Comparing PfGW456L13_4961 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_4961 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 9 hits to proteins with known functional sites (download)
5ti1H Crystal structure of fumarylacetoacetate hydrolase from burkholderia xenovorans lb400
52% identity, 98% coverage: 8:433/434 of query aligns to 14:428/430 of 5ti1H
P16930 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) (see 14 papers)
49% identity, 96% coverage: 18:433/434 of query aligns to 10:415/419 of P16930
Sites not aligning to the query:
P35505 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Mus musculus (Mouse) (see 3 papers)
48% identity, 96% coverage: 18:433/434 of query aligns to 10:415/419 of P35505
1hyoB Crystal structure of fumarylacetoacetate hydrolase complexed with 4- (hydroxymethylphosphinoyl)-3-oxo-butanoic acid (see paper)
48% identity, 96% coverage: 18:433/434 of query aligns to 12:417/419 of 1hyoB
2hzyA Mouse fumarylacetoacetate hydrolase complexes with a transition-state mimic of the complete substrate (see paper)
48% identity, 96% coverage: 18:433/434 of query aligns to 10:415/416 of 2hzyA
1qcoA Crystal structure of fumarylacetoacetate hydrolase complexed with fumarate and acetoacetate (see paper)
48% identity, 96% coverage: 18:433/434 of query aligns to 10:415/416 of 1qcoA
8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid (see paper)
27% identity, 40% coverage: 200:374/434 of query aligns to 143:274/303 of 8sutA
Sites not aligning to the query:
8skyB Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
27% identity, 40% coverage: 200:374/434 of query aligns to 142:273/303 of 8skyB
Sites not aligning to the query:
6sbiA X-ray structure of murine fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate (see paper)
35% identity, 19% coverage: 184:265/434 of query aligns to 41:122/216 of 6sbiA
Sites not aligning to the query:
>PfGW456L13_4961 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_4961
MTQTSITRSWVASANGHADFPLQNLPLGVFSLNGSAPRSGVAIGEHIFDLQAALEAGLFD
GAAKAAVEATRGGQLNAFFELGREARVALRERLLELFAEGSTLHGKIEAQGAKLLPLAAD
CEMHLPAKINDYTDFYVGIEHAQNVGKLFRPDNPLLPNYKYVPIGYHGRASTIRPSGTDV
RRPKGQTLPAGQSEPTFGPCARLDYELELGIWIGQGNDMGDSIAIGDAADHIAGFCLLND
WSARDIQAWEYQPLGPFLSKSFITSISPWVVTAEALEPFRRAQPARPQGDPQPLPYLLDK
RDQAAGAFDIELEVLLLTEAMREQNLPAHRLTLSNTGHMYWTVAQMVAHHSVNGCQLQAG
DLFGSGTLSGPQSGQFGSLLEITEGGKKPIELASGEVRKFLEDGDEIILRGRCRRDGFAS
IGFGECRGKVLPAR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory