SitesBLAST
Comparing PfGW456L13_3657 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_3657 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q00796 Sorbitol dehydrogenase; SDH; (R,R)-butanediol dehydrogenase; L-iditol 2-dehydrogenase; Polyol dehydrogenase; Ribitol dehydrogenase; RDH; Xylitol dehydrogenase; XDH; EC 1.1.1.-; EC 1.1.1.4; EC 1.1.1.14; EC 1.1.1.56; EC 1.1.1.9 from Homo sapiens (Human) (see 10 papers)
33% identity, 93% coverage: 10:325/339 of query aligns to 14:337/357 of Q00796
- C45 (= C41) binding
- H70 (= H64) binding
- E71 (= E65) binding
- R110 (≠ S101) to P: in SORDD; results in protein aggregation
- H135 (≠ V115) to R: in SORDD; results in protein aggregation
- A153 (= A134) to D: in SORDD; uncertain significance; results in protein aggregation; dbSNP:rs145813597
- I184 (= I165) binding
- D204 (= D185) binding
- R209 (= R190) binding
- Q239 (≠ F224) to L: in dbSNP:rs1042079
- N269 (≠ R257) to T: in dbSNP:rs930337
- VGL 273:275 (≠ ASV 261:263) binding
- VFR 297:299 (≠ TLC 285:287) binding
- V322 (≠ I310) to I: in SORDD; uncertain significance; dbSNP:rs149975952
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
1pl6A Human sdh/nadh/inhibitor complex (see paper)
33% identity, 93% coverage: 10:325/339 of query aligns to 13:336/356 of 1pl6A
- active site: C44 (= C41), G45 (= G42), S46 (= S43), H49 (≠ G46), H69 (= H64), E70 (= E65), R99 (vs. gap), D102 (≠ G94), C105 (≠ I97), S113 (vs. gap), F117 (vs. gap), P156 (= P138), G160 (≠ A142)
- binding 4-[2-(hydroxymethyl)pyrimidin-4-yl]-n,n-dimethylpiperazine-1-sulfonamide: C44 (= C41), S46 (= S43), I56 (= I53), F59 (≠ D56), H69 (= H64), E155 (= E137), L274 (≠ V263), F297 (≠ L286)
- binding nicotinamide-adenine-dinucleotide: G181 (= G163), P182 (≠ A164), I183 (= I165), D203 (= D185), L204 (= L186), R208 (= R190), C249 (= C238), T250 (≠ S239), V272 (≠ A261), G273 (≠ S262), L274 (≠ V263), F297 (≠ L286), R298 (≠ C287)
- binding zinc ion: C44 (= C41), H69 (= H64)
Sites not aligning to the query:
3qe3A Sheep liver sorbitol dehydrogenase (see paper)
32% identity, 97% coverage: 10:338/339 of query aligns to 8:343/351 of 3qe3A
- active site: C39 (= C41), G40 (= G42), S41 (= S43), H44 (≠ G46), H64 (= H64), E65 (= E65), R94 (vs. gap), D97 (≠ G94), C100 (≠ I97), S108 (vs. gap), F112 (vs. gap), P151 (= P138), G155 (≠ A142), K339 (= K334)
- binding glycerol: Y45 (≠ F47), F54 (≠ D56), T116 (vs. gap), R293 (≠ C287)
- binding zinc ion: C39 (= C41), H64 (= H64), E65 (= E65)
P07846 Sorbitol dehydrogenase; SDH; L-iditol 2-dehydrogenase; Polyol dehydrogenase; Xylitol dehydrogenase; XDH; EC 1.1.1.-; EC 1.1.1.14; EC 1.1.1.9 from Ovis aries (Sheep) (see paper)
32% identity, 97% coverage: 10:338/339 of query aligns to 12:346/354 of P07846
- C43 (= C41) binding
- Y49 (≠ F47) binding
- H67 (= H64) binding
- E68 (= E65) binding
- E153 (= E137) binding
- R296 (≠ C287) binding
- Y297 (= Y288) binding
P27867 Sorbitol dehydrogenase; SDH; L-iditol 2-dehydrogenase; Polyol dehydrogenase; Xylitol dehydrogenase; XDH; EC 1.1.1.-; EC 1.1.1.14; EC 1.1.1.9 from Rattus norvegicus (Rat) (see paper)
31% identity, 97% coverage: 10:338/339 of query aligns to 14:349/357 of P27867
1e3jA Ketose reductase (sorbitol dehydrogenase) from silverleaf whitefly (see paper)
32% identity, 97% coverage: 10:337/339 of query aligns to 7:344/348 of 1e3jA
- active site: C38 (= C41), G39 (= G42), S40 (= S43), H43 (≠ G46), H63 (= H64), E64 (= E65), C93 (vs. gap), C96 (vs. gap), C99 (vs. gap), C107 (≠ M91), T111 (≠ A95), P150 (= P138), G154 (≠ A142), K341 (= K334)
- binding phosphate ion: A174 (= A162), A196 (= A184), R197 (≠ D185), S198 (= S187), R201 (= R190)
- binding zinc ion: C38 (= C41), H63 (= H64), E64 (= E65), C93 (vs. gap), C96 (vs. gap), C99 (vs. gap), C107 (≠ M91)
6ie0B X-ray crystal structure of 2r,3r-butanediol dehydrogenase from bacillus subtilis
31% identity, 99% coverage: 5:339/339 of query aligns to 2:346/347 of 6ie0B
4ej6A Crystal structure of a putative zinc-binding dehydrogenase (target psi-012003) from sinorhizobium meliloti 1021
31% identity, 94% coverage: 2:318/339 of query aligns to 1:322/343 of 4ej6A
- active site: C40 (= C41), G41 (= G42), T42 (≠ S43), H45 (≠ G46), H61 (= H64), E62 (= E65), C91 (vs. gap), C94 (vs. gap), C97 (vs. gap), C105 (≠ M91), R109 (≠ A95), P147 (= P138), C151 (≠ A142)
- binding zinc ion: C91 (vs. gap), C94 (vs. gap), C97 (vs. gap), C105 (≠ M91)
Sites not aligning to the query:
4ejmA Crystal structure of a putative zinc-binding dehydrogenase (target psi-012003) from sinorhizobium meliloti 1021 bound to NADP
31% identity, 94% coverage: 2:318/339 of query aligns to 1:322/342 of 4ejmA
- active site: C40 (= C41), G41 (= G42), T42 (≠ S43), H45 (≠ G46), H61 (= H64), E62 (= E65), C91 (vs. gap), C94 (vs. gap), C97 (vs. gap), C105 (≠ M91), R109 (≠ A95), P147 (= P138), C151 (≠ A142)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G170 (= G161), G172 (= G163), V173 (≠ A164), I174 (= I165), T194 (≠ D185), R195 (≠ L186), Q196 (≠ S187), K199 (≠ R190), C240 (= C238), E245 (≠ G243), T246 (≠ V244), L263 (≠ A261), V265 (= V263), I291 (≠ C287)
- binding zinc ion: C91 (vs. gap), C94 (vs. gap), C97 (vs. gap), C105 (≠ M91)
Sites not aligning to the query:
5vm2A Crystal structure of eck1772, an oxidoreductase/dehydrogenase of unknown specificity involved in membrane biogenesis from escherichia coli
27% identity, 95% coverage: 10:332/339 of query aligns to 8:337/347 of 5vm2A
- active site: C39 (= C41), G40 (= G42), S41 (= S43), H44 (≠ G46), H65 (= H64), E66 (= E65), C95 (vs. gap), C98 (vs. gap), C101 (≠ A92), C109 (≠ G100), D113 (≠ G104), P153 (= P138), G157 (≠ A142)
- binding magnesium ion: H65 (= H64), E66 (= E65), E152 (= E137)
- binding zinc ion: C95 (vs. gap), C98 (vs. gap), C101 (≠ A92), C109 (≠ G100)
Sites not aligning to the query:
A2QAC0 L-arabinitol 4-dehydrogenase; LAD; EC 1.1.1.12 from Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513) (see 2 papers)
31% identity, 91% coverage: 26:333/339 of query aligns to 42:365/386 of A2QAC0
- M70 (= M60) mutation to F: Abolishes enzyme activity.
- DI 213:214 (≠ DL 185:186) mutation to SR: Alters cofactor specificity from NAD to NADP; when associated with T-359.
- Y318 (≠ L286) mutation to F: Increases affinity for D-sorbitol.
- A359 (= A327) mutation to T: Alters cofactor specificity from NAD to NADP; when associated with 213-SR-214.
Q96V44 L-arabinitol 4-dehydrogenase; LAD; EC 1.1.1.12 from Hypocrea jecorina (Trichoderma reesei) (see paper)
31% identity, 92% coverage: 26:338/339 of query aligns to 53:374/377 of Q96V44
- DI 224:225 (≠ DL 185:186) mutation to SR: Alters cofactor specificity from NAD to NADP; when associated with T-362.
- A362 (= A327) mutation to T: Alters cofactor specificity from NAD to NADP; when associated with 224-SR-225.
B6HI95 L-arabinitol 4-dehydrogenase; LAD; EC 1.1.1.12 from Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum) (see paper)
28% identity, 90% coverage: 30:333/339 of query aligns to 43:364/385 of B6HI95
- DI 212:213 (≠ DL 185:186) mutation to SR: Alters cofactor specificity from NAD to NADP; when associated with T-358.
- S358 (≠ A327) mutation to T: Alters cofactor specificity from NAD to NADP; when associated with 212-SR-213.
4ilkA Crystal structure of short chain alcohol dehydrogenase (rspb) from e. Coli cft073 (efi target efi-506413) complexed with cofactor nadh
29% identity, 98% coverage: 5:337/339 of query aligns to 4:335/337 of 4ilkA
- active site: C40 (= C41), G41 (= G42), S42 (= S43), H45 (≠ G46), H59 (= H64), E60 (= E65), C89 (≠ G94), C92 (vs. gap), C95 (vs. gap), C103 (vs. gap), A107 (= A95), P145 (= P138), A149 (= A142), K332 (= K334)
- binding manganese (ii) ion: C40 (= C41), H59 (= H64), E60 (= E65), E144 (= E137)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G168 (= G161), G170 (= G163), P171 (≠ A164), I172 (= I165), D193 (= D185), R194 (≠ L186), R198 (= R190), N213 (≠ P205), A235 (≠ C238), A236 (≠ S239), C237 (≠ G240), I241 (≠ V244), M258 (≠ A261), F260 (≠ V263)
- binding zinc ion: C89 (≠ G94), C92 (vs. gap), C95 (vs. gap), C103 (vs. gap)
3m6iA L-arabinitol 4-dehydrogenase (see paper)
30% identity, 90% coverage: 28:333/339 of query aligns to 36:350/358 of 3m6iA
- active site: C49 (= C41), G50 (= G42), S51 (= S43), H54 (≠ G46), H74 (= H64), E75 (= E65), C104 (vs. gap), C107 (vs. gap), C110 (vs. gap), C118 (≠ A95), D122 (≠ V99), P160 (= P138), A164 (= A142)
- binding nicotinamide-adenine-dinucleotide: C49 (= C41), V163 (= V141), G185 (= G163), P186 (≠ A164), I187 (= I165), D207 (= D185), R212 (= R190), C255 (= C238), T256 (≠ S239), I278 (≠ A261), G279 (≠ S262), V280 (= V263), R304 (≠ C287)
- binding zinc ion: C49 (= C41), H74 (= H64), C104 (vs. gap), C107 (vs. gap), C110 (vs. gap), C118 (≠ A95)
Sites not aligning to the query:
Q7SI09 L-arabinitol 4-dehydrogenase; LAD; EC 1.1.1.12 from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) (see 2 papers)
30% identity, 90% coverage: 28:333/339 of query aligns to 40:354/363 of Q7SI09
- C53 (= C41) binding
- F59 (= F47) mutation F->A,S,Y: No effect.
- H78 (= H64) binding
- E79 (= E65) binding
- C108 (vs. gap) binding
- C111 (vs. gap) binding
- C114 (vs. gap) binding
- C122 (≠ A95) binding
- E163 (= E137) binding
- PI 190:191 (≠ AI 164:165) binding
- D211 (= D185) binding
- DI 211:212 (≠ DL 185:186) mutation to SR: Alters cofactor specificity from NAD to NADP; when associated with T-348.
- R216 (= R190) binding
- I282 (≠ A261) binding
- QYR 306:308 (≠ TLC 285:287) binding
- S348 (≠ A327) mutation to T: Alters cofactor specificity from NAD to NADP; when associated with 211-SR-212.
7y9pA Xylitol dehydrogenase s96c/s99c/y102c mutant(thermostabilized form) from pichia stipitis (see paper)
28% identity, 95% coverage: 15:337/339 of query aligns to 13:354/357 of 7y9pA
4uejA Closed state of galactitol-1-phosphate 5-dehydrogenase from e. Coli in complex with glycerol. (see paper)
29% identity, 96% coverage: 16:339/339 of query aligns to 12:346/346 of 4uejA
- active site: C38 (= C41), G39 (= G42), S40 (= S43), P43 (≠ G46), H59 (= H64), E60 (= E65), C89 (vs. gap), C92 (vs. gap), C95 (vs. gap), C103 (vs. gap), D107 (≠ A95), P145 (= P138), G149 (≠ A142), K341 (= K334)
- binding glycerol: H59 (= H64), E144 (= E137)
- binding zinc ion: C89 (vs. gap), C92 (vs. gap), C95 (vs. gap), C103 (vs. gap)
4a2cA Crystal structure of galactitol-1-phosphate dehydrogenase from escherichia coli (see paper)
29% identity, 96% coverage: 16:339/339 of query aligns to 12:346/346 of 4a2cA
- active site: C38 (= C41), G39 (= G42), S40 (= S43), P43 (≠ G46), H59 (= H64), E60 (= E65), C89 (vs. gap), C92 (vs. gap), C95 (vs. gap), C103 (vs. gap), D107 (≠ A95), P145 (= P138), G149 (≠ A142), K341 (= K334)
- binding zinc ion: C89 (vs. gap), C92 (vs. gap), C95 (vs. gap), C103 (vs. gap)
2ejvA Crystal structure of threonine 3-dehydrogenase complexed with NAD+
29% identity, 94% coverage: 22:339/339 of query aligns to 19:341/343 of 2ejvA
- active site: C38 (= C41), G39 (= G42), T40 (≠ S43), H43 (≠ G46), H63 (= H64), E64 (= E65), C93 (≠ V78), C96 (≠ R81), C99 (≠ M84), C107 (≠ M91), Q111 (≠ A95), P149 (= P138), A153 (= A142), K336 (= K334)
- binding nicotinamide-adenine-dinucleotide: G172 (= G161), G174 (= G163), P175 (≠ A164), I176 (= I165), S195 (≠ A184), D196 (= D185), P197 (≠ L186), R201 (= R190), F238 (≠ C238), S239 (= S239), N241 (≠ V241), A244 (≠ V244), L261 (≠ A261), G262 (≠ S262), I263 (≠ V263)
- binding zinc ion: C38 (= C41), H63 (= H64), E64 (= E65), C96 (≠ R81), C99 (≠ M84), C107 (≠ M91)
Query Sequence
>PfGW456L13_3657 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_3657
MNHVMKQVRLHGPRDLRVDEVPLPSPGETDVLVEVAACGVCGSDLGFYESGGIRRDGAPM
PLGHEFSGVIREVGTAVVHYRPGMRVVVNPMANGAMIGVGSDEGALANLVRVRNVNSGPI
LHQLPANLPLEVAALVEPLAVALHAVNRSRVTAGESVLVLGAGAIGLGIVACLKARGISQ
IAVADLSAGRLEIAAGLGANLTLDPTRDDLWSELARAHGSVPTFLGTQAPATQVIFECSG
VSGVLHEAIARARDAARITVASVYKQPQAFDFSILQVKELELIGTLCYPTEFAQALELLA
SGAFDPESMISHRFSLDDVAQAYKTAADPQRSAKVIIKP
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory