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Comparing RR42_RS05110 FitnessBrowser__Cup4G11:RR42_RS05110 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
75% identity, 98% coverage: 11:489/489 of query aligns to 5:483/483 of 4npiA
- active site: N152 (= N158), K175 (= K181), E251 (= E257), C285 (= C291), E387 (= E393), E464 (= E470)
- binding (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R109), L157 (= L163), W160 (= W166), E251 (= E257), C285 (= C291), Y445 (= Y451), R447 (= R453), F453 (= F459)
- binding nicotinamide-adenine-dinucleotide: I148 (= I154), S149 (= S155), P150 (= P156), W151 (= W157), K175 (= K181), E178 (= E184), G208 (= G214), G213 (= G219), E214 (= E220), F227 (= F233), G229 (= G235), E230 (= E236), T233 (= T239), G253 (= G259), C285 (= C291), K335 (= K341), E387 (= E393), F389 (= F395)
4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
75% identity, 98% coverage: 11:489/489 of query aligns to 5:483/483 of 4i2rA
- active site: N152 (= N158), K175 (= K181), E251 (= E257), C285 (= C291), E387 (= E393), E464 (= E470)
- binding (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R109), L157 (= L163), C285 (= C291), Y445 (= Y451), R447 (= R453), F453 (= F459)
- binding nicotinamide-adenine-dinucleotide: I148 (= I154), S149 (= S155), W151 (= W157), N152 (= N158), K175 (= K181), E178 (= E184), G208 (= G214), F227 (= F233), T228 (= T234), G229 (= G235), E230 (= E236), T233 (= T239), E251 (= E257), L252 (= L258), G253 (= G259), C285 (= C291), E387 (= E393), F389 (= F395)
4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
75% identity, 98% coverage: 11:489/489 of query aligns to 5:483/483 of 4i25A
- active site: N152 (= N158), K175 (= K181), E251 (= E257), C285 (= C291), E387 (= E393), E464 (= E470)
- binding (2E,4E)-2-amino-6-oxohexa-2,4-dienoic acid: R103 (= R109), L157 (= L163), C285 (= C291), Y445 (= Y451), R447 (= R453), F453 (= F459)
- binding nicotinamide-adenine-dinucleotide: I148 (= I154), S149 (= S155), P150 (= P156), W151 (= W157), N152 (= N158), K175 (= K181), E178 (= E184), G208 (= G214), G213 (= G219), F227 (= F233), T228 (= T234), G229 (= G235), E230 (= E236), T233 (= T239), E251 (= E257), L252 (= L258), C285 (= C291), E387 (= E393), F389 (= F395)
5kllA Crystal structure of 2-hydroxymuconate-6-semialdehyde derived tautomeric intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase n169d (see paper)
75% identity, 98% coverage: 11:489/489 of query aligns to 5:483/483 of 5kllA
- active site: D152 (≠ N158), K175 (= K181), E251 (= E257), C285 (= C291), E387 (= E393), E464 (= E470)
- binding (3~{E},5~{E})-6-oxidanyl-2-oxidanylidene-hexa-3,5-dienoic acid: R103 (= R109), D152 (≠ N158), L157 (= L163), W160 (= W166), C285 (= C291), Y445 (= Y451), R447 (= R453), F453 (= F459)
5kj5B Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase n169d in complex with NAD+ (see paper)
75% identity, 98% coverage: 11:489/489 of query aligns to 6:484/484 of 5kj5B
- active site: D153 (≠ N158), K176 (= K181), E252 (= E257), C286 (= C291), E388 (= E393), E465 (= E470)
- binding nicotinamide-adenine-dinucleotide: I149 (= I154), S150 (= S155), P151 (= P156), W152 (= W157), D153 (≠ N158), L158 (= L163), K176 (= K181), G209 (= G214), K210 (≠ G215), G214 (= G219), F228 (= F233), T229 (= T234), G230 (= G235), E231 (= E236), T234 (= T239), E252 (= E257), L253 (= L258), C286 (= C291), E388 (= E393), F390 (= F395), F454 (= F459)
4ou2A A 2.15 angstroms x-ray crystal structure of e268a 2-aminomuconate 6- semialdehyde dehydrogenase catalytic intermediate from pseudomonas fluorescens (see paper)
75% identity, 98% coverage: 11:489/489 of query aligns to 5:483/483 of 4ou2A
- active site: N152 (= N158), K175 (= K181), A251 (≠ E257), C285 (= C291), E387 (= E393), E464 (= E470)
- binding (2Z,4E)-2,6-dihydroxyhexa-2,4-dienoic acid: R103 (= R109), L157 (= L163), C285 (= C291), Y445 (= Y451), R447 (= R453), F453 (= F459)
- binding nicotinamide-adenine-dinucleotide: I148 (= I154), S149 (= S155), P150 (= P156), W151 (= W157), N152 (= N158), K175 (= K181), G208 (= G214), G213 (= G219), E214 (= E220), F227 (= F233), T228 (= T234), G229 (= G235), E230 (= E236), T233 (= T239), A251 (≠ E257), L252 (= L258), G253 (= G259), C285 (= C291), E387 (= E393), F389 (= F395)
4u3wA X-ray crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase from burkholderia cenocepacia
75% identity, 99% coverage: 8:489/489 of query aligns to 3:484/485 of 4u3wA
Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human) (see paper)
43% identity, 98% coverage: 8:488/489 of query aligns to 9:486/487 of Q9H2A2
- R109 (= R109) mutation to A: About 65-fold loss of catalytic efficiency.
- N155 (= N158) mutation to A: Complete loss of activity.
- R451 (= R453) mutation to A: Complete loss of activity.
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 98% coverage: 9:489/489 of query aligns to 17:490/491 of 5gtlA
- active site: N165 (= N158), K188 (= K181), E263 (= E257), C297 (= C291), E394 (= E393), E471 (= E470)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I154), P163 (= P156), K188 (= K181), A190 (≠ S183), E191 (= E184), Q192 (≠ E185), G221 (= G214), G225 (≠ T218), G241 (= G235), S242 (≠ E236), T245 (= T239), L264 (= L258), C297 (= C291), E394 (= E393), F396 (= F395)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 98% coverage: 9:489/489 of query aligns to 17:490/491 of 5gtkA
- active site: N165 (= N158), K188 (= K181), E263 (= E257), C297 (= C291), E394 (= E393), E471 (= E470)
- binding nicotinamide-adenine-dinucleotide: I161 (= I154), I162 (≠ S155), P163 (= P156), W164 (= W157), K188 (= K181), E191 (= E184), G221 (= G214), G225 (≠ T218), A226 (≠ G219), F239 (= F233), G241 (= G235), S242 (≠ E236), T245 (= T239), Y248 (≠ T242), L264 (= L258), C297 (= C291), Q344 (≠ H338), R347 (≠ K341), E394 (= E393), F396 (= F395)
6vr6D Structure of aldh9a1 complexed with NAD+ in space group p1 (see paper)
39% identity, 94% coverage: 29:489/489 of query aligns to 33:486/493 of 6vr6D
- active site: N156 (= N158), E253 (= E257), C287 (= C291), E467 (= E470)
- binding nicotinamide-adenine-dinucleotide: I152 (= I154), G153 (≠ S155), W155 (= W157), K179 (= K181), A212 (≠ G216), G215 (= G219), Q216 (≠ E220), F229 (= F233), G231 (= G235), S232 (≠ E236), T235 (= T239), I239 (= I243)
P49189 4-trimethylaminobutyraldehyde dehydrogenase; TMABA-DH; TMABALDH; Aldehyde dehydrogenase E3 isozyme; Aldehyde dehydrogenase family 9 member A1; Formaldehyde dehydrogenase; Gamma-aminobutyraldehyde dehydrogenase; R-aminobutyraldehyde dehydrogenase; EC 1.2.1.47; EC 1.2.1.3; EC 1.2.1.46; EC 1.2.1.19 from Homo sapiens (Human) (see 2 papers)
39% identity, 94% coverage: 29:489/489 of query aligns to 34:487/494 of P49189
- C116 (≠ N113) to S: in allele ALDH9A1*2
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed; alternate
- 2 modified: N-acetylserine; in 4-trimethylaminobutyraldehyde dehydrogenase, N-terminally processed
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
41% identity, 98% coverage: 11:489/489 of query aligns to 29:505/515 of 2d4eC
- active site: N173 (= N158), K196 (= K181), E271 (= E257), C305 (= C291), E409 (= E393), E486 (= E470)
- binding nicotinamide-adenine-dinucleotide: I169 (= I154), T170 (≠ S155), P171 (= P156), W172 (= W157), K196 (= K181), A198 (≠ S183), G229 (= G214), G233 (= G219), A234 (≠ E220), T248 (= T234), G249 (= G235), E250 (= E236), T253 (= T239), E271 (= E257), L272 (= L258), C305 (= C291), E409 (= E393), F411 (= F395), F475 (= F459)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
40% identity, 98% coverage: 12:489/489 of query aligns to 7:479/489 of 4o6rA
- active site: N150 (= N158), K173 (= K181), E248 (= E257), C282 (= C291), E383 (= E393), E460 (= E470)
- binding adenosine monophosphate: I146 (= I154), V147 (≠ S155), K173 (= K181), G206 (= G214), G210 (= G219), Q211 (≠ E220), F224 (= F233), G226 (= G235), S227 (≠ E236), T230 (= T239), R233 (≠ T242)
4neaA 1.90 angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betb) from staphylococcus aureus in complex with NAD+ and bme-free cys289 (see paper)
40% identity, 96% coverage: 10:479/489 of query aligns to 19:485/505 of 4neaA
- active site: N166 (= N158), K189 (= K181), E264 (= E257), C298 (= C291), E399 (= E393), E476 (= E470)
- binding nicotinamide-adenine-dinucleotide: P164 (= P156), K189 (= K181), E192 (= E184), G222 (= G215), G226 (= G219), G242 (= G235), G243 (≠ E236), T246 (= T239), H249 (≠ T242), I250 (= I243), C298 (= C291), E399 (= E393), F401 (= F395)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
40% identity, 98% coverage: 12:489/489 of query aligns to 6:477/487 of 4go4A
- active site: N149 (= N158), K172 (= K181), E247 (= E257), C281 (= C291), E381 (= E393), E458 (= E470)
- binding nicotinamide-adenine-dinucleotide: I145 (= I154), V146 (≠ S155), W148 (= W157), N149 (= N158), F154 (≠ L163), K172 (= K181), G205 (= G214), G209 (= G219), Q210 (≠ E220), F223 (= F233), T224 (= T234), G225 (= G235), S226 (≠ E236), T229 (= T239), E247 (= E257), G249 (= G259), C281 (= C291), E381 (= E393), F383 (= F395)
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
39% identity, 98% coverage: 10:489/489 of query aligns to 7:482/489 of 4cazA
- active site: N152 (= N158), K175 (= K181), E251 (= E257), C285 (= C291), E386 (= E393), E463 (= E470)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (= I154), G149 (≠ S155), W151 (= W157), N152 (= N158), K175 (= K181), E178 (= E184), G208 (= G215), G212 (= G219), F226 (= F233), T227 (= T234), G228 (= G235), G229 (≠ E236), T232 (= T239), V236 (≠ I243), E251 (= E257), L252 (= L258), C285 (= C291), E386 (= E393), F388 (= F395)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
39% identity, 98% coverage: 10:489/489 of query aligns to 7:482/489 of 2woxA
- active site: N152 (= N158), K175 (= K181), E251 (= E257), C285 (= C291), E386 (= E393), E463 (= E470)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (= I154), G149 (≠ S155), W151 (= W157), N152 (= N158), K175 (= K181), S177 (= S183), E178 (= E184), G208 (= G215), G212 (= G219), F226 (= F233), T227 (= T234), G228 (= G235), G229 (≠ E236), T232 (= T239), V236 (≠ I243), E251 (= E257), L252 (= L258), C285 (= C291), E386 (= E393), F388 (= F395)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
39% identity, 98% coverage: 10:489/489 of query aligns to 7:482/489 of 2wmeA
- active site: N152 (= N158), K175 (= K181), E251 (= E257), C285 (= C291), E386 (= E393), E463 (= E470)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (≠ S155), W151 (= W157), K175 (= K181), S177 (= S183), E178 (= E184), G208 (= G215), G212 (= G219), F226 (= F233), G228 (= G235), G229 (≠ E236), T232 (= T239), V236 (≠ I243)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
39% identity, 98% coverage: 10:489/489 of query aligns to 8:483/490 of Q9HTJ1
- GAWN 150:153 (≠ SPWN 155:158) binding
- K162 (= K167) active site, Charge relay system
- KPSE 176:179 (= KPSE 181:184) binding
- G209 (= G215) binding
- GTST 230:233 (≠ ESRT 236:239) binding
- E252 (= E257) active site, Proton acceptor
- C286 (= C291) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E393) binding
- E464 (= E470) active site, Charge relay system
Query Sequence
>RR42_RS05110 FitnessBrowser__Cup4G11:RR42_RS05110
MPKQNIPLIRHYIDGEFVASAGTFPDTCPVDGHLVANVCEADAALVDRAVQAARRALQGP
WGQLDVQQRAALLHRIADGIEARFDAFVAAEVEDTGRPEHQARTLDVARAVTNLRTFADL
AKTAGNELYETPTADGAGALNYTVRKPVGVVGIISPWNLPLLLLTWKVAPALACGNTVVA
KPSEETPASAALLAEVIHQAGVPHGVFNLLHGFGGGSTGEFLTRHDGIDAITFTGESRTG
STIMRAVADGVKEISFELGGKNAAVVFADADFDAAVAGVLRSSFTNAGQVCLCSERVFVA
RPIFDAFVAALKARTQALKLGHPGDDGVDMGPLISRGHRDKVESYFRLAVEEGATVVCGG
KVPVFGDARDDGAYVMPTIWTGLPDSARCVTEEIFGPVCHIAPFDSEEEVIARVNDSAYG
LACALWTTNLTRAHRVARQVRVGLTWVNTWYLRDLRTPFGGVGLSGLGREGGRHSLDFYS
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory