity.
G371 (= G352) mutation to V: Remains in the endoplasmic reticulum.

Sites not aligning to the query:

22:23 Dileucine internalization motif; LL→AA: Targeted to plasma membrane; sialic acid uptake strongly activated at acidic pH.
39 R→C: Markedly decreases H(+)-coupled sialic acid transporter activity.

Q9Y2C5 Probable small intestine urate exporter; Solute carrier family 17 member 4 from Homo sapiens (Human) (see 2 papers)
26% identity, 76% coverage: 77:433/467 of query aligns to 110:457/497 of Q9Y2C5

query
sites
Q9Y2C5

M

Q

G

G

Y

I

L

I

F

L

S

S

A

S

F

L

S

N

W

Y

A

G

Y

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F

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K

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V

M

G

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A

A

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C

F

F

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T

T

V

L

M

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M

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P

M

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V

A

H

A

F

N

I

A

G

G

M

-

V

-

V

V

P

A

L

L

L

I

A

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L

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R

R

F

I

L

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L

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G

G

A

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A

A

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I

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A

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A

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A

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A

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A

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A

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T

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I

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G

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W

E

P

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Y

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V

F

F

I

Y

I

I

M

F

G

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A

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I

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C

V

A

I

C

G

C

A

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I

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P

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D

L

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-

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-

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A

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G

A

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W

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P

I

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Y

Y

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A

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N

I

L

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D

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A

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A

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C

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I

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G

F

L

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A

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D

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F

I

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L

-

S

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R

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G

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R

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K

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F

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T
x
A

I

I

G

G

L

V

L

L

L

F

S

-

A

P

S

S

I

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I

I

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N

S

Y

L

A

P

-

W

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V

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A

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A

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M

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M

V

T

L

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M

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L

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A

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S

F

A

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I

K

S

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S

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F

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M

S

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W

A

T

L

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-

N

V

F

A

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D

D

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I

A

A

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R

E

-

L

Y

I

T

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G

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V

L

F

L

N

Q

A

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F

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G

A

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T

I

A

A

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G

I

A

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I

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S

P

P

V

T

V

A

I

A

G

G

Y

F

I

F

L

I

Q

S

T

Q

T

D

G

S

S

E

F

F

A372 (≠ T350) to T: in dbSNP:rs11754288

Sites not aligning to the query:

66 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→A: Loss of glycosylation and significant reduction in the tranport of thyroid hormones T3 and T4; when associated with A-75 and A-90.
75 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→A: Loss of glycosylation and significant reduction in the tranport of thyroid hormones T3 and T4; when associated with A-66 and A-90.
90 modified: carbohydrate, N-linked (GlcNAc...) asparagine; N→A: Loss of glycosylation and significant reduction in the tranport of thyroid hormones T3 and T4; when associated with A-75 and A-90.

Q03567 Uncharacterized transporter slc-17.2 from Caenorhabditis elegans (see paper)
21% identity, 75% coverage: 78:426/467 of query aligns to 84:430/493 of Q03567

query
sites
Q03567

G

G

Y

M

L

V

F

L

S

S

A

S

F

F

S

F

W

Y

A

G

Y

Y

V

I

I

G

F

S

L

Q

I

I

P

I

S

G

G

G

W

H

L

L

T

A

D

S

R

R

I

Y

G

G

S

G

K

K

L

R

S

V

M

V

M

F

L

V

A

T

V

I

V

L

I

G

W

S

S

A

C

L

F

L

T

T

V

L

M

L

M

N

G

P

M

V

V

A

H

A

F

R

I

T

G

S

M

E

V

Y

V

A

P

-

L

-

L

L

L

A

A

I

L

L

R

R

F

A

L

A

L

I

G

G

A

F

A

L

E

Q

S

G

P

A

V

T

G

F

P

P

A

A

S

M

G

H

R

T

I

M

I

W

A

S

A

V

W

W

F

G

P

P

S

P

S

L

E

E

R

L

G

S

I

V

A

L

G

T

A

G

I

V

F

T

N

Y

S

A

A

G

Q

A

Y

Q

L

I

S

G

L

N

A

V

V

I

F

V

T

L

P

P

V

L

M

S

G

G

W

F

L

L

C

C

-

E

-

Y

-

G

Y

F

T

D

Y

G

G

G

W

W

E

P

Y

S

V

I

F

F

I

Y

I

I

M

I

G

G

A

V

I

F

G

G

L

V

V

L

I

W

G

T

A

A

I

V

W

W

K

Y

F

V

Y

S

-

D

L

K

P

P

I

A

D

T

H

H

P

P

K

R

M

I

N

T

S

P

E

E

L

K

E

Q

Y

Y

I

I

R

-

A

-

G

-

D

-

G

-

L

V

V

T

D

A

L

V

E

E

S

A

L

-

K

-

S

S

K

M

A

G

A

K

N

D

T

T

G

G

K

K

G

V

M

P

K

S

L

T

G

P

E

W

I

I

G

-

Q

K

L

I

F

L

R

T

S

S

R

P

M

A

L

V

V

W

G

A

I

C

F

W

L

A

A

G

Q

H

Y

F

C

A

I

G

T

D

S

W

I

G

T

A

W

Y

F

T

F

M

M

L

T

V

W

S

F

L

P

P

I

S

Y

F

L

L

V

K

K

D

E

V

R

L

G

G

F

L

D

N

I

L

L

S

Q

S

A

L

G

G

F

A

I

V

A

A

A

S

I

I

P

P

A

Y

L

I

C

A

G

Y

L

F

V

L

G

A

G

I

V

N

S

A

S

G

G

G

F

V

I

L

S

A

D

D

L

-

I

T

L

L

K

R

K

S

T

K

G

G

S

I

L

L

S

S

I

T

-

L

-

N

A

T

R

R

K

R

T

A

P

A

I

M

T

L

I

V

G

A

L

L

L

I

L

G

S

Q

A

G

S

I

I

F

I

L

L

V

-

A

-

S

-

G

-

Y

C

C

N

G

Y

C

A

G

E

Q

S

D

A

-

A

V

V

L

V

V

V

I

L

F

M

I

S

T

L

C

A

G

F

M

F

A

G

I

K

S

G

G

F

L

G

Q

S

Y

M

A

G

G

W

F

T

V

V

V

V

N

A

Y

D

L

T

E

A

I

P

A

K

P

E

P

L

F

I

S

G

G

T

T

T

V

G

M

G

G

V

T

F

G

N

N

A

T

F

I

G

S

N

A

T

L

A

A

G

G

I

I

V

I

T

S

P

P

V

A

V

V

I

S

G

S

Y

Y

I

L

Sites not aligning to the query:

69 modified: carbohydrate, N-linked (GlcNAc...) asparagine

O60669 Monocarboxylate transporter 2; MCT 2; Solute carrier family 16 member 7 from Homo sapiens (Human) (see paper)
23% identity, 80% coverage: 95:466/467 of query aligns to 76:434/478 of O60669

query
sites
O60669

S

S

G

S

W

V

L

L

T

V

D

N

R

K

I

Y

G

G

S

S

K

R

L

-

S

-

M

-

L

-

A

P

V

V

I

I

W

A

S

G

C

G

F

L

T

L

V

C

M

C

M

L

G

G

M

M

V

V

-

L

-

A

H

S

F

F

I

S

G

S

M

S

V

V

P

Q

L

L

L

Y

L

L

A

T

L

M

R

G

F

F

L

I

L

T

G

G

A

L

A

G

E

L

S

A

P

F

V

N

G

L

P

Q

A

P

S

A

G

L

R

T

I

I

A

G

A

K

W

Y

F

F

P

-

S

Y

S

R

E

K

R
|
R

G

P

I

M

A

A

G
x
N

A

G

I

L

F

A

N

M

S

A

A

G

Q

S

Y

P

L

V

S

F

L

L

A

S

V

S

F

L

T

A

P

P

V

F

M

N

G

Q

W

Y

L

L

C

F

Y

N

T

T

Y

F

G

G

W

W

E

K

Y

G

V

S

F

F

I

L

I

I

M

L

G

G

A

S

I

-

G

-

L

L

V

L

I

L

G

N

A

A

I

C

W

V

W

A

K

G

F

S

Y

L

Y

M

L

R

P

P

I

L

D

G

H

P

P

N

K

Q

M

T

N

T

S

S

E

K

E

S

L

K

E

N

Y

K

I

T

R

G

A

K

G

T

D

E

G

D

L

D

V

S

D

S

L

P

E

K

S

K

L

I

K

K

S

T

K

K

A

K

A

S

N

T

T

W

G

E

K

K

G

V

M

N

K

K

L

Y

G

L

E

D

I

F

G

-

Q

S

L

L

F

F

R

K

S

H

R

R

M

G

L

F

V

L

G

-

I

I

F

Y

L

L

A

S

Q

G

Y

N

C

V

I

I

T

M

S

F

I

L

T

G

W

F

F
|
F

F

A

M

P

T

I

W

I

F

F

P

L

I

A

Y

P

L

Y

V

A

K

K

E

D

R

Q

G

G

F

I

D

D

I

E

L

Y

Q

S

A

A

G

A

F

F

I

L

A

L

A

S

I

V

P

M

A

A

L

F

C

V

G
x
D

L

M

V

F

G

A

G
x
R

V

P

S

S

S

V

G

G

F

L

I

I

S

A

D
x
N

L

-

I

-

L

-

K

-

T

-

G

-

S

-

L

-

S

-

I

-

A

S

R

K

K

Y

T

I

P

R

I

P

T

R

I

I

G

Q

L

Y

L

F

S

S

A

F

S

A

I

I

-

M

-

F

-

N

-

G

-

V

-

C

-

H

I

L

L

L

C

C

N

P

Y

L

A

A

E

Q

S

D

A

Y

A

T

V

S

V

L

V

V

V

L

L

Y

M

A

S

-

L

-

A

V

F

F

G

G

K

L

G

G

F
|
F

G

G

S

S

M

V

G
x
S

W

-

T

S

V

V

V

L

A

F

D
x
E

T

T

A

L

P

-

K

M

E

D

L

L

I

V

G

G

T

A

T

P

G

-

V

-

F

-

N

-

A

R

F

F

G

S

N

S

T

A

A

V

G

G

I

L

V

V

T

T

-

I

-

V

-

E

-

C

-

G

-

P

-

V

-

L

-

G

P

P

V

P

V

L

I

A

G

G

Y

K

I

L

L

V

Q

D

T

L

T

T

G

G

S

E

F

Y

D

K

G

-

A

-

L

Y

L

M

Y

Y

V

M

G

S

A

C

H

G

G

A

L

I

V

V

A

V

V

A

A

A

S

S

Y

V

W

W

L

L

I

L

V

I

G

G

K

N

I

A

Q

I

R

N

F

Y

K

R

L

L

H

L

P

A

K

K

R143 (= R166) mutation to A: Reduces pyruvate transmembrane transporter activity. Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization. Dominant negative mutant.
N147 (≠ G170) mutation to A: Reduces pyruvate transmembrane transporter activity. Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization.
F262 (= F289) mutation to A: No effect on protein abundance. Does not affect cell surface localization.
D293 (≠ G320) May be protonated during monocarboxylate transport; mutation to N: Reduced proton-dependent active symport, but not pyruvate transport.
R297 (≠ G324) mutation R->L,D: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization.
N305 (≠ D332) mutation to A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization.
F351 (= F384) mutation to A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization.
S355 (≠ G388) mutation S->G,A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization.
E360 (≠ D394) mutation to A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization.

Sites not aligning to the query:

18 W→A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization. Dominant negative mutant.
20 W→A: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization. Dominant negative mutant.
34 Y→F: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization.
38 K→D: Reduces pyruvate transmembrane transporter activity. No effect on protein abundance. Does not affect cell surface localization.
70 Y→A: No effect on protein abundance. Does not affect cell surface localization.
445 T → S: in dbSNP:rs3763980

Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
22% identity, 87% coverage: 29:434/467 of query aligns to 13:410/452 of Q5EXK5

query
sites
Q5EXK5

A

A

T

P

T

V

K

G

K

A

S

R

S

Q

Y

W

R

R

F

V

L

I

I

I

L

C

A

C

L

F

I

L

T

V

I

V

V

M

L

L

A

-

L

-

S

D

T

G

G

F

D

D

R

T

A

A

L

I

S

G

V

F

A

I

G

A

T

P

D

D

M

I

S

R

K

S

E

H

L

W

G

Q

I

L

S

T

S

A

V

G

E

D

M

L

G

A

Y

P

L

L

F

F

S

G

A

A

F

G

S

L

W

L

A

G

Y

L

V

T

I

A

F

G

L

A

I

L

P

L

S

C

G

G

W

P

L

L

T

S

D
|
D

R

R

I

F

G

G

S

R

K

K

L

R

S

V

M

I

M

E

L

F

A

C

V

V

V

A

I

L

W

F

S

G

C

L

F

F

T

S

V

L

M

L

M

S

G

A

M

F

V

A

H

P

F

D

I

L

G

Q

M

M

V

L

V

V

P

-

L

-

A

F

L

L

R

R

F

F

L

L

L

T

G

G

A

L

A

G

E

L

S

G

P

G

V

A

G

M

P

P

A

N

S

T

G

I

R

T

I

M

I

T

A

S

A

E

W

Y

F

L

P

P

S

A

S

R

E

R

R

R

G

G

I

A

A

L

G

V

A

T

I

L

F

M

N

F

S

C

A

G

Q

F

Y

T

L

L

S

G

L

S

A

A

V

F

F

G

T

G

P

V

V

V

M

S

G

A

W

Q

L

L

C

V

Y

P

T

L

Y

I

G

G

W

W

E

H

Y

G

V

I

F

L

I

V

I

L

M

G

G

G

A

V

I

L

G

P

L

L

V

I

I

L

G

A

A

V

I

A

W

L

W

V

K

P

F

L

-

L

-

P

-

E

-

S

-

P

-

R

Y

W

Y

Q

L

I

P

R

I

R

D

Q

H

L

P

P

K

Q

M

A

N

T

S

I

E

A

E

R

L

T

E

V

Y

G

I

A

R

I

A

T

G

G

D

E

G

R

L

Y

V

N

D

D

L

T

E

H

S

F

L

W

K

L

S

D

K

E

A

P

A

A

N

A

T

G

G

A

K

K

G

-

M

-

K

-

L

-

G

G

E

S

I

I

G

S

Q

Q

L

L

F

F

R

A

S

G

R

R

M

-

L

-

V

-

G

-

I

-

F

-

L

-

A

-

Q

Q

Y

L

C

A

I

I

T

T

S

L

I

M

T

L

W

W

-

V

F

F

M

M

T

S

W

L

F

L

P

I

I

I

Y

Y

-

L

-

S

-

W

-

M

-

P

-

T

L

L

V

L

K

N

E

H

R

R

G

G

F

I

D

D

I

L

L

Q

Q

H

A

A

G

S

F

W

I

V

A

T

A

A

I

A

P

F

A

Q

L

I

C

G

G

G

L

T

V

F

G

G

G

A

V

L

S

L

G

G

F
x
V

I

L

S

M

D
|
D

L

-

I

-

L

-