SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing PfGW456L13_4041 Enoyl-CoA hydratase (EC 4.2.1.17) / Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase (EC 5.3.3.8) / 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) / 3-hydroxybutyryl-CoA epimerase (EC 5.1.2.3) to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1wdlA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form ii (native4) (see paper)
93% identity, 100% coverage: 1:715/715 of query aligns to 1:715/715 of 1wdlA

query
sites
1wdlA

M

M

I

I

Y

Y

E

E

G

G

K

K

A

A

I

I

T

T

V

V

K

T

A

A

L

L

E

E

S

S

G

G

I

I

V

V

E

E

L

L

K

K

F

F

D

D

L

L

K

K

G

G

E

E

S

S

V

V

N

N

K

K

F

F

N

N

R

R

L

L

T

T

L

L

N

N

E

E

L

L

R

R

Q

Q

A

A

V

V

D

D

T

A

I

I

K

K

A

A

D

D

A

A

S

S

I

V

K

K

G

G

V

V

I

I

V

V

S

S

S

S

G

G

K

K

D

D

V

V

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F

F

V

V

D

E

N

N

F

F

K

K

L

L

P

P

D

D

A

A

E

E

L

L

V

I

A

A

G

G

N
|
N

L

L

E

E

A

A

N
|
N

K

K

I

I

F

F

S

S

D

D

F

F

E

E

D

D

L

L

N

N

V

V

P

P

T

T

V

V

A

A

A

A

I

I

N

N

G

G

I

I

A

A

L

L

G

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G
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G

G

G

L

L

E
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E

M

M

C

C

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L

A

A

A

A

D

D

Y

F

R

R

V

V

M

M

S

A

T

D

K

S

A

A

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K

I

I

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G

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L

P
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P

E
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E

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V

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K

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L

G

G

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I

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Y

P
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P

G
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G

F

F

G

G

G

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T

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V

R

R

L

L

P

P

R

R

L

L

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I

G

G

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V

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D

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N

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A

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V

E

E

W

W

I

I

A

A

A

S

G

G

K

K

E

E

N

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R

R

P

A

E

E

D

D

A

A

L

L

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K

V

V

G

S

A

A

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V

D

D

A

A

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V

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V

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P

A

E

D

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K

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Q

G

D

A

A

A

A

A

L

L

E

D

L

L

I

I

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K

R

R

A

A

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S

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G

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E

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D

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Y

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A

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K

R

R

Q

Q

P

P

K

K

L

L

E

E

K

K

L

L

K

K

L

L

N

N

A

A

I

I

E

E

Q

Q

M

M

M

M

A

A

F

F

E

E

T

T

A

A

K

K

G

G

F

F

V

V

A

A

G

G

Q

Q

A

A

G

G

P

P

N

N

Y

Y

P

P

A

A

P

P

V

V

E

E

A

A

I

I

K

K

T

T

I

I

Q

Q

K

K

A

A

A

A

N

N

F

F

G

G

R

R

D

D

K

K

A

A

L

L

E

E

I

V

E

E

A

A

A

A

G

G

F

F

V

A

K

K

L

L

A

A

K

K

T

T

S

S

A

A

A

S

Q

N

S

C

L

L

I

I

G

G

L

L

F

F

L

L

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N

D

D

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Q

E

E

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L

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K

K

K

K

K

A

A

K

K

A

V

Y

Y

D

D

E

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I

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A

A

K

K

D

D

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V

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K

Q

Q

A

A

A

A

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L

L

G
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G

A
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A

G

G

I
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I

M
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M

G

G

G

G

G

G

I

I

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Y

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S

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A

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S

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K

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G

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T

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P

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I

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L

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M

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K

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I

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N

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E

H

H

G

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L

A

A

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E

A

A

A

A

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K

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L

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V

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G

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R

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D

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K

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G

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M

M

T

T

A

P

A

A

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A

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E

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L

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G

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I

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R

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P

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T

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L

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S

Y

Y

G

G

D

D

F

F

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H

N

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D

L

L

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V

V

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E

E

A
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A

V
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V

V
|
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E
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E

N

N

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P

K

K

V

V

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K

Q

Q

A

A

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V

L

L

A

A

E

E

V

V

E

E

D

N

K

H

V

V

K

R

E

E

D

D

T

A

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I

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L

A

A

S

S

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N

T
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S
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S

T

T

I

I

S

S

I

I

T

S

L

L

L

L

A

A

K

K

A

A

L

L

K

K

R

R

P

P

E

E

N

N

F

F

V

V

G

G

M

M

H
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H

F

F

F

F

N

N

P

P

V

V

H

H

M

M

M

M

P

P

L

L

V

V

E
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E

V

V

I

I

R

R

G

G

E

E

K

K

S

S

S

S

E

D

L

L

A

A

V

V

A

A

T

T

T

T

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V

A

A

Y

Y

A

A

K

K

K

K

M

M

G

G

K

K

N

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

L

L

V

V

N
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N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

G

G

G

G

F

F

A

A

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K

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L

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V

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S

A

A

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R

I

I

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D

K

K

I

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M

M

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E

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K

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F

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G

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W

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P

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M

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G

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P

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A

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Y

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M

M

D

D

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G

G

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D

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T

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H

H

H

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G

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R

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D

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V

M

M

A

A

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E

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G

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F

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P

D

D

R

R

M

M

K

K

D

D

D

D

R

R

R

R

S

S

A

A

V

I

D

D

V

A

L

L

Y

Y

E

E

A

A

K

K

R

R

L

L

G

G

Q

Q

K

K

N

N

G

G

K

K

G

G

F

F

Y

Y

A

A

Y

Y

E

E

T

A

D

D

K

K

K

K

G

G

K

K

Q

Q

K

K

K

K

V

L

A

V

D

D

P

S

S

S

V

V

L

L

E

E

V

V

L

L

K

K

P

P

I

I

V

V

Y

Y

E

E

Q

Q

R

R

E

D

V

V

T

T

D

D

E

E

D

D

I

I

I

I

N

N

W

W

M

M

M

M

I

I

P

P

L

L

C

C

L

L

E

E

T

T

V

V

R

R

C

C

L

L

E

E

D

D

G

G

I

I

V

V

E

E

T

T

A

A

A

A

E

E

A

A

D

D

M

M

G

G

L

L

V

V

Y

Y

G

G

I

I

G

G

F

F

P

P

P

L

F

F

R

R

G

G

G

G

A

A

L

L

R

R

Y

Y

I

I

D

D

S

S

I

I

G

G

V

V

A

A

E

E

F

F

V

V

A

A

L

L

A

A

D

D

Q

Q

Y

Y

A

A

D

E

L

L

G

G

A

A

L

L

Y

Y

H

H

P

P

T

T

A

A

K

K

L

L

R

R

E

E

M

M

A

A

K

K

N

N

G

G

Q

Q

S

S

F

F

F

F

G

G

active site: A69 (= A69), N89 (= N89), N93 (= N93), G117 (= G117), E120 (= E120), P139 (= P139), E140 (= E140), P147 (= P147), G148 (= G148), S430 (= S430), H451 (= H451), E463 (= E463), N501 (= N501)
binding nicotinamide-adenine-dinucleotide: G321 (= G321), A322 (= A322), I324 (= I324), M325 (= M325), D344 (= D344), I345 (= I345), A400 (= A400), V401 (= V401), V402 (= V402), E403 (= E403), K408 (= K408), V411 (= V411), N428 (= N428), T429 (= T429), S430 (= S430)

P28793 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Pseudomonas fragi (see paper)
93% identity, 100% coverage: 1:715/715 of query aligns to 1:715/715 of P28793

query
sites
P28793

M

M

I

I

Y

Y

E

E

G

G

K

K

A

A

I

I

T

T

V

V

K

T

A

A

L

L

E

E

S

S

G

G

I

I

V

V

E

E

L

L

K

K

F

F

D

D

L

L

K

K

G

G

E

E

S

S

V

V

N

N

K

K

F

F

N

N

R

R

L

L

T

T

L

L

N

N

E

E

L

L

R

R

Q

Q

A

A

V

V

D

D

T

A

I

I

K

K

A

A

D

D

A

A

S

S

I

V

K

K

G

G

V

V

I

I

V

V

S

S

S

S

G

G

K

K

D

D

V

V

F

F

I

I

V

V

G

G

A

A

D

D

I

I

T

T

E

E

F

F

V

V

D

E

N

N

F

F

K

K

L

L

P

P

D

D

A

A

E

E

L

L

V

I

A

A

G

G

N

N

L

L

E

E

A

A

N

N

K

K

I

I

F

F

S

S

D

D

F

F

E

E

D

D

L

L

N

N

V

V

P

P

T

T

V

V

A

A

A

A

I

I

N

N

G

G

I

I

A

A

L

L

G

G

G

G

G

G

L

L

E

E

M

M

C

C

L

L

A

A

A

A

D

D

Y

F

R

R

V

V

M

M

S

A

T

D

K

S

A

A

K

K

I

I

G

G

L

L

P

P

E

E

V

V

K

K

L

L

G

G

I

I

Y

Y

P

P

G

G

F

F

G

G

G

G

T

T

V

V

R

R

L

L

P

P

R

R

L

L

I

I

G

G

A

V

D

D

N

N

A

A

I

V

E

E

W

W

I

I

A

A

A

S

G

G

K

K

E

E

N

N

R

R

P

A

E

E

D

D

A

A

L

L

K

K

V

V

G

S

A

A

V

V

D

D

A

A

V

V

V

V

A

T

P

A

E

D

Q

K

L

L

Q

G

D

A

A

A

A

A

L

L

E

D

L

L

I

I

K

K

R

R

A

A

I

I

S

S

G

G

E

E

F

L

D

D

Y

Y

K

K

A

A

K

K

R

R

Q

Q

P

P

K

K

L

L

E

E

K

K

L

L

K

K

L

L

N

N

A

A

I

I

E

E

Q

Q

M

M

M

M

A

A

F

F

E

E

T

T

A

A

K

K

G

G

F

F

V

V

A

A

G

G

Q

Q

A

A

G

G

P

P

N

N

Y

Y

P

P

A

A

P

P

V

V

E

E

A

A

I

I

K

K

T

T

I

I

Q

Q

K

K

A

A

A

A

N

N

F

F

G

G

R

R

D

D

K

K

A

A

L

L

E

E

I

V

E

E

A

A

A

A

G

G

F

F

V

A

K

K

L

L

A

A

K

K

T

T

S

S

A

A

A

S

Q

N

S

C

L

L

I

I

G

G

L

L

F

F

L

L

N

N

D
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D

Q

Q

E

E

L

L

K

K

K

K

K

K

A

A

K

K

A

V

Y

Y

D

D

E

K

I

I

A

A

K

K

D

D

V

V

K

K

Q

Q

A

A

A

A

V

V

L

L

G

G

A

A

G

G

I

I

M
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M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

S

S

K

K

G

G

T

T

P

P

I

I

L

L

M

M

K

K

D
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D

I

I

N

N

E

E

H

H

G

G

I

I

E

E

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Q

G

G

L

L

A

A

E

E

A

A

A

A

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K

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L

L

L

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G

G

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R

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V

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D

K

K

G

G

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R

M

M

T

T

A

P

A

A

K

K

M

M

A

A

E

E

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V

L

L

N

N

G

G

I

I

R

R

P

P

T

T

L

L

S

S

Y

Y

G

G

D

D

F

F

G

G

H

N

V

V

D

D

L

L

V

V

V

V

E

E

A

A

V
|
V

V
|
V

E
|
E

N

N

P

P

K

K

V

V

K
|
K

Q

Q

A

A

V

V

L

L

A

A

E

E

V

V

E

E

D

N

K

H

V

V

K

R

E

E

D

D

T

A

I

I

L

L

A

A

S

S

N

N

T

T

S
|
S

T

T

I

I

S

S

I

I

T

S

L

L

L

L

A

A

K

K

A

A

L

L

K

K

R

R

P

P

E

E

N

N

F

F

V

V

G

G

M

M

H

H

F

F

F

F

N
|
N

P

P

V

V

H

H

M

M

M

M

P

P

L

L

V

V

E

E

V

V

I

I

R

R

G

G

E

E

K

K

S

S

S

S

E

D

L

L

A

A

V

V

A

A

T

T

T

T

V

V

A

A

Y

Y

A

A

K

K

K

K

M

M

G

G

K

K

N

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

L

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

G

G

G

G

F

F

A

A

K

K

L

L

V

V

S

S

A

A

G

G

V

V

D

D

F

F

V

V

R

R

I

I

D

D

K

K

I

V

M

M

E

E

K

K

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

Y

Y

L

L

M

M

D

D

V

V

V

V

G

G

I

I

D

D

T

T

G

G

H

H

H

H

G

G

R

R

D

D

V

V

M

M

A

A

E

E

G

G

F

F

P

P

D

D

R

R

M

M

K

K

D

D

D

D

R

R

R

R

S

S

A

A

V

I

D

D

V

A

L

L

Y

Y

E

E

A

A

K

K

R

R

L

L

G

G

Q

Q

K

K

N

N

G

G

K

K

G

G

F

F

Y

Y

A

A

Y

Y

E

E

T

A

D

D

K

K

K

K

G

G

K

K

Q

Q

K

K

K

K

V

L

A

V

D

D

P

S

S

S

V

V

L

L

E

E

V

V

L

L

K

K

P

P

I

I

V

V

Y

Y

E

E

Q

Q

R

R

E

D

V

V

T

T

D

D

E

E

D

D

I

I

I

I

N

N

W

W

M

M

M

M

I

I

P

P

L

L

C

C

L

L

E

E

T

T

V

V

R

R

C

C

L

L

E

E

D

D

G

G

I

I

V

V

E

E

T

T

A

A

A

A

E

E

A

A

D

D

M

M

G

G

L

L

V

V

Y
|
Y

G

G

I

I

G

G

F

F

P

P

P

L

F

F

R

R

G

G

G

G

A

A

L

L

R

R

Y

Y

I

I

D

D

S

S

I

I

G

G

V

V

A

A

E

E

F

F

V

V

A

A

L

L

A

A

D

D

Q

Q

Y

Y

A

A

D

E

L

L

G

G

A

A

L

L

Y

Y

H

H

P

P

T

T

A

A

K

K

L

L

R

R

E

E

M

M

A

A

K

K

N

N

G

G

Q

Q

S

S

F

F

F

F

G

G

D297 (= D297) binding
M325 (= M325) binding
D344 (= D344) binding
VVE 401:403 (= VVE 401:403) binding
K408 (= K408) binding
S430 (= S430) binding
N454 (= N454) binding
N501 (= N501) binding
Y660 (= Y660) binding

1wdmA Fatty acid beta-oxidation multienzyme complex from pseudomonas fragi, form i (native3) (see paper)
92% identity, 100% coverage: 1:715/715 of query aligns to 1:707/707 of 1wdmA

query
sites
1wdmA

M

M

I

I

Y

Y

E

E

G

G

K

K

A

A

I

I

T

T

V

V

K

T

A

A

L

L

E

E

S

S

G

G

I

I

V

V

E

E

L

L

K

K

F

F

D

D

L

L

K

K

G

G

E

E

S

S

V

V

N

N

K

K

F

F

N

N

R

R

L

L

T

T

L

L

N

N

E

E

L

L

R

R

Q

Q

A

A

V

V

D

D

T

A

I

I

K

K

A

A

D

D

A

A

S

S

I

V

K

K

G

G

V

V

I

I

V

V

S

S

S

S

G

G

K

K

D

D

V

V

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F

F

V

V

D

E

N

N

F

F

K

K

L

L

P

P

D

D

A

A

E

E

L

L

V

I

A

A

G

G

N
|
N

L

L

E

E

A

A

N
|
N

K

K

I

I

F

F

S

S

D

D

F

F

E

E

D

D

L

L

N

N

V

V

P

P

T

T

V

V

A

A

A

A

I

I

N

N

G

G

I

I

A

A

L

L

G

G

G
|
G

G

G

L

L

E
|
E

M

M

C

C

L

L

A

A

A

A

D

D

Y

F

R

R

V

V

M

M

S

A

T

D

K

S

A

A

K

K

I

I

G

G

L

L

P
|
P

E
|
E

V

V

K
|
K

L

L

G

G

I

I

Y

Y

P
|
P

G
|
G

F

F

G

G

G

G

T

T

V

V

R

R

L

L

P

P

R

R

L

L

I

I

G

G

A

V

D

D

N

N

A

A

I

V

E

E

W

W

I

I

A

A

A

S

G

G

K

K

E

E

N

N

R

R

P

A

E

E

D

D

A

A

L

L

K

K

V

V

G

S

A

A

V

V

D

D

A

A

V

V

V

V

A

T

P

A

E

D

Q

K

L

L

Q

G

D

A

A

A

A

A

L

L

E

D

L

L

I

I

K

K

R

R

A

A

I

I

S

S

G

G

E

E

F

L

D

D

Y

Y

K

K

A

A

K

K

R

R

Q

Q

P

P

K

K

L

L

E

E

K

K

L

L

K

K

L

L

N

N

A

A

I

I

E

E

Q

Q

M

M

M

M

A

A

F

F

E

E

T

T

A

A

K

K

G

G

F

F

V

V

A

A

G

G

Q

Q

A

A

G

G

P

P

N

N

Y

Y

P

P

A

A

P

P

V

V

E

E

A

A

I

I

K

K

T

T

I

I

Q

Q

K

K

A

A

A

A

N

N

F

F

G

G

R

R

D

D

K

K

A

A

L

L

E

E

I

V

E

E

A

A

A

A

G

G

F

F

V

A

K

K

L

L

A

A

K

K

T

T

S

S

A

A

A

S

Q

N

S

C

L

L

I

I

G

G

L

L

F

F

L

L

N

N

D
|
D

Q

Q

E

E

L

L

K

K

K

K

K

K

A

A

K

K

A

V

Y

Y

D

D

E

K

I

I

A

A

K

K

D

D

V

V

K

K

Q

Q

A

A

A

A

V

V

L

L

G
|
G

A
|
A

G

G

I
|
I

M
|
M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

S

S

K

K

G

G

T

T

P

P

I

I

L

L

M

M

K
|
K

D
|
D

I
|
I

N

N

E

E

H

H

G

G

I

I

E

E

Q

Q

G

G

L

L

A

A

E

E

A

A

A

A

K

K

L

L

L

L

V

V

G

G

R

R

V

V

D

D

K

K

G

G

R

R

M

M

T

T

A

P

A

A

K

K

M

M

A

A

E

E

V

V

L

L

N

N

G

G

I

I

R

R

P

P

T

T

L

L

S

S

Y

Y

G

G

D

D

F

F

G

G

H

N

V

V

D

D

L

L

V

V

V

V

E

E

A
|
A

V
|
V

V

V

E
|
E

N

N

P

P

K

K

V

V

K
|
K

Q

Q

A

A

V

V

L

L

A

A

E

E

V

V

E

E

D

N

K

H

V

V

K

R

E

E

D

D

T

A

I

I

L

L

A

A

S

S

N
|
N

T
|
T

S
|
S

T

T

I

I

S

S

I

I

T

S

L

L

L

L

A

A

K

K

A

A

L

L

K

K

R

R

P

P

E

E

N

N

F

F

V

V

G

G

M

M

H
|
H

F
|
F

F

F

N
|
N

P

P

V

V

H

H

M

M

M
|
M

P

P

L

L

V

V

E
|
E

V

V

I

I

R

R

G

G

E

E

K

K

S

S

S

S

E

D

L

L

A

A

V

V

A

A

T

T

T

T

V

V

A

A

Y

Y

A

A

K

K

K

K

M

M

G

G

K

K

N

N

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

L

L

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

G

G

G

G

F

F

A

A

K

K

L

L

V

V

S

S

A

A

G

G

V

V

D

D

F

F

V

V

R

R

I

I

D

D

K

K

I

V

M

M

E

E

K

K

F

F

G

G

W

W

P
|
P

M
|
M

G

G

P

P

A

A

Y

Y

L

L

M

M

D

D

V

V

V
|
V

G

G

I

I

D

D

T

T

G

G

H

H

H

H

G

G

R

R

D

D

V

V

M

M

A

A

E

E

G

G

F

F

P

P

D

D

R

R

M

M

K

K

D

D

D

D

R

R

R

R

S

S

A

A

V

I

D

D

V

A

L

L

Y

Y

E

E

A

A

K

K

R

R

L

L

G

G

Q

Q

K

K

N

N

G

G

K

K

G

G

F

F

Y

Y

A

A

Y

Y

E

-

T

-

D

-

K

-

K

-

G

-

K

-

Q

-

K

K

K

K

V

L

A

V

D

D

P

S

S

S

V

V

L

L

E

E

V

V

L

L

K

K

P

P

I

I

V

V

Y

Y

E

E

Q

Q

R

R

E

D

V

V

T

T

D

D

E

E

D

D

I

I

I

I

N

N

W

W

M

M

M

M

I

I

P

P

L

L

C

C

L

L

E

E

T

T

V

V

R

R

C

C

L

L

E

E

D

D

G

G

I

I

V

V

E

E

T

T

A

A

A

A

E

E

A

A

D

D

M

M

G

G

L

L

V
|
V

Y
|
Y

G

G

I

I

G
|
G

F

F

P

P

P
x
L

F

F

R

R

G

G

G

G

A

A

L

L

R

R

Y

Y

I

I

D

D

S

S

I

I

G

G

V

V

A

A

E

E

F

F

V

V

A

A

L

L

A

A

D

D

Q

Q

Y

Y

A

A

D

E

L

L

G

G

A

A

L

L

Y

Y

H

H

P

P

T

T

A

A

K

K

L

L

R

R

E

E

M

M

A

A

K

K

N

N

G

G

Q

Q

S

S

F

F

F

F

G

G

active site: A69 (= A69), N89 (= N89), N93 (= N93), G117 (= G117), E120 (= E120), P139 (= P139), E140 (= E140), P147 (= P147), G148 (= G148), S430 (= S430), H451 (= H451), E463 (= E463), N501 (= N501)
binding acetyl coenzyme *a: K142 (= K142), D297 (= D297), M459 (= M459), N501 (= N501), P534 (= P534), M535 (= M535), V544 (= V544), V651 (= V659), Y652 (= Y660), G655 (= G663), L658 (≠ P666)
binding nicotinamide-adenine-dinucleotide: G321 (= G321), A322 (= A322), I324 (= I324), M325 (= M325), K343 (= K343), D344 (= D344), I345 (= I345), A400 (= A400), V401 (= V401), E403 (= E403), K408 (= K408), N428 (= N428), T429 (= T429), S430 (= S430), F452 (= F452), N454 (= N454)

6tnmA E. Coli aerobic trifunctional enzyme subunit-alpha (see paper)
57% identity, 100% coverage: 1:714/715 of query aligns to 1:714/719 of 6tnmA

query
sites
6tnmA

M

M

I

L

Y

Y

E

K

G

G

K

D

A

T

I

L

T

Y

V

L

K

D

A

W

L

L

E

E

S

D

G

G

I

I

V

A

E

E

L

L

K

V

F

F

D

D

L

A

K

P

G

G

E

-

S

S

V

V

N

N

K

K

F

L

N

D

R

T

L

A

T

T

L

V

N

A

E

S

L

L

R

G

Q

E

A

A

V

I

D

G

T

V

I

L

K

E

A

Q

D

Q

A

S

S

D

I

L

K

K

G

G

V

L

I

L

V

L

S

R

S

S

G

N

K

K

D

A

V

A

F

F

I

I

V

V

G

G

A
|
A

D

D

I

I

T

T

E

E

F
|
F

V

L

D

S

N

L

F

F

K

L

L

V

P

P

D

E

A

E

E

Q

L

L

V

S

A

Q

G

W

N

L

L

H

E

F

A

A

N

N

K

S

I

V

F

F

S

N

D

R

F

L

E

E

D

D

L

L

N

P

V

V

P

P

T

T

V

I

A

A

A

A

I

V

N

N

G

G

I

Y

A

A

L

L

G

G

G
|
G

G

G

L

C

E
|
E

M

C

C

V

L

L

A

A

A

T

D

D

Y

Y

R

R

V

L

M

A

S

T

T

P

K

D

A

L

K

R

I

I

G

G

L

L

P
|
P

E
|
E

V

T

K

K

L

L

G

G

I

I

Y

M

P

P

G
|
G

F

F

G

G

G

G

T

S

V

V

R

R

L

M

P

P

R

R

L

M

I

L

G

G

A

A

D

D

N

S

A

A

I

L

E

E

W

I

I

I

A

A

A

A

G

G

K

K

E

D

N

V

R

G

P

A

E

D

D

Q

A

A

L

L

K

K

V

I

G

G

A

L

V

V

D

D

A

G

V

V

V

V

A

K

P

A

E

E

Q

K

L

L

Q

V

D

E

A

G

A

A

L

K

E

A

L

V

I

L

K

R

R

Q

A

A

I

I

S

N

G

G

E

D

F

L

D

D

Y

W

K

K

A

A

K

K

R

R

Q

Q

P

P

K

K

L

L

E

E

K

P

L

L

K

K

L

L

N

S

A

K

I

I

E

E

Q

A

M

T

M

M

A

S

F

F

E

T

T

I

A

A

K

K

G

G

F

M

V

V

A

A

G

Q

Q

T

A

A

G

G

P

K

N

H

Y

Y

P

P

A

A

P

P

V

I

E

T

A

A

I

V

K

K

T

T

I

I

Q

E

K

A

A

A

A

A

N

R

F

F

G

G

R

R

D

E

K

E

A

A

L

L

E
x
N

I

L

E

E

A

N

A

K

G

S

F

F

V

V

K

P

L

L

A

A

K

H

T

T

S

N

A

E

A

A

Q

R

S

A

L

L

I

V

G

G

L

I

F

F

L

L

N

N

D

D

Q

Q

E

Y

L

V

K

K

K

G

K

K

A

A

K

K

A

K

Y

L

D

T

E

K

I

D

A

V

K

E

D

T

V

P

K

K

Q

Q

A

A

A

A

V

V

L

L

G

G

A

A

G

G

I

I

M

M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

S

W

K

K

G

G

T

V

P

P

I

V

L

V

M

M

K

K

D
|
D

I
|
I

N

N

E

D

H

K

G

S

I

L

E

T

Q

L

G

G

L

M

A

T

E

E

A

A

A

A

K

K

L

L

L

L

V

N

G

K

R

Q

V

L

D

E

K

R

G

G

R

K

M

I

T

D

A

G

A

L

K

K

M

L

A

A

E

G

V

V

L

I

N

S

G

T

I

I

R

H

P

P

T

T

L

L

S

D

Y

Y

G

A

D

G

F

F

G

D

H

R

V

V

D

D

L

I

V

V

V

V

E

E

A

A

V
|
V

V
|
V

E

E

N

N

P

P

K

K

V
|
V

K

K

Q

K

A

A

V

V

L

L

A

A

E

E

V

T

E

E

D

Q

K

K

V

V

K

R

E

Q

D

D

T

T

I

V

L

L

A

A

S

S

N

N

T

T

S
|
S

T

T

I

I

S

P

I

I

T

S

L

E

L

L

A

A

K

N

A

A

L

L

K

E

R

R

P

P

E

E

N

N

F

F

V

C

G

G

M

M

H
|
H

F

F

F

F

N

N

P

P

V

V

H

H

M

R

M

M

P

P

L

L

V

V

E
|
E

V

I

I

I

R

R

G

G

E

E

K

K

S

S

S

S

E

D

L

E

A

T

V

I

A

A

T

K

T

V

V

V

A

A

Y

W

A

A

K

S

K

K

M

M

G

G

K

K

N

T

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

L

F

V

V

N
|
N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

G

A

G

G

F

F

A

S

K

Q

L

L

V

L

S

R

A

D

G

G

V

A

D

D

F

F

V

R

R

K

I

I

D

D

K

K

I

V

M

M

E

E

K

K

-

Q

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

Y

Y

L

L

M

L

D

D

V

V

V

V

G

G

I

I

D

D

T

T

G

A

H

H

H

H

G

A

R

Q

D

A

V

V

M

M

A

A

E

A

G

G

F

F

P

P

D

Q

R

R

M

M

K

Q

D

K

D

D

R

Y

R

R

S

D

A

A

V

I

D

D

V

A

L

L

Y

F

E

D

A

A

K

N

R

R

L

F

G

G

Q

Q

K
|
K

N

N

G

G

K

L

G

G

F

F

Y

W

A

R

Y

Y

E

K

T

E

D

D

K

S

K

K

G

G

K

K

Q

P

K

K

K

K

V

E

A

E

D

D

P

A

S

A

V

V

L

E

E

D

V

L

L

L

K

A

P

E

I

V

V

S

Y

Q

E

P

Q

K

R

R

E

D

V

F

T

S

D

E

E

E

D

E

I

I

I

I

N

A

W

R

M

M

M

M

I

I

P

P

L

M

C

V

L

N

E

E

T

V

V

V

R

R

C

C

L

L

E

E

D

E

G

G

I

I

V

I

E

A

T

T

A

P

A

A

E

E

A

A

D

D

M

M

G

A

L

L

V

V

Y

Y

G

G

I

L

G

G

F

F

P

P

P

P

F

F

R

H

G

G

G

G

A

A

L

F

R

R

Y

W

I

L

D

D

S

T

I

L

G

G

V

S

A

A

E

K

F

Y

V

L

A

D

L

M

A

A

D

Q

Q

Q

Y

Y

A

Q

D

H

L

L

G

G

A

P

L

L

Y

Y

H

E

P

V

T

P

A

E

K

G

L

L

R

R

E

N

M

K

A

A

K

R

N

H

G

N

Q

E

S

P

F

Y

F

Y

active site: A68 (= A69), F73 (= F74), G116 (= G117), E119 (= E120), P138 (= P139), E139 (= E140), G147 (= G148), N271 (≠ E272), S429 (= S430), H450 (= H451), E462 (= E463), N500 (= N501)
binding adenosine-5'-triphosphate: D343 (= D344), I344 (= I345), V400 (= V401), V401 (= V402), V406 (= V407), K584 (= K584)

P21177 Fatty acid oxidation complex subunit alpha; EC 4.2.1.17; EC 5.1.2.3; EC 5.3.3.8; EC 1.1.1.35 from Escherichia coli (strain K12) (see 2 papers)
57% identity, 100% coverage: 1:714/715 of query aligns to 1:714/729 of P21177

query
sites
P21177

M

M

I

L

Y

Y

E

K

G

G

K

D

A

T

I

L

T

Y

V

L

K

D

A

W

L

L

E

E

S

D

G

G

I

I

V

A

E

E

L

L

K

V

F

F

D

D

L

A

K

P

G

G

E

-

S

S

V

V

N

N

K

K

F

L

N

D

R

T

L

A

T

T

L

V

N

A

E

S

L

L

R

G

Q

E

A

A

V

I

D

G

T

V

I

L

K

E

A

Q

D

Q

A

S

S

D

I

L

K

K

G

G

V

L

I

L

V

L

S

R

S

S

G

N

K

K

D

A

V

A

F

F

I

I

V

V

G

G

A

A

D

D

I

I

T

T

E

E

F

F

V

L

D

S

N

L

F

F

K

L

L

V

P

P

D

E

A

E

E

Q

L

L

V

S

A

Q

G

W

N

L

L

H

E

F

A

A

N

N

K

S

I

V

F

F

S

N

D

R

F

L

E

E

D

D

L

L

N

P

V

V

P

P

T

T

V

I

A

A

A

A

I

V

N

N

G

G

I

Y

A

A

L

L

G

G

G
|
G

G

G

L

C

E

E

M

C

C

V

L

L

A

A

A

T

D

D

Y

Y

R

R

V

L

M

A

S

T

T

P

K

D

A

L

K

R

I

I

G

G

L

L

P

P

E

E

V

T

K

K

L

L

G

G

I

I

Y

M

P

P

G

G

F

F

G

G

G

G

T

S

V

V

R

R

L

M

P

P

R

R

L

M

I

L

G

G

A

A

D

D

N

S

A

A

I

L

E

E

W

I

I

I

A

A

A

A

G

G

K

K

E

D

N

V

R

G

P

A

E

D

D

Q

A

A

L

L

K

K

V

I

G

G

A

L

V

V

D

D

A

G

V

V

V

V

A

K

P

A

E

E

Q

K

L

L

Q

V

D

E

A

G

A

A

L

K

E

A

L

V

I

L

K

R

R

Q

A

A

I

I

S

N

G

G

E

D

F

L

D

D

Y

W

K

K

A

A

K

K

R

R

Q

Q

P

P

K

K

L

L

E

E

K

P

L

L

K

K

L

L

N

S

A

K

I

I

E

E

Q

A

M

T

M

M

A

S

F

F

E

T

T

I

A

A

K

K

G

G

F

M

V

V

A

A

G

Q

Q

T

A

A

G

G

P

K

N

H

Y

Y

P

P

A

A

P

P

V

I

E

T

A

A

I

V

K

K

T

T

I

I

Q

E

K

A

A

A

A

A

N

R

F

F

G

G

R

R

D

E

K

E

A

A

L

L

E

N

I

L

E

E

A

N

A

K

G

S

F

F

V

V

K

P

L

L

A

A

K

H

T

T

S

N

A

E

A

A

Q

R

S

A

L

L

I

V

G

G

L

I

F

F

L

L

N

N

D

D

Q

Q

E

Y

L

V

K

K

K

G

K

K

A

A

K

K

A

K

Y

L

D

T

E

K

I

D

A

V

K

E

D

T

V

P

K

K

Q

Q

A

A

A

A

V

V

L

L

G

G

A

A

G
|
G

I

I

M

M

G

G

G

G

G

G

I

I

A

A

Y

Y

Q

Q

S

S

A

A

S

W

K

K

G

G

T

V

P

P

I

V

L

V

M

M

K

K

D

D

I

I

N

N

E

D

H

K

G

S

I

L

E

T

Q

L

G

G

L

M

A

T

E

E

A

A

A

A

K

K

L

L

L

L

V

N

G

K

R

Q

V

L

D

E

K

R

G

G

R

K

M

I

T

D

A

G

A

L

K

K

M

L

A

A

E

G

V

V

L

I

N

S

G

T

I

I

R

H

P

P

T

T

L

L

S

D

Y

Y

G

A

D

G

F

F

G

D

H

R

V

V

D

D

L

I

V

V

V

V

E

E

A

A

V

V

V

V

E

E

N

N

P

P

K

K

V

V

K

K

Q

K

A

A

V

V

L

L

A

A

E

E

V

T

E

E

D

Q

K

K

V

V

K

R

E

Q

D

D

T

T

I

V

L

L

A

A

S

S

N

N

T

T

S

S

T

T

I

I

S

P

I

I

T

S

L

E

L

L

A

A

K

N

A

A

L

L

K

E

R

R

P

P

E

E

N

N

F

F

V

C

G

G

M

M

H
|
H

F

F

F

F

N

N

P

P

V

V

H

H

M

R

M

M

P

P

L

L

V

V

E

E

V

I

I

I

R

R

G

G

E

E

K

K

S

S

S

S

E

D

L

E

A

T

V

I

A

A

T

K

T

V

V

V

A

A

Y

W

A

A

K

S

K

K

M

M

G

G

K

K

N

T

P

P

I

I

V

V

V

V

N

N

D

D

C

C

P

P

G

G

F

F

L

F

V

V

N

N

R

R

V

V

L

L

F

F

P

P

Y

Y

F

F

G

A

G

G

F

F

A

S

K

Q

L

L

V

L

S

R

A

D

G

G

V

A

D

D

F

F

V

R

R

K

I

I

D

D

K

K

I

V

M

M

E

E

K

K

-

Q

F

F

G

G

W

W

P

P

M

M

G

G

P

P

A

A

Y

Y

L

L

M

L

D

D

V

V

V

V

G

G

I

I

D

D

T

T

G

A

H

H

H

H

G

A

R

Q

D

A

V

V

M

M

A

A

E

A

G

G

F

F

P

P

D

Q

R

R

M

M

K

Q

D

K

D

D

R

Y

R

R

S

D

A

A

V

I

D

D

V

A

L

L

Y

F

E

D

A

A

K

N

R

R

L

F

G

G

Q

Q

K

K

N

N

G

G

K

L

G

G

F

F

Y

W

A

R

Y

Y

E

K

T

E

D

D

K

S

K

K

G

G

K

K

Q

P

K

K

K

K

V

E

A

E

D

D

P

A

S

A

V

V

L

E

E

D

V

L

L

L

K

A

P

E

I

V

V

S

Y

Q

E

P

Q

K

R

R

E

D

V

F

T

S

D

E

E

E

D

E

I

I

I

I

N

A

W

R

M

M

M

M

I

I

P

P

L

M

C

V

L

N

E

E

T

V

V

V

R

R

C

C

L

L

E

E

D

E

G

G

I

I

V

I

E

A

T

T

A

P

A

A

E

E

A

A

D

D

M

M

G

A

L

L

V

V

Y

Y

G

G

I

L

G

G

F

F

P

P

P

P

F

F

R

H

G

G

G

G

A

A

L

F

R

R

Y

W

I

L

D

D

S

T

I

L

G

G

V

S

A

A

E

K

F

Y

V

L

A

D

L

M

A

A

D

Q

Q

Q

Y

Y

A

Q

D

H

L

L

G

G

A

P

L

L

Y

Y

H

E

P

V

T

P

A

E

K

G

L

L

R

R

E

N

M

K

A

A

K

R

N

H

G

N

Q

E

S

P

F

Y

F

Y

G116 (= G117) mutation to F: Absence of both enoyl-CoA hydratase and 3-hydroxyacyl-CoA epimerase activities. Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase is only slightly affected.
G322 (= G323) mutation to A: 10-fold increase in KM for NADH.
H450 (= H451) active site, For 3-hydroxyacyl-CoA dehydrogenase activity; mutation H->A,Q: Almost complete loss of 3-hydroxyacyl-CoA dehydrogenase activity.

6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
36% identity, 99% coverage: 7:714/715 of query aligns to 3:703/707 of 6yswA

query
sites
6yswA

A

A

I

F

T

T

V

L

K

N

A

V

L

R

E

L

S

D

G

N

I

I

V

A

E

V

L

I

K

T

F

I

D

D

L

V

K

P

G

G

E
|
E

S

K

V
x
M

N

N

K
x
T

F

L

N

K

R

A

L

E

T

F

L

A

N

S

E

Q

L

V

R

R

Q

A

A

I

V

I

D

K

T

Q

I

L

K

R

A

E

D

N

A

K

S

E

I

L

K

R

G

G

V

V

I

V

-

F

V

V

S

S

S

A

G

K

K

P

D

D

V

N

F

F

I

I

V
x
A

G

G

A
|
A

D
|
D

I
|
I

T
x
N

E

M

F
x
I

V

G

D

N

N

C

F

K

K

T

L

A

P

Q

D

E

A

A

E

E

L

A

V

L

A
|
A

G

-

N

-

L

R

E

Q

A

G

N
x
Q

K

Q

I

L

F

M

S

A

D

E

F

I

E

H

D

A

L

L

N

P

V

I

P

Q

T

V

V

I

A

A

A

A

I

I

N

H

G

G

I

A

A

C

L

L

G

G

G
|
G

G

G

L

L

E
|
E

M

L

C

A

L

L

A

A

A

C

D

H

Y

G

R

R

V

V

M

C

S

T

T

D

K

D

A

P

K

K

-

T

-

V

I

L

G

G

L

L

P
|
P

E
|
E

V

V

K

Q

L
|
L

G

G

I

L

Y

L

P

P

G
|
G

F

S

G

G

G

G

T

T

V

Q

R

R

L

L

P

P

R

R

L

L

I

I

G

G

A

V

D

S

N

T

A

A

I

L

E

E

W

M

I

I

A

L

A

T

G

G

K

K

E

Q

N

L

R

R

P

A

E

K

D

Q

A

A

L

L

K

K

V

L

G

G

A

L

V

V

D

D

A

D

V

V

V

V

A

P

P

H

E

S

Q

I

L

L

Q

L

D

E

A

A

A

A

L

V

E

E

L

L

I

A

K

K

R

K

A

E

I

-

S

-

G

-

E

-

F

-

D

R

Y

P

K

S

A

S

K

R

R

P

Q

L

P

P

K

V

L

R

E

E

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active site: A66 (= A69), I71 (≠ F74), A84 (= A87), Q88 (≠ N93), G112 (= G117), E115 (= E120), P136 (= P139), E137 (= E140), G145 (= G148), D264 (≠ E272), S422 (= S430), H443 (= H451), E455 (= E463), N493 (= N501)
binding coenzyme a: E23 (= E27), M25 (≠ V29), T27 (≠ K31), A64 (≠ V67), A66 (= A69), D67 (= D70), I68 (= I71), N69 (≠ T72), P136 (= P139), E137 (= E140), L140 (= L143), F286 (= F294), F287 (≠ L295), T290 (≠ Q298), K293 (= K301)

P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
34% identity, 96% coverage: 29:714/715 of query aligns to 61:761/763 of P40939

query
sites
P40939

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