SitesBLAST
Comparing RR42_RS02175 FitnessBrowser__Cup4G11:RR42_RS02175 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P0DUV9 2-hydroxyacyl-CoA lyase; AcHACL; HACL; 2-hydroxyisobutyryl-CoA lyase; EC 4.1.-.- from Actinomycetospora chiangmaiensis (strain DSM 45062 / JCM 15998 / CCTCC AA 205017 / NBRC 104400 / YIM 0006) (see paper)
31% identity, 96% coverage: 8:528/541 of query aligns to 22:551/590 of P0DUV9
- G43 (≠ N29) binding
- Q255 (≠ E238) binding
- RS 273:274 (≠ FG 251:252) binding
- R362 (= R346) binding
- GDL 410:412 (≠ GEF 385:387) binding
- R417 (≠ Q392) binding
- G433 (= G407) binding
- D460 (= D434) binding
- GA 461:462 (≠ GT 435:436) binding
- N487 (≠ D461) binding
- NRAWNI 487:492 (≠ DARWNA 461:466) binding
- A489 (≠ R463) binding
- E493 (= E467) mutation to A: 10-fold decrease of 2-HIB-CoA cleavage rate, 6-fold increase in KM.; mutation to K: No cleavage of 2-HIB-CoA.; mutation to Q: 50-fold decrease of 2-HIB-CoA cleavage rate, 1.5-fold increase in KM.
Sites not aligning to the query:
- 561:564 binding
- 566:590 C-terminal lid
7pt1A Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with substrate 2-hib-coa and inactive cofactor 3-deaza-thdp (see paper)
31% identity, 96% coverage: 8:528/541 of query aligns to 8:537/574 of 7pt1A
- binding S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} 2-hydroxy-2-methylpropanethioate: L113 (≠ F113), Q114 (= Q114), G256 (vs. gap), S257 (≠ G249), R259 (≠ F251), S260 (≠ G252), Q279 (≠ T271), Y352 (≠ W350), R403 (≠ Q392), L404 (≠ A393), G419 (= G407)
- binding magnesium ion: D446 (= D434), N473 (≠ D461), A475 (≠ R463)
- binding 2-{4-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-methylthiophen-2-yl}ethyl trihydrogen diphosphate: E51 (= E51), T74 (= T74), P77 (= P77), G396 (= G385), D397 (≠ E386), L398 (≠ F387), G419 (= G407), L421 (≠ I409), G445 (= G433), D446 (= D434), G447 (= G435), A448 (≠ T436), N473 (≠ D461), A475 (≠ R463), W476 (= W464), N477 (= N465), I478 (≠ A466), E479 (= E467)
Sites not aligning to the query:
- binding S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} 2-hydroxy-2-methylpropanethioate: 547, 552
7pt4A Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with a covalently bound reaction intermediate as well as products formyl-coa and acetone (see paper)
31% identity, 96% coverage: 8:528/541 of query aligns to 8:537/580 of 7pt4A
- binding s-{(9r,13s,15r)-17-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl} thioformate : Q241 (≠ E238), G256 (vs. gap), S257 (≠ G249), R259 (≠ F251), S260 (≠ G252), Y278 (≠ F270), Q279 (≠ T271), Y352 (≠ W350), R403 (≠ Q392), L404 (≠ A393)
- binding magnesium ion: D446 (= D434), N473 (≠ D461), A475 (≠ R463)
- binding thiamine diphosphate: G396 (= G385), D397 (≠ E386), L398 (≠ F387), G419 (= G407), L421 (≠ I409), G445 (= G433), D446 (= D434), G447 (= G435), A448 (≠ T436), N473 (≠ D461), A475 (≠ R463), W476 (= W464), N477 (= N465), I478 (≠ A466), E479 (= E467)
Sites not aligning to the query:
- binding s-{(9r,13s,15r)-17-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-9,13,15-trihydroxy-10,10-dimethyl-13,15-dioxido-4,8-dioxo-12,14,16-trioxa-3,7-diaza-13,15-diphosphaheptadec-1-yl} thioformate : 552
7pt4B Actinobacterial 2-hydroxyacyl-coa lyase (achacl) structure in complex with a covalently bound reaction intermediate as well as products formyl-coa and acetone (see paper)
31% identity, 96% coverage: 8:528/541 of query aligns to 8:537/584 of 7pt4B
- binding magnesium ion: D446 (= D434), N473 (≠ D461), A475 (≠ R463)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1r,11r,15s,17r)-19-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-1,11,15,17-tetrahydroxy-12,12-dimethyl-15,17-dioxido-6,10-dioxo-14,16,18-trioxa-2-thia-5,9-diaza-15,17-diphosphanonadec-1-yl}-5-(2-{[(r)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: S257 (≠ G249), R259 (≠ F251), S260 (≠ G252), Q279 (≠ T271), Y352 (≠ W350), G395 (= G384), G396 (= G385), D397 (≠ E386), L398 (≠ F387), L399 (≠ G388), R403 (≠ Q392), L404 (≠ A393), G419 (= G407), L421 (≠ I409), G445 (= G433), D446 (= D434), G447 (= G435), A448 (≠ T436), N473 (≠ D461), A475 (≠ R463), W476 (= W464), N477 (= N465), I478 (≠ A466), E479 (= E467)
Sites not aligning to the query:
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1r,11r,15s,17r)-19-[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-1,11,15,17-tetrahydroxy-12,12-dimethyl-15,17-dioxido-6,10-dioxo-14,16,18-trioxa-2-thia-5,9-diaza-15,17-diphosphanonadec-1-yl}-5-(2-{[(r)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: 547, 561
3d7kA Crystal structure of benzaldehyde lyase in complex with the inhibitor mbp (see paper)
32% identity, 98% coverage: 7:536/541 of query aligns to 5:549/554 of 3d7kA
- active site: L24 (= L26), G26 (= G28), A27 (≠ N29), H28 (= H30), I29 (= I31), E49 (= E51), T72 (= T74), L111 (≠ F113), Q112 (= Q114), A113 (≠ E115), G114 (vs. gap), W162 (≠ T163), L255 (≠ N244), T283 (≠ L272), G392 (= G384), G418 (= G407), M420 (≠ I409), D447 (= D434), N474 (≠ D461), S476 (≠ R463), W477 (= W464), A479 (= A466), T480 (≠ E467), F483 (≠ I470), L545 (≠ G532)
- binding calcium ion: D447 (= D434), N474 (≠ D461), S476 (≠ R463)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(S)-hydroxy[(R)-hydroxy(methoxy)phosphoryl]phenylmethyl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: H25 (≠ S27), G26 (= G28), A27 (≠ N29), E49 (= E51), T72 (= T74), Q112 (= Q114), G392 (= G384), A393 (≠ G385), L394 (≠ E386), T395 (≠ F387), G418 (= G407), M420 (≠ I409), G446 (= G433), D447 (= D434), G448 (= G435), S449 (≠ T436), Y452 (≠ F439), N474 (≠ D461), S476 (≠ R463), W477 (= W464), G478 (≠ N465), A479 (= A466), T480 (≠ E467)
4qq8C Crystal structure of the formolase fls in space group p 43 21 2 (see paper)
31% identity, 98% coverage: 7:536/541 of query aligns to 5:549/569 of 4qq8C
- active site: L24 (= L26), G26 (= G28), I27 (≠ N29), H28 (= H30), I29 (= I31), E49 (= E51), T72 (= T74), L111 (≠ F113), Q112 (= Q114), A113 (≠ E115), G114 (vs. gap), W162 (≠ T163), L255 (≠ N244), T283 (≠ L272), G392 (= G384), N418 (≠ G407), M420 (≠ I409), D447 (= D434), N474 (≠ D461), S476 (≠ R463), W477 (= W464), W479 (≠ A466), T480 (≠ E467), F483 (≠ I470), L545 (≠ G532)
- binding magnesium ion: D447 (= D434), N474 (≠ D461), S476 (≠ R463)
- binding thiamine diphosphate: H25 (≠ S27), E49 (= E51), Q112 (= Q114), G392 (= G384), G393 (= G385), L394 (≠ E386), T395 (≠ F387), N418 (≠ G407), M420 (≠ I409), G446 (= G433), D447 (= D434), G448 (= G435), S449 (≠ T436), Y452 (≠ F439), N474 (≠ D461), S476 (≠ R463), W477 (= W464), G478 (≠ N465), W479 (≠ A466), T480 (≠ E467)
6xn8A Crystal structure of 2-hydroxyacyl coa lyase (hacl) from rhodospirillales bacterium urhd0017
29% identity, 96% coverage: 7:528/541 of query aligns to 6:535/540 of 6xn8A
- active site: V25 (≠ L26), G27 (= G28), F28 (≠ N29), P29 (≠ H30), I30 (= I31), E50 (= E51), V73 (≠ T74), F112 (= F113), Q113 (= Q114), E114 (= E115), D162 (≠ T163), F277 (≠ L272), G388 (= G385), G414 (= G407), M416 (≠ I409), D441 (= D434), N468 (≠ D461), G470 (≠ R463), I471 (≠ W464), P473 (vs. gap), G474 (vs. gap), E477 (vs. gap)
- binding adenosine-5'-diphosphate: R152 (= R153), G211 (= G211), K212 (≠ P212), S237 (= S239), G270 (= G265), R272 (= R267), D295 (= D290), I296 (≠ A291), G313 (≠ A313), D314 (= D314), G315 (≠ V315)
- binding magnesium ion: D441 (= D434), N468 (≠ D461), G470 (≠ R463)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: E50 (= E51), V73 (≠ T74), P76 (= P77), H80 (≠ N81), Y367 (≠ V364), A389 (vs. gap), G390 (vs. gap), T391 (vs. gap), G414 (= G407), M416 (≠ I409), G440 (= G433), D441 (= D434), S442 (≠ G435), A443 (≠ T436), F446 (= F439), N468 (≠ D461), G470 (≠ R463), I471 (≠ W464), G472 (vs. gap)
Q9UJ83 2-hydroxyacyl-CoA lyase 1; 2-hydroxyphytanoyl-CoA lyase; 2-HPCL; Phytanoyl-CoA 2-hydroxylase 2; EC 4.1.2.63 from Homo sapiens (Human) (see 2 papers)
28% identity, 97% coverage: 7:531/541 of query aligns to 16:560/578 of Q9UJ83
- D455 (= D434) mutation D->S,R: Does not affect subcellular localization. Abolishes lyase activity. Does not affect subcellular localization, abolishes lyase activity, does not affect oligomerisation and does not bind TTP; when associated with S-456.
- S456 (≠ G435) mutation to R: Does not affect subcellular localization. Abolishes lyase activity. Does not affect subcellular localization, abolishes lyase activity, does not affect oligomerisation and does not bind TTP; when associated with S-455.
Sites not aligning to the query:
- 576:578 Microbody targeting signal
6lpiB Crystal structure of ahas holo-enzyme (see paper)
28% identity, 98% coverage: 3:531/541 of query aligns to 4:520/539 of 6lpiB
- active site: I27 (≠ L26), G29 (= G28), G30 (≠ N29), S31 (≠ H30), I32 (= I31), E53 (= E51), C76 (≠ T74), F115 (= F113), Q116 (= Q114), E117 (= E115), K165 (≠ T163), M256 (≠ Q253), A283 (≠ K273), V375 (≠ G384), G401 (= G407), M403 (≠ I409), D428 (= D434), N455 (≠ D461), A457 (≠ R463), L458 (≠ W464), L460 (≠ A466), V461 (≠ E467), Q464 (≠ I470)
- binding flavin-adenine dinucleotide: R155 (= R153), G212 (= G211), G213 (≠ P212), G214 (≠ A213), T236 (≠ G231), L237 (≠ I232), M238 (≠ P233), L254 (≠ F251), M256 (≠ Q253), H257 (vs. gap), G276 (= G265), A277 (≠ K266), R278 (= R267), D280 (= D269), R282 (≠ L272), A283 (≠ K273), D300 (= D290), I301 (≠ A291), D319 (= D314), V320 (= V315), M380 (≠ Q389), G398 (= G404)
- binding magnesium ion: D428 (= D434), N455 (≠ D461)
- binding thiamine diphosphate: E53 (= E51), C76 (≠ T74), P79 (= P77), G376 (= G385), Q377 (≠ E386), H378 (≠ F387), G401 (= G407), M403 (≠ I409), G427 (= G433), D428 (= D434), G429 (= G435), S430 (≠ T436), M433 (≠ F439), N455 (≠ D461), A457 (≠ R463), L458 (≠ W464), G459 (≠ N465), L460 (≠ A466), V461 (≠ E467)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
26% identity, 84% coverage: 7:463/541 of query aligns to 14:491/598 of 6desA
- active site: Y33 (≠ L26), G35 (= G28), G36 (≠ N29), A37 (≠ H30), I38 (= I31), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (≠ T163), K229 (≠ S221), M265 (≠ A250), V292 (≠ L272), V408 (vs. gap), L433 (≠ A406), G434 (= G407), M436 (≠ I409), D461 (= D434), N488 (= N460), E490 (≠ A462), Q491 (≠ R463)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (≠ A250), D290 (≠ F270), R291 (≠ T271)
- binding flavin-adenine dinucleotide: R161 (= R153), G218 (= G211), A219 (≠ P212), G220 (≠ A213), N223 (vs. gap), T245 (≠ M237), L246 (≠ E238), Q247 (≠ S239), L263 (= L248), G285 (= G265), A286 (≠ K266), R287 (= R267), D289 (= D269), R291 (≠ T271), V292 (≠ L272), E318 (≠ D290), I319 (≠ A291), N323 (≠ E295), D337 (= D314), V338 (= V315), Q412 (≠ G388), M413 (≠ Q389), G431 (= G404)
- binding magnesium ion: D461 (= D434), N488 (= N460), E490 (≠ A462)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (vs. gap), G409 (= G385), Q410 (≠ E386), H411 (≠ F387), G434 (= G407), M436 (≠ I409), G460 (= G433), D461 (= D434), A462 (≠ G435), S463 (≠ T436), N488 (= N460), E490 (≠ A462), Q491 (≠ R463)
Sites not aligning to the query:
- active site: 493, 494, 497, 519, 524, 525
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: 497
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: 492, 493, 494
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
26% identity, 84% coverage: 7:463/541 of query aligns to 14:491/598 of 6depA
- active site: Y33 (≠ L26), G35 (= G28), G36 (≠ N29), A37 (≠ H30), I38 (= I31), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (≠ T163), K229 (≠ S221), M265 (≠ A250), V292 (≠ L272), V408 (vs. gap), L433 (≠ A406), G434 (= G407), M436 (≠ I409), D461 (= D434), N488 (= N460), E490 (≠ A462), Q491 (≠ R463)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (≠ F270), R291 (≠ T271)
- binding flavin-adenine dinucleotide: R161 (= R153), G218 (= G211), A219 (≠ P212), G220 (≠ A213), N223 (vs. gap), T245 (≠ M237), L246 (≠ E238), Q247 (≠ S239), L263 (= L248), G264 (= G249), G285 (= G265), A286 (≠ K266), R287 (= R267), D289 (= D269), R291 (≠ T271), V292 (≠ L272), E318 (≠ D290), I319 (≠ A291), N323 (≠ E295), D337 (= D314), V338 (= V315), M413 (≠ Q389), G431 (= G404)
- binding magnesium ion: D461 (= D434), N488 (= N460), E490 (≠ A462)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (vs. gap), G409 (= G385), Q410 (≠ E386), H411 (≠ F387), G434 (= G407), M436 (≠ I409), G460 (= G433), D461 (= D434), A462 (≠ G435), S463 (≠ T436), M466 (≠ F439), N488 (= N460), E490 (≠ A462), Q491 (≠ R463)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (vs. gap), G409 (= G385), Q410 (≠ E386), H411 (≠ F387), G434 (= G407), M436 (≠ I409), G460 (= G433), D461 (= D434), A462 (≠ G435), S463 (≠ T436), M466 (≠ F439), N488 (= N460), E490 (≠ A462), Q491 (≠ R463)
Sites not aligning to the query:
- active site: 493, 494, 497, 519, 524, 525
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: 493, 497
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: 492, 493, 494
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: 492, 493, 494
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
26% identity, 84% coverage: 7:463/541 of query aligns to 16:493/600 of 6derA
- active site: Y35 (≠ L26), G37 (= G28), G38 (≠ N29), A39 (≠ H30), I40 (= I31), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (≠ T163), K231 (≠ S221), M267 (≠ A250), V294 (≠ L272), V410 (vs. gap), L435 (≠ A406), G436 (= G407), M438 (≠ I409), D463 (= D434), N490 (= N460), E492 (≠ A462), Q493 (≠ R463)
- binding flavin-adenine dinucleotide: R163 (= R153), G220 (= G211), A221 (≠ P212), G222 (≠ A213), N225 (vs. gap), T247 (≠ M237), L248 (≠ E238), Q249 (≠ S239), L265 (= L248), H268 (≠ F251), G287 (= G265), A288 (≠ K266), R289 (= R267), D291 (= D269), R293 (≠ T271), V294 (≠ L272), E320 (≠ D290), I321 (≠ A291), N325 (≠ E295), G338 (≠ A313), D339 (= D314), V340 (= V315), Q414 (≠ G388), M415 (≠ Q389), G433 (= G404)
- binding Metosulam: R293 (≠ T271)
- binding magnesium ion: D463 (= D434), N490 (= N460), E492 (≠ A462)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (vs. gap), G411 (= G385), Q412 (≠ E386), H413 (≠ F387), G436 (= G407), M438 (≠ I409), G462 (= G433), D463 (= D434), A464 (≠ G435), S465 (≠ T436), N490 (= N460), E492 (≠ A462), Q493 (≠ R463)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (vs. gap), G411 (= G385), Q412 (≠ E386), H413 (≠ F387), G436 (= G407), M438 (≠ I409), G462 (= G433), D463 (= D434), A464 (≠ G435), S465 (≠ T436), M468 (≠ F439), N490 (= N460), E492 (≠ A462), Q493 (≠ R463)
Sites not aligning to the query:
- active site: 495, 496, 499, 521, 526, 527
- binding Metosulam: 495, 499, 570
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: 494, 495, 496
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: 494, 496
1ozgA The crystal structure of klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate (see paper)
28% identity, 98% coverage: 7:538/541 of query aligns to 8:544/549 of 1ozgA
- active site: I27 (≠ L26), G29 (= G28), A30 (≠ N29), K31 (≠ H30), I32 (= I31), E52 (= E51), T75 (= T74), H114 (≠ F113), Q115 (= Q114), S116 (≠ E115), Q164 (≠ T163), L257 (≠ A250), E284 (≠ G275), M389 (≠ G384), Q415 (≠ G407), M417 (≠ I409), D442 (= D434), D469 (= D461), G471 (≠ R463), Y472 (≠ W464), M474 (≠ A466), V475 (≠ E467), Q478 (≠ I470), Y538 (≠ G532)
- binding 2-hydroxyethyl dihydrothiachrome diphosphate: M389 (≠ G384), G390 (= G385), S391 (≠ E386), F392 (= F387), Q415 (≠ G407), M417 (≠ I409), G441 (= G433), D442 (= D434), G443 (= G435), D469 (= D461), G471 (≠ R463), Y472 (≠ W464), N473 (= N465), M474 (≠ A466), V475 (≠ E467), Y538 (≠ G532)
- binding magnesium ion: D442 (= D434), D469 (= D461), G471 (≠ R463)
- binding phosphate ion: G253 (vs. gap), R254 (≠ S247), Q261 (vs. gap), R347 (≠ E330), R398 (≠ A393), Y401 (vs. gap)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
27% identity, 84% coverage: 7:463/541 of query aligns to 12:486/593 of 6deoA
- active site: Y31 (≠ L26), G33 (= G28), G34 (≠ N29), A35 (≠ H30), I36 (= I31), E57 (= E51), T80 (= T74), F119 (= F113), Q120 (= Q114), E121 (= E115), K169 (≠ T163), K224 (≠ S221), M260 (≠ A250), V287 (≠ L272), V403 (vs. gap), L428 (≠ A406), G429 (= G407), M431 (≠ I409), D456 (= D434), N483 (= N460), E485 (≠ A462), Q486 (≠ R463)
- binding flavin-adenine dinucleotide: R159 (= R153), G213 (= G211), A214 (≠ P212), G215 (≠ A213), N218 (vs. gap), T240 (≠ M237), L241 (≠ E238), Q242 (≠ S239), L258 (= L248), G280 (= G265), A281 (≠ K266), R282 (= R267), D284 (= D269), R286 (≠ T271), V287 (≠ L272), E313 (≠ D290), I314 (≠ A291), N318 (≠ E295), D332 (= D314), V333 (= V315), M408 (≠ Q389), G426 (= G404)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (≠ A250), D285 (≠ F270), R286 (≠ T271)
- binding magnesium ion: D456 (= D434), N483 (= N460), E485 (≠ A462)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (vs. gap), G404 (= G385), Q405 (≠ E386), H406 (≠ F387), G429 (= G407), M431 (≠ I409), G455 (= G433), D456 (= D434), A457 (≠ G435), S458 (≠ T436), M461 (≠ F439), N483 (= N460), E485 (≠ A462), Q486 (≠ R463)
Sites not aligning to the query:
4rjkG Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii (see paper)
26% identity, 97% coverage: 5:528/541 of query aligns to 1:529/553 of 4rjkG
- binding magnesium ion: D437 (= D434), D464 (= D461), T466 (≠ R463)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: E47 (= E51), Q110 (= Q114)
- binding thiamine diphosphate: I384 (≠ G384), G385 (= G385), S386 (≠ E386), H387 (≠ F387), Q410 (≠ G407), L412 (≠ I409), G436 (= G433), D437 (= D434), G438 (= G435), G439 (≠ T436), T466 (≠ R463), Y467 (≠ W464), D468 (≠ N465), M469 (≠ A466), V470 (≠ E467)
Sites not aligning to the query:
4rjkF Acetolactate synthase from bacillus subtilis bound to lthdp - crystal form ii (see paper)
26% identity, 97% coverage: 5:528/541 of query aligns to 1:529/552 of 4rjkF
- binding magnesium ion: D437 (= D434), D464 (= D461), T466 (≠ R463)
- binding pyruvic acid: A25 (≠ N29), K26 (≠ H30)
- binding thiamine diphosphate: P23 (≠ S27), E47 (= E51), P73 (= P77), G385 (= G385), S386 (≠ E386), H387 (≠ F387), Q410 (≠ G407), L412 (≠ I409), G436 (= G433), D437 (= D434), G438 (= G435), G439 (≠ T436), T466 (≠ R463), Y467 (≠ W464), D468 (≠ N465), M469 (≠ A466), V470 (≠ E467)
Sites not aligning to the query:
4rjiC Acetolactate synthase from bacillus subtilis bound to thdp - crystal form i (see paper)
26% identity, 97% coverage: 4:528/541 of query aligns to 1:530/555 of 4rjiC
- binding magnesium ion: D438 (= D434), D465 (= D461), T467 (≠ R463)
- binding thiamine diphosphate: P24 (≠ S27), E48 (= E51), P74 (= P77), S387 (≠ E386), H388 (≠ F387), Q411 (≠ G407), G437 (= G433), D438 (= D434), G439 (= G435), G440 (≠ T436), T467 (≠ R463), Y468 (≠ W464), D469 (≠ N465), M470 (≠ A466), V471 (≠ E467)
Sites not aligning to the query:
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
27% identity, 84% coverage: 7:463/541 of query aligns to 16:494/601 of 6deqA
- active site: Y35 (≠ L26), G37 (= G28), G38 (≠ N29), A39 (≠ H30), I40 (= I31), E61 (= E51), T84 (= T74), F123 (= F113), Q124 (= Q114), E125 (= E115), K173 (≠ T163), K232 (≠ S221), M268 (≠ A250), V295 (≠ L272), V411 (vs. gap), L436 (≠ A406), G437 (= G407), M439 (≠ I409), D464 (= D434), N491 (= N460), E493 (≠ A462), Q494 (≠ R463)
- binding flavin-adenine dinucleotide: R163 (= R153), G221 (= G211), A222 (≠ P212), G223 (≠ A213), N226 (vs. gap), T248 (≠ M237), L249 (≠ E238), Q250 (≠ S239), L266 (= L248), G288 (= G265), A289 (≠ K266), R290 (= R267), D292 (= D269), R294 (≠ T271), V295 (≠ L272), E321 (≠ D290), I322 (≠ A291), D340 (= D314), V341 (= V315), M416 (≠ Q389), G434 (= G404)
- binding magnesium ion: D464 (= D434), N491 (= N460), E493 (≠ A462)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (≠ A250), R294 (≠ T271)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (vs. gap), G412 (= G385), Q413 (≠ E386), H414 (≠ F387), M439 (≠ I409), G463 (= G433), D464 (= D434), A465 (≠ G435), S466 (≠ T436), N491 (= N460), E493 (≠ A462), Q494 (≠ R463)
Sites not aligning to the query:
- active site: 496, 497, 500, 522, 527, 528
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: 496, 497, 500, 571
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: 495, 496, 497
5d6rB Acetolactate synthase from klebsiella pneumoniae in complex with mechanism-based inhibitor
28% identity, 98% coverage: 7:538/541 of query aligns to 7:541/548 of 5d6rB
- active site: I26 (≠ L26), G28 (= G28), A29 (≠ N29), K30 (≠ H30), I31 (= I31), E51 (= E51), T74 (= T74), H113 (≠ F113), Q114 (= Q114), S115 (≠ E115), Q163 (≠ T163), L254 (≠ A250), E281 (≠ G275), M386 (≠ G384), Q412 (≠ G407), M414 (≠ I409), D439 (= D434), D466 (= D461), G468 (≠ R463), Y469 (≠ W464), M471 (≠ A466), V472 (≠ E467), Q475 (≠ I470), Y535 (≠ G532)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(Z)-2-fluoro-1-hydroxy-2-phosphonoethenyl]-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: M386 (≠ G384), G387 (= G385), S388 (≠ E386), Q412 (≠ G407), M414 (≠ I409), D439 (= D434), G440 (= G435), G468 (≠ R463), Y469 (≠ W464), N470 (= N465), M471 (≠ A466), Y535 (≠ G532)
- binding magnesium ion: R63 (= R63), Q212 (≠ T216), D439 (= D434), D466 (= D461), G468 (≠ R463)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
26% identity, 84% coverage: 7:463/541 of query aligns to 14:490/597 of 6demA
- active site: Y33 (≠ L26), G35 (= G28), G36 (≠ N29), A37 (≠ H30), I38 (= I31), E59 (= E51), T82 (= T74), F121 (= F113), Q122 (= Q114), E123 (= E115), K171 (≠ T163), K228 (≠ S221), M264 (≠ A250), V291 (≠ L272), V407 (vs. gap), L432 (≠ A406), G433 (= G407), M435 (≠ I409), D460 (= D434), N487 (= N460), E489 (≠ A462), Q490 (≠ R463)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (≠ A250), D289 (≠ F270), R290 (≠ T271)
- binding flavin-adenine dinucleotide: R161 (= R153), G217 (= G211), A218 (≠ P212), G219 (≠ A213), N222 (vs. gap), T244 (≠ M237), L245 (≠ E238), Q246 (≠ S239), L262 (= L248), G284 (= G265), A285 (≠ K266), R286 (= R267), D288 (= D269), R290 (≠ T271), V291 (≠ L272), E317 (≠ D290), I318 (≠ A291), N322 (≠ E295), D336 (= D314), V337 (= V315), M412 (≠ Q389), G430 (= G404)
- binding magnesium ion: D460 (= D434), N487 (= N460), E489 (≠ A462)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (vs. gap), G408 (= G385), Q409 (≠ E386), H410 (≠ F387), M435 (≠ I409), G459 (= G433), D460 (= D434), A461 (≠ G435), S462 (≠ T436), M465 (≠ F439), N487 (= N460), E489 (≠ A462), Q490 (≠ R463)
Sites not aligning to the query:
- active site: 492, 493, 496, 518, 523, 524
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: 492, 496, 567
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: 491, 492, 493
Query Sequence
>RR42_RS02175 FitnessBrowser__Cup4G11:RR42_RS02175
MAKSHRGADALAGTLAKAGVRRIFTLSGNHIMPVFDACLEAEIALIHTRHEAATVHMADA
WSRITGEVGMAMVTGGPGHANAVSALYTAQMSEAPLVLLSGHAPNSQRGFGAFQEMRQAE
MAAPVTKASWASASADTVAADIALAMRIAQSGRPGPVHLSLPTDALENAVTRAGEPASIA
APQEAPAFDARTASEVLAALAAAKRPLILAGPAWLTASGRSRTAELEARTGIPVVGMESP
RGNNDPSLGAFGQMLAQADCILLLGKRLDFTLKFGRPPAFAADCNFLQIDADDAELERSR
RAAGARVLLARRADVGSAIAQLLACATGREQHCAWLEDVKAAIRYRPEAWKTASSRGALH
PAQVCSPLQPILESHPEAVLVSDGGEFGQWAQACLQAPHRVINGPAGAIGSALPMALAAR
LAKPDAPVIAMMGDGTTGFHIAEFDTAVRYGLPFVAVVGNDARWNAEYQIQLNSYGKDRL
VGCELLPTRYDQVCAAFGGYGEFVQAPEQLLPAVQRAIASGRPACVNVRMEGVPAPVVAR
K
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory