Comparing PfGW456L13_3593 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_3593 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 4 hits to proteins with known functional sites (download)
O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
44% identity, 98% coverage: 4:201/202 of query aligns to 540:734/758 of O14289
Sites not aligning to the query:
P9WK95 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
38% identity, 95% coverage: 1:191/202 of query aligns to 1:184/198 of P9WK95
Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
30% identity, 83% coverage: 12:179/202 of query aligns to 7:170/170 of Q58667
2pkpA Crystal structure of 3-isopropylmalate dehydratase (leud)from methhanocaldococcus jannaschii dsm2661 (mj1271) (see paper)
36% identity, 53% coverage: 12:119/202 of query aligns to 7:103/167 of 2pkpA
>PfGW456L13_3593 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_3593
MQPFDFVSGSAAPLLASNIDTDVIMPKQFLKGIDRKGLDKGLFFDLRFLESGEPNPGFIL
NQPAWNDAAFLVVGPNFGCGSSREHAVWGLKQVGIRALIGTSFAGIFYDNCQRNGVLAIQ
LTEVQLNQIAALTSNPATARISVNLPEQTIELADGNVIPFGIDELRKQSLLLGLDAVGTT
LQRAEQIRSFEARHLAENPWLG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory