Comparing PfGW456L13_4960 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_4960 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2v6kA Structure of maleyl pyruvate isomerase, a bacterial glutathione-s- transferase in zeta class, in complex with substrate analogue dicarboxyethyl glutathione (see paper)
46% identity, 100% coverage: 1:210/211 of query aligns to 3:213/214 of 2v6kA
2jl4A Holo structure of maleyl pyruvate isomerase, a bacterial glutathione- s-transferase in zeta class (see paper)
46% identity, 100% coverage: 1:210/211 of query aligns to 1:211/212 of 2jl4A
O86043 Maleylpyruvate isomerase; MPI; Naphthalene degradation protein L; EC 5.2.1.4 from Ralstonia sp. (see paper)
46% identity, 100% coverage: 1:210/211 of query aligns to 1:211/212 of O86043
Q9WVL0 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Mus musculus (Mouse)
41% identity, 99% coverage: 3:211/211 of query aligns to 8:211/216 of Q9WVL0
1fw1A Glutathione transferase zeta/maleylacetoacetate isomerase (see paper)
43% identity, 99% coverage: 3:211/211 of query aligns to 4:207/208 of 1fw1A
2cz2A Crystal structure of glutathione transferase zeta 1-1 (maleylacetoacetate isomerase) from mus musculus (form-1 crystal)
41% identity, 99% coverage: 3:211/211 of query aligns to 5:208/212 of 2cz2A
O43708 Maleylacetoacetate isomerase; MAAI; GSTZ1-1; Glutathione S-transferase zeta 1; EC 5.2.1.2; EC 2.5.1.18 from Homo sapiens (Human) (see 10 papers)
42% identity, 99% coverage: 3:211/211 of query aligns to 8:211/216 of O43708
4kaeA Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound dicarboxyethyl glutathione and citrate in the active site
42% identity, 100% coverage: 1:211/211 of query aligns to 8:213/220 of 4kaeA
4kdyA Crystal structure of maleylacetoacetate isomerase from anaeromyxobacter dehalogenans 2cp-1, target efi-507175, with bound gsh in the active site
42% identity, 100% coverage: 1:211/211 of query aligns to 10:215/222 of 4kdyA
4pxoA Crystal structure of maleylacetoacetate isomerase from methylobacteriu extorquens am1 with bound malonate and gsh (target efi-507068)
36% identity, 100% coverage: 1:211/211 of query aligns to 3:215/216 of 4pxoA
3n5oA Crystal structure of putative glutathione transferase from coccidioides immitis bound to glutathione (see paper)
37% identity, 100% coverage: 1:211/211 of query aligns to 4:224/228 of 3n5oA
D2YW48 Probable glutathione S-transferase; EC 2.5.1.18 from Coccidioides immitis (strain RS) (Valley fever fungus)
37% identity, 100% coverage: 1:211/211 of query aligns to 6:226/231 of D2YW48
3qawA Crystal structure of a glutathione-s-transferase from antarctic clam laternula elliptica in a complex with glutathione (see paper)
27% identity, 99% coverage: 4:211/211 of query aligns to 4:212/219 of 3qawA
5f06A Crystal structure of glutathione transferase f7 from populus trichocarpa (see paper)
43% identity, 38% coverage: 1:80/211 of query aligns to 2:77/213 of 5f06A
4gf0A Crystal structure of glutahtione transferase homolog from sulfitobacter, target efi-501084, with bound glutathione
28% identity, 77% coverage: 24:186/211 of query aligns to 26:186/208 of 4gf0A
Sites not aligning to the query:
4g9hA Crystal structure of glutahtione s-transferase homolog from yersinia pestis, target efi-501894, with bound glutathione
26% identity, 94% coverage: 1:198/211 of query aligns to 3:192/202 of 4g9hA
4zb8A Crystal structure of the glutathione transferase ure2p6 from phanerochaete chrysosporium in complex with oxidized glutathione. (see paper)
37% identity, 39% coverage: 1:82/211 of query aligns to 7:87/220 of 4zb8A
Sites not aligning to the query:
4zbdA Crystal structure of the glutathione transferase ure2p6 from phanerochaete chrysosporium in complex with glutathione reduced by x- ray irradiation at 100k (see paper)
37% identity, 39% coverage: 1:82/211 of query aligns to 6:86/219 of 4zbdA
Sites not aligning to the query:
2dsaA Ternary complex of bphk, a bacterial gst (see paper)
25% identity, 89% coverage: 1:187/211 of query aligns to 1:179/200 of 2dsaA
2gdrA Crystal structure of a bacterial glutathione transferase (see paper)
27% identity, 89% coverage: 1:187/211 of query aligns to 1:179/202 of 2gdrA
>PfGW456L13_4960 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_4960
MELYTYYRSTSSYRVRIALALKGLDYQSLPVNLIAPQGGEHRQPPYLGINPQGRVPALRT
DEGELLIQSPAIIEYLEERYPQVPLLSKDLAARAHERGVAAVIGCDVHPLHNVSVLNRLR
QSGHDEPQVVEWIGHWIGQGLATVEQLIGDDGYCFGPEPGLADVYLIPQLYAAERFNVSL
EAYPRIRRVAALAATHPAFIKAHPANQPDTP
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory