SitesBLAST

5i1fA Crystal structure of utp-glucose-1-phosphate uridylyltransferase from burkholderia vietnamiensis in complex with uridine-5'-diphosphate- glucose
48% identity, 95% coverage: 2:265/277 of query aligns to 5:267/290 of 5i1fA

query
sites
5i1fA

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binding uridine-5'-diphosphate-glucose: P11 (= P8), V12 (≠ A9), A13 (= A10), G14 (= G11), K28 (= K25), E29 (= E26), Q106 (= Q102), A109 (≠ M105), L110 (≠ K106), G111 (= G107), L112 (= L108), A115 (= A111), L132 (= L128), D134 (= D130), D135 (= D131), Y172 (= Y170), G173 (= G171), E192 (= E190), K193 (= K191), V205 (≠ I203), V206 (≠ I204), G207 (= G205), T233 (= T231)

5ve7A Crystal structure of utp-glucose-1-phosphate uridylyltransferase from burkholderia ambifaria in complex with utp
48% identity, 95% coverage: 2:265/277 of query aligns to 3:261/282 of 5ve7A

query
sites
5ve7A

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binding uridine 5'-triphosphate: P9 (= P8), V10 (≠ A9), A11 (= A10), G12 (= G11), L13 (≠ Y12), G14 (= G13), T15 (= T14), R16 (= R15), K26 (= K25), E27 (= E26), Q104 (= Q102), A107 (≠ M105), L108 (≠ K106), G109 (= G107), L110 (= L108), A113 (= A111), L130 (= L128), D132 (= D130)

2ux8G Crystal structure of sphingomonas elodea atcc 31461 glucose-1- phosphate uridylyltransferase in complex with glucose-1-phosphate. (see paper)
48% identity, 95% coverage: 2:265/277 of query aligns to 5:265/288 of 2ux8G

query
sites
2ux8G

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binding 1-O-phosphono-alpha-D-glucopyranose: L110 (= L108), Y170 (= Y170), G171 (= G171), E190 (= E190), V203 (≠ I203), Y207 (= Y207), T231 (= T231)

6knlA Uridine and triphosphate-bound ugpase from acinetobacter baumannii
38% identity, 96% coverage: 1:265/277 of query aligns to 1:268/290 of 6knlA

query
sites
6knlA

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binding triphosphate: G11 (= G11), L12 (≠ Y12), G13 (= G13), T14 (= T14), R15 (= R15), K79 (≠ T79), K81 (= K81)
binding uridine: P8 (= P8), V9 (≠ A9), A10 (= A10), G11 (= G11), K25 (= K25), Q103 (= Q102), P106 (≠ M105), L107 (≠ K106), G108 (= G107), L109 (= L108), A112 (= A111), P130 (≠ A129), D131 (= D130)

6k8dA Udp-glucose pyrophosphorylase with upg from acinetobacter baumanii
38% identity, 96% coverage: 1:265/277 of query aligns to 1:268/290 of 6k8dA

query
sites
6k8dA

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x
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F

F

A

A

V

V

V

L

L
|
L

A
x
P

D
|
D

D

V

L

L

C

V

L

K

N

D

L

G

E

S

G

G

D

Q

G

N

V

D

L

L

S

S

Q

R

M

M

I

I

A

S

L

R

Y

Y

K

N

Q

S

F

S

R

Q

C

A

S

A

I

Q

V

I

A

M

I

V

Q

E

E

A

V

V

P

P

N

D

D

H

Q

L

T

V

H

D

K

Q

Y
|
Y

G
|
G

I

I

I

V

-

D

A

V

G

A

E

Q

Q

S

I

P

R

N

E

E

G

G

-

E

I

S

Y

I

R

A

V

M

N

Q

S

G

M

I

V

V

E
|
E

K

K

P

P

K

P

P

V

E

G

D

A

A

A

P

P

S

S

N

N

L

L

A

S

I
x
V

I

V

G

G

R

R

Y
|
Y

I

V

L

L

T

P

A

A

D

K

I

I

F

M

D

Q

L

L

I

L

A

E

D

N

T

T

E

P

P

K

G

G

K

A

G

G

G

N

E

E

I

I

Q

Q

I

L

T

T

D

D

A

A

L

I

M

A

K

M

Q

L

A

Q

Q

D

S

T

G

D

C

T

V

V

L

E

A

A

Y

Y

K

R

F

M

E

Q

G

G

H

Q

R

T

F

F

D

D

C

C

G

G

G

S

A

K

E

L

G

G

Y

Y

I

L

D

K

A

A

T

V

binding uridine-5'-diphosphate-glucose: P8 (= P8), V9 (≠ A9), A10 (= A10), G11 (= G11), Q103 (= Q102), P106 (≠ M105), L107 (≠ K106), G108 (= G107), L109 (= L108), A112 (= A111), L129 (= L128), P130 (≠ A129), D131 (= D130), Y171 (= Y170), G172 (= G171), E193 (= E190), V206 (≠ I203), Y210 (= Y207)

6ikzB Udp-glucose pyrophosphorylase from acinetobacter baumanii
38% identity, 96% coverage: 1:265/277 of query aligns to 1:263/285 of 6ikzB

query
sites
6ikzB

M

M

I

I

R

K

K

K

C

A

L

V

F

L

P
|
P

A
x
V

A
|
A

G
|
G

Y
x
L

G
|
G

T
|
T

R
|
R

F

F

L

L

P

P

A

A

T

S

K

K

S

S

M

I

P

P

K
|
K

E

E

M

M

L

V

P

T

I

V

V

V

N

D

K

R

P

P

L

A

I

I

Q

E

Y

Y

G

V

V

V

E

R

E

E

A

A

R

V

D

E

A

A

G

G

L

I

Q

E

H

Q

M

I

A

I

I

L

V

V

T

T

G

H

R

S

G

S

K

K

R

A

A

S

L

I

E

E

D

N

H

Y

F

F

D

D

I

R

S

N

Y

F

E

E

L

L

E

E

H

T

Q

T

I

L

R

E

G

Q

T

K

D

K

K

K

E

F

N

D

Y

L

L

L

N

A

G

E

T

I

R

T

E

Q

L

I

M

V

-

P

D

E

T

H

C

V

T

S

F

V

S

I

Y

S

T

V

R

R

Q
|
Q

V

P

E

Q

M
x
P

K
x
L

G
|
G

L
|
L

G

G

H

H

A
|
A

I

V

L

L

S

C

G

A

R

K

P

S

L

V

I

V

G

G

D

E

E

D

P

D

F

F

A

A

V

V

V

L

L

L

A
x
P

D
|
D

D

V

L

L

C

V

L

K

N

D

L

G

E

S

G

G

D

Q

G

N

V

D

L

L

S

S

Q

R

M

M

I

I

A

S

L

R

Y

Y

K

N

Q

S

F

S

R

Q

C

A

S

A

I

Q

V

I

A

M

I

V

Q

E

E

A

V

V

P

P

N

D

D

H

Q

L

T

V

H

D

K

Q

Y

Y

G

G

I

I

I

V

-

D

A

V

G

A

E

Q

Q

S

I

P

R

N

E

E

G

G

-

E

I

S

Y

I

R

A

V

M

N

Q

S

G

M

I

V

V

E

E

K

K

P

P

K

P

P

V

E

G

D

A

A

A

P

P

S

S

N

N

L

L

A

S

I

V

G

G

R

R

Y

Y

I

V

L

L

T

P

A

A

D

K

I

I

F

M

D

Q

L

L

I

L

A

E

D

N

T

T

E

P

P

-

G

-

K

-

G

-

E

E

I

I

Q

Q

I

L

T

T

D

D

A

A

L

I

M

A

K

M

Q

L

A

Q

Q

D

S

T

G

D

C

T

V

V

L

E

A

A

Y

Y

K

R

F

M

E

Q

G

G

H

Q

R

T

F

F

D

D

C

C

G

G

G

S

A

K

E

L

G

G

Y

Y

I

L

D

K

A

A

T

V

binding uridine 5'-triphosphate: P8 (= P8), V9 (≠ A9), A10 (= A10), G11 (= G11), L12 (≠ Y12), G13 (= G13), T14 (= T14), R15 (= R15), K25 (= K25), Q103 (= Q102), P106 (≠ M105), L107 (≠ K106), G108 (= G107), L109 (= L108), A112 (= A111), P130 (≠ A129), D131 (= D130)

2ux8A Crystal structure of sphingomonas elodea atcc 31461 glucose-1- phosphate uridylyltransferase in complex with glucose-1-phosphate. (see paper)
40% identity, 95% coverage: 2:265/277 of query aligns to 5:232/255 of 2ux8A

query
sites
2ux8A

I

L

R

R

K

K

C

A

L

V

F

F

P

P

A

V

A

A

G

G

Y

L

G

G

T

T

R

R

F

F

L

L

P

P

A

A

T

T

K

K

S

A

M

M

P

P

K

K

E

E

M

M

L

L

P

P

I

V

V

V

N

D

K

R

P

P

L

L

I

I

Q

Q

Y

Y

G

A

V

V

E

D

E

E

A

A

R

V

D

E

A

A

G

G

L

I

Q

E

H

Q

M

M

A

I

I

F

V

V

T

T

G

G

R

R

G

G

K

K

R

S

A

A

L

L

E

E

D

D

H

H

F

F

D

D

I

I

S

A

Y

Y

E

E

L

L

E

E

H

A

Q

T

I

M

R

A

G

A

T

R

D

G

K

K

E

S

-

L

N

D

Y

V

L

L

N

D

G

G

T

T

R

R

E

-

L

-

M

L

D

K

T

P

C

G

T

N

F

I

S

A

Y

Y

T

V

R

R

Q

Q

V

Q

E

E

M

P

K

M

G

G

L
|
L

G

G

H

H

A

A

I

V

L

W

S

C

G

A

R

R

P

D

L

I

I

V

G

G

D

D

E

E

P

P

F

F

A

A

V

V

V

L

L
|
L

A

P

D

D

D
|
D

L

F

C

M

L

F

N

G

L

Q

E

P

G

-

D

-

G

G

V

C

L

L

S

K

Q

Q

M

M

I

V

A

D

L

A

Y

Y

K

N

Q

K

F

V

R

G

C

G

S

N

I

L

V

I

A

C

I

A

Q

E

E

I

V

-

P

-

N

-

D

-

Q

-

T

-

H

-

K

-

Y

-

G

-

I

I

I

T

A

P

G

G

E

T

Q

Q

I

-

R

-

E

D

G

G

I

V

Y

L

R

-

V

-

N

-

S

-

M

-

V

-

E

-

K

-

P

-

K

-

P

-

E

-

D

-

A

T

P

E

S

V

N

N

L

L

A

S

I
x
V

I
|
I

G
|
G

R

R

Y
|
Y

I

I

L

L

T

Q

A

P

D

E

I

V

F

M

D

R

L

I

I

L

A

E

D

N

T

Q

E

-

P

-

G

-

K

-

G

-

E

-

I

-

Q

G

I

L

T

T

D

D

A

A

L

M

M

Q

K

R

Q

M

A

I

Q

G

S

D

G

Q

C

P

V

F

L

H

A

G

Y

V

K

T

F

F

E

Q

G

G

H

T

R

R

F

Y

D

D

C

C

G

G

G

D

A

K

E

A

G

G

Y

F

I

I

D

Q

A

A

T

N

binding 1-O-phosphono-alpha-D-glucopyranose: L110 (= L108), L130 (= L128), D133 (= D131), V178 (≠ I203), I179 (= I204), G180 (= G205), Y182 (= Y207)

2pa4B Crystal structure of udp-glucose pyrophosphorylase from corynebacteria glutamicum in complex with magnesium and udp-glucose (see paper)
38% identity, 95% coverage: 2:264/277 of query aligns to 3:267/299 of 2pa4B

query
sites
2pa4B

I

V

R

K

K

T

C

V

L

V

F

V

P
|
P

A
|
A

G
|
G

Y

L

G

G

T

T

R

R

F

F

L

L

P

P

A

A

T

T

K

K

S

T

M

V

P

P

K
|
K

E
|
E

M

L

L

L

P

P

I

V

V

V

N

D

K

T

P

P

L

G

I

I

Q

E

Y

L

G

I

V

A

E

A

E

E

A

A

R

A

D

E

A

L

G

G

L

A

Q

T

H

R

M

L

A

A

I

I

V

I

T

T

G

A

R

P

G

N

K

K

R

A

A

G

L

V

E

L

D

A

H

H

F

F

D

E

I

R

S

S

Y

S

E

E

L

L

E

E

H

E

Q

T

I

L

R

M

G

E

T

R

D

G

K

K

E

T

N

D

Y

Q

L

V

N

E

G

I

T

I

R

R

E

R

L

A

M

A

D

D

T

L

C

I

T

K

F

A

S

V

Y

P

T

V

R

T

Q
|
Q

V

D

E

K

M
x
P

K
x
L

G
|
G

L
|
L

G

G

H

H

A
|
A

I

V

L

G

S

L

G

A

R

E

P

S

L

V

I

L

G

D

D

D

E

D

P

E

-

D

-

V

F

V

A

A

V

V

V

M

L
|
L

A
x
P

D
|
D

L

L

C

V

L

L

N

P

L

T

E

-

G

-

D

-

G

G

V

V

L

M

S

E

Q

R

M

M

I

A

A

Q

L

V

Y

R

K

A

Q

E

F

F

R

G

C

G

S

S

I

V

V

L

A

C

I

A

Q

V

E

E

V

V

P

S

N

E

D

A

Q

D

T

V

H

S

K

K

Y
|
Y

G
|
G

I

I

-

F

-

E

I

I

A

E

G

A

E

D

Q

T

I

K

R

D

E

S

G

D

I

V

Y

K

R

K

V

V

N

K

S

G

M

M

V

V

E
|
E

K
|
K

P

P

K

A

P

I

E

E

D

D

A

A

P

P

S

S

N

R

L

L

A

A

I
x
A

I
x
T

G
|
G

R

R

Y

Y

I

L

L

L

T

D

A

R

D

K

I

I

F

F

D

D

L

A

I

L

A

R

D

R

T

I

E

T

P

P

G

G

K

A

G

G

E

E

I

L

Q

Q

I

L

T

T

D

D

A

A

L

I

M

D

K

L

Q

L

A

I

Q

D

S

E

G

G

-

H

C

P

V

V

L

H

A

I

Y

V

K

I

F

H

E

Q

G

G

H

K

R
|
R

F

H

D

D

C

L

G

G

G

N

A

P

E

G

G

G

Y

Y

I

I

D

P

A

A

binding uridine-5'-diphosphate-glucose: P9 (= P8), A10 (= A9), A11 (= A10), G12 (= G11), K26 (= K25), E27 (= E26), Q103 (= Q102), P106 (≠ M105), L107 (≠ K106), G108 (= G107), L109 (= L108), A112 (= A111), L131 (= L128), P132 (≠ A129), D133 (= D130), D134 (= D131), Y170 (= Y170), G171 (= G171), E192 (= E190), K193 (= K191), A205 (≠ I203), T206 (≠ I204), G207 (= G205), R255 (= R252)

5z09A St0452(y97n)-utp binding form (see paper)
27% identity, 97% coverage: 4:272/277 of query aligns to 2:226/401 of 5z09A

query
sites
5z09A

K

K

C

A

L

F

F

I

P
x
L

A
|
A

G
|
G

Y
x
S

G
|
G

T
x
E

R
|
R

F

L

L

E

P

P

A

I

T

T

K

H

S

T

M

R

P

P

K
|
K

E

A

M

F

L

V

P

P

I

I

V

L

N

S

K

K

P

P

L

L

I

I

Q

E

Y

Y

G

Q

V

I

E

E

E

Y

A

L

R

R

D

K

A

C

G

G

L

I

Q

R

H

D

M

I

A

T

I

V

V

I

T

-

G

-

R

-

G

-

K

-

R

-

A

-

L

-

E

-

D

-

H

-

F

-

D

-

I

-

S

-

Y

-

E

-

L

-

E

-

H

-

Q

-

I

V

R

S

G

S

T

K

D

N

K

K

E

E

N

Y

Y

F

L

E

N

K

G

K

T

L

R

K

E

E

L

I

M

S

D

I

T

V

C

-

T

-

F

-

S

-

Y

-

T

T

R
x
Q

Q

K

V

D

E

D

M

I

K
|
K

G
|
G

L
x
T

G

G

H

A

A
|
A

I

I

L

L

S

S

G

A

R

K

P

-

L

-

I

F

G

N

D

D

E

E

P

-

F

-

A

A

V

L

V

I

L

I

A
x
N

D
x
G

D
|
D

L

L

C

F

L

F

N

S

L

N

E

E

G

K

D

E

G

-

V

-

L

I

S

C

Q

N

M

I

I

I

A

T

L

L

Y

K

K

E

Q

N

F

-

R

-

C

-

S

-

I

-

V

-

A

A

I

I

Q

I

E

G

V

V

P

K

N

V

D

S

Q

N

T

P

H

K

K

D

Y

Y

G

G

I

V

I

L

A

-

G

-

E

-

Q

-

I

V

R

L

E

D

G

N

I

Q

Y

N

R

N

V

L

N

S

S

K

M

I

V

I

E

E

K

K

P

P

K

-

P

-

E

E

D

I

A

P

P

P

S

S

N

N

L

L

A

I

I

N

I

A

G

G

R

I

Y

Y

I

K

L

L

T

N

A

S

D

D

I

I

F

F

D

T

L

Y

I

L

A

D

D

K

T

I

E

S

P

I

G

S

K

E

G

R

G

G

E

E

I

L

Q

E

I

L

T

T

D

D

A

A

L

I

M

N

K

L

Q

M

A

A

Q

K

S

D

G

H

C

R

V

V

L

K

A

V

Y

I

K

E

F

Y

E

E

G

G

H

Y

R

W

F

M

D

D

C

I

G

G

G

K

A

P

E

W

G

N

Y

I

I

I

D

D

A

V

T

N

N

K

F

W

C

A

Y

L

E

D

N

N

L

L

binding uridine 5'-triphosphate: L6 (≠ P8), A7 (= A9), A8 (= A10), G9 (= G11), S10 (≠ Y12), G11 (= G13), E12 (≠ T14), R13 (= R15), K23 (= K25), Q73 (≠ R101), K78 (= K106), G79 (= G107), T80 (≠ L108), A83 (= A111), N97 (≠ A129), G98 (≠ D130), D99 (= D131)

Sites not aligning to the query:

binding uridine 5'-triphosphate: 344

2ggqA Complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii
27% identity, 97% coverage: 4:272/277 of query aligns to 2:226/401 of 2ggqA

query
sites
2ggqA

K

K

C

A

L

F

F

I

P
x
L

A

A

A
|
A

G
|
G

Y
x
S

G
|
G

T
x
E

R
|
R

F

L

L

E

P

P

A

I

T

T

K

H

S

T

M

R

P

P

K
|
K

E

A

M

F

L

V

P

P

I

I

V

L

N

S

K

K

P

P

L

L

I

I

Q

E

Y

Y

G

Q

V

I

E

E

E

Y

A

L

R

R

D

K

A

C

G

G

L

I

Q

R

H

D

M

I

A

T

I

V

V

I

T

-

G

-

R

-

G

-

K

-

R

-

A

-

L

-

E

-

D

-

H

-

F

-

D

-

I

-

S

-

Y

-

E

-

L

-

E

-

H

-

Q

-

I

V

R

S

G

S

T

K

D

N

K

K

E

E

N

Y

Y

F

L

E

N

K

G

K

T

L

R

K

E

E

L

I

M

S

D

I

T

V

C

-

T

-

F

-

S

-

Y

-

T

T

R
x
Q

Q

K

V

D

E

D

M

I

K
|
K

G
|
G

L

T

G

G

H

A

A
|
A

I

I

L

L

S

S

G

A

R

K

P

-

L

-

I

F

G

N

D

D

E

E

P

-

F

-

A

A

V

L

V

I

L

I

A

Y

D

G

D

D

L

L

C

F

L

F

N

S

L

N

E

E

G

K

D

E

G

-

V

-

L

I

S

C

Q

N

M

I

I

I

A

T

L

L

Y

K

K

E

Q

N

F

-

R

-

C

-

S

-

I

-

V

-

A

A

I

I

Q

I

E

G

V

V

P

K

N

V

D

S

Q

N

T

P

H

K

K

D

Y

Y

G

G

I

V

I

L

A

-

G

-

E

-

Q

-

I

V

R

L

E

D

G

N

I

Q

Y

N

R

N

V

L

N

S

S

K

M

I

V

I

E

E

K

K

P

P

K

-

P

-

E

E

D

I

A

P

P

P

S

S

N

N

L

L

A

I

I

N

I

A

G

G

R

I

Y

Y

I

K

L

L

T

N

A

S

D

D

I

I

F

F

D

T

L

Y

I

L

A

D

D

K

T

I

E

S

P

I

G

S

K

E

G
x
R

G

G

E
|
E

I

L

Q

E

I

L

T

T

D

D

A

A

L

I

M

N

K

L

Q

M

A

A

Q

K

S

D

G

H

C

R

V

V

L

K

A

V

Y

I

K

E

F

Y

E

E

G

G

H

Y

R

W

F

M

D

D

C

I

G

G

G

K

A

P

E

W

G

N

Y

I

I

I

D

D

A

V

T

N

N

K

F

W

C

A

Y

L

E

D

N

N

L

L

active site: R13 (= R15)
binding thymidine-5'-triphosphate: L6 (≠ P8), A8 (= A10), G9 (= G11), S10 (≠ Y12), G11 (= G13), E12 (≠ T14), R13 (= R15), K23 (= K25), Q73 (≠ R101), K78 (= K106), G79 (= G107), A83 (= A111), R179 (≠ G225), E181 (= E227)

Sites not aligning to the query:

binding thymidine-5'-triphosphate: 344

Q975F9 Bifunctional sugar-1-phosphate nucleotidylyltransferase/acetyltransferase; EC 2.7.7.24; EC 2.7.7.9; EC 2.7.7.83; EC 2.7.7.23; EC 2.3.1.276; EC 2.3.1.157 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see 3 papers)
27% identity, 97% coverage: 4:272/277 of query aligns to 2:226/401 of Q975F9

query
sites
Q975F9

K

K

C

A

L

F

F

I

P

L

A

A

A
|
A

G
|
G

Y
x
S

G
|
G

T
x
E

R
|
R

F

L

L

E

P

P

A

I

T

T

K

H

S

T

M

R

P

P

K

K

E

A

M

F

L

V

P

P

I

I

V

L

N

S

K

K

P

P

L

L

I

I

Q

E

Y

Y

G

Q

V

I

E

E

E

Y

A

L

R

R

D

K

A

C

G

G

L

I

Q

R

H

D

M

I

A

T

I

V

V

I

T

-

G

-

R

-

G

-

K

-

R

-

A

-

L

-

E

-

D

-

H

-

F

-

D

-

I

-

S

-

Y

-

E

-

L

-

E

-

H

-

Q

-

I

V

R

S

G

S

T

K

D

N

K

K

E

E

N

Y

Y

F

L

E

N

K

G

K

T

L

R

K

E

E

L

I

M

S

D

I

T

V

C

-

T

-

F

-

S

-

Y

-

T

T

R
x
Q

Q

K

V

D

E

D

M

I

K

K

G
|
G

L
x
T

G

G

H

A

A

A

I

I

L

L

S

S

G

A

R

K

P

-

L

-

I

F

G

N

D

D

E

E

P

-

F

-

A

A

V

L

V

I

L

I

A
x
Y

D

G

D

D

L

L

C

F

L

F

N

S

L

N

E

E

G

K

D

E

G

-

V

-

L

I

S

C

Q

N

M

I

I

I

A

T

L

L

Y

K

K

E

Q

N

F

-

R

-

C

-

S

-

I

-

V

-

A

A

I

I

Q

I

E

G

V

V

P

K

N

V

D

S

Q

N

T

P

H

K

K

D

Y

Y

G

G

I

V

I

L

A

-

G

-

E

-

Q

-

I

V

R

L

E

D

G

N

I

Q

Y

N

R

N

V

L

N

S

S

K

M

I

V

I

E
|
E

K

K

P

P

K

-

P

-

E

E

D

I

A

P

P

P

S

S

N

N

L

L

A

I

I

N

I

A

G

G

R

I

Y

Y

I

K

L

L

T

N

A

S

D

D

I

I

F

F

D

T

L

Y

I

L

A

D

D

K

T

I

E

S

P

I

G

S

K

E

G

R

G

G

E

E

I

L

Q

E

I

L

T

T

D

D

A

A

L

I

M

N

K

L

Q

M

A

A

Q

K

S

D

G

H

C

R

V

V

L

K

A

V

Y

I

K

E

F

Y

E

E

G

G

H

Y

R

W

F

M

D

D

C

I

G

G

G

K

A

P

E

W

G

N

Y

I

I

I

D

D

A

V

T

N

N

K

F

W

C

A

Y

L

E

D

N

N

L

L

AGSGER 8:13 (≠ AGYGTR 10:15) binding
Q73 (≠ R101) binding
G79 (= G107) binding
T80 (≠ L108) mutation T->A,G,Q: Increases both GlcNAc-1-P UTase and Glc-1-P UTase activities.; mutation T->D,H: Decrease in GlcNAc-1-P UTase activity but increase in Glc-1-P UTase activity.; mutation T->E,K,L,M,R,W,Y: Strong decrease in GlcNAc-1-P UTase activity and loss of Glc-1-P UTase activity.; mutation T->F,I: Loss of both GlcNAc-1-P UTase and Glc-1-P UTase activities.; mutation T->N,S: Strong increase in GlcNAc-1-P UTase activity and decrease in Glc-1-P UTase activity.; mutation to N: Loss of GlcNAc-1-P UTase activity; when associated with V-97.
Y97 (≠ A129) mutation Y->A,D,F,G,I,K,T,V: Increases GlcNAc-1-P UTase activity. Decreases Glc-1-P UTase activity.; mutation Y->C,E,P,R,W: Decreases GlcNAc-1-P UTase and Glc-1-P UTase activities.; mutation Y->H,L,M,N,Q,S: Increases GlcNAc-1-P UTase and Glc-1-P UTase activities.; mutation to V: Loss of GlcNAc-1-P UTase activity; when associated with N-80.
E146 (= E190) mutation E->A,C,F,G,I,K,L,M,P,Q,R,V,W,Y: Loss of both GlcNAc-1-P UTase and Glc-1-P UTase activities.; mutation E->D,N: Decrease in GlcNAc-1-P UTase and Glc-1-P UTase activities.; mutation E->H,S,T: Decrease in GlcNAc-1-P UTase activity and loss of Glc-1-P UTase activity.

Sites not aligning to the query:

308 H→A: Strong decrease in GalN-1-P AcTase activity and almost loss of GlcN-1-P AcTase activity.
311 Y→A: Strong decrease in GalN-1-P AcTase activity and increase in GlcN-1-P AcTase activity.
331 N→A: Strong decrease in GalN-1-P AcTase activity and decrease in GlcN-1-P AcTase activity.
337 K→A: Slight decrease in GalN-1-P AcTase activity and increase in GlcN-1-P AcTase activity.
340 K→A: Decrease in GalN-1-P AcTase activity and increase in GlcN-1-P AcTase activity.
391:401 mutation Missing: No change in GlcNAc-1-P UTase activity. Shows 38% less GalN-1-P AcTase activity than the wild-type, but increases GlcN-1-P AcTase activity 16.8 times. Significantly affects the thermostability of the entire protein.
397:401 mutation Missing: No change in GlcNAc-1-P UTase activity. Shows 20% less GalN-1-P AcTase activity than the wild-type, but increases GlcN-1-P AcTase activity 4.8 times. Does not affect thermostability.

5fuhA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
28% identity, 84% coverage: 1:232/277 of query aligns to 6:206/298 of 5fuhA

query
sites
5fuhA

M

M

I

K

R

R

K

K

C

G

L

I

F

I

P

L

A

A

A

G

G

G

Y

S

G

G

T

T

R

R

F

L

L

H

P

P

A

A

T

T

K

L

S

A

M

I

P

S

K

K

E

Q

M

L

L

L

P

P

I

V

V

Y

N

D

K

K

P

P

L

M

I

I

Q

Y

Y

Y

G

P

V

L

E
x
S

E
x
T

A

L

R

M

D
x
L

A

A

G

G

L

I

Q

R

H

E

M

I

A

L

I

I

V

I

-

S

-

T

-

P

-

Q

-

D

T

T

G

P

R

R

G

F

K

Q

R

Q

A

L

L

L

E

G

D

D

H

G

F

S

D

N

I

W

S

G

Y

L

E

D

L

L

E

Q

H

-

Q

-

I

-

R

-

G

-

T

-

D

-

K

-

E

-

N

-

Y

-

L

-

N

-

G

-

T

-

R

-

E

-

L

-

M

-

D

-

T

-

C

-

T

-

F

-

S

-

Y

Y

T

A

R

V

Q

Q

V

P

E

S

M

P

K

D

G

G

L

L

G

A

H

Q

A

A

I

F

L

L

S

I

G

G

R

E

P

S

L

F

I

I

G

G

D

N

E

D

P

L

F

S

A

A

V

L

V

V

L

L

A

G

D

D

D

N

L

L

C
x
Y

L
x
Y

N
x
G

L

H

E

D

G
x
F

D
x
H

G

E

V

L

L

L

S

G

Q

S

M

-

I

-

A

A

L

S

Y

Q

K

R

Q

Q

F

T

R

G

C

A

S

S

I

V

V

F

A

A

I

Y

Q

H

E

V

V

L

P

D

N

P

D

E

Q

-

T

-

H

-

K

R

Y

Y

G

G

I

V

A

E

G

F

E

D

Q

Q

I

G

R

G

E

K

G

A

I

I

Y

-

R

-

V

-

N

-

S

S

M

L

V

E

E

E

K

K

P

P

K

L

P

-

E

-

D

E

A

P

P

K

S

S

N

N

L

Y

A

A

I

V

I

T

G

G

R

L

Y

Y

I

F

L

Y

T

D

A

Q

D

Q

I

V

F

V

D

D

L

I

I

A

A

R

D

D

T

L

E

K

P

P

G

S

K

P

G

R

G

G

E

E

I

L

Q

E

I

I

T

T

D

D

binding N-[6-amino-1-(3-bromobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-N-methylbenzenesulfonamide: S46 (≠ E41), T47 (≠ E42), L50 (≠ D45), Y118 (≠ C133), Y119 (≠ L134), G120 (≠ N135), F123 (≠ G138), H124 (≠ D139)

Sites not aligning to the query:

binding N-[6-amino-1-(3-bromobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-N-methylbenzenesulfonamide: 254, 255, 256, 260, 261, 264, 265

4b4bA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
28% identity, 84% coverage: 1:232/277 of query aligns to 6:206/298 of 4b4bA

query
sites
4b4bA

M

M

I

K

R

R

K

K

C

G

L

I

F

I

P

L

A

A

A

G

G

G

Y

S

G

G

T

T

R

R

F

L

L

H

P

P

A

A

T

T

K

L

S

A

M

I

P

S

K

K

E

Q

M

L

L

L

P

P

I

V

V

Y

N

D

K

K

P

P

L

M

I

I

Q

Y

Y

Y

G

P

V

L

E

S

E

T

A

L

R

M

D
x
L

A

A

G

G

L

I

Q

R

H

E

M

I

A

L

I

I

V

I

-

S

-

T

-

P

-

Q

-

D

T

T

G

P

R

R

G

F

K

Q

R

Q

A

L

L

L

E

G

D

D

H

G

F

S

D

N

I

W

S

G

Y

L

E

D

L

L

E

Q

H

-

Q

-

I

-

R

-

G

-

T

-

D

-

K

-

E

-

N

-

Y

-

L

-

N

-

G

-

T

-

R

-

E

-

L

-

M

-

D

-

T

-

C

-

T

-

F

-

S

-

Y

Y

T

A

R

V

Q

Q

V

P

E

S

M

P

K

D

G

G

L

L

G

A

H

Q

A

A

I

F

L

L

S

I

G

G

R

E

P

S

L

F

I

I

G

G

D

N

E

D

P

L

F

S

A

A

V

L

V

V

L

L

A

G

D

D

D

N

L

L

C

Y

L

Y

N

G

L

H

E

D

G

F

D

H

G

E

V

L

L

L

S

G

Q

S

M

-

I

-

A

A

L

S

Y

Q

K

R

Q

Q

F

T

R

G

C

A

S

S

I

V

V

F

A

A

I

Y

Q

H

E

V

V

L

P

D

N

P

D

E

Q

-

T

-

H

-

K

R

Y

Y

G

G

I

V

A

E

G

F

E

D

Q

Q

I

G

R

G

E

K

G

A

I

I

Y

-

R

-

V

-

N

-

S

S

M

L

V

E

E

E

K

K

P

P

K

L

P

-

E

-

D

E

A

P

P

K

S

S

N

N

L

Y

A

A

I

V

I

T

G

G

R

L

Y

Y

I

F

L

Y

T

D

A

Q

D

Q

I

V

F

V

D

D

L

I

I

A

A

R

D

D

T

L

E

K

P

P

G

S

K

P

G

R

G

G

E

E

I

L

Q

E

I

I

T

T

D

D

binding 1-(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione: L50 (≠ D45)

Sites not aligning to the query:

binding 1-(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione: 254, 255, 256, 260, 261, 264

4b2xB Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
28% identity, 84% coverage: 1:232/277 of query aligns to 10:210/302 of 4b2xB

query
sites
4b2xB

M

M

I

K

R

R

K

K

C

G

L

I

F

I

P

L

A

A

A

G

G

G

Y

S

G

G

T

T

R

R

F

L

L

H

P

P

A

A

T

T

K

L

S

A

M

I

P

S

K

K

E

Q

M

L

L

L

P

P

I

V

V

Y

N

D

K

K

P

P

L

M

I

I

Q

Y

Y

Y

G

P

V

L

E

S

E

T

A

L

R

M

D
x
L

A

A

G

G

L

I

Q

R

H

E

M

I

A

L

I

I

V

I

-

S

-

T

-

P

-

Q

-

D

T

T

G

P

R

R

G

F

K

Q

R

Q

A

L

L

L

E

G

D

D

H

G

F

S

D

N

I

W

S

G

Y

L

E

D

L

L

E

Q

H

-

Q

-

I

-

R

-

G

-

T

-

D

-

K

-

E

-

N

-

Y

-

L

-

N

-

G

-

T

-

R

-

E

-

L

-

M

-

D

-

T

-

C

-

T

-

F

-

S

-

Y

Y

T

A

R

V

Q

Q

V

P

E

S

M

P

K

D

G

G

L

L

G

A

H

Q

A

A

I

F

L

L

S

I

G

G

R

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P

S

L

F

I

I

G

G

D

N

E

D

P

L

F

S

A

A

V

L

V

V

L

L

A

G

D

D

D

N

L

L

C
x
Y

L

Y

N

G

L

H

E

D

G
x
F

D

H

G

E

V

L

L

L

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G

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M

-

I

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A

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N

P

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-

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-

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Y

Y

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G

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A

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K

G

A

I

I

Y

-

R

-

V

-

N

-

S

S

M

L

V

E

E

E

K

K

P

P

K

L

P

-

E

-

D

E

A

P

P

K

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S

N

N

L

Y

A

A

I

V

I

T

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G

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L

Y

Y

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F

L

Y

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D

A

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D

Q

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F

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D

L

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I

A

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D

D

T

L

E

K

P

P

G

S

K

P

G

R

G

G

E

E

I

L

Q

E

I

I

T

T

D

D

binding 6-amino-1-butyl-5-(cyclopentylamino)pyrimidine-2,4(1H,3H)-dione: L54 (≠ D45), Y122 (≠ C133), F127 (≠ G138)

Sites not aligning to the query:

binding 6-amino-1-butyl-5-(cyclopentylamino)pyrimidine-2,4(1H,3H)-dione: 258, 259, 260, 264, 265, 268, 269

5fu8A Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
28% identity, 84% coverage: 1:232/277 of query aligns to 5:205/297 of 5fu8A

query
sites
5fu8A

M

M

I

K

R

R

K

K

C

G

L

I

F

I

P

L

A

A

A

G

G

G

Y

S

G

G

T

T

R

R

F

L

L

H

P

P

A

A

T

T

K

L

S

A

M

I

P

S

K

K

E

Q

M

L

L

L

P

P

I

V

V

Y

N

D

K

K

P

P

L

M

I

I

Q

Y

Y

Y

G

P

V

L

E
x
S

E
x
T

A

L

R

M

D
x
L

A

A

G

G

L

I

Q

R

H

E

M

I

A

L

I

I

V

I

-

S

-

T

-

P

-

Q

-

D

T

T

G

P

R

R

G

F

K

Q

R

Q

A

L

L

L

E

G

D

D

H

G

F

S

D

N

I

W

S

G

Y

L

E

D

L

L

E

Q

H

-

Q

-

I

-

R

-

G

-

T

-

D

-

K

-

E

-

N

-

Y

-

L

-

N

-

G

-

T

-

R

-

E

-

L

-

M

-

D

-

T

-

C

-

T

-

F

-

S

-

Y

Y

T

A

R

V

Q

Q

V

P

E

S

M

P

K

D

G

G

L

L

G

A

H

Q

A

A

I

F

L

L

S

I

G

G

R

E

P

S

L

F

I

I

G

G

D

N

E

D

P

L

F

S

A

A

V

L

V

V

L

L

A

G

D

D

D

N

L

L