SitesBLAST
Comparing PfGW456L13_3737 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_3737 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
44% identity, 99% coverage: 2:494/496 of query aligns to 1:488/491 of 5gtlA
- active site: N165 (= N171), K188 (= K194), E263 (= E269), C297 (= C303), E394 (= E400), E471 (= E477)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I167), P163 (= P169), K188 (= K194), A190 (= A196), E191 (≠ M197), Q192 (≠ E198), G221 (= G227), G225 (= G231), G241 (= G247), S242 (= S248), T245 (≠ V251), L264 (= L270), C297 (= C303), E394 (= E400), F396 (= F402)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
44% identity, 99% coverage: 2:494/496 of query aligns to 1:488/491 of 5gtkA
- active site: N165 (= N171), K188 (= K194), E263 (= E269), C297 (= C303), E394 (= E400), E471 (= E477)
- binding nicotinamide-adenine-dinucleotide: I161 (= I167), I162 (≠ V168), P163 (= P169), W164 (= W170), K188 (= K194), E191 (≠ M197), G221 (= G227), G225 (= G231), A226 (≠ G232), F239 (= F245), G241 (= G247), S242 (= S248), T245 (≠ V251), Y248 (≠ S254), L264 (= L270), C297 (= C303), Q344 (= Q350), R347 (≠ S353), E394 (= E400), F396 (= F402)
7radA Crystal structure analysis of aldh1b1
42% identity, 96% coverage: 21:494/496 of query aligns to 16:486/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I167), I159 (≠ V168), P160 (= P169), W161 (= W170), N162 (= N171), M167 (≠ I176), K185 (= K194), E188 (≠ M197), G218 (= G227), G222 (= G231), A223 (≠ G232), T237 (= T246), G238 (= G247), S239 (= S248), V242 (= V251), E261 (= E269), L262 (= L270), C295 (= C303), E392 (= E400), F394 (= F402)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (= L116), E117 (≠ A120), F163 (= F172), E285 (≠ L293), F289 (≠ L297), N450 (≠ V458), V452 (≠ L460)
7mjdA Crystal structure analysis of aldh1b1
42% identity, 96% coverage: 21:494/496 of query aligns to 16:486/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I167), I159 (≠ V168), P160 (= P169), W161 (= W170), N162 (= N171), M167 (≠ I176), K185 (= K194), E188 (≠ M197), G218 (= G227), G222 (= G231), F236 (= F245), T237 (= T246), G238 (= G247), S239 (= S248), V242 (= V251), E261 (= E269), L262 (= L270), C295 (= C303), E392 (= E400), F394 (= F402)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ A120), E285 (≠ L293), F289 (≠ L297), N450 (≠ V458), V452 (≠ L460)
7mjcA Crystal structure analysis of aldh1b1
42% identity, 96% coverage: 21:494/496 of query aligns to 16:486/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I167), I159 (≠ V168), P160 (= P169), W161 (= W170), N162 (= N171), K185 (= K194), E188 (≠ M197), G218 (= G227), G222 (= G231), T237 (= T246), G238 (= G247), S239 (= S248), V242 (= V251), E261 (= E269), L262 (= L270), C295 (= C303), E392 (= E400), F394 (= F402)
7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/489 of 7a6qB
- active site: N163 (= N171), E262 (= E269), C296 (= C303), E470 (= E477)
- binding nicotinamide-adenine-dinucleotide: I159 (= I167), W162 (= W170), K186 (= K194), E189 (≠ M197), G219 (= G227), G223 (= G231), S240 (= S248), V243 (= V251), K342 (= K349)
- binding (3-oxidanylidene-3-sodiooxy-propanoyl)oxysodium: A32 (= A35), T33 (≠ V36), C34 (≠ V37), P36 (= P39), D103 (≠ S105), E189 (≠ M197), Q190 (≠ E198), F218 (≠ G226), I339 (≠ V346), D340 (≠ S347)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (≠ A120), D141 (≠ G149), N143 (≠ K151), N451 (≠ V458), L453 (= L460), A455 (≠ P462)
7a6qA Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/489 of 7a6qA
- active site: N163 (= N171), E262 (= E269), C296 (= C303), E470 (= E477)
- binding nicotinamide-adenine-dinucleotide: I159 (= I167), T160 (≠ V168), W162 (= W170), K186 (= K194), A188 (= A196), E189 (≠ M197), G219 (= G227), G223 (= G231), S240 (= S248), V243 (= V251), K342 (= K349), K346 (≠ S353)
- binding 3-(2-phenylimidazo[1,2-a]pyridin-6-yl)benzenecarbonitrile: G118 (≠ A120), D141 (≠ G149), N143 (≠ K151), N451 (≠ V458), L453 (= L460), Y454 (≠ D461)
5fhzA Human aldehyde dehydrogenase 1a3 complexed with NAD(+) and retinoic acid (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/489 of 5fhzA
- active site: N163 (= N171), K186 (= K194), E262 (= E269), C296 (= C303), E393 (= E400), E470 (= E477)
- binding nicotinamide-adenine-dinucleotide: I159 (= I167), T160 (≠ V168), W162 (= W170), K186 (= K194), E189 (≠ M197), G219 (= G227), G223 (= G231), F237 (= F245), G239 (= G247), S240 (= S248), T241 (= T249), V243 (= V251), G264 (= G271), Q343 (= Q350), E393 (= E400)
- binding retinoic acid: G118 (≠ A120), R121 (≠ E123), F164 (= F172), M168 (≠ I176), W171 (= W179), C295 (≠ V302), C296 (= C303), L453 (= L460)
7qk9A Crystal structure of the aldh1a3-atp complex (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 16:486/489 of 7qk9A
- binding adenosine-5'-triphosphate: I158 (= I167), T159 (≠ V168), P160 (= P169), W161 (= W170), K185 (= K194), E188 (≠ M197), G218 (= G227), G222 (= G231), F236 (= F245), S239 (= S248), V242 (= V251)
P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 2 papers)
41% identity, 96% coverage: 21:494/496 of query aligns to 35:505/512 of P47895
- R89 (≠ S73) to C: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514652
- K204 (= K194) binding
- E207 (≠ M197) binding
- GSTEVG 257:262 (≠ GSTAVG 247:252) binding
- Q361 (= Q350) binding
- E411 (= E400) binding
- A493 (≠ V482) to P: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514653
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylalanine
5l13A Structure of aldh2 in complex with 2p3 (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/494 of 5l13A
- active site: N163 (= N171), K186 (= K194), E262 (= E269), C296 (= C303), E393 (= E400), E470 (= E477)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F172), M168 (≠ I176), W171 (= W179), F290 (≠ L297), C295 (≠ V302), C296 (= C303), C297 (≠ A304), D451 (≠ V458), F453 (≠ L460)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/494 of 4kwgA
- active site: N163 (= N171), K186 (= K194), E262 (= E269), C296 (= C303), E393 (= E400), E470 (= E477)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F172), M168 (≠ I176), C295 (≠ V302), C296 (= C303), C297 (≠ A304), D451 (≠ V458), F453 (≠ L460)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/494 of 4kwfA
- active site: N163 (= N171), K186 (= K194), E262 (= E269), C296 (= C303), E393 (= E400), E470 (= E477)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F172), M168 (≠ I176), W171 (= W179), E262 (= E269), C295 (≠ V302), C296 (= C303), C297 (≠ A304), D451 (≠ V458), F453 (≠ L460), F459 (= F466)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/494 of 3sz9A
- active site: N163 (= N171), K186 (= K194), E262 (= E269), C296 (= C303), E393 (= E400), E470 (= E477)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F172), C295 (≠ V302), C296 (= C303), D451 (≠ V458), F453 (≠ L460), F459 (= F466)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/494 of 3injA
- active site: N163 (= N171), K186 (= K194), E262 (= E269), C296 (= C303), E393 (= E400), E470 (= E477)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ A120), F164 (= F172), L167 (= L175), F286 (≠ L293), F290 (≠ L297), D451 (≠ V458), F453 (≠ L460)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/494 of 2vleA
- active site: N163 (= N171), K186 (= K194), E262 (= E269), C296 (= C303), E393 (= E400), E470 (= E477)
- binding daidzin: M118 (≠ A120), F164 (= F172), M168 (≠ I176), W171 (= W179), F286 (≠ L293), F290 (≠ L297), C295 (≠ V302), C296 (= C303), D451 (≠ V458), V452 (≠ L459), F453 (≠ L460)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/494 of 1o01B
- active site: N163 (= N171), K186 (= K194), E262 (= E269), C296 (= C303), E393 (= E400), E470 (= E477)
- binding (2e)-but-2-enal: C296 (= C303), C297 (≠ A304), F453 (≠ L460)
- binding nicotinamide-adenine-dinucleotide: I159 (= I167), I160 (≠ V168), P161 (= P169), W162 (= W170), K186 (= K194), E189 (≠ M197), G219 (= G227), G223 (= G231), A224 (≠ G232), F237 (= F245), G239 (= G247), S240 (= S248), I243 (≠ V251), L263 (= L270), G264 (= G271), C296 (= C303), Q343 (= Q350), E393 (= E400), F395 (= F402)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/494 of 1cw3A
- active site: N163 (= N171), K186 (= K194), E262 (= E269), C296 (= C303), E393 (= E400), E470 (= E477)
- binding magnesium ion: V34 (= V37), D103 (≠ S105), Q190 (≠ E198)
- binding nicotinamide-adenine-dinucleotide: I159 (= I167), I160 (≠ V168), P161 (= P169), W162 (= W170), K186 (= K194), G219 (= G227), G223 (= G231), A224 (≠ G232), F237 (= F245), G239 (= G247), S240 (= S248), I243 (≠ V251), L263 (= L270), G264 (= G271), C296 (= C303), Q343 (= Q350), K346 (≠ S353), E393 (= E400), F395 (= F402)
P51977 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Ovis aries (Sheep) (see 2 papers)
41% identity, 96% coverage: 21:494/496 of query aligns to 24:494/501 of P51977
5ac0A Ovis aries aldehyde dehydrogenase 1a1 in complex with a duocarmycin analog (see paper)
41% identity, 96% coverage: 21:494/496 of query aligns to 17:487/494 of 5ac0A
- active site: N163 (= N171), K186 (= K194), E262 (= E269), C296 (= C303), E393 (= E400), E470 (= E477)
- binding 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one: M114 (≠ L116), F164 (= F172), W171 (= W179), Y290 (≠ L297), C295 (≠ V302), C296 (= C303)
- binding nicotinamide-adenine-dinucleotide: I159 (= I167), I160 (≠ V168), P161 (= P169), W162 (= W170), K186 (= K194), E189 (≠ M197), G219 (= G227), G223 (= G231), A224 (≠ G232), F237 (= F245), G239 (= G247), S240 (= S248), V243 (= V251), G264 (= G271), C296 (= C303), Q343 (= Q350), K346 (≠ S353), E393 (= E400)
Query Sequence
>PfGW456L13_3737 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_3737
MSNVEILPQVAAFLERRHGCFIDGQWVLAEGDSIAVVNPATGQTLCETLDAPLELVERAV
QSSHKAFKSGVWSSLRPADRERILLNFTRLVEEHAEELAQLETLSQGKSINMARALDLNA
TVEFMRYMSGWATKIEGQTFDVSIPLPPGAKFTAFTKREPVGVVVGIVPWNFPLLIAAWK
LMPALATGCTVIIKPAMETPLTAMRLAELALEAGIPAGVFNVVTGGGASVGGVLTQHPLV
SKVSFTGSTAVGKSVGVACMENMTRFSLELGGKNPMIVLADADIEKAVQGAILGGLLNNG
QVCAAASRFYVHRSIHDQFVEALAAAVSSMPIGAGMNCDAAINPLVSRKQQQSVLKHIEL
ARQQGARVVTGGELLEGDGFFVQPTILADIDHSMAVAREEVFGPVLGVMPFDDEDAVIEL
ANDNRYGLAASLWTNDLGKAMNLVPRIEAGTVWVNAHVLLDPAMPFGGVKQSGMGREFGR
AVIEAYTELKSVCIAH
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory