SitesBLAST

S109 (≠ E200) to W: in D2HGA1; unknown pathological significance; significant loss of catalytic activity; dbSNP:rs142050154
N127 (≠ I218) to K: in D2HGA1; unknown pathological significance; complete loss of catalytic activity; dbSNP:rs762857195
G131 (= G222) to V: in D2HGA1; unknown pathological significance; complete loss of catalytic activity
I147 (≠ V239) to S: in D2HGA1; severe phenotype; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs121434361
M153 (≠ L245) to T: in D2HGA1; unknown pathological significance; significant loss of catalytic activity; to V: in D2HGA1; unknown pathological significance; significant loss of catalytic activity; dbSNP:rs1432270139
C172 (≠ V272) to Y: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs773735172
P189 (≠ A289) to L: in D2HGA1; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs587783517
A205 (= A305) to V: in D2HGA1; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs750889931
A231 (≠ P331) to V: in D2HGA1; unknown pathological significance; significant loss of catalytic activity
G233 (= G333) to S: in D2HGA1; unknown pathological significance; no effect on catalytic activity; dbSNP:rs374535734
D375 (≠ S529) to Y: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs267606759
R386 (= R540) binding ; binding ; binding ; mutation to A: Loss of catalytic activity.
T390 (= T543) binding ; binding ; mutation to A: Significantly reduced catalytic activity.
V399 (≠ A552) to M: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs746519212
K401 (= K554) binding ; binding ; mutation to A: Loss of catalytic activity.

Sites not aligning to the query:

15 R → G: in dbSNP:rs4675887
169:521 natural variant: Missing (in D2HGA1; unknown pathological significance)
400:521 natural variant: Missing (in D2HGA1; unknown pathological significance; complete loss of catalytic activity)
419 R → H: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs199908032
426 A → T: in D2HGA1; unknown pathological significance; no effect on catalytic activity; dbSNP:rs146578303
434 binding ; H→A: Loss of catalytic activity.
436 G → V: slight reduction in catalytic activity
439 N → D: in D2HGA1; mild phenotype; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs121434362
441 binding ; H→A: Loss of catalytic activity.
443 binding ; N→A: Significantly reduced catalytic activity.
444 V → A: in D2HGA1; severe phenotype; unknown pathological significance; significant reduction in catalytic activity; dbSNP:rs121434360
446 A → V: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs746956176
475 binding ; E→A: Loss of catalytic activity.
476 binding ; binding ; binding ; H→A: Loss of catalytic activity.
477 G → R: in D2HGA1; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs1453924640

3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
23% identity, 19% coverage: 172:429/1324 of query aligns to 22:222/465 of 3pm9A

query
sites
3pm9A

D

D

G

P

L

L

S

E

R

L

V

E

S

A

H

Y

V

I

T

T

D

E

A

E

T

R

D

N

W

L

R

Y

V

R

E

G

Y

H

P

S

F

P

V

L

V

V

L

L

T

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P

D

G

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S

E

T

E

E

I

V

A

V

G

A

M

I

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C

K

K

G

L

C

A

F

N

E

E

L

A

G

R

L

V

T

A

I

L

I

V

P
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P

R
x
Q

G
|
G

G
x
N

T
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T

G
|
G

Y
x
L

T

V

G

G

G
|
G

A
x
Q

V

T

P

P

L

H

T

N

P

G

M

-

S

E

A

V

V

V

I

I

N

S

T
x
L

E

K

K

R

L

M

E

D

Q

K

L

I

G

R

P

E

V

I

E

D

Q

T

T

S

D

S

L

-

P

-

G

-

V

-

S

-

H

-

K

-

V

-

G

N

T

T

I

I

F

T

S

V

G

E

A

A

G

G

V

A

V

I

T

L

R

Q

R

R

V

V

A

Q

D

E

A

K

A

A

D

A

K

E

A

V

G

D

L

R

V

L

F

F

A

P

V

L

D

S

P
x
L

T
x
G

S
x
A

I

Q

D

G

A

S

S
x
C

C
x
T

I

I

G
|
G

N
|
N

V

L

A
x
S

M
x
T

N

N

A
|
A

G
|
G

G

G

K

T

K

A

A

A

V

L

L

A

W

Y

G

G

T
x
L

A

A

L

R

D

D

N

M

L

A

A

L

W

G

W

V

R

E

M

V

V

V

D

L

P

A

E

D

G

G

N

R

W

V

L

M

E

N

V

L

T

L

R

-

L

-

D

-

H

-

N

-

L

-

G

-

K

-

I

-

H

-

D

-

V

-

A

-

V

-

A

-

T

-

F

-

E

-

L

-

K

-

W

-

S

-

D

-

G

-

N

-

R

-

A

-

P

-

G

-

E

-

K

-

P

-

L

-

R

-

T

-

E

-

T

-

L

-

A

-

I

-

E

-

G

-

R

S

K

K

F

L

R

K

K

K

E

D

G

N

L

T

G

G

K

Y

D

D

V

L

T

R

D

D

K

L

F

F

L

-

A

-

G

-

L

-

P

-

G

-

I

I

Q

G

K

A

E
|
E

G
|
G

C

T

D

L

G
|
G

I
|
I

T

T

S

A

A

A

R

T

W

L

I

K

L

L

H

F

R

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M

K

P

P

A

R

H

A

V

V

R

E

T

T

active site: A149 (= A308), L159 (≠ T318)
binding flavin-adenine dinucleotide: P69 (= P219), Q70 (≠ R220), G71 (= G221), G72 (= G222), N73 (≠ G223), T74 (= T224), G75 (= G225), L76 (≠ Y226), G79 (= G229), Q80 (≠ A230), L91 (≠ T242), L133 (≠ P292), G134 (≠ T293), A135 (≠ S294), C139 (≠ S298), T140 (≠ C299), G142 (= G301), G143 (= G302), N144 (= N303), S146 (≠ A305), T147 (≠ M306), A149 (= A308), G150 (= G309), E200 (= E407), G201 (= G408), G204 (= G411), I205 (= I412), I206 (= I413)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 423, 424, 460

P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
27% identity, 11% coverage: 185:333/1324 of query aligns to 59:201/496 of P39976

query
sites
P39976

D

D

W

W

R

M

V

K

E

K

Y

Y

-

R

-

G

-

Q

P

S

F

N

V

L

V

I

L

L

T

L

P

P

D

N

T

S

E

T

E

D

E

K

I

V

A

S

G

K

M

I

V

M

K

K

G

Y

C

C

F

N

E

D

L

K

G

K

L

L

T

A

I

V

P

P

R

Q

G

G

G

N

T

T

G

D

Y

L

T

V

G

G

G

A

A

S

V

V

P

P

L

V

T

F

P

D

-

E

-

I

M

V

S

L

A

S

V

L

I

R

N

N

T

M

E

N

K

K

L

V

E

R

Q

D

L

F

G

D

P

P

V

V

E

S

Q

-

T

-

D

-

L

-

P

-

G

-

V

-

S

-

H

-

K

-

V

-

G

G

T

T

I

F

F

K

S

C

G

D

A

A

G

G

V

V

T

M

R

R

R

D

V

A

A

H

D

Q

A

F

A

L

D

H

K

D

A

H

G

D

L

H

V

I

F

F

A

P

V

L

D

D

P

L

T

P

S

S

I

R

D

N

A

N

S

C

C

Q

I

V

G

G

N

V

V

V

A

S

M

T

N

N

A

A

G

G

K

L

K

N

A

F

V

L

L

R

W

Y

G

G

T

S

A

L

L

H

D

G

N

N

L

V

A

L

W

G

W

L

R

E

M

V

V

V

D

L

P

P

E

N

G

G

Sites not aligning to the query:

17 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
29% identity, 12% coverage: 189:348/1324 of query aligns to 38:184/459 of P9WIT1

query
sites
P9WIT1

E

Q

Y

K

P

P

F

A

V

Y

V

A

L

A

T

K

P

P

D

A

T

T

E

P

E

E

I

V

A

A

G

Q

M

L

V

L

K

K

G

A

C

A

F

S

E

E

L

N

G

G

L

V

T

P

I

V

I

T

P

A

R

R

G

G

G

S

G

G

T

C

G

G

Y

L

T

S

G

G

G

A

A

A

V

R

P

P

L

V

T

E

P

G

M

-

S

G

A

L

V

L

I

I

N

S

T

F

E

D

K

R

L

M

E

N

Q

K

L

V

G

L

P

E

V

V

E

D

Q

-

T

-

D

-

L

-

P

-

G

-

V

T

S

A

H

N

K

Q

V

V

G

A

T

V

I

V

F

Q

S

P

G

G

A

V

G

A

V

L

V

T

T

D

R

L

R

D

V

A

A

A

D

T

A

A

A

-

D

-

K

D

A

T

G

G

L

L

V

R

F

Y

A

T

V

V

D

Y

P

P

T

G

S

E

I

L

D

-

A

S

S

S

C

S

I

V

G

G

N

N

V

V

A

G

M

T

N

N

A

A

G

G

K

M

K

R

A

A

V

V

L

K

W

Y

G

G

T

V

A

A

L

R

D

H

N

N

L

V

A

L

W

G

W

L

R

Q

M

A

V

V

D

L

P

P

E

T

G

G

N

-

W

-

L

-

E

E

V

I

T

I

R

R

L

T

D

G

H

G

N

R

L

M

G

A

K

K

I

V

Sites not aligning to the query:

354 modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
26% identity, 11% coverage: 190:338/1324 of query aligns to 44:182/467 of 7qh2C

query
sites
7qh2C

Y

Y

P

P

F

E

V

V

V

L

L

I

T

K

P

V

D

T

T

S

E

T

E

E

I

V

A

S

G

K

M

I

V

M

K

K

G

Y

C

A

F

Y

E

E

L

H

G

N

L

I

T

P

I

V

P
x
V

R
|
R

G
|
G

G
x
S

G
|
G

T
|
T

G
|
G

Y
x
L

T

V

G

G

G
x
A

A
x
C

V

V

P

P

L

L

T

F

P

G

M

-

S

G

A

I

V

M

I

L

N

E

T

T

E

T

K

L

L

M

E

N

Q

N

L

I

G

L

P

E

V

L

E

D

Q

T

T

E

D

N

L

L

P

-

G

-

V

-

S

-

H

-

K

-

V

-

G

-

T

T

I

V

F

T

S

V

G

E

A

P

G

G

V

V

V

L

T

L

R

M

R

E

V

L

A

S

D

K

A

F

A

V

D

E

K

E

A

N

G

D

L

L

V

F

F

Y

A

P

V

P

D

D

P
|
P

T
x
G

S
x
E

I

K

D

S

A
|
A

S
x
T

C

-

I

I

G
x
A

G
|
G

N
|
N

V

I

A
x
S

M
x
T

N

N

A
|
A

G
|
G

G

G

K

M

K

R

A

A

V

V

L

K

W

Y

G

G

T

V

A

T

L

R

D

D

N

Y

L

V

A

R

W

G

W

L

R

T

M

V

V

V

D

L

P

A

E

N

G

G

N

E

W

I

L

I

E

E

V

L

binding flavin-adenine dinucleotide: V73 (≠ P219), R74 (= R220), G75 (= G221), S76 (≠ G222), G77 (= G223), T78 (= T224), T78 (= T224), G79 (= G225), L80 (≠ Y226), A83 (≠ G229), C84 (≠ A230), P137 (= P292), G138 (≠ T293), E139 (≠ S294), E139 (≠ S294), A142 (= A297), T143 (≠ S298), A145 (≠ G301), G146 (= G302), N147 (= N303), S149 (≠ A305), T150 (≠ M306), A152 (= A308), G153 (= G309)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 32, 37, 37, 203, 204, 207, 208, 209, 332, 422, 423, 459
binding fe (iii) ion: 377, 384, 422

2uuvC Alkyldihydroxyacetonephosphate synthase in p1 (see paper)
23% identity, 13% coverage: 167:334/1324 of query aligns to 85:253/491 of 2uuvC

query
sites
2uuvC

D

D

N

Q

I

L

K

K

F

D

D

D

G

K

L

L

S

A

R

R

V

I

S

T

H

H

-

T

-

F

-

G

-
x
K

-

S

V

L

T

R

D

D

A

L

T

I

D

R

W

V

R

R

V

I

-

G

-

Q

-

V

-

K

E

N

Y

A

P

P

F

D

V

L

V

I

L

V

T

L

P

P

D

H

T

S

E

H

E

E

I

V

A

E

G

R

M

L

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V

K

Q

G

L

C

A

F

H

E

K

L

Y

G

N

L

V

T

V

I

I

P
|
P

R
x
M

G
|
G

T
x
S

G
x
N

Y
x
I

T

V

G

G

G
x
A

A
x
I

V

E

P

P

L

V

T

E

P

R

M

F

S

T

A

V

V

S

I

I

N

D

T

M

E

R

K

R

L

M

E

N

Q

K

L

V

G

L

P

W

V

V

E

D

Q

R

T

R

D

E

L

M

P

-

G

-

V

-

S

-

H

-

K

-

V

-

G

-

T

T

I

A

F

C

S

I

G

Q

A

V

G

G

V

I

V

M

T

G

R

P

R

E

V

L

A

E

D

K

A

Q

A

L

D

H

K

K

A

Q

G

G

L

V

V

S

F

L

A

G

V

H

D

D

P
|
P

T
x
D

S
|
S

I

F

D

E

A

F

S
|
S

C
x
T

I

L

G
|
G

N
x
W

V

L

A
|
A

M
x
T

N

C

A
x
S

G
x
S

G

G

K
x
H

K

Q

A

S

V

D

L

K

W

Y

G

G

T

D

A

I

L

E

D

D

N

M

L

A

A

V

W

S

W

F

R

R

M

T

V

V

D

T

P

P

E

T

G

G

N

T

binding flavin-adenine dinucleotide: K101 (vs. gap), P146 (= P219), M147 (≠ R220), G148 (= G221), G149 (= G222), G150 (= G223), S151 (≠ T224), N152 (≠ G225), I153 (≠ Y226), A156 (≠ G229), I157 (≠ A230), P211 (= P292), D212 (≠ T293), S213 (= S294), S217 (= S298), T218 (≠ C299), G220 (= G301), G221 (= G302), W222 (≠ N303), A224 (= A305), T225 (≠ M306), S227 (≠ A308), S228 (≠ G309), H230 (≠ K311)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 13, 270, 271, 274, 275, 276, 402, 489

O96759 Alkyldihydroxyacetonephosphate synthase; Alkyl-DHAP synthase; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Dictyostelium discoideum (Social amoeba) (see paper)
23% identity, 13% coverage: 167:334/1324 of query aligns to 108:278/611 of O96759

query
sites
O96759

D

D

N

Q

I

L

K

K

F

D

D

D

G

K

L

L

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A

R

R

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S

T

H

H

-

T

-

F

-

G

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K

-

S

V

L

T

R

D

D

A

L

T

I

D

R

W

V

R

R

V

I

-

G

-

Q

-

V

-

K

E

N

Y

A

P

P

F

D

V

L

V

I

L

V

T

L

P

P

D

H

T

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E

H

E

E

I

V

A

E

G

R

M

L

V

V

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Q

G

L

C

A

F

H

E

K

L

Y

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N

L

V

T

V

I

I

P
|
P

R
x
M

G
|
G

T
x
S

G
x
N

Y

I

T

V

G

G

G

A

A

I

V

E

P

P

L

V

T

S

P

N

-

E

-

R

M

F

S

T

A

V

V

S

I

I

N

D

T

M

E

R

K

R

L

M

E

N

Q

K

L

V

G

L

P

W

V

V

E

D

Q

R

T

R

D

E

L

M

P

-

G

-

V

-

S

-

H

-

K

-

V

-

G

-

T

T

I

A

F

C

S

I

G

Q

A

V

G

G

V

I

V

M

T

G

R

P

R

E

V

L

A

E

D

K

A

Q

A

L

D

H

K

K

A

Q

G

G

L

V

V

S

F

L

A

G

V

H

D

D

P

P

T
x
D

S
|
S

I
x
F

D
x
E

A
x
F

S
|
S

C
x
T

I

L

G

G

N

W

V

L

A

A

M
x
T

N
x
C

A
x
S

G
x
S

G
|
G

K
x
H

K

Q

A

S

V

D

L

K

W

Y

G

G

T

D

A

I

L

E

D

D

N

M

L

A

A

V

W

S

W

F

R

R

M

T

V

V

D

T

P

P

E

T

G

G

N

T

169:175 (vs. 219:225, 57% identical) binding
237:243 (vs. 293:299, 29% identical) binding
TCSSGH 250:255 (≠ MNAGGK 306:311) binding

Sites not aligning to the query:

301:307 binding
352 R→H: 30-fold reduction in activity.
447 R→L: Loss of activity. The FAD binds poorly to the mutant enzyme.
508 active site, Proton donor/acceptor; Y→F: Loss of activity.
544 H→I: Loss of activity.
545 H→I: Loss of activity.
546 H→I: Loss of activity.

O00116 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Aging-associated gene 5 protein; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Homo sapiens (Human) (see 2 papers)
26% identity, 11% coverage: 191:333/1324 of query aligns to 206:343/658 of O00116

query
sites
O00116

P

P

F

D

V

I

V

V

L

L

T

W

P

P

D

T

T

C

E

H

E

D

I

V

A

V

G

K

M

I

V

V

K

N

G

L

C

A

F

C

E

K

L

Y

G

N

L

L

T

C

I

I

P

P

R

I

G

G

T

T

G

S

Y

V

T

S

G

Y

G

G

A

L

V

M

-

C

P

P

L

A

T

D

P

E

M

T

S

R

A

T

V

I

I

I

-

S

-

L

N

D

T

T

E

S

K

Q

L

M

E

N

Q

R

L

I

G

L

P

W

V

V

E

D

Q

E

T

N

D

N

L

L

P

-

G

-

V

-

S

-

H

-

K

-

V

-

G

-

T

T

I

A

F

H

S

V

G

E

A

A

G

G

V

I

V

T

T

G

R

Q

R

E

V

L

A

E

D

R

A

Q

A

L

D

K

K

E

A

S

G

G

L

Y

V

C

F

T

A

G

V

H

D

E

P

P

T

D

S

S

I

L

D

E

A

F

S

S

C

T

I

V

G

G

N

W

V

V

A

S

M

T

N

R

A

A

G

S

G

G

K

M

K

K

A

K

V

N

L

I

W

Y

G

G

T

N

A

I

L

E

D

D

N

L

L

V

A

V

W

H

W

I

R

K

M

M

V

V

D

T

P

P

E

R

G

G

Sites not aligning to the query:

182 R → Q: in RCDP3; severely reduced protein levels
419 Important for enzyme activity; R → H: in RCDP3; loss of enzyme activity; dbSNP:rs121434411
471 E → K: in RCDP3; severely reduced protein levels
568 T → M: in RCDP3; does not affect protein levels; dbSNP:rs387907214

2uuuA Alkyldihydroxyacetonephosphate synthase in p212121 (see paper)
23% identity, 13% coverage: 167:334/1324 of query aligns to 97:267/550 of 2uuuA

query
sites
2uuuA

D

D

N

Q

I

L

K

K

F

D

D

D

G

K

L

L

S

A

R

R

V

I

S

T

H

H

-

T

-

F

-

G

-
x
K

-

S

V

L

T

R

D

D

A

L

T

I

D

R

W

V

R

R

V

I

-

G

-

Q

-

V

-

K

E

N

Y

A

P

P

F

D

V

L

V

I

L

V

T

L

P

P

D

H

T

S

E

H

E

E

I

V

A

E

G

R

M

L

V

V

K

Q

G

L

C

A

F

H

E

K

L

Y

G

N

L

V

T

V

I

I

P
|
P

R
x
M

G
|
G

T
x
S

G
x
N

Y
x
I

T

V

G

G

G
x
A

A
x
I

V

E

P

P

L

V

T

S

P

N

-

E

-

R

M

F

S

T

A

V

V

S

I

I

N

D

T

M

E

R

K

R

L

M

E

N

Q

K

L

V

G

L

P

W

V

V

E

D

Q

R

T

R

D

E

L

M

P

-

G

-

V

-

S

-

H

-

K

-

V

-

G

-

T

T

I

A

F

C

S

I

G

Q

A

V

G

G

V

I

V

M

T

G

R

P

R

E

V

L

A

E

D

K

A

Q

A

L

D

H

K

K

A

Q

G

G

L

V

V

S

F

L

A

G

V

H

D

D

P
|
P

T
x
D

S
|
S

I

F

D

E

A

F

S
|
S

C
x
T

I

L

G
|
G

N
x
W

V

L

A
|
A

M
x
T

N

C

A
x
S

G
x
S

G

G

K
x
H

K

Q

A

S

V

D

L

K

W

Y

G

G

T

D

A

I

L

E

D

D

N

M

L

A

A

V

W

S

W

F

R

R

M

T

V

V

D

T

P

P

E

T

G

G

N

T

binding flavin-adenine dinucleotide: K113 (vs. gap), P158 (= P219), M159 (≠ R220), G160 (= G221), G161 (= G222), G162 (= G223), S163 (≠ T224), N164 (≠ G225), I165 (≠ Y226), A168 (≠ G229), I169 (≠ A230), P225 (= P292), D226 (≠ T293), S227 (= S294), S231 (= S298), T232 (≠ C299), G234 (= G301), G235 (= G302), W236 (≠ N303), A238 (= A305), T239 (≠ M306), S241 (≠ A308), S242 (≠ G309), H244 (≠ K311)
binding hexadecan-1-ol: I165 (≠ Y226)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 19, 283, 284, 287, 288, 289, 426, 546
binding hexadecan-1-ol: 53, 58, 425, 426, 428, 429, 432, 439, 441, 474, 492

5adzC Ether lipid-generating enzyme agps in complex with inhibitor 1a (see paper)
25% identity, 11% coverage: 191:333/1324 of query aligns to 126:263/557 of 5adzC

query
sites
5adzC

P

P

F

D

V

I

V

V

L

L

T

W

P

P

D

T

T

C

E

H

E

D

I

V

A

V

G

K

M

I

V

V

K

N

G

L

C

A

F

C

E

K

L

Y

G

N

L

L

T

C

I

I

P
|
P

R
x
I

G
|
G

T
|
T

G
x
S

Y
x
V

T

S

G

Y

G
|
G

A
x
L

V

M

-

C

P

P

L

A

T

D

P

E

M

T

S

R

A

T

V

I

I

I

-

S

-

L

N

D

T

T

E

S

K

Q

L

M

E

N

Q

R

L

I

G

L

P

W

V

V

E

D

Q

E

T

N

D

N

L

L

P

-

G

-

V

-

S

-

H

-

K

-

V

-

G

-

T

T

I

A

F

H

S

V

G

E

A

A

G

G

V

I

V

T

T

G

R

Q

R

E

V

L

A

E

D

R

A

Q

A

L

D

K

K

E

A

S

G

G

L

Y

V

C

F

T

A

G

V

H

D

E

P
|
P

T
x
D

S
|
S

I

L

D

E

A

F

S
|
S