SitesBLAST
Comparing RR42_RS06570 FitnessBrowser__Cup4G11:RR42_RS06570 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5yssB Crystal structure of aminocaproic acid cyclase in complex with NAD (+) (see paper)
70% identity, 100% coverage: 2:258/258 of query aligns to 2:255/255 of 5yssB
- binding nicotinamide-adenine-dinucleotide: G11 (= G11), T13 (= T13), S14 (= S14), G15 (= G15), I16 (= I16), G35 (= G35), F36 (= F36), L60 (≠ M62), N86 (= N88), G88 (= G90), I89 (= I91), A137 (= A139), Y151 (= Y153), K155 (= K157), P181 (= P183), G182 (= G184), V184 (= V186), T186 (= T188)
2q2qD Structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas putida (see paper)
67% identity, 100% coverage: 2:258/258 of query aligns to 2:255/255 of 2q2qD
- active site: G15 (= G15), S138 (= S140), Y151 (= Y153), K155 (= K157), R196 (= R198)
- binding nicotinamide-adenine-dinucleotide: G11 (= G11), T13 (= T13), S14 (= S14), G15 (= G15), I16 (= I16), F36 (= F36), D59 (= D61), L60 (≠ M62), N86 (= N88), G88 (= G90), L109 (≠ I111), I136 (= I138), S138 (= S140), Y151 (= Y153), K155 (= K157), P181 (= P183), G182 (= G184), W183 (= W185), V184 (= V186), T186 (= T188), L188 (= L190), V189 (= V191)
2ztlA Closed conformation of d-3-hydroxybutyrate dehydrogenase complexed with NAD+ and l-3-hydroxybutyrate (see paper)
65% identity, 100% coverage: 1:258/258 of query aligns to 1:260/260 of 2ztlA
- active site: G15 (= G15), N114 (= N112), S142 (= S140), Y155 (= Y153), K159 (= K157), L200 (≠ R198)
- binding (3s)-3-hydroxybutanoic acid: Q94 (= Q92), S142 (= S140), H144 (= H142), K152 (= K150), Y155 (= Y153), Q196 (= Q194)
- binding nicotinamide-adenine-dinucleotide: G11 (= G11), G15 (= G15), I16 (= I16), F36 (= F36), L64 (≠ M62), N90 (= N88), A91 (= A89), G92 (= G90), L113 (≠ I111), Y155 (= Y153), K159 (= K157), P185 (= P183), W187 (= W185), V188 (= V186), T190 (= T188), V193 (= V191)
1wmbA Crystal structure of NAD dependent d-3-hydroxybutylate dehydrogenase (see paper)
65% identity, 100% coverage: 1:258/258 of query aligns to 1:260/260 of 1wmbA
5b4tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and a substrate d-3- hydroxybutyrate (see paper)
60% identity, 100% coverage: 1:258/258 of query aligns to 1:260/260 of 5b4tA
- active site: G15 (= G15), N114 (= N112), S142 (= S140), Y155 (= Y153), K159 (= K157), I200 (≠ R198)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q92), S142 (= S140), H144 (= H142), K152 (= K150), Y155 (= Y153), W187 (= W185), Q196 (= Q194)
- binding nicotinamide-adenine-dinucleotide: G11 (= G11), T13 (= T13), G15 (= G15), I16 (= I16), F36 (= F36), D63 (= D61), L64 (≠ M62), N90 (= N88), G92 (= G90), L113 (≠ I111), I140 (= I138), Y155 (= Y153), K159 (= K157), P185 (= P183), G186 (= G184), W187 (= W185), V188 (= V186), T190 (= T188), L192 (= L190), V193 (= V191)
3w8dA Crystal structure of d-3-hydroxybutyrate dehydrogenase from alcaligenes faecalis complexed with NAD+ and an inhibitor methylmalonate
60% identity, 100% coverage: 1:258/258 of query aligns to 1:260/260 of 3w8dA
- active site: G15 (= G15), N114 (= N112), S142 (= S140), Y155 (= Y153), K159 (= K157), I200 (≠ R198)
- binding methylmalonic acid: Q94 (= Q92), S142 (= S140), H144 (= H142), K152 (= K150), Y155 (= Y153), W187 (= W185), Q196 (= Q194), W257 (= W255)
- binding nicotinamide-adenine-dinucleotide: G11 (= G11), T13 (= T13), S14 (= S14), G15 (= G15), I16 (= I16), F36 (= F36), A62 (= A60), D63 (= D61), L64 (≠ M62), N90 (= N88), A91 (= A89), G92 (= G90), L113 (≠ I111), S142 (= S140), Y155 (= Y153), K159 (= K157), P185 (= P183), G186 (= G184), W187 (= W185), V188 (= V186), T190 (= T188), L192 (= L190), V193 (= V191)
3vdrA Crystal structure of d-3-hydroxybutyrate dehydrogenase, prepared in the presence of the substrate d-3-hydroxybutyrate and NAD(+) (see paper)
60% identity, 100% coverage: 1:258/258 of query aligns to 1:260/260 of 3vdrA
- active site: G15 (= G15), N114 (= N112), S142 (= S140), Y155 (= Y153), K159 (= K157), I200 (≠ R198)
- binding (3R)-3-hydroxybutanoic acid: Q94 (= Q92), H144 (= H142), K152 (= K150), Y155 (= Y153), W187 (= W185), Q196 (= Q194), W257 (= W255)
- binding acetoacetic acid: Q94 (= Q92), H144 (= H142), K152 (= K150), Y155 (= Y153), W187 (= W185), Q196 (= Q194), W257 (= W255)
- binding nicotinamide-adenine-dinucleotide: G11 (= G11), T13 (= T13), I16 (= I16), F36 (= F36), D63 (= D61), L64 (≠ M62), N90 (= N88), A91 (= A89), G92 (= G90), L113 (≠ I111), K159 (= K157), G186 (= G184), V188 (= V186), T190 (= T188), L192 (= L190), V193 (= V191)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G11), T13 (= T13), I16 (= I16), F36 (= F36), D63 (= D61), L64 (≠ M62), N90 (= N88), A91 (= A89), G92 (= G90), L113 (≠ I111), S142 (= S140), Y155 (= Y153), K159 (= K157), G186 (= G184), V188 (= V186), T190 (= T188), L192 (= L190), V193 (= V191)
3vdqA Crystal structure of alcaligenes faecalis d-3-hydroxybutyrate dehydrogenase in complex with NAD(+) and acetate (see paper)
60% identity, 100% coverage: 1:258/258 of query aligns to 1:260/260 of 3vdqA
- active site: G15 (= G15), N114 (= N112), S142 (= S140), Y155 (= Y153), K159 (= K157), I200 (≠ R198)
- binding acetate ion: Q94 (= Q92), H144 (= H142), K152 (= K150), W187 (= W185), L192 (= L190), Q196 (= Q194)
- binding nicotinamide-adenine-dinucleotide: G11 (= G11), S14 (= S14), I16 (= I16), F36 (= F36), D63 (= D61), L64 (≠ M62), N90 (= N88), A91 (= A89), G92 (= G90), L113 (≠ I111), I140 (= I138), S142 (= S140), Y155 (= Y153), K159 (= K157), P185 (= P183), G186 (= G184), W187 (= W185), V188 (= V186), T190 (= T188), L192 (= L190), V193 (= V191)
1x1tA Crystal structure of d-3-hydroxybutyrate dehydrogenase from pseudomonas fragi complexed with NAD+ (see paper)
60% identity, 100% coverage: 1:258/258 of query aligns to 1:236/236 of 1x1tA
- active site: G15 (= G15), N114 (= N112), S142 (= S140), Y155 (= Y153), K159 (= K157)
- binding cacodylate ion: S142 (= S140), H144 (= H142), Y155 (= Y153), W187 (= W185), W233 (= W255)
- binding nicotinamide-adenine-dinucleotide: G11 (= G11), T13 (= T13), S14 (= S14), G15 (= G15), I16 (= I16), G35 (= G35), F36 (= F36), D63 (= D61), L64 (≠ M62), N90 (= N88), G92 (= G90), L113 (≠ I111), S142 (= S140), Y155 (= Y153), K159 (= K157), P185 (= P183), W187 (= W185), V188 (= V186), T190 (= T188)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
39% identity, 100% coverage: 1:258/258 of query aligns to 4:261/261 of 6zzsD
- active site: G18 (= G15), S143 (= S140), Y156 (= Y153)
- binding nicotinamide-adenine-dinucleotide: G14 (= G11), S17 (= S14), I19 (= I16), D38 (≠ G35), M39 (≠ F36), D64 (= D61), V65 (≠ M62), N91 (= N88), A92 (= A89), G93 (= G90), M141 (≠ I138), A142 (= A139), S143 (= S140), Y156 (= Y153), K160 (= K157), P186 (= P183), G187 (= G184), V189 (= V186), T191 (= T188), L193 (= L190)
- binding 3-oxidanylidenepentanoic acid: Q95 (= Q92), S143 (= S140), N145 (≠ H142), K153 (= K150), Y156 (= Y153), Q197 (= Q194)
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
39% identity, 100% coverage: 1:258/258 of query aligns to 3:260/260 of 6zzqA
- active site: G17 (= G15), S142 (= S140), Y155 (= Y153)
- binding acetoacetic acid: Q94 (= Q92), S142 (= S140), K152 (= K150), Y155 (= Y153), Q196 (= Q194)
- binding nicotinamide-adenine-dinucleotide: G13 (= G11), S16 (= S14), G17 (= G15), I18 (= I16), D37 (≠ G35), M38 (≠ F36), D63 (= D61), V64 (≠ M62), N90 (= N88), A91 (= A89), G92 (= G90), M140 (≠ I138), A141 (= A139), S142 (= S140), Y155 (= Y153), K159 (= K157), Y187 (≠ W185), V188 (= V186), T190 (= T188)
3sjuA Hedamycin polyketide ketoreductase bound to NADPH (see paper)
38% identity, 97% coverage: 5:254/258 of query aligns to 1:251/255 of 3sjuA
- active site: G11 (= G15), S138 (= S140), Y151 (= Y153), K155 (= K157), Y196 (≠ R198)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G7 (= G11), S10 (= S14), A31 (= A39), R32 (≠ E40), D33 (≠ A41), C56 (≠ A60), D57 (= D61), V58 (≠ M62), S84 (≠ N88), A85 (= A89), G86 (= G90), I136 (= I138), Y151 (= Y153), K155 (= K157), P181 (= P183), G182 (= G184), Y183 (≠ W185), V184 (= V186), T186 (= T188), M188 (≠ L190)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
37% identity, 99% coverage: 2:256/258 of query aligns to 3:246/247 of 4jroC
- active site: G16 (= G15), S142 (= S140), Q152 (≠ K150), Y155 (= Y153), K159 (= K157)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G11), S14 (≠ T13), R15 (≠ S14), G16 (= G15), I17 (= I16), N35 (= N34), Y36 (≠ G35), N37 (≠ F36), G38 (= G37), S39 (≠ D38), N63 (≠ D61), V64 (≠ M62), N90 (= N88), A91 (= A89), I93 (= I91), I113 (= I111), S142 (= S140), Y155 (= Y153), K159 (= K157), P185 (= P183), I188 (≠ V186), T190 (= T188)
6zzpA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and 3-oxovalerate (see paper)
39% identity, 98% coverage: 2:255/258 of query aligns to 8:262/265 of 6zzpA
- binding nicotinamide-adenine-dinucleotide: G17 (= G11), S20 (= S14), G21 (= G15), I22 (= I16), D41 (= D38), I42 (vs. gap), M66 (≠ A60), D67 (= D61), V68 (≠ M62), N94 (= N88), A95 (= A89), G96 (= G90), M145 (≠ I138), S147 (= S140), Y160 (= Y153), K164 (= K157), P190 (= P183), F192 (≠ W185), V193 (= V186), T195 (= T188), L197 (= L190), V198 (= V191)
- binding 3-oxidanylidenepentanoic acid: Q98 (= Q92), S147 (= S140), H149 (= H142), K157 (= K150), Y160 (= Y153), F192 (≠ W185), Q201 (= Q194)
6zzoC Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from psychrobacter arcticus complexed with NAD+ and acetoacetate (see paper)
39% identity, 98% coverage: 2:255/258 of query aligns to 8:262/265 of 6zzoC
- binding acetoacetic acid: Q98 (= Q92), H149 (= H142), K157 (= K150), F192 (≠ W185), Q201 (= Q194)
- binding nicotinamide-adenine-dinucleotide: G17 (= G11), S20 (= S14), G21 (= G15), I22 (= I16), D41 (= D38), I42 (vs. gap), M66 (≠ A60), D67 (= D61), V68 (≠ M62), N94 (= N88), A95 (= A89), G96 (= G90), M145 (≠ I138), Y160 (= Y153), K164 (= K157), P190 (= P183), F192 (≠ W185), V193 (= V186), T195 (= T188), L197 (= L190), V198 (= V191)
7tzpG Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
37% identity, 99% coverage: 2:256/258 of query aligns to 6:246/247 of 7tzpG
- binding 1,4-dihydronicotinamide adenine dinucleotide: G15 (= G11), R18 (≠ S14), G19 (= G15), I20 (= I16), D39 (vs. gap), R40 (vs. gap), C63 (≠ A60), I65 (≠ M62), N91 (= N88), G93 (= G90), I94 (= I91), V114 (≠ I111), Y155 (= Y153), K159 (= K157), I188 (≠ V186), T190 (= T188), T193 (≠ V191)
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
33% identity, 100% coverage: 1:257/258 of query aligns to 2:247/248 of 6ixmC
- active site: G16 (= G15), S142 (= S140), Y155 (= Y153), K159 (= K157)
- binding nicotinamide-adenine-dinucleotide: G12 (= G11), S15 (= S14), G16 (= G15), I17 (= I16), D36 (≠ G35), I37 (≠ F36), A61 (= A60), D62 (= D61), T63 (≠ M62), N89 (= N88), A90 (= A89), M140 (≠ I138), S142 (= S140), Y155 (= Y153), K159 (= K157), P185 (= P183), A186 (≠ G184), Y187 (≠ W185), I188 (≠ V186), L192 (= L190)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
35% identity, 98% coverage: 2:255/258 of query aligns to 6:240/243 of 4i08A
- active site: G19 (= G15), N113 (= N112), S141 (= S140), Q151 (≠ K150), Y154 (= Y153), K158 (= K157)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G11), S17 (≠ T13), R18 (≠ S14), I20 (= I16), T40 (≠ D38), N62 (vs. gap), V63 (vs. gap), N89 (= N88), A90 (= A89), G140 (≠ A139), S141 (= S140), Y154 (= Y153), K158 (= K157), P184 (= P183), G185 (= G184), T189 (= T188)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
34% identity, 98% coverage: 2:255/258 of query aligns to 6:244/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G11), S17 (≠ T13), R18 (≠ S14), I20 (= I16), T40 (≠ D38), N62 (vs. gap), V63 (vs. gap), N89 (= N88), A90 (= A89), I92 (= I91), V139 (≠ I138), S141 (= S140), Y154 (= Y153), K158 (= K157), P184 (= P183), G185 (= G184), I187 (≠ V186), T189 (= T188), M191 (≠ L190)
8dt1C Crystal structure of a putative d-beta-hydroxybutyrate dehydrogenase from burkholderia cenocepacia j2315 in complex with NAD
37% identity, 100% coverage: 2:258/258 of query aligns to 2:259/259 of 8dt1C
- binding nicotinamide-adenine-dinucleotide: G11 (= G11), S14 (= S14), G15 (= G15), I16 (= I16), D35 (≠ G35), L36 (≠ F36), M60 (≠ A60), V62 (≠ M62), N88 (= N88), A89 (= A89), M139 (≠ I138), Y154 (= Y153), K158 (= K157), P184 (= P183), G185 (= G184), F186 (≠ W185), V187 (= V186), T189 (= T188)
Query Sequence
>RR42_RS06570 FitnessBrowser__Cup4G11:RR42_RS06570
MLKGKTALVTGSTSGIGLGIAQALAAQGANIIVNGFGDAEAAKREIAQAGAGIRVGYHGA
DMSKSAEIEDMMRYADAEFGGADILVNNAGIQHVANIEDFPPERWDAIIAINLTSAFHTT
RLALPGMKRKDWGRIINIASAHGLVASAQKSAYVAAKHGIVGLTKVTALETAQTGVTANA
ICPGWVLTPLVQKQVEARAQKDGIPVEQAKHELVIEKQPSGQFVTPDELGALAVFLASDA
ARQVRGVAWNMDGGWVAQ
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory