Comparing PfGW456L13_945 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_945 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 19 hits to proteins with known functional sites (download)
3v77A Crystal structure of a putative fumarylacetoacetate isomerase/hydrolase from oleispira antarctica (see paper)
58% identity, 88% coverage: 17:210/221 of query aligns to 15:209/224 of 3v77A
1nkqA Crystal structure of yeast ynq8, a fumarylacetoacetate hydrolase family protein
43% identity, 87% coverage: 19:210/221 of query aligns to 10:222/247 of 1nkqA
6fogA X-ray structure of homo sapiens fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate at 1.94a resolution. (see paper)
39% identity, 91% coverage: 20:220/221 of query aligns to 15:214/218 of 6fogA
Sites not aligning to the query:
Q6P587 Acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; YisK-like protein; EC 3.7.1.5; EC 4.1.1.112 from Homo sapiens (Human) (see 3 papers)
39% identity, 91% coverage: 20:220/221 of query aligns to 20:219/224 of Q6P587
6sbiA X-ray structure of murine fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate (see paper)
40% identity, 91% coverage: 20:221/221 of query aligns to 14:214/216 of 6sbiA
6j5yA Crystal structure of fumarylpyruvate hydrolase from pseudomonas aeruginosa in complex with mn2+ and pyruvate (see paper)
33% identity, 96% coverage: 8:220/221 of query aligns to 14:230/233 of 6j5yA
3qdfA Crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase from mycobacterium marinum (see paper)
33% identity, 91% coverage: 19:220/221 of query aligns to 63:247/252 of 3qdfA
6iymA Fumarylacetoacetate hydrolase (eafah) from psychrophilic exiguobacterium antarcticum (see paper)
32% identity, 94% coverage: 14:221/221 of query aligns to 65:275/277 of 6iymA
8skyB Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
33% identity, 88% coverage: 12:206/221 of query aligns to 82:286/303 of 8skyB
8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid (see paper)
33% identity, 88% coverage: 12:206/221 of query aligns to 83:287/303 of 8sutA
8gstC Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Pyruvate bound-form) (see paper)
32% identity, 82% coverage: 17:198/221 of query aligns to 70:248/290 of 8gstC
8gsrA Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Apo-form) (see paper)
32% identity, 82% coverage: 17:198/221 of query aligns to 70:248/290 of 8gsrA
4dbhA Crystal structure of cg1458 with inhibitor (see paper)
33% identity, 91% coverage: 19:220/221 of query aligns to 63:266/269 of 4dbhA
6j5xB Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
32% identity, 81% coverage: 19:198/221 of query aligns to 69:247/280 of 6j5xB
6j5xA Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
32% identity, 81% coverage: 19:198/221 of query aligns to 69:247/280 of 6j5xA
6v77B Crystal structure of a putative hpce protein from mycobacterium smegmatis
31% identity, 90% coverage: 19:218/221 of query aligns to 71:273/279 of 6v77B
1gttA Crystal structure of hpce (see paper)
30% identity, 82% coverage: 16:197/221 of query aligns to 221:391/421 of 1gttA
6jvwB Crystal structure of maleylpyruvate hydrolase from sphingobium sp. Syk-6 in complex with manganese (ii) ion and pyruvate (see paper)
29% identity, 85% coverage: 19:206/221 of query aligns to 78:246/264 of 6jvwB
3r6oA Crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7- dioateisomerase from mycobacterium abscessus (see paper)
30% identity, 82% coverage: 18:198/221 of query aligns to 63:231/265 of 3r6oA
>PfGW456L13_945 FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_945
MSYQHQYVDGTRIHFPLGKVVCIGRNYAEHAKELDNPVPTEPLLFIKPGSCVVPLEGGFS
IPTERGSVHYEAEIAVLIGKPLSTKPSREEVLDAISGFAPALDLTLRDKQAELKSKGLPW
EIAKSFDGAAVLAPFVSGSTFADLTDIGIRLTINGEVRQDGNSSAMLNPIVPMIQHMAGC
FSLQAGDVILTGTPVGVGPLNVGDEIVLELPGASSFTSSVR
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Lawrence Berkeley National Laboratory