Comparing PfGW456L13_841 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_841 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 15 hits to proteins with known functional sites (download)
3vayA Crystal structure of 2-haloacid dehalogenase from pseudomonas syringae pv. Tomato dc3000 (see paper)
74% identity, 97% coverage: 3:230/235 of query aligns to 2:229/230 of 3vayA
4ygrA Crystal structure of had phosphatase from thermococcus onnurineus (see paper)
34% identity, 60% coverage: 89:228/235 of query aligns to 69:211/215 of 4ygrA
Sites not aligning to the query:
6z1kA A de novo enzyme for the morita-baylis-hillman reaction bh32.6 (see paper)
28% identity, 88% coverage: 3:208/235 of query aligns to 2:207/231 of 6z1kA
3i76B The crystal structure of the orthorhombic form of the putative had- hydrolase yfnb from bacillus subtilis bound to magnesium reveals interdomain movement
30% identity, 94% coverage: 6:227/235 of query aligns to 6:226/229 of 3i76B
6q7nA Crystal structure of bh32 alkylated with the mechanistic inhibitor 2- bromoacetophenone (see paper)
27% identity, 88% coverage: 3:208/235 of query aligns to 2:207/230 of 6q7nA
4ffdA Crystal structure of engineered protein. Northeast structural genomics consortium target or48
27% identity, 88% coverage: 3:208/235 of query aligns to 2:207/230 of 4ffdA
3qnmA Haloalkane dehalogenase family member from bacteroides thetaiotaomicron of unknown function
28% identity, 94% coverage: 6:227/235 of query aligns to 6:230/231 of 3qnmA
2no5B Crystal structure analysis of a dehalogenase with intermediate complex (see paper)
27% identity, 68% coverage: 71:229/235 of query aligns to 52:225/226 of 2no5B
Sites not aligning to the query:
Q51645 (S)-2-haloacid dehalogenase 4A; 2-haloalkanoic acid dehalogenase IVA; Halocarboxylic acid halidohydrolase IVA; L-2-haloacid dehalogenase IVA; EC 3.8.1.2 from Burkholderia cepacia (Pseudomonas cepacia) (see 2 papers)
27% identity, 68% coverage: 71:229/235 of query aligns to 52:225/231 of Q51645
Sites not aligning to the query:
2x4dB Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase lhpp
34% identity, 59% coverage: 61:198/235 of query aligns to 51:184/213 of 2x4dB
Sites not aligning to the query:
4g9bA Crystal structure of beta-phosphoglucomutase homolog from escherichia coli, target efi-501172, with bound mg, open lid
26% identity, 100% coverage: 1:234/235 of query aligns to 2:221/227 of 4g9bA
1zrmA Crystal structure of the reaction intermediate of l-2-haloacid dehalogenase with 2-chloro-n-butyrate (see paper)
28% identity, 56% coverage: 89:220/235 of query aligns to 76:213/220 of 1zrmA
Sites not aligning to the query:
Q53464 (S)-2-haloacid dehalogenase; 2-haloalkanoic acid dehalogenase; Halocarboxylic acid halidohydrolase; L-2-haloacid dehalogenase; L-DEX; EC 3.8.1.2 from Pseudomonas sp. (strain YL) (see 2 papers)
28% identity, 56% coverage: 89:220/235 of query aligns to 78:215/232 of Q53464
Sites not aligning to the query:
4knvA The crystal structure of apo human hdhd4 from se-mad (see paper)
27% identity, 59% coverage: 90:227/235 of query aligns to 87:232/241 of 4knvA
Sites not aligning to the query:
2x4dA Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase lhpp
49% identity, 19% coverage: 154:198/235 of query aligns to 188:232/270 of 2x4dA
Sites not aligning to the query:
>PfGW456L13_841 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_841
MSIQLITFDLDDTLWDTAPVIVSAEAVLREWLTEHAPNLGAVPVEHLWAIRERVLSNEPG
LKHRISALRRRVLFHALEESGYGHDEASDLADKSFEVFLHARHQIEVFPEVEPTLEILAN
HYALGVVTNGNADVRRLGLADYFKFALCAEDIGIAKPDARLFQEALQRGGVTAESAVHIG
DHPGDDIAGAQQAGMRAIWFNPAGKVWEAERLPDAEIRSLSDLPALLARWNSVSN
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory